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Diah Ayu Maharani
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Faculty of Dentistry Universitas Indonesia Jl. Salemba Raya No. 4, Jakarta 10430
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INDONESIA
Journal of Dentistry Indonesia
Published by Universitas Indonesia
ISSN : 16939697     EISSN : 23554800     DOI : 10.14693/jdi
Core Subject : Health,
Dentistry
Journal of Dentistry Indonesia (JDI) is a scientific journal that is published three times annually (April, August and December). This journal aims for continuous dissemination of updates in relation to dentistry and its related fields in the form of original articles, case reports and reviews. Its first publication was in 1993, under the name of Majalah Kedokteran Gigi Indonesia, published by the Faculty of Dentistry Universitas Indonesia. All submitted manuscripts are subjected for double-blind peer reviews and editorial reviews processes before being granted acceptance. The Editors welcome manuscripts in the following key thematic areas in oral and maxillofacial sciences: Cariology Community Dentistry and Oral Epidemiology Conservative Dentistry Dental Biomaterial Dental Education Dental Traumatology Endodontics Esthetic Dentistry Healthcare Economics Implant Dentistry Oral Biosciences Oral and Maxillofacial Surgery Oral Medicine Oral Microbiology Oral Pathology Oral Radiology Oral Rehabilitation Orthodontics Pediatric Dentistry Periodontology and Periodontal Medicine
Arjuna Subject : Kedokteran Gigi - Kedokteran Gigi (Lain-Lain)
Articles 333 Documents
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Matrix Metalloproteinase-9 (MMP-9) Levels in Dentinal Fluid as a Diagnostic Biomarker for Irreversible Pulpitis Megantoro, Aryo; Wairooy, Valeria Widita; Meidyawati, Ratna; Bachtiar, Endang Winiati
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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Abstract

Objective: Pulpitis is an inflammatory condition of the dental pulp. The inflammatory status can be accurately assessed by histological examination. Biomarkers, such as matrix metalloproteinases (MMPs), are effective indicators of inflammation severity. Among these, matrix metalloproteinase-9 (MMP-9) has emerged as a key mediator of inflammatory processes associated with pulpitis. However, its clinical application as a biomarker remains limited owing to challenges in its extraction. This study aimed to evaluate the effectiveness of MMP-9 extracted from the dentinal fluid as a biomarker for pulpitis. Methods: Dentinal fluid was collected using the blunt tip of a sterile paper point, following clean excavation of the cavities. The paper point was placed in a sterile tube containing phosphate-buffered saline (PBS) and stored at −20 ºC. MMP-9 levels were analyzed using enzyme-linked immunosorbent assay (ELISA). Results: MMP-9 was detected in three of four patients diagnosed with irreversible pulpitis. Kruskal-Wallis test revealed a statistically significant difference in MMP-9 levels in the irreversible pulpitis group (p < 0.05). Conclusion: MMP-9 in dentinal fluid is a potential biomarker for irreversible pulpitis. However, further research is required to validate their diagnostic utility in clinical practice.
The Cytotoxicity and Anti-Inflammatory Properties of 1’s-1’-Acetoxychavicol Acetate (Aca) on Oral Cells Sabri, Nur Umairah Atiqah; Muhammad Zahidan, Nor Syazwani; Said, Zulfahmi; Adnan, Siti Noor Adnalizawati; Ab Malik, Normaliza
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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Abstract

Objective: Mouthwash is widely used to maintain oral health by reducing the prevalence of pathogenic microbiomes. Nonetheless, chlorhexidine, a common active ingredient, is associated with side effects including teeth staining, mucosal peeling, mouth and tongue numbness. This has prompted interest in natural alternatives. This study aimed to identify the cytotoxicity and anti-inflammatory properties of 1’S-1’-acetoxychavicol acetate (ACA) isolated from Alpinia conchigera rhizome against human primary gingival fibroblast and keratinocyte (HPGF and HPGK). Methods: Cytotoxicity of ACA (1.57 mg/mL) against HPGF and HPGK was assessed using the MTT assay. Meanwhile, the anti-inflammatory property of ACA was analyzed based on the concentration of interleukin-6 (IL-6) and lactate dehydrogenase (LDH) synthesized by HPGF and HPGK in response to injury stimulation by lipopolysaccharide (LPS). Results: Treatment with ACA was non-cytotoxic to HPGF and HPGK, with cell viability maintained above 80% after 24 hours. In addition, ACA showed anti-inflammatory activity by reducing the concentration of IL-6 and LDH produced by HPGF and HPGK in response to LPS, reflecting the ACA possibly protecting the cells from inflammation. Conclusion: ACA isolated from A. conchigera rhizome demonstrated non-cytotoxic and anti-inflammatory properties in oral epithelial cells, suggesting its potential to be incorporated in the mouthwash.
Individualized Oral Care Using Photobiomodulation and Tailored Brushing Method in a Patient with Maxillofacial Trauma – A Case Report Reghunath, Shruthi; Ramesh, Roshni; Kumar, S Santhosh; Sasi, Anoop; Mohamed, Shahana C; Joy, Bilha; Jayasree, Aswathy
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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Abstract

Patients who report to the dental outpatient department following maxillofacial trauma often exhibit suboptimal oral hygiene, which is frequently attributed to challenges in sustaining oral care stemming from pain and restricted mouth opening after the injury. This case report aims to provide an individualized protocol of oral care and pain management for patients with maxillofacial trauma. Case report: A treatment protocol combining the Tailored Brushing Method (TBM), a personalized approach for at-home oral hygiene, and photobiomodulation using low-level laser was performed on a 24-year-old patient with maxillofacial trauma and poor oral hygiene. Results: The TBM is successful in achieving good patient adherence to at-home oral hygiene protocols. The results showed that the application of low-level laser soon after the trauma helped in pain control and augmented the patient’s compliance with the necessary procedures. This application was also shown to be effective in healing intraoral soft tissues. Conclusion: This case report highlights the TBM’s success in improving patient compliance and the effect of photobiomodulation in managing pain and enhancing the healing of soft tissues. In the precision periodontics era, this personalized oral care approach will offer significant therapeutic advantages in the management of patients with maxillofacial trauma.

Page 34 of 34 | Total Record : 333

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