cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Sulastrianah
Contact Email
sulastrianahmuhtadi@gmail.com
Phone
+6285242541601
Journal Mail Official
sulastrianahmuhtadi@gmail.com
Editorial Address
Kampus Hijau Bumi Tridharma Anduonohu Kendari Universitas Halu Oleo Fakultas Kedokteran
Location
Kota kendari,
Sulawesi tenggara
INDONESIA
Medula
Published by Universitas Halu Oleo
ISSN : 23391006     EISSN : 24430218     DOI : http://dx.doi.org/10.33772/medula
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
MEDULA mengundang kontribusi bagi penelitian original dan fundamental pada bidang kesehatan sebagai sebuah artikel yang melewati proses review.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol 4, No 1 (2016)" : 6 Documents clear
Uji Efek Antipiretik dan Antiinflamasi Ekstrak Etanol Buah Pare (Momordica charantia L.) terhadap Mencit Jantan Parawansah Parawansah; Wahyuni Wahyuni; Zakiyatul Mahmudah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 4, No 1 (2016)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.557 KB) | DOI: 10.46496/medula.v4i1.2559

Abstract

This research was carried out to determine the content of secondary metabolites contained in the ethanol extract of bitter melon (Momordica charantia L.) and antipyretic and antiinflammatory effects on mice. Bitter melon extract obtained by maceration method using ethanol 96%. Bitter melo ethanol extract was made in three variations of dose 50 mg / KgBW, 150 mg / KgBW, and 250 mg / KgBW. The content of secondary metabolites determined phytochemical Skrining by TLC (thin layer chromatography) with specific reagent. Antipyretic effect performed by vaccine DPT (Diphtheria Pertussis Tetanus) as inducers of fever and Parasetamol 500 mg as a positive control and antiinflammatory effect using the method of edema artificial on the soles of the mice foot with carrageenan 2% as an aphrodisiac edema and Diclofenac Sodium 50 mg as a positive control. Subjects used is a white male mice were given intraperitoneally (i.p). Analysis of the data using ANOVA statistical analysis and continued with LSD Post Hoc test. Phytochemical screening results showed that ethanol extract of bitter melon contains alkaloids, tannins, flavonoids, saponins, and triterpenoids. The results indicated that ethanol extract of bitter melon at dose of 150 mg/KgBW has antipyretic effect with total temperature decrease 1,1oC and anti-inflammatory effects with the largest of inflammation inhibition percent by 68.57%. One way ANOVA analysis signify a probability value (p) < 0.05 with 95 % of confidence level that indicate a significant influence of ethanol extract of bitter melon to its antipyretic and antiinflammatory effects on male mice.Keywords : Antipyretic, Anti-inflammatory, Momordica charantia, Bitter melon
Uji Aktivitas Ekstrak Etanol Daun Dadap Serep (Erythrina lithosperma Miq) sebagai Antibakteri terhadap Bakteri Salmonella typhi Andi Noor Kholidha; I Putu Wira Putra Suherman; Hartati Hartati
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 4, No 1 (2016)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.842 KB) | DOI: 10.46496/medula.v4i1.2555

