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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 14 Documents
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Search results for , issue "Suppl. 4, No. 1 (2022)" : 14 Documents clear
Radiochemical Purity Test of Fractionated Sestamibi Kit Labelled with Technetium-99m Hasna Chaerunisa; N. Elly Rosilawati; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.33332

Abstract

Coronary Heart Disease (CHD) is a heart disorder caused by blockage of blood vessels. CHD can bedetected by Myocardial Perfusion Imaging (MPI). MPI is performed by injecting a radiopharmaceuticalinto the patient's body. 99mTc-sestamibi is a radiopharmaceutical that is commonly used in MPI.Sestamibi is available in the form of a multidose vial, but the cost of the examination will be expensiveif it is only used for one patient. Cost effectiveness can be increased by fractionating the sestamibi kitbefore labelled by 99mTc. 99mTc-sestamibi needs to be tested for quality control before it is administeredto the patients. One of the tests is the radiochemical purity test. The aim of this study was to determinethe radiochemical purity of the fractionated sestamibi kit labelled by 50 mCi 99mTc. 2 vials of sestamibikit were fractionated by adding 5 mL of 0.9% NaCl solution to each vial and divided into 10 new vials.Radiochemical purity was measured using the thin layer chromatography (TLC) method. The resultsof this study indicated that all samples had radiochemical purity of 100% up to 6 hours after labelling.
Molecular Docking Study: Phyllanthus niruri L.'s Active Compounds as Dengue Haemorrhagic Fever Therapy Riska Prasetiawati; Silviyanita Isna Seftila; Benny Permana; Novriyanti Lubis
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.42824

Abstract

Dengue Haemorrhagic Fever is a disease caused by the dengue virus through a mosquito vector Aedesaegypti. NS3 Helicase is known as one of nonstructural proteins consisting of some essential enzymesfor virus replication. Nowadays ivermectin has been developed as an anti-dengue haemorrhagic feverwith therapy target NS3 Helicase. The therapeutics drug for dengue haemorrhagic fever has not beenfound specifically. Methanol extract of meniran (Phyllanthus niruri L.) reported the activity to denguevirus with a concentration of 15,63 μg/mL. This research aimed to study the interactions and affinityof the active compound of meniran with the receptor (NS3 Helicase) and to know ADME and toxicityprofile. From 56 active compounds of meniran, there was one best candidate as dengue haemorrhagicfever therapy which has energy binding (ΔG) and Inhibition Constanta (IC) lower than native ligandand ivermectin, it is nirurin with energy binding -4.87 kcal/mol. These candidate compounds havegood absorption and distribution profiles so they are thought to be candidates for dengue fever therapyby targeting the NS3 Helicase receptor which is better than ivermectin and native ligands.
Antihyperuricemia Activity Of Kupa (Syzygium polycephalum) Seed Extracts In Male White Mice Ira Rahmiyani; Trian Nur'aripin; Anisa Pebiansyah; Resha R. Shaleha
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.42882

Abstract

Hyperuricemia is a clinical condition of increasing uric acid in the blood beyond normal. Increasedlevels of uric acid can accumulate monosodium urate crystals. Kupa fruit seeds contain flavonoids,saponins, tannins, and polyphenols which have antihyperuricemia activity. This study aims todetermine the best antihyperuricemia activity of several kupa seed extracts. The study was conductedin vivo using male white mice. Negative, positive, n-hexane extract, ethanol extract, and ethyl acetateextract were induced by acetylsalicylic acid 5.04 mg/20gBW of mice and fructose 67.2 mg/20gBWof mice orally for 3 days. On the 3rd day of treatment, the positive group was given allopurinol 0.997mg/20gBW and the 3 test groups were each given a different extract of 1.82 mg/20gBW mice orallyfor 7 days. The results showed the ethanol extract of Kupa fruit seeds had the best antihyperuricemiaactivity with a decrease in uric acid levels of 68.29%. Based on the results, the group of mice treatedwith ethanol extract had significantly different activity from the negative control group p <α (0.015<0.05). The ethanol extract showed the best antihyperuricemia activity approaching allopurinol as apositive control.
Antioxidant Activities of Scrub Body Lotion Extract of Surian Leaves (Toona sinensis) with Powder Scrub Date Seeds (Phoenix dactylifera) Uce Lestari; Yuliawati Yuliawati; Fathnur Sani; Yuliana Yuliana; Muhaimin Muhaimin
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.42828

