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MEDISAINS
Published by Universitas Muhammadiyah Purwokerto
ISSN : 16937309     EISSN : 26212366     DOI : -
Core Subject : Health,
Medicine & Pharmacology Nursing Public Health
MEDISAINS: Jurnal Ilmiah Ilmu-ilmu kesehatan merupakan sarana penyebarluasan ilmu pengetahuan, riset, teknologi dan inovasi dibidang kesehatan yang diterbitkan tiga kali dalam setahun (April, Agustus dan Desember). Jurnal Medisains adalah jurnal peer reviewed dan Open-Access yang dikelola oleh Fakultas Ilmu Kesehatan Universitas Muhammadiyah Purwokerto dan di terbitkan dibawah Lembaga Publikasi Ilmiah dan Penerbitan (LPIP) Universitas Muhammadiyah Purwokerto.
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Articles 13 Documents
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Search results for , issue "vol. 24 no. 2 (2026)" : 13 Documents clear
Development and content validation of a multidimensional assessment instrument for patients with cancer: a Delphi study Wahyu Dewi Sulistyarini; Marina Kristi Layun Rining; Vera Veriyallia; Rifdinia Bregita; Samuel Kevin Ruslim; Agustinus Darmadi Haryanto; Lidya Vera Sianturi; Christantie Effendy; Aminah; Reza Heddy Aprinda
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.30392

Abstract

Background: Although several assessment instruments are available for patients with cancer, most focus primarily on physical symptoms and do not comprehensively assess patients' physical, psychological, social, and spiritual needs. Objective: This study aimed to develop a multidimensional assessment instrument for patients with cancer and evaluate its content validity. Method: An instrument development study was conducted through literature review, item synthesis, and a two-round Delphi process involving 12 multidisciplinary experts. An initial 37-item instrument covering physical, psychological, social, and spiritual domains was developed. Content validity and expert consensus were evaluated using the Item-level Content Validity Index (I-CVI) and interquartile range (IQR). Results: Of the initial 37 items, 35 were retained following two Delphi rounds. Fifteen items were revised to improve clarity and conceptual alignment, whereas two psychological items were removed because of insufficient content validity and conceptual inconsistency. The final instrument comprised 35 items representing four multidimensional domains, with acceptable expert consensus across all retained items. Conclusion: The developed 35-item multidimensional assessment instrument demonstrated satisfactory content validity and expert consensus. It provides a preliminary framework for comprehensively assessing the multidimensional needs of patients with cancer and supports further psychometric evaluation before clinical implementation.
Factors associated with maternal compliance with food safety principles in supplementary food management: a cross-sectional study Wahyu Ersila; Suparni Suparni; Siti Khuzaiyah; Syavira Nooryana; Susri Utami
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.30677

Abstract

Background: Food safety is essential for protecting the health and nutritional status of young children because unsafe food preparation, handling, and storage increase the risk of infection, undernutrition, and impaired growth. However, evidence on the combined influence of maternal, psychological, and environmental factors on maternal compliance with food safety principles in supplementary food management remains limited. Purpose: This study aimed to identify factors associated with maternal compliance with food safety principles in supplementary food management for children aged 6–59 months. Methods: An analytical cross-sectional study was conducted among 1,634 mothers of children aged 6–59 months in Pekalongan Regency, Central Java, Indonesia. Participants were recruited using consecutive sampling. Data were collected through a structured online questionnaire. Associations were examined using chi-square tests and multivariable binary logistic regression, with results reported as adjusted odds ratios (AORs) and 95% confidence intervals (CIs). Results: Maternal age, educational level, employment status, household income, and knowledge were not independently associated with compliance. In contrast, positive attitudes were associated with approximately threefold higher odds of compliance (AOR = 3.094; 95% CI: 2.366–4.045), whereas high motivation demonstrated the strongest association (AOR = 8.675; 95% CI: 6.654–11.311). Adequate facilities and infrastructure support were also associated with higher compliance (AOR = 1.909; 95% CI: 1.475–2.472). Conclusion: Maternal attitudes, motivation, and infrastructure support were independently associated with compliance with food safety principles. Interventions integrating behavioural change strategies with improvements in household food preparation environments may strengthen safe supplementary food management.
Effects of an Islamic health education module on spirituality and medication adherence among older adults with chronic diseases: a sequential explanatory mixed-methods study Fatnan Setyo Hariwibowo; Kusbaryanto Kusbaryanto
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.24664