Abstract

Dadap serep (Erythrina lithosperma Miq) is one of the plants that grow in Indonesia. Dadap serep leaves are commonly used as a traditional medicin. It can be used as an antimicrobial. This study aims to determine the inhibition of Dadap Serep (Erythrina lithosperma Miq) Leaf Extract  on the growth of the bacteria Salmonella typhi. The methods used in this research was an analytic experimental test. The samples of this study are Leaf Extract of Dadap Serep (Erythrina lithosperma Miq), which is divided into eight concentration, i.e. the concentration of 200,000 ppm, 100,000 ppm, 50,000 ppm, 25,000 ppm, 12,500 ppm, 6,250 ppm, 3,125 ppm, 1,560 ppm and two control i.e. a positive controls and a negative controls. Each test was repeated three times. Antibacterial activity test performed by disc diffusion method, wherein the diameter of each extract was determined and assessed their effectiveness inhibitory zone with chloramphenicol. Minimum Inhibitory Concentration (MIC) was determined by disc diffusion method togeth er with the inhibition test. We then measured at the lowest concentration of extract that they can inhibit the bacteria Salmonella typhiTop of FormBottom of Form. The results showed that the leaves of Dadap Serep (Erythrina lithosperma Miq) has antibacterial activity against growth of bacteria Salmonella typhi. MIC seen from the leaves of Dadap Serep is 50,000 ppm with inhibition zone diameter of 1.3 mm were formed. Diameter of clear zone is highest at a concentration of 200,000 ppm with inhibition zone diameter formed is 4.83 mm. Phytochemical test results on Leaf of Dadap Serep (Erythrina lithosperma Miq) retrieved alkaloids, flavonoids, tannins and saponins are positive.From this research it can be concluded that the extracts from dadap serep leaves (Erythrina lithosperma Miq) has antibacterial activity against growth of bacteria Salmonella typhi.Keywords: Dadap serep leaves (Erythrina lithosperma Miq), Salmonella typhi, Minimum inhibitory concentration (MIC), Antibacterial test
Validitas, Reliabilatas dan Dampak Pembelajaran terhadap Tes Objective Structured Clinical Examintaion (OSCE) Ashaeryanto Ashaeryanto
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 4, No 1 (2016)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.726 KB) | DOI: 10.46496/medula.v4i1.2560

Abstract

Objective Structured Clinical Examination (OSCE) was developed for the first time by Harden at1975 which was used for evaluating clinical skill ability of OSCE Implementation that could give learning positive and negative impact. Objective: To explain validity, reliability of OSCE and investigate OSCE Test Implementation (Objective Structured Clinical Examintaion) impact to learning, especially in study behavior aspect.  Discussion: Van  Der  Vleuten  explains that  OSCE  is  a  good  and  useful  method  in  clinical skill evaluation which is based on 5 criterias namely OSCE test have reliability, validity, educational impact, cost efficiency, acceptability. Reliability can be seen in examiner consistency, case variation, and implementation in prosperous time. OSCE have high content, face, concurernt, and construct validity. OSCE can give positive and negative learning impact.Keywords: OSCE, educational impact, performance assessments,validity
Analisis Kadar Kolesterol Low Density Lipoproteinsebagai Faktor Risiko Komplikasi pada Pasien Diabetes Melitus Tipe 2 Pranita Aritrina; Asnah Marzuki; Fitriani Mangarengi
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 4, No 1 (2016)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.678 KB) | DOI: 10.46496/medula.v4i1.2556

Abstract

Dyslipidemia in type 2 diabetes mellitus (T2DM) can be increased the cardiovascular risk and this condition was equivalent with the elevated of LDL-cholesterol. In type 2 diabetes, LDL was small, dense and more aterogenic. This research was an observational study used cross sectional approach. The samples were 50 samples consist of twenty five of T2DM with non-CHD patient (50%) and twenty five of T2DM with CHD patient (50%) with age 45 years old or more. The level of serum LDL was measured by photometry used ABX Pentra 400. The data was analyzed by statistical method. The result study was conducted that normal LDL level was 9 (18%) patients and abnormal LDL level was 16 (32%) in T2DM with non-CHD patient. While in patient with T2DM with CHD had abnormal LDL level overall (50%). The high level of LDL in T2DM was accelerated complication occurrence, mainly coronary heart disease (CHD).Keywords: Type 2 diabetes mellitus (T2DM), dyslipidemia, LDL level, CHD complication
Aktivitas Antibakteri Ekstrak Etanol Porifera (Spongia Officinalis ) terhadap Staphylococcus Aureus ATCC 25923 Indria Hafizah; Fine Farhani Muliati; Sulastrianah Sulastrianah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 4, No 1 (2016)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.837 KB) | DOI: 10.46496/medula.v4i1.2557

