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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 7 Documents
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Search results for , issue "Vol 9, No. 3, 2022" : 7 Documents clear
Antibacterial Activity of Mangosteen Leaf and Bark Fraction Against Salmonella spp Causes Diabetic Ulcers Salmah Wilujeng Anggraini; Susanti Erikania; Vevi Maritha
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.33709

Abstract

Diabetes mellitus is a degenerative disease due to impaired cell function β-pancreas in insulin production causing hyperglycemics accompanied by microvascular complications such as diabetic ulcers. This condition is aggravated by bacterial contamination, one of which is Salmonella spp. The use of natural ingredients that have the potential for the treatment of diabetic ulcers is the mangosteen plant (Garcinia mangostana L.), so the identification of Salmonella spp in diabetic ulcers and testing the antibacterial activity of ethyl acetate and n-hexan leaves and mangosteen stem skins is carried out. The method started from the stage of bacterial identification using selective media, gram staining, biochemical testing, and antibacterial activity tests by diffusion of discs. Results showed that Salmonella spp was positif in SSA-specific media, biochemical tests, red bacteria, rod-shaped. Antibiotic sensitivity tests obtained by ciprofloxacin had the strongest activity of 30.20±1.37mm. The largest antibacterial activity result at a concentration of 100% obtained the ethyl acetate fraction of mangosteen leaves is 17.30±0.5mm compared to the fraction of n-hexane leaves of 8.81±0.32mm, ethyl acetate fraction and n-hexan mangosteen stem skin of 13.28±0.95mm, 7.42±0.45mm
Authentication of Lemongrass Oil By Gas Chromatography-Mass Spectroscopy (GC-MS) Combination Chemometrics Any Guntarti; Husnun Khairunnisa Pratiwi; Laela Hayu Nurani; Ibnu Gholib Gandjar
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.32558

Abstract

The addition of something foreign to lemongrass essential oil has been done since ancient times. One way is to add turpentine oil which aims to increase the volume and grade of the smell. The purpose of this study was to determine the authentication of citronella oil using the gas chromatography-mass spectrometry (GC-MS) method combined with multivariate PCA analysis. Fragrant lemongrass oil was isolated by distillation of water and using simplicia in the form of powdered dried Cymbpogon citratus leaves. The oil obtained was treated with anhydrous Na2SO4. The results of the characteristics and quality requirements of citronella oil are compared with the SNI. The results of GC-MS analysis were the relative levels of essential oils. The results of the characteristic test meet the quality requirements of SNI 06-3953-1995, except for the yield requirements. The results of analysis by GC-MS, the essential content of citronella oil was citronella (37.47%), geraniol (25.03%), trans-caryophilene (3.69%), citronellol (11.68%), and delta cadinene. (2.44%). Chemometric principle component analysis (PCA) can group samples of fragrant lemongrass oil, turpentine oil and lemongrass oil products on the market.
Virtual Screening of Flavonoid Compounds as A Main Protease Inhibitor for Anti-Sars-Cov-2 Candidates Saeful Amin; Fadhilah Utami; Selvira Anandia Intan Maulidya
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.33682

Abstract

In 2019, the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was discovered in Hubei Province, China. After one year, no drug therapy has been approved, necessitating the development of SARS-CoV-2 drugs. To screen new drug candidates from natural product databases, the in-silico method, a drug discovery process based on computer simulations, can be utilized. Flavonoid is one of the most common compounds found in nature. They are secondary metabolites compounds contains phenolic functional group that can be virtually screened by predicting antiviral activity, drug likeness prediction, pharmacokinetic prediction, toxicity prediction, and molecular docking simulation Virtual screening is used in molecular docking simulations to design drugs based on activity prediction, compound similarity with oral drugs based on similar physical properties, pharmacokinetic profiles that include absorption and distribution, toxicity, and interactions of compounds with targets. The main protease used by target receptors is an enzyme that is important in determining SARS-CoV-2 survival. The structure of SARS-CoV-2 main protease code ID PDB 5RL4, 5R7Y and 7BUY is used in molecular docking simulation. The results of virtual screening of 80 flavonoid compounds showed that there are two most potential compounds, namely naringin and rutin that have lower ∆G values than the three native ligands, predictions of toxicity and good activity and a fairly good distribution profile.
Identification of Antibiotic-Producing Isolates from the Soil of Pesantren Darul Aman Gombara, Makassar Fhahri Mubarak; Wahyu Hendrarti; Hamdayani Lance Abidin; Arfan Abu Bakar
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.32257

Abstract

One source of antibiotics-producing microorganisms that are now widely used as a treatment for infections comes from the soil. Soil is an excellent medium for the growth and development of various microorganisms. The search for new antibiotics is currently urgently needed, because their use is not following the instructions, causing disease resistance. This study aims to get antimicrobial-producing microbial isolates that can inhibit the test microbes and identify the type of isolates. The first stage of microbial isolation was the dilution of the soil sample from 10-1 to 10-5 using the method of pouring on Nutrient Agar (NA) and Potato Dextrose Agar (PDA) medium. It carried further testing of antimicrobial activity against several test microbes out. The results of the isolation got 4 isolates of bacteria and 4 isolates of fungi with different identification of each isolate. In the test microbe, Escherichia coli isolates that gave activity were isolates IB1, IB2, IB3. In the Staphylococcus aureus test bacteria, the isolate that produces activity is the isolate IB1, IB2, IB3, IB4, IJ2, Meanwhile, for the test fungus Candida albicans was inhibited by isolates IB1, IJ1, IJ2, IJ3 and IJ4.
Design and Cloning of Gene Encoding SLPI C-Terminal Domain in Escherichia coli TOP10 Evi Umayah Ulfa; Ni Nyoman Tri Puspaningsih
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.36918