Abstract

Background: Medication adherence among older adults with chronic diseases is influenced by clinical, behavioral, psychosocial, and spiritual factors. However, structured health education integrating Islamic spiritual values remains limited in Indonesia. Purpose: This study aimed to evaluate changes in spirituality and medication adherence following an Islamic health education intervention and to explore participants’ experiences of the intervention. Methods: A sequential explanatory mixed-methods design was used, consisting of a single-group pretest–posttest quantitative phase followed by a qualitative phase. The study involved 158 Muslim adults aged ≥60 years with chronic diseases at PKU Muhammadiyah Hospital Temanggung, Indonesia. Spirituality and medication adherence were assessed using the daily spiritual experience scale (DSES) and the eight-item morisky medication adherence scale (MMAS-8), respectively. Sixteen participants were subsequently selected for in-depth interviews. Results: The mean DSES score increased from 48.72±7.84 to 57.91±6.45 (mean difference=9.19; 95% CI: 8.38–10.00; p<0.001; Cohen’s d=1.79). The median MMAS-8 score increased from 5 (IQR: 4–6) to 7 (IQR: 6–8; p<0.001; r=0.28). Qualitative findings indicated that the integration of Islamic values strengthened spiritual meaning, emotional calmness, motivation, and discipline in medication-taking. However, forgetfulness, treatment fatigue, physical limitations, and dependence on family support remained barriers to medication adherence. Conclusion: The Islamic health education module was associated with improvements in spirituality and medication adherence among older adults with chronic diseases.
Prognostic significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and Ki-67 expression in diffuse large B-cell lymphoma Ni Made Renny Anggreni Rena; Sang Ayu Putu Gandhitri
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.28576

Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy with heterogeneous outcomes, highlighting the need for accessible and reliable prognostic markers, particularly in resource-limited settings. Inflammation-based indices such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), together with the proliferation marker Ki-67, have been investigated as prognostic biomarkers; however, their prognostic value remains inconsistent across studies. Purpose: This study aimed to evaluate the prognostic value of baseline NLR, PLR, and Ki-67 expression for one-year overall survival in patients with DLBCL. Methods: A retrospective cohort study was conducted at Prof. Dr. I.G.N.G. Ngoerah General Hospital, Indonesia, involving 43 adult patients with histopathologically and immunohistochemically confirmed DLBCL. Overall survival was estimated using the Kaplan–Meier method, and differences between groups were assessed using the log-rank test. Associations between NLR, PLR, Ki-67 expression, and survival were evaluated using univariate Cox proportional hazards regression. Results: The one-year overall survival rate was 60.5%. NLR ≥4 was not significantly associated with survival (HR=0.802; p=0.664), while NLR ≥7.6 showed a higher but non-significant hazard of death (HR=2.374; p=0.107). Similarly, PLR ≥170 (HR=1.514; p=0.401) and PLR ≥213 (HR=1.909; p=0.191) were not significantly associated with survival. Among the evaluated Ki-67 cut-off values (70%, 80%, and 90%), only Ki-67 ≥90% was significantly associated with poorer one-year survival (HR=4.240; 95% CI: 1.470–12.260; p=0.008). Conclusion: Ki-67 expression ≥90% was the only evaluated biomarker significantly associated with poorer one-year overall survival in patients with DLBCL. These findings suggest that very high Ki-67 expression may have practical prognostic value for risk stratification, particularly in settings with limited access to advanced molecular diagnostics.
Comparative cholesterol-lowering effects of ethanolic leaf extracts of Paederia foetida and Abrus precatorius: an in vivo study khoirul ngibad; Elok Faiqotul Jannah; Tengku Rahmadito Putra Samudra; Gaby Ayu Patricia; Cicik Wijayanti; Hidayatullah Hidayatullah
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.29373

