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Diah Ayu Maharani
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Journal of Dentistry Indonesia
Published by Universitas Indonesia
ISSN : 16939697     EISSN : 23554800     DOI : 10.14693/jdi
Core Subject : Health,
Dentistry
Journal of Dentistry Indonesia (JDI) is a scientific journal that is published three times annually (April, August and December). This journal aims for continuous dissemination of updates in relation to dentistry and its related fields in the form of original articles, case reports and reviews. Its first publication was in 1993, under the name of Majalah Kedokteran Gigi Indonesia, published by the Faculty of Dentistry Universitas Indonesia. All submitted manuscripts are subjected for double-blind peer reviews and editorial reviews processes before being granted acceptance. The Editors welcome manuscripts in the following key thematic areas in oral and maxillofacial sciences: Cariology Community Dentistry and Oral Epidemiology Conservative Dentistry Dental Biomaterial Dental Education Dental Traumatology Endodontics Esthetic Dentistry Healthcare Economics Implant Dentistry Oral Biosciences Oral and Maxillofacial Surgery Oral Medicine Oral Microbiology Oral Pathology Oral Radiology Oral Rehabilitation Orthodontics Pediatric Dentistry Periodontology and Periodontal Medicine
Arjuna Subject : Kedokteran Gigi - Kedokteran Gigi (Lain-Lain)
Articles 343 Documents
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Matrix Metalloproteinase-9 (MMP-9) Levels in Dentinal Fluid as a Diagnostic Biomarker for Irreversible Pulpitis Megantoro, Aryo; Wairooy, Valeria Widita; Meidyawati, Ratna; Bachtiar, Endang Winiati
Journal of Dentistry Indonesia Vol. 32, No. 3
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Abstract

Objective: Pulpitis is an inflammatory condition of the dental pulp. The inflammatory status can be accurately assessed by histological examination. Biomarkers, such as matrix metalloproteinases (MMPs), are effective indicators of inflammation severity. Among these, matrix metalloproteinase-9 (MMP-9) has emerged as a key mediator of inflammatory processes associated with pulpitis. However, its clinical application as a biomarker remains limited owing to challenges in its extraction. This study aimed to evaluate the effectiveness of MMP-9 extracted from the dentinal fluid as a biomarker for pulpitis. Methods: Dentinal fluid was collected using the blunt tip of a sterile paper point, following clean excavation of the cavities. The paper point was placed in a sterile tube containing phosphate-buffered saline (PBS) and stored at −20 ºC. MMP-9 levels were analyzed using enzyme-linked immunosorbent assay (ELISA). Results: MMP-9 was detected in three of four patients diagnosed with irreversible pulpitis. Kruskal-Wallis test revealed a statistically significant difference in MMP-9 levels in the irreversible pulpitis group (p < 0.05). Conclusion: MMP-9 in dentinal fluid is a potential biomarker for irreversible pulpitis. However, further research is required to validate their diagnostic utility in clinical practice.
The Cytotoxicity and Anti-Inflammatory Properties of 1’s-1’-Acetoxychavicol Acetate (Aca) on Oral Cells Sabri, Nur Umairah Atiqah; Muhammad Zahidan, Nor Syazwani; Said, Zulfahmi; Adnan, Siti Noor Adnalizawati; Ab Malik, Normaliza
Journal of Dentistry Indonesia Vol. 32, No. 3
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Objective: Mouthwash is widely used to maintain oral health by reducing the prevalence of pathogenic microbiomes. Nonetheless, chlorhexidine, a common active ingredient, is associated with side effects including teeth staining, mucosal peeling, mouth and tongue numbness. This has prompted interest in natural alternatives. This study aimed to identify the cytotoxicity and anti-inflammatory properties of 1’S-1’-acetoxychavicol acetate (ACA) isolated from Alpinia conchigera rhizome against human primary gingival fibroblast and keratinocyte (HPGF and HPGK). Methods: Cytotoxicity of ACA (1.57 mg/mL) against HPGF and HPGK was assessed using the MTT assay. Meanwhile, the anti-inflammatory property of ACA was analyzed based on the concentration of interleukin-6 (IL-6) and lactate dehydrogenase (LDH) synthesized by HPGF and HPGK in response to injury stimulation by lipopolysaccharide (LPS). Results: Treatment with ACA was non-cytotoxic to HPGF and HPGK, with cell viability maintained above 80% after 24 hours. In addition, ACA showed anti-inflammatory activity by reducing the concentration of IL-6 and LDH produced by HPGF and HPGK in response to LPS, reflecting the ACA possibly protecting the cells from inflammation. Conclusion: ACA isolated from A. conchigera rhizome demonstrated non-cytotoxic and anti-inflammatory properties in oral epithelial cells, suggesting its potential to be incorporated in the mouthwash.
