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Nexus Biomedika
Published by Universitas Sebelas Maret
ISSN : -     EISSN : -     DOI : -
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
Arjuna Subject : -
Articles 292 Documents
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Pengaruh Pemberian Ekstrak Kulit Manggis (Garcinia mangostana, Linn.) dalam Mencegah Peningkatan Kadar Kreatinin Darah pada Tikus (Rattus norvegicus) yang Diinduksi Gentamisin Surya Adhi Prakoso; Endang Sri Hardjanti; Nur Hafidha Hikmayani
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Gentamicin may cause nephrotoxicity and inhibits blood creatinine excretion. Xanthone from mangosteen pericarp has antioxidant and antiinflammation effects and can potentially protect kidney from inflammatory-mediated gentamicins nephrotoxicity. Gentamicin-induced renal damage can be identified from the elevation of blood creatinine levels. The purpose of this research was to find the potential of mangosteen pericarp extract to prevent the elevation of blood creatinine levels. Methods: This was an experimental research with pre and posttest controlled group design. Samples were 30 male Wistar-strain rats, 2-3 months old with approximately 200 gram of weight. Samples were randomly divided into 3 groups:control group (KN) administered Na CMC 0.5% orally, negative control group (K-) administered gentamicin 100 mg/kgBW intraperitoneally, and treatment group (KD) administered gentamicin 100 mg/kgBW intraperitoneally and 125 mg/kgBW mangosteen pericarp extract orally. Blood creatinine levels were assessed before treatment and 10 days after treatment by spectrophotometer. Data collected were analysed by Kruskal-Wallis and Mann-Whitney tests. Results: There was significant difference of blood creatinine levels before and after treatment among the three groups (p<0.001). Mann-Whitney tests showed statistically significant differences of creatinine level between KN-K- and KD-K- (p<0.001). No significant difference of blood creatinine levels was found for KN-KD comparison(p=0.06). Conclusion: Mangosteen pericarp extract at dose of 125 mg/kgBW prevented the elevation of blood creatinine levels in Wistar rats induced by gentamicin. Keywords: mangosteen pericarp extract, gentamicin, blood creatinine level
Hepatoprotector effect of Sesbania grandiflora L flowers extract to Liver Cell Structure Damage of Mice caused by Over Reheated Palm Oil Rizka Abida Fastiati; Endang Listyaningsih; Yusuf Mashuri
Nexus Biomedika Vol 4, No 2 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background:Sesbania grandiflora L flower has high antioxidant activity. This activity is caused by phytochemical ingredients of Sesbania grandiflora L flower, such as vitamin C, flavonoids and tannin. The aims of this research were to know the hepatoprotector effect of Sesbania grandiflora L flowers extract to the liver cell structure damage of mice caused by over reheated palm oil and to find out dose escalation of Sesbania grandiflora L flowers extract that can enhance the effect. Methods:This research was laboratory experimental study with the post-test only controlled group design. The tested animal used in this experiment were male mice, Swiss webster strain.The research population were 30 male mice divided into 5 groups, each group consisted of 6 mice. The negative control group (KKn) was given distilled water, while the positive control group (KKp) was given over reheated palm oil. The 1st treatment group (KP1), the 2nd treatment group (KP2) and the 3rd treatment group (KP3), all, were given Over Reheated Palm Oil as much as 0.06 ml/ 20 gr BW andSesbania grandiflora L flowers extract with dose 7 mg, 14 mg and 28 mg per 20 gr BW of mice, consecutively. The liver histological images were assessed by the sum of the cell nuclear pyknosis, karyorrhexis, and karyolysis. Data were analyzed by using One-Way ANOVA test and Post Hoc Test (LSD) (?=0.05). Results:One-Way ANOVA test showed that p value was 0.000 (p < 0.05).The results of the post hoc multiple comparisons test showed the significant differences between group KKn-KKp, KKn-KP1, KKn-KP2, KKn-KP3, KKp-KP1, KKp-KP2, KKp-KP3, KP1-KP2, KP1-KP3, and KP2-KP3 Conclusions:Sesbania grandiflora L flowers extract has a protective effect on liver cell structure damage of mice (Mus musculus) caused by over reheated palm oil and the escalated dose of Sesbania grandiflora L flowers extract can enhance the effect. Keywords:Histological structure of liver damage, over reheated palm oil, Sesbania grandiflora L.

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