Abstract

Free radicals from exposure to ultraviolet radiation (UVB) cause dull, rough, dry, cracked skin andpremature aging so that they can damage skin tissue and result in fatal skin cancer. To prevent this,antioxidants are needed. Plants that have potential as antioxidants are Surian leaves and date seedswhich contain lots of flavonoids and phenolics. To make it easier to use, it is processed into a scrubbody lotion using a date seed powder scrub (Phoenix dactylifera). This study aimed to find a scrubbody lotion formula that has the best physical properties and is stable during storage and the bestformula has the strongest antioxidant activity. Each formula contains ethanol extract of Surian leaves(Toona sinensis) with a concentration of 0.1%; 0.3%; 0.5%; 0.7%; 0.9%. After that, an evaluationof the physical properties of scrub body lotion preparation was carried out. From the results of theevaluation of the physical properties of the best scrub body lotion preparations, stable in storage andhedonic tests and safe for irritation tests, formula 5 contains ethanol extract of surian leaves with aconcentration of 0.9% and has an antioxidant activity of IC50 28,554 ppm with a very strong category.
Antibacterial Activities of Guava Leaves and Klutuk Banana by In Vitro as Antidiarrhea Ira Rahmiyani; Anna Yuliana; Mitha Anggitha; Vera Nurviana
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.42944

Abstract

Klutuk banana fruit and red shoots of guava leave added with salt used by Batra in Jayaratu SingaparnaVillage to treat diarrhea. The green shoots of guava used by the community in treating diarrhea thanklutuk bananas. This study aims to compare the activity of klutuk banana flesh (K) and red shoots ofguava leaves (M) with the addition of salt (G), which Batra commonly uses with green shoots of guavaleaves (H) used by the general public and their combinations to inhibiting Escherichia coli bacteria.This study was conducted in vitro with Simplicia test samples of guava leaf shoots and banana klutukcharacterized. Each sample was crushed, and the extract was taken and tested for antibacterial activity.Data analysis used One Way Analysis of Variant (Anova) and continued with the Least SignificantDifference (LSD) test. The results showed that samples M, H, K, HG, MHG, and MH providedresistance to E. coli ATCC 25922 with a significance value of 0.000 (p<0.05), whereas the HG and Hgroups did not show a significant difference (P >0.05). The red and green shoots of guava leaves, singlyor in combination have potent antibacterial activity. The variety of red shoots and green leaves of guavawith a mixture of salt (MHG) concentration of 100% (1:1:1) had the highest MIC value compared tothe other groups.
Molecular Docking and Toxicity from Temulawak Rhizome (Curcuma xanthorrhiza Roxb.) against COX-2 Meilinda setya praceka; Ellen N. Yunita; Cleopatra D. Semesta; Refitha N. Putri; Nazwa N. Mikdar; Elsa N. Sitinjak; Luthfi U. Setyawati; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.43808

Abstract

Temulawak rhizome (Curcuma xanthorrhiza Roxb.) is a rhizome that comes from the Zingiberaceaetribe. Temulawak rhizome is commonly used as a traditional medicine in Indonesia as an antiinflammatory.The purpose of this study was to provide information on the potential of temulawakrhizome as a COX-2 inhibitor drug candidate and its toxicity to shrimp larvae (Artemia salina Leach.).The methods used are Lipinski Rule of Five prediction, PreADMET, molecular docking, pharmacophorescreening, and BSLT toxicity test. The results obtained show that the lowest Gibbs energy is producedby curcumin (-9.65 kcal/mol), has a pharmacophore hit value, meets the Lipinski rule of five, predictsa good pharmacophore profile, but curcumin has mutagenic properties and is classified as toxic afterbeing tested. with the BSLT method. So that it can be concluded that curcumin has the potential tobecome an anti-inflammatory drug, but further studies are needed and modifications to the molecularstructure of the compound can be carried out so that the tested compound can produce better activity.
Formulation And Characterization Of Buccal Film Nanoemulsion Apigenin As Antidiabetic Ardianes Firmansya; Fajar Setiawan; Lusi Nurdianti; Anna Yuliana
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.42829

Abstract

Apigenin (4`,5,7-trihydroxyflavone) is a flavonoid of subclass flavones that have antidiabetictherapeutic activity but limitations BCS Class II low solubility of 2.16 μg/L. To overcome theselimitations, the development of nanoemulsion formulation technology, increasing solubility increasesdissolution, absorption and bioavailability. It is incorporated into the buccal film for easy applicationand direct access to the systemic circulation. This study aims to obtain apigenin nanoemulsion withthe best characterization and buccal film that meets the characterization. The method was carried outexperimentally in the manufacture of nanoemulsions by spontaneous emulsification, a buccal filmby solvent casting, and the characterization. 10 nanoemulsion formulas met the characterizationwith globule size <20.34nm, polydispersity index <0.131, zeta potential close to 0mV, pH 6.23-6.59, %transmittance close to 100% and best F10 incorporated into buccal film has 29x the solubilitycompared to apigenin with p≤0.05. All buccal films met the characterization with F3 having a 2x fasteronset of release than F1&F2 with 86.07% diffusion and 97.9333 mg/sheet. Thus, it was concludedthat the formulation and characterization of buccal film fulfilled the characterization and F10 apigeninnanoemulsion increased the solubility 29-fold with the buccal film F3 having a faster onset of release.
Formulation of Peel-off Gel Face Mask from Pandanus amaryllifolius (Roxb.) Leaves Extract Tubagus Akmal; Yenni P. Tanjung; Sofa P. Nurlaela
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.43015