Individualized Oral Care Using Photobiomodulation and Tailored Brushing Method in a Patient with Maxillofacial Trauma – A Case Report Reghunath, Shruthi; Ramesh, Roshni; Kumar, S Santhosh; Sasi, Anoop; Mohamed, Shahana C; Joy, Bilha; Jayasree, Aswathy
Journal of Dentistry Indonesia Vol. 32, No. 3
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Abstract

Patients who report to the dental outpatient department following maxillofacial trauma often exhibit suboptimal oral hygiene, which is frequently attributed to challenges in sustaining oral care stemming from pain and restricted mouth opening after the injury. This case report aims to provide an individualized protocol of oral care and pain management for patients with maxillofacial trauma. Case report: A treatment protocol combining the Tailored Brushing Method (TBM), a personalized approach for at-home oral hygiene, and photobiomodulation using low-level laser was performed on a 24-year-old patient with maxillofacial trauma and poor oral hygiene. Results: The TBM is successful in achieving good patient adherence to at-home oral hygiene protocols. The results showed that the application of low-level laser soon after the trauma helped in pain control and augmented the patient’s compliance with the necessary procedures. This application was also shown to be effective in healing intraoral soft tissues. Conclusion: This case report highlights the TBM’s success in improving patient compliance and the effect of photobiomodulation in managing pain and enhancing the healing of soft tissues. In the precision periodontics era, this personalized oral care approach will offer significant therapeutic advantages in the management of patients with maxillofacial trauma.
Time and Dose Dependent Effects of Adipose-Derived Stromal Vascular Fraction Exosomes on Human Dental Pulp Stem Cell Proliferation Alinda, Sylva Dinie; Margono, Anggraini; Julianto, Indah; Bagio, Dini Asrianti
Journal of Dentistry Indonesia Vol. 33, No. 1
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Background: Cell proliferation is essential for tissue repair and immunomodulation in regenerative dentistry. Adipose-derived stromal vascular fraction (AD-SVF) is a promising autologous source for tissue engineering. Its exosomes (AD-SVF Exo), as cell-free products stable under ischemic conditions, represent an ethical and attractive modality for dental tissue regeneration and broader regenerative applications. Prior study indicates that AD-SVF Exo can enhance human dental pulp stem cell (hDPSC) migration and proliferation, particularly at low concentrations, but their detailed time- and dose-dependent proliferative effects remain unclear. This study aimed to investigate the time- and dose-dependent effects of low-concentration AD-SVF Exo on hDPSC proliferation in vitro. Methods: AD-SVF exosomes were isolated by size-exclusion chromatography and characterized by flow cytometry and nanoparticle tracking analysis, then applied to hDPSCs at multiple concentrations. Proliferation was evaluated using the Cell Counting Kit-8 assay. One-way ANOVA with LSD post hoc testing was performed (α = 0.05). Results: AD-SVF exosomes (mean size 103 ± 24 nm) expressed CD9 and CD63. All tested concentrations significantly increased hDPSC proliferation versus control in a time- and dose-dependent pattern, with lower doses generally producing the most favorable responses. Conclusions: AD-SVF exosomes enhance hDPSC proliferation in a time- and dose-dependent manner, supporting their potential as a cell-free adjunct in regenerative dentistry.
