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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 1,648 Documents
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Air movement, gender and risk of sick building headache among employees in a Jakarta office
Medical Journal of Indonesia Vol. 12 No. 3 (2003): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i3.109

Abstract

Even though office buildings are usually equipped with ventilation system or air conditioning to create a comfortable working environment, yet there is still found a number of sick building syndrome (SBS) symptoms. One of the symptoms of SBS is SBS headache. Therefore, it is crucial to identify risk factors related to SBS headache. Cases were subjects who have suffered SBS headache, and controls were subjects who did not suffered headache for the last one month. Cases and controls were selected through a survey on all of employees in the said office during the period of May to August 2002. Total respondents were 240 employees including 36 people suffered SBS headache (15%). Compared to the normal air movement, faster air movement decreased the risk of SBS headache by 57% [adjusted odds ratio (OR) = 0.43; 95% confidence intervals (CI): 0.19-0.95]. Female employees, compared to the males ones, had a higher risk of getting SBS headache by almost three times (adjusted OR = 2.96: 95% CI: 1.29-6.75). Employees who had breakfast irregularly, had a lower risk to SBS headache than those who have breakfast regularly (adjusted OR=0.31; 95% CI: 0.09-0.84). Temperature, humidity and smoking habits were not noted correlated to SBS headache. Female workers had greater risk of suffering SBS headache. In addition slower air movement increased the risk of SBS headache. Therefore, it is recommended to improve the progress of air in order to reduce the risk of SBS headache, especially for female workplace. (Med J Indones 2003; 12: 171-7)
The expression of follicle-stimulating hormone receptor in ovary and testis
Medical Journal of Indonesia Vol. 12 No. 3 (2003): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i3.110

Abstract

Follicle-stimulating hormone receptor (FSHR) is exclusively expressed in granulose cells of the ovary and Sertoli cells of the testis.The highly cell-specific of gene expression revealed that transcriptional events unique to these two cell types areresponsible for activation of the FSHR gene. Even though its mechanisms are still unclear, several progress regarding the mechanism that control its basal transcription and regulation has been made. It has been identified several important elements that responsible for the transcription of the TATA-less FSHR gene such as: E box element (CACG(A)TG, –124/–119), an inverted GATA (TATC, –88/–85), E2F (TTTCGCG, –45/–39), and regulator element-3 (–197/–171). The functional studies shown that mutations through these regulatory elements significantly decrease the promoter function with greatest impact detected when mutation was done in E-box element. The site-specific CpG methylation within the core promoter seems play an important role in the regulation of rat and mouse FSHR gene expression. (Med J Indones 2003; 12: 187-93)
The use of 17β Estradiol gel and progestogen tablet for hormone replacement therapy (HRT) in menopause
Medical Journal of Indonesia Vol. 12 No. 3 (2003): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i3.111

Abstract

The treatment and prevention of disease in menopausal women due to deficiency of estrogen hormone are done through the administration of estrogen hormone, known as hormone replacement therapy (HRT). The administration of HRT is commonly done through the administration of tablets. However, the administration of tablet will result in metabolism in the colon and liver. Tablets are usually used on a daily basis such that it may lead to boredom and results in gastrointestinal disorder. The administration of gel, on the other hand, is done by applying the gel to the body and therefore metabolism in the colon and liver can be prevented. In women with uterus, estrogen must be combined with progestogen. The type of progestogen recommended is the one with natural derivative and which possesses antimineralocorticoid properties, such that fluid retention can be avoided. One of the types of progestogen which does not result in fluid retention is nomogestrol acetate. Nomogestrol acetate will also inhibit 17β hydrosisteroiddehydrogency enzyme type 1, such that estradiol (E2) is prevented from being transformed into estron (E1). As a result, E2 level in the breast tissue is kept at minimum, thereby reducing the risk of breast cancer. (Med J Indones 2003; 12: 194-8) Keywords: , ,,,
Clinical Manifestation of Acute Myocardial Infarction in the Elderly
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.112

Abstract

A retrospective study were performed in patients with acute myocardial infarction (AMI) that hospitalized in ICCU Cipto Mangunkusumo hospital, Jakarta during the period of January 1994 until Decmber 1999. There were 513 patients hospitalized with MCI, 227 patients (44.2%) were classified as elderly, and 35.2% of them were female. Most of the elderly AMI patients reported typical chest pain just like their younger counterparts. Elderly AMI patients tend to come later to the hospital, and more Q-wave myocardial infarction were identified compared to non- Q-wave myocardial infarction. Risk factors of diabetes mellitus and hypertension were more common among the elderly. The prevalence of atrial fibrillation and the mortality rate were higher among elderly AMI patients. (Med J Indones 2003; 12: 229-35)
Effect of Hormone Replacement Therapy (HRT) and low-dose combined oral pill on skin thickness, lipid profile and blood chemistry of menopausal women
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.113

Abstract

This study to evaluate the effect of hormone replacement therapy ( HRT ) and low-dose combinated oral pill on skin thickness , lipid profile and blood chemistry on menopausal woman.This study was carried out in one year randomized prospective study. 36 women were divided into 18 women receiving HRT and the other 18 receiving low-dose oral pill. The result of this study showed an increase in skin thickness (collagen) in both groups. But Those received low dose oral pill showed more . The increase of the skin thickness can prevent osteoporosis. The administration of HRT or low-dose oral pill could cause allteration in blood lipip profile and blood chemistry. But The changes were still within in normal limit. The administration of low-dose oral pill can be considered in postmeno-pausal women. (Med J Indones 2003; 12: 224-8)
Renal impairment in β thalassemia major patients receiving repeated blood transfusion
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.114