Abstract

Background: Hypercholesterolemia is a major risk factor for cardiovascular disease. Although statins are effective, their long-term use may be associated with adverse effects, encouraging investigation of plant-derived alternatives. Comparative in vivo evidence regarding the cholesterol-lowering effects of Paederia foetida and Abrus precatorius remains limited. Purpose: This study aimed to compare the cholesterol-lowering effects of ethanolic leaf extracts of P. foetida and A. precatorius in an experimental model of hypercholesterolemia. Methods: Fifty-four mice were randomly allocated into nine groups, including negative and positive controls, a simvastatin group, and three dose groups each of P. foetida and A. precatorius extracts (3.5, 7, and 14 mg/20 g body weight). Hypercholesterolemia was induced using propylthiouracil and a high-fat diet. The extracts were administered for three days. Changes in total cholesterol levels were analyzed using one-way ANOVA followed by Tukey’s post hoc test. Results: Cholesterol reduction differed significantly among the experimental groups (p<0.001). Both extracts reduced total cholesterol compared with the positive control. At the highest tested dose (14 mg/20 g body weight), A. precatorius showed a numerically greater reduction than P. foetida (25.33 vs. 19.17 mg/dL), while simvastatin produced the greatest reduction (48.67 mg/dL). Conclusions: Both extracts demonstrated cholesterol-lowering activity in hypercholesterolemic mice, with A. precatorius showing greater efficacy than P. foetida at the highest tested dose.
Comparative antibacterial activity of Ziziphus spina-christi and Piper betle extracts against Escherichia coli across different concentrations Amiruddin Eso; Sulastrianah; Sufiah Asri Mulyawati; Aanisah Rahman; Arif Eka Surya; Aliyyah Zhafirah Bafadal; Annisa Dwi Aulia Putri
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.30324

Abstract

Background: Antimicrobial resistance among Gram-negative bacteria, including Escherichia coli, has increased the need to explore alternative antibacterial agents. Although medicinal plants have demonstrated antibacterial potential, comparative evidence on the activity of Ziziphus spina-christi and Piper betle extracts against E. coli across different concentrations remains limited. Objective: This study aimed to compare the antibacterial activity of ethanolic extracts of Z. spina-christi and P. betle against E. coli and to evaluate the effects of extract type, concentration, and their interaction. Method: A laboratory experimental study using a 2×3 factorial completely randomized design with additional positive and negative control groups was conducted. Ethanolic extracts of Z. spina-christi and P. betle were evaluated at concentrations of 1500, 2000, and 2500 ppm using the disk diffusion method. Inhibition-zone diameters were analyzed using two-way analysis of variance followed by Tukey’s honestly significant difference test.  Results: The mean inhibition-zone diameter of Z. spina-christi increased from 8.83±0.76 mm at 1500 ppm to 30.33±2.08 mm at 2500 ppm, whereas that of P. betle increased from 16.33±0.38 mm to 23.08±3.51 mm. Concentration significantly affected antibacterial activity (F(2,12)=105.02; p<0.001), whereas extract type showed no significant main effect (F(1,12)=1.89; p=0.194). A significant interaction between extract type and concentration was observed (F(2,12)=29.34; p<0.001). Conclusion: The antibacterial activity of Z. spina-christi and P. betle extracts against E. coli varied according to concentration, with a significant interaction between extract type and concentration. The greatest inhibition among the extract treatments was observed with Z. spina-christi at 2500 ppm.
Serial wound changes during hydrogel-assisted autolytic debridement combined with antimicrobial dressings in diabetes-related wounds: a case series Juli Widiyanto, S.Kep., M.Kes (Epid); Silvia Elki Putri; Pratiwi Gasril; Alma’ratus Sholikhah Putri Ramdhani; Zaidatul Akmal Othman
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.30517