In Silico Model of Musa acuminata Stem as an Anticancer on Oral Squamous Cell Carcinoma against EGFR Rachmayani, Nevrila Dewi; Carabelly, Amy Nindia; Firdaus, I Wayan Arya Krishnawan; Apriasari, Maharani Laillyza; Utami, Juliyatin Putri
Journal of Dentistry Indonesia Vol. 33, No. 1
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Background: Oral squamous cell carcinoma (OSCC) is characterized by overexpression of the epidermal growth factor receptor (EGFR). Citral, eucalyptol, and caffeic acid phenethyl ester (CAPE), which are derived from Musa acuminata, have shown anticancer activity. This study evaluated the potential of citral, eucalyptol, and CAPE from Musa acuminata as anticancer agents for OSCC by targeting EGFR using an in silico approach. Methods: Potential biological activity was predicted using Prediction of Activity Spectra for Substances (PASS) Online. Molecular docking was conducted with AutoDock Vina, and BIOVIA Discovery Studio was used to analyze binding affinity, interaction types, and bond distances between the compounds and active-site residues of EGFR. Results: CAPE showed the strongest binding affinity (-8.6 kcal/mol), whereas citral and eucalyptol each showed a binding affinity of -5.4 kcal/mol. CAPE formed a conventional hydrogen bond with CYS775 at 2.65 Å and hydrophobic interactions with PHE856, LEU777, and MET766, through π-alkyl and π-π T-shaped interactions. These interaction distances were within the effective range of <3.5 Å, indicating a stable ligand-protein complex. Conclusions: These in silico findings suggest that CAPE derived from Musa acuminata is a promising anticancer candidate for OSCC through its interaction with EGFR.
Antibacterial and Antibiofilm Effects of Ziziphus mauritiana Leaf Extract Against Staphylococcus aureus Poedjiastoeti, Wiwiek; Rasad, Irvan Septrian Syah Putra; Tanzil, Felicia Klarissa; Gunardi, Indrayadi; Widyarman, Armelia Sari
Journal of Dentistry Indonesia Vol. 33, No. 1
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Background: Tooth extraction is a common dental procedure often complicated by postoperative infections, with Staphylococcus aureus as a key opportunistic pathogen. Rising antibiotic resistance and side effects of conventional antiseptics like chlorhexidine highlight the need for natural alternatives. This study evaluated the antibacterial and antibiofilm potential of 96% ethanol extract from Ziziphus mauritiana leaves against S. aureus. Methods: The extract was prepared by maceration and tested in vitro using microdilution for minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against S. aureus ATCC 25923. Antibiofilm activity was assessed via crystal violet staining on mature biofilms, with confirmation by qPCR-based absolute quantification of bacterial load using S. aureus-specific 16S rRNA primers. Statistical analysis included Shapiro–Wilk, ANOVA, and Tukey HSD tests. Results: The extract showed MIC between 125–250 mg/mL and MBC at 250 mg/mL. Concentrations of 1000, 500, and 250 mg/mL inhibited >80% biofilm biomass, comparable to 0.2% chlorhexidine. qPCR confirmed significant bacterial load reduction at 1000 and 500 mg/mL. Conclusions: Z. mauritiana leaf extract demonstrates promising antibacterial and antibiofilm activity against S. aureus, supporting its potential as a natural agent for managing post-extraction infections, though further studies on clinical isolates, cytotoxicity, and formulations are warranted.
Retrospective CBCT Evaluation of Missed Root Canals and Their Association with Periapical Lesions in a Makkah-based Population Alqahtani, Mashael; Mohamed Elsherief, Samia; Afifi, Ibtesam Kamel
Journal of Dentistry Indonesia Vol. 33, No. 1
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Background: Missed root canals are common and can cause persistent periapical disease, making the assessment of their prevalence essential for improving diagnostic accuracy and treatment outcomes. This study aimed to investigate the prevalence of missed canals and evaluate their association with periapical lesions in root canal–treated teeth in the Makkah population. Methods: This retrospective cross-sectional study analysed 815 cone-beam computed tomography scans obtained from Umm Al-Qura University between 2019 and 2024. Missed canals and their association with periapical lesions were assessed by two independent observers. Statistical analysis was performed using the chi-square test. Results: Missed canals were detected in 21% of maxillary and 14.2% of mandibular root canal–treated teeth. A highly significant association was observed among maxillary teeth (p < 0.001), whereas no statistically significant association was found for mandibular teeth (p = 0.25). Periapical lesions were present in 77.9% of maxillary teeth and 69.2% of mandibular teeth with missed canals. Conclusions: Missed canals are common in root canal–treated teeth in the Makkah diverse population and are strongly associated with a high prevalence of periapical lesions. Meticulous canal detection and consideration of population-specific anatomical variations are essential to reduce missed canals, prevent periapical pathology, and enhance endodontic treatment outcomes.