Abstract

β-thalassemia major is a disease caused by β polypeptide chain synthesis disorder which is inherited in an autosomal recessive manner from both parents and which is marked by little or no β-globin chain synthesis. Treatment for β-thalassemia major patients is by giving repeated blood transfusions, which causes iron accumulation, leading to hemochromatosis. Iron accumulation can occur in various body organ, including the kidneys. The aim of this study was to investigate the existence of renal impairment in β-thalassemia major patients. The subjects of this study were β-thalassemia major patients aged 15 - 28 years old who had received 6 units of packed red cells or more within 6 months. In this study, urine and serum samples of the subjects were taken and examined. Assay of serum iron was performed with Hitachi 737. Results were that 94.7% patients showed an increase in transferrin saturation and 40% of them had hemochromatosis; 73.4% had microalbuminuria; 1.3% had albuminuria and 21.3% had increased urinary β2- microglobulin (β2-m). A total of 78.6% of patients showed renal impairment. Conclusion of this study suggested that glomerular dysfunction happens in an earlier stage of the disease process. The high incidence of microalbuminuria is also attributed to defective ability of the proximal tubular cells to reabsorb protein besides dysfunction of the glomeruli. (Med J Indones 2003; 12: 215-223)
Rhabdomyolysis in Indonesian marathon athlete
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.115

Abstract

Serum and urine myoglobin assessments were conducted on 37 national marathon athletes who participated in the Asian Marathon III & Proklamaton XV. Three athletes showed a myoglobin value of < 50 ug/L and the other 34 athletes showed a myoglobin value of 211-3300 ug/L. Rhabdomyolysis were only found in 2 athletes, thus the prevalence of rhabdomyolysis is 6.1%. A correlation was found between myoglobinemia value and the athlete’s performance. (Med J Indones 2003; 12: 207-14)
The correlation between high sensitivity C-Reactive Protein level and the Extent of Coronary Lesion and Cardiac Systolic Function in Coronary Heart Disease
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.116

Abstract

To determine the mean value of high sensitivity C-Reactive Protein (hs-CRP), association between plasma level of hs-CRP with extent of disease and systolic function. A cross sectional study had been conducted to 106 coronary artery disease patients (90 stable angina pectoris, 11 unstable angina pectoris and 5 acute myocardial infarction). Plasma quantitative level of hs-CRP with cor angiography to determine extent of disease and ejection fraction were measured. The mean of hs-CRP levels in patients with SVD were 5,5 ± 7,6 mg/L, DVD were 6,6 ± 21,7 mg/L and TVD were 5,5 ± 8,0 mg/L and p=0,056, respectively. There were no significant association between hs- CRP levels with extent of disease. Systolic function had negative correlation with levels of hs-CRP (p=0,015, r=-0,235). This study showed that plasma level of hs-CRP cannot reflect the extent of disease, and it had negative correlation with systolic function. (Med J Indones 2003; 12: 201-6)
Fermentation of phytic acid from lamtoro gung seeds (Leucaena leucocephala) to produce inositol and tannin as pharmaceutical commodity
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.117

Abstract

The research was done to define the effect of tempe yeast concentration on inositol and tannin contents of fermented lamtoro gung seeds (Leucaena leucocephala). This is a research with completely randomized design using four doses of tempe yeast, i.e. 0 %, 5 %, 10 %, and 15 %. Each treatment was replicated 4 times. The resulted data were analyzed by analysis of variance and the significant differences were tested by least significantly difference test. Tannin was analyzed by Lowenthal-Procter method. The result of the research showed that the treatment had significant effects (P<0.05) on the parameter measured. The highest inositol with lowest tannin contents were found by using 15 % tempe yeast and duration of fermentation 96 hours, that is 0.2631 %. (Med J Indones 2003; 12: 236-42)
High protein and iron-folate crackers supplementation on the iron status of pregnant women
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.118

Abstract

Previous studies have revealed that several factors influenced the relatively low success of iron supplementation for pregnant women. The factors included poor distribution, low coverage and compliance, as well as low absorption. The aim of this study is to measure the iron status of pregnant women after consuming crackers containing fish powder and iron-folate. This study was carried out in the Purworejo district (Central Java) from February through October 2002. Using a randomized controlled trial (RCT) design, 70 pregnant women in their second-third month of pregnancy were recruited, and divided into two groups. Ten women dropped out during the study. The first group consisted of 28 women were given protein – iron enriched crackers (PIEC group), while the second group of 32 women were given iron–enriched crackers (IEC group) for a total of 12 weeks. The results showed that the hemoglobin (Hb) levels and serum transferrin receptors (sTfR) of both groups were increased. Serum ferritins (SF) of both groups were decreased. At the end of the study, the increase in Hb and sTfR levels between the two groups were significantly different, while the decrease in SF was not significantly different. Animal protein from fish powder tended to improve absorption of non-heme iron among pregnant women, resulting in improved Hb and sTfR levels. (Med J Indones 2003; 12: 243-6)

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