Abstract

Background: Diabetes-related wounds are challenging to manage because impaired tissue repair, necrotic tissue, infection risk, and poor metabolic control may delay wound healing. Hydrogel dressings can support autolytic debridement by maintaining a moist wound environment, while antimicrobial dressings may be used as adjuncts when microbial burden is clinically relevant. Clinical documentation of serial wound changes during their combined use remains limited. This case series aimed to describe serial wound changes during hydrogel-assisted autolytic debridement combined with antimicrobial dressings in patients with diabetes-related wounds. Case Presentation: Three women with type 2 diabetes mellitus and necrotic or devitalized wounds were treated at an independent wound care clinic in Pekanbaru, Indonesia. Wound status was assessed using the Bates-jensen wound assessment tool (BJWAT) and serial photographs at baseline and on days 4, 8, and 12. Hydrogel-assisted autolytic debridement combined with antimicrobial dressings was applied as part of local wound management. BJWAT scores decreased from 28 to 18 in Case 1, from 20 to 10 in Case 2, and from 33 to 27 in Case 3. Serial wound assessments showed changes in wound appearance over the 12-day observation period, with varying degrees of improvement across the three cases. Conclusion: Decreases in BJWAT scores and improvements in wound appearance were observed across the three cases during the 12-day wound-care period. These findings provide descriptive clinical observations of wound progression during hydrogel-assisted autolytic debridement combined with antimicrobial dressings but do not establish the effectiveness of this treatment approach. Further controlled studies with longer follow-up and standardized assessment of wound characteristics and relevant patient-related factors are needed.
Paternal knowledge, maternal self-efficacy, and exclusive breastfeeding following a digital paternal-support intervention: a quasi-experimental study Evy Nurachma; Diah Evawana; Fara Imelda Theresia; Elisa Goretti; Lidia Lushinta
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.30658

Abstract

Background: Most breastfeeding interventions primarily target mothers, while evidence regarding digitally delivered paternal support and its effects on maternal breastfeeding self-efficacy and exclusive breastfeeding remains limited. Objective: This study aimed to assess changes in paternal knowledge and maternal breastfeeding self-efficacy following a digital paternal-support intervention and to identify factors associated with exclusive breastfeeding. Method: A quasi-experimental pretest–posttest study with a non-equivalent control group was conducted from January to March 2026 at Loa Bakung Health Center, Samarinda, Indonesia. Sixty mother–father couples were included, with 30 couples in each group. The intervention group received a digital paternal-support intervention, while the control group received routine breastfeeding education. Changes in paternal knowledge and maternal breastfeeding self-efficacy were assessed using paired t-tests, while factors associated with exclusive breastfeeding were examined using multivariable logistic regression. Results: Paternal knowledge and maternal breastfeeding self-efficacy increased significantly from pretest to posttest following the digital paternal-support intervention (both p<0.001). In multivariable analysis, paternal support was positively associated with exclusive breastfeeding (AOR=4.52; 95% CI: 2.81–7.25; p<0.001), whereas maternal employment was negatively associated with exclusive breastfeeding (AOR=0.45; 95% CI: 0.26–0.78; p=0.003). Maternal education was not significantly associated with exclusive breastfeeding (AOR=1.21; 95% CI: 0.61–2.40; p=0.575). Conclusions: Paternal knowledge and maternal breastfeeding self-efficacy increased following the digital paternal-support intervention. Paternal support was positively associated with exclusive breastfeeding, whereas maternal employment was negatively associated with this outcome. These findings support further evaluation of digitally delivered paternal-support strategies using comparative analyses that directly assess intervention effects.
Ketogenic diet adherence and cardiovascular biomarkers following digital education and structured family support among adults at risk for coronary heart disease: a mixed-methods study Andika Herlina; vinorika Nofia; Siska Sakti Angraini; Siti Aisyah Nur; Wan Nor Aliza; Wan Abdul Rahman
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.30848