Abstract

Elevated levels of neutrophil elastase in CPOD (Chronic Obstructive Pulmonary Disease) airways are regarded as the main trigger of lung destruction and inflammation. SLPI (Secretory leukocyte protease inhibitor), an inhibitor protease, represents an attractive candidate for treatment in chronic lung diseases due to proteases excess. The antiprotease active site of SLPI has been located on the C-terminal domain. This study aimed to design and clone the gene encoding the C-terminal domain of SLPI (SLPIc). The gene encoding SLPIc was optimized and predicted solubility using OptimumGene™ and SoDoPe software. The nucleotide sequence of the optimized SLPIc was synthesized, inserted into the pGEX 4T-2 vector commercially by Genscript, and transformed into the Escherichia coli TOP10. The pGEX 4T-2 vector contains a glutathione S transferase (GST) gene located before the MCS to generate a recombinant protein for fusion with GST. For purification purposes, the His-tag synthesized together with SLPIc. The optimized SLPIc nucleotide sequence gave a CAI value of 0.81, GC content 52.31, and a CFD of 2%. The solubility probability of SLPI fused with GST increased from 0.124 to 0.4656. Confirmation of the transformant using restriction and sequencing analysis showed that the gene encoding of SLPI domain C-terminal optimized in the pGEX 4T-2 plasmid was successfully transformed into E. coli TOP10 as novelty of this study. The optimized SLPIc gene in pGEX 4T-2 has a high probability of being expressed in E. coli based on in-silico analysis.
Accute Toxicity of Extract From Melinjo (Gnetum Gnemon L) Leaf With Fixed Dose Procedure Method Herlina Herlina; Annisa Amriani; Dina Permata Wijaya; Ayu Adelia Lestari
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.33683

Abstract

Melinjo leaves has several benefits as antidiabetic, antihyperglycemia, antioxidant and diuretic. In this experiment the acute toxicity test of ethanol extract of melinjo (Gnetum gnemon L). leaves on male white rats of wistar strain with fixed dose procedure method. The result of the screening of the phytochemical showed that the leaves of beluntas contained alcaloid, flavonoid, saponin, fenolic, and tanin. Ethanol extract of melinjo leaves was obtained by maceration using ethanol 70%. From the observational study, the dose 2000 mg/kg BW was chosen as starting dose for the main study. Experimental animal subject used in the main study were 10 male white rats of wistar which were divided into 2 group, normal group and treatment group with a dose of 2000 mg/kgBW. The result showed that there were no death or toxicity sign in all experimental animals. During the 14 days observation period, there were no significant changes in body weight of rats either in normal control group and treatmen group with a dose of 2000 mg/kg BW (p>0.05). Melinjo leaves had no effect on the macroscopic organs of liver, kidneys and heart of the test animals (p>0.05). The average level of biochemical parameters in the normal group is SGOT 54.13±11.428 U/L, SGPT 47.476±21.655 U/L, creatinine 0.632±0.199 mg/dL, and urea 14.46±2.267 mg/dL, while the 2000 mg/kg BW dose group is SGOT 60.192±14.198 U/L, SGPT 55.968±22.998 U/L, creatinine 0.756±0.204 mg/dL, and urea 16±2.561 mg/dL. It showed that the ethanol extract of melinjo leaves with a dose of 2000 mg/kgBW are the category of practically non-toxic.
Knowledge and Perception of Self-Medication of Cough Medication in Pedicab Drivers in Surabaya Amelia Lorensia; Rivan Virlando Suryadinata; Melly Eva Idamayanti; Gora Dirga Kusuma; Nyoman Yoga Diputra
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.33003

Abstract

Pedicab drivers who are exposed to pollution and have a smoking habit are at high risk of developing COPD (chronic obstructive pulmonary disease). The initial disturbance that occurs is a decrease in lung function which often causes complaints of cough symptoms. A person's knowledge and perception can influence how the pattern of self-medicating cough treatment so far. The purpose of this study was to determine the knowledge and perception of Self-medication of cough medicine. The research design was cross-sectional. The material of this research was in the form of information from subjects using direct questions and answers (interviews) with knowledge and perceptions of self-medicating cough medicine questionnaire. This research was conducted from September to December 2018 and used descriptive data analysis. The respondents involved were 163 peoples. Most respondents had a low level of knowledge of self-medication of cough medicine (97 of 163). The results of perception of self-medication of cough medicine indicated that most respondents had negative level (78 of 163). There was a relationship between knowledge and perception about self-medication of cough medicine (p=0.006). The proper health education strategy by increasing knowledge can also improve perceptions of self-medicine of cough medicine.

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