Abstract

Staphylococcus aureus is the most  dangerous of all of the many comman staphylococcal bacteria. It stains gram positive and is non moving small round shaped or non motile cocci..Porifera (Spongia officinalis) are lowly organised less evelved animals and can be used as the medication resources. The aim of this study was to inveftigate antibacterial extract etanol  of Porifera (Spongia officinalis)against the growth of Staphylococcus aureus ATCC 25923.Present study was an experimental in vitro test. Antibacterial activity assays were carried out by the disc diffusion method. Antibacterial activity was determined by the clear zone formed around the papaer disc and minimum inhibitor concentration which could inhibit the growth of Staphylococcus aureus ATCC 25923.The results are supported by the presence of secondary metabolite by phytochemical test such as alkaloid, terpenoid, steroid, saponin and tanin.Extract ethanolof Spongia officinalis. Extract etanol Spongia officinalishas antibacterial activity againts Staphylococcus aureus ATCC 25923. Minimum inhibitory concentration from the ekstrak etanol Spongia officinalis was 10 ppm.Conclution ; Extract etanol Spongia officinalishas antibacterial activity againts Staphylococcus aureus ATCC 25923Keywords: Spongia officinalis, Staphylococcus aureus, Antibacterial activities, MIC (Minimal Inhibitory Consentration)
Uji Daya Hambat Fraksi Rumput Laut Merah Kappaphycus sp. terhadap Pertumbuhan Bakteri Staphylococcus aureus Sufiah Asri Mulyawati; Yusmiati Yusmiati; Amiruddin Eso
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 4, No 1 (2016)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (283.822 KB) | DOI: 10.46496/medula.v4i1.2558

Abstract

Background:Staphylococcus aureus is gram positive bacteria can cause skin infections, pericarditis, osteomyelitis, septic arthritis, endocarditis and toxic shock syndrome. S. aureus common infection cause and found massively to be resistant to some antibiotics. Kappaphycus sp. is one type of red seaweed that has an bioactive compounds as antibacterial activity. Research Purposes:The purpose of this research determine the fraction of red seaweed Kappaphycus sp. to inhibition the growth of bacteria staphylococcus aureusResearch Methods:this research used experimental of design post test control only. Samples were obtained from the sub Tononggeu, Abeli. Inhibition test using disc diffusion method of various types of concentrations of fractions. Minimum inhibitory concentration (MIC) is determined by the lowest concentration that could inhibit the growth of bacteria. Positive control cefadroxil and negative control DMSO 10%. Research result:The result of this research shown that the fraction of n-hexane and ethyl acetate red seaweed Kappaphycus sp. has activity against bacterial growth Staphylococcus aureus seen with the clear zone. Diameter of clear zone obtained in n-hexane fraction is 27,3 mm (4000 ppm), 23,3 mm (2000 ppm), 22,3 mm (1000 ppm), 4,3 mm (500 ppm), 2 mm (250 ppm) and is 0 mm (125 ppm), while the fraction of ethyl acetate 24,6 mm (4000 ppm), 22 mm (2000 ppm), 19,6 mm (1000 ppm), 4,3 mm (500 ppm), 1,3 mm (250 ppm) and 0 mm (125 ppm). MIC of n-hexane fraction was 250 ppm with a diameter of 2 mm, and the ethyl acetate fraction was 250 ppm with a diameter of 1,3 mm. Conclusion:The conclusion of this research is the fraction of n-hexane and ethyl acetate fraction red seaweed Kappaphycus sp. has particulary inhibitory effect on bacterial growth staphylococcus aureusKeywords: Inhibition, Kappaphycus sp., antibacterial, Staphylococcus aureus.

Page 1 of 1 | Total Record : 6

 1 

Filter by Year

2016 2016


Reset
Filter By Issues
All Issue Vol 10, No 1 (2022) Vol 9, No 2 (2022) Vol 9, No 1 (2021) Vol 8, No 2 (2021) Vol 8, No 1 (2020) Vol 7, No 2 (2020) Vol 7, No 1 (2019) Vol 6, No 3 (2019): Edisi Suplemen Vol 6, No 2 (2019) Vol 6, No 1 (2018) Vol 5, No 2 (2018) Vol 5, No 1 (2017) Vol 4, No 2 (2017) Vol 4, No 1 (2016) Vol 3, No 2 (2016) Vol 3, No 1 (2015) Vol 2, No 2 (2015) Vol 2, No 1 (2014) Vol 1, No 2 (2014) Vol 2, No 1 (2013) Vol 1, No 1 (2013) More Issue