Abstract

UV exposure is the most significant environmental risk factor that can be altered for skin cancer andmany other skin conditions. An antioxidant is a compound that can protect the skin from sun radiation.Pandanus amaryllifolius is a plant that has antioxidant activity because it contains polyphenols. Theobjective of this study is to formulate a pandan Wangi leaf extract peel-off gel facial mask and analyzehow variations in the extract's concentration affect the physical and chemical evaluation. In this study,three formulas were made with varying concentrations of extract, namely F1 (1%), F2 (3%), and F3(5%). The preparation was evaluated for 28 days at a controlled room temperature (180C-300C+20C).The evaluation carried out included a physical evaluation (organoleptic, spreadability, homogeneity,viscosity, dry time) and a chemical evaluation (pH). The results showed that F1, F2, and F3 met therequirements for physical and chemical evaluation. Variations in the concentration of Pandan Wangileaf extract had a significant effect (p<0.05) on the results of the preparation evaluation which includedorganoleptic, spreadability, and viscosity. While for the evaluation of homogeneity, dry time, and pHdid not show significant results (p> 0.05). These results indicate that pandanus leaf extract (Pandanusamaryllifolius Roxb.) can be formulated into a peel-off gel facial mask.
Physical Stability of Sea Buckthorn Oil Nanoemulsion with Tween 80 Variations Ayu Shabrina; Icha Sabrina Milenia Khansa
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.42809

Abstract

Sea buckthorn oil (SBO) contains fatty acids that have an anti-aging effect. The delivery system ofSBO can be improved by a nanoemulsion system. The purpose of this study was to determine thephysical stability of SBO nanoemulsion (NSB) with Tween 80 variation. NSB was made with 1% SBOand Tween 80 variation of 35% (FI); 40% (FII) and 45% (FIII). NSB was stored in a climatic chamberat 30 ± 2°C and RH of 65%±5% for 90 days. Samples were taken before storage on the 15th, 30th,60th, and 90th days. Evaluations were carried out including appearance, particle size, polydispersityindex (PI), transmittance percentage (TP), pH, and viscosity. Quantitative data were analyzed withmultivariate analysis. The result showed that NSB formulas were yellowish-orange and clear. Thedroplet size in FII and FIII was stable (p > 0.05) with a range of 12-15 nm with PI < 0,5. All formulashad TP > 95% with a pH of 7.50–7.6. The viscosity of all formulas was 1.2-1.9 dPa.s and characterizedas Newtonian. Increasing the concentration of tween 80 can reduce droplet size and PI. Tween 80 at aconcentration of 35-45% produces sea buckthorn nanoemulsion which is stable for 90 days of storage.
Sensitivity Assay of Resistant Escherichia coli to Fosfomycin, Kanamycin, Rifampicin, Ceftriaxone, Imipenem, and Vancomycin Tina Rostinawati Rostinawati; Rikadianan rikadianan; Imam Adi Wicaksono
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.42856

Abstract

Antibiotic resistance is a major global health problem and continues to increase, so there is a need forbetter evaluation and therapeutic advice for Urinary Tract Infection (UTI) patients. It had isolated E. colifrom clinical isolates that were resistant to antibiotics of β-lactam, the first generation of cephalosporinand fluoroquinolone. Characterization of bacterial sensitivity should be analyzed to other antibioticswith different mechanisms. Therefore, this study aims to analyze the antibiotic activity of fosfomycin,kanamycin, rifampicin, ceftriaxone, imipenem, and vancomycin against to resistant Escherichia coliclinical isolates of UTI. The sensitivity test in this study used the Kirby-Bauer disc diffusion methodand data analysis using SPSS version 24. The results revealed the diameter of inhibition zone (mm) ofantibiotics of fosfomycin, ceftriaxone, imipenem, kanamycin, rifampicin, and vancomycin respectivelyi.e. 38±1; 36.3±1.15; 35±1; 31.6±1,15; 28±1; and 26.3±0.17. Based on statistical analysis there weresignificant differences in the activity of fosfomycin, ceftriaxone, imipenem, kanamycin, rifampicin,and vancomycin.

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