Comparison of ChatGPT, Claude AI, and Dental Students in the Detection of Artifacts on Panoramic Radiography Erol, Elif Çeçen; Aktuna Belgin, Ceren; Serindere, Gözde; Gunduz, Kaan
Journal of Dentistry Indonesia Vol. 33, No. 1
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Background: Accurate radiographic diagnosis requires images obtained with proper technique. Artifacts are unwanted irregularities or densities not produced by the primary X-ray beam and may obscure anatomical details in radiographic images. This retrospective study aimed to evaluate the performance of ChatGPT, Claude AI, and intern dental students in detecting artifacts in panoramic radiographs (PRs). Methods: Between January and December 2024, panoramic radiographs of 40 patients containing 74 artifacts (motion, mispositioning, airway/soft tissue, and foreign body/metal artifacts) were retrospectively evaluated. The artifact detection performance of ChatGPT-4.0, Claude AI 3.5 Sonnet, and intern dental students was subsequently evaluated and compared with the radiologist-defined gold standard. Results: Dental students demonstrated higher overall accuracy than both AI models in detecting artifacts on PRs. Among the LLMs, Claude AI showed higher accuracy than ChatGPT in detecting motion artifacts (65.0% vs 42.5%), foreign body/metal artifacts (90.0% vs 62.5%), and patient mispositioning (85.0% vs 67.5%), whereas ChatGPT performed better in identifying airway/soft tissue artifacts (87.5% vs 65.0%). Conclusions: ChatGPT and Claude AI demonstrated lower performance than dental students in detecting artifacts in panoramic radiographs. These findings suggest that human evaluation remains essential in radiographic interpretation, and further development of LLMs is needed for reliable clinical application.
Evaluation of an Audiovisual Educational Tool with Reinforcement Messages for Orthodontic Patients: A 6-Month Randomized Controlled Trial Restrepo Quijano, Laura; Vasco Gomez, Maria Paula; Hurtado Velasquez, Natalia; Benitez Moreno, Luis Fabian
Journal of Dentistry Indonesia Vol. 33, No. 1
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Background: Orthodontic treatment increases the risk of bacterial plaque accumulation; therefore, oral hygiene education is essential to prevent complications, but its impact is usually limited when it is not reinforced with effective tools. This study aims to evaluate an audiovisual educational tool with reinforcement messages, compared with a verbal explanation about the proper use of the orthodontic oral hygiene kit. Methods: This was a randomized controlled trial that included 62 patients randomly assigned to an intervention group: 31 patients who received an educational video plus three reinforcement messages via WhatsApp, and a control group: 31 patients who received a verbal explanation about orthodontic hygiene. Initial measurement of the O'Leary plaque index was performed, and the measurement was repeated 6 months later. Results: The intervention group showed a mean reduction of 31.16 points, compared to 7.67 points in the control group, with a mean difference between groups of 23.49 points (95% CI: 19.84 to 27.14; p < 0.001). Conclusions: The audiovisual educational tool with reinforcement messages was significantly more effective than the verbal explanation in improving oral hygiene in orthodontic patients.
Oral Health Behaviors and Oral Health Status in Elementary School Children in East Kalimantan, Indonesia Andayani, Lia Hapsari; Elisanditya, Amabelle; Soulisa, Abdul Gani; Lestari, Sri
Journal of Dentistry Indonesia Vol. 33, No. 1
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Background: Children's oral health can be influenced by various factors, including health behaviors, dietary patterns, and oral health knowledge. This study aimed to determine the correlation between oral health behaviors and oral health status in elementary school children. Methods: This cross-sectional study involved 182 elementary school children in Bontang, East Kalimantan, taken by convenience sampling. Health behavior data were acquired by 12-item questionnaires based on the WHO guideline. Examination of dental and oral health status was done by using the DMFT Index and OHI-S. Chi-square was used to determine the correlation between oral health behaviors and oral health status. Results: Majority of children had DMFT score index less than or equal to 8 (86.3%) and OHI-S score more than or equal to 1 (54.4%). There was a significant difference between age (p = 0.012) and the dental caries status of children. There was also a significant difference between consumption of biscuits (p = 0.018) and the dental caries status of children. Conclusions: Elementary school children in Bontang, East Kalimantan, still have poor oral health behaviors. Education on the importance of daily toothbrushing, regular dental visits, healthy eating habits, and the use of fluoride-containing toothpaste still needs to be improved.

Page 34 of 35 | Total Record : 343

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