Abstract

Background: Adherence to ketogenic diets remains challenging among adults at risk for coronary heart disease (CHD), potentially limiting the sustainability of dietary interventions. Evidence regarding the combined use of digital education and structured family support in relation to dietary adherence, psychosocial outcomes, and cardiovascular biomarkers remains limited, particularly in Indonesian primary healthcare settings. Purpose: This study aimed to assess ketogenic diet adherence, psychosocial outcomes, and cardiovascular biomarkers following digital education combined with structured family support among adults at risk for CHD and to explore factors influencing dietary adherence. Methods: This quantitative-dominant sequential explanatory mixed-methods study included a quasi-experimental pretest–posttest control-group phase involving 60 adults at risk for CHD. The intervention group received six months of digital ketogenic diet education combined with structured family support, whereas the control group received routine nutritional education. Outcomes included ketogenic diet adherence, self-efficacy, perceived family support, LDL cholesterol, HDL cholesterol, triglycerides, and small dense LDL (sd-LDL). Quantitative outcomes were analyzed using analysis of covariance (ANCOVA), with adjustment for relevant baseline covariates. The subsequent qualitative phase used interviews and focus group discussions, followed by thematic analysis to explore factors influencing dietary adherence. Results: The intervention group showed significantly greater improvements in ketogenic diet adherence, self-efficacy, and perceived family support vs. control group (p<0.001). Significant between-group differences were also observed in sd-LDL, LDL cholesterol, triglycerides, and HDL cholesterol (p<0.05). Qualitative findings indicated that practical family involvement, emotional support, and flexible access to digital education facilitated dietary adherence, whereas habitual consumption of carbohydrate-rich foods remained an important barrier. Conclusion: Digital ketogenic diet education combined with structured family support was associated with greater improvements in dietary adherence, psychosocial outcomes, and cardiovascular biomarkers among adults at risk for CHD. Qualitative findings further identified family involvement and accessible digital education as facilitators of adherence, while habitual carbohydrate consumption remained a barrier. Further studies are warranted to confirm these findings using larger samples and more rigorous experimental designs.
Optimization of toothpaste containing the ethyl acetate fraction of Stelechocarpus burahol leaves and its antibacterial activity against Streptococcus mutans Zhicizha Estara Suyit; Titik Sunarni; Ilham Kuncahyo
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 2 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i2.30870

Abstract

Background: Dental caries is associated with cariogenic microorganisms, particularly Streptococcus mutans. Stelechocarpus burahol leaves contain bioactive compounds with potential antibacterial activity, but their incorporation into an optimized toothpaste formulation remains insufficiently investigated. Purpose: This study aimed to evaluate the antibacterial activity of S. burahol leaf fractions against S. mutans and to optimize a toothpaste formulation containing the most active fraction using Carbopol 940, sodium carboxymethyl cellulose, and glycerin. Method: his laboratory experimental study included ethanolic extraction, solvent fractionation, antibacterial screening, and toothpaste optimization using Simplex Lattice Design. Antibacterial activity against S. mutans was evaluated using diffusion and dilution methods. The toothpaste formulations were assessed for pH, viscosity, homogeneity, and antibacterial activity. Model adequacy and numerical optimization were analyzed using Design-Expert version 13. Results: The ethyl acetate fraction showed the highest antibacterial activity, with an inhibition zone of 19.39±1.50 mm, a minimum inhibitory concentration of 1.562%, and a minimum bactericidal concentration of 3.125%. The optimum formulation contained 1% Carbopol 940, 1% sodium carboxymethyl cellulose, and 5% glycerin, with a desirability value of 0.819. The optimized toothpaste had a pH of 8.25, viscosity of 258.33±7.64 dPa·s, and an inhibition zone of 13.32±0.29 mm. The experimental responses were within their respective prediction intervals. Conclusion: The ethyl acetate fraction of S. burahol leaves was successfully incorporated into an optimized toothpaste formulation while maintaining antibacterial activity against S. mutans. Further studies are needed to assess formulation stability, active-compound release, antibiofilm activity, and safety.

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