Garuda - Garba Rujukan Digital

Pranita Aritrina

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Author-ID : 2865550

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hubungan Kadar Kolesterol Total dan Trigliserida dengan Kejadian Diabetes Mellitus Tipe 2 di Daerah Pesisir Kota Kendari Andi Noor Kholidha; Tien Tien; Pranita Aritrina; Fifi Nirmala
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 5, No 2 (2018)
Publisher : Halu Oleo University

Background: Type 2 Diabetes mellitus is a common health problem which may result chronic complications. Risk factors such as dyslipidemia, obesity, family history, and genetics play important role in the pathogenesis of the disease. Study on total cholesterol and trygliseride have been carried out in several countries which show relations between total cholesterol and trygliseride with type 2 diabetes mellitus. Purpose: This study aims to determine the relationship between total cholesterol and trigliseride with type 2 diabetes mellitus in the coastal areas of Kendari City. Methods: This study used analytical observational method, with case control approach. The independent variables used in this research is cholesterol total and trigliseride meanwhile the dependent variable is the type2 diabetes mellitus. The location of this research is working area of Public Health Centre located in the coastal area of Kendari City. Result: total cholesterol levels show sig. p value 1,369 based on Chi Square Test, which showed there was no difference in total cholesterol levels. Meanwhile, the triglyceride levels also did not show a significant difference between case and control groups. (p = 0.101). Conclusion: There was no correlation between the increase of total cholesterol level and triglyceride levels with the incidence of DM Type 2 in Kendari City.Keyword: Total Cholesterol, Trigliseride, Type 2 Diabetes mellitus, Coastal Area.

Uji Antioksidan Ekstrak Etanol Buah dan Biji Mengkudu (Morinda citrifolia L.) dengan Metode DPPH (1,1-diphenyl-2-picrylhydrazyl) Pranita Aritrina; Parawansah Parawansah; Nurul Ardani
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 5, No 1 (2017)
Publisher : Halu Oleo University

ABSTRACT Background: Free radicals and antioxidant were widely discussed in world of health because most of the diseases were initiated by presence of oxidation reaction in the body. The process of free radical formation could be inhibited by the presence of antioxidant. Antioxidant was a compound that can protect the biological system in the body. Research Purpose: This research aimed to analyze the potential of fruits and seeds of Morinda citrifolia L. as antioxidant which could counteract free radicals using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. Research Method:This research used experimental method with post test only control design. The research was located in Integrated Laboratory of Faculty of Medicine and Pharmacy Laboratory of Faculty of Pharmacy of Halu Oleo University. Samples of this research were fruit and seed ethanol extract of Morinda citrifolia L.which were taken in West Kendari, Kendari City. The independent variables from this research were fruit ethanol extract and seed ethanol extract of cheese fruit and dependent variable was antioxidant potential. Potential and antioxidant activity (IC50) were tested by measuring DPPH (1,1-diphenyl-2-picrylhydrazyl) uptake using a spectrophotometer. Antioxidant activity (IC50) was analyzed using a linear regression equation. Research Result:The result of this research showed that there was a color changing of DPPH from purple to yellow on fruits ethanol extract and seeds ethanol extract of Morinda citrifolia L. and had antioxidant activity about IC50 398,99 ppm and 401,37 ppm, respectively.Conclusion: Conclusion from this research revealed that fruit ethanol extract and seed ethanol extract of Morinda citrifolia L.has weak antioxidant activity.Keywords : Antioxidant activity, DPPH method, IC50, Morinda citrifolia L.

Analisis Kadar Kolesterol Low Density Lipoproteinsebagai Faktor Risiko Komplikasi pada Pasien Diabetes Melitus Tipe 2 Pranita Aritrina; Asnah Marzuki; Fitriani Mangarengi
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 4, No 1 (2016)
Publisher : Halu Oleo University

Dyslipidemia in type 2 diabetes mellitus (T2DM) can be increased the cardiovascular risk and this condition was equivalent with the elevated of LDL-cholesterol. In type 2 diabetes, LDL was small, dense and more aterogenic. This research was an observational study used cross sectional approach. The samples were 50 samples consist of twenty five of T2DM with non-CHD patient (50%) and twenty five of T2DM with CHD patient (50%) with age 45 years old or more. The level of serum LDL was measured by photometry used ABX Pentra 400. The data was analyzed by statistical method. The result study was conducted that normal LDL level was 9 (18%) patients and abnormal LDL level was 16 (32%) in T2DM with non-CHD patient. While in patient with T2DM with CHD had abnormal LDL level overall (50%). The high level of LDL in T2DM was accelerated complication occurrence, mainly coronary heart disease (CHD).Keywords: Type 2 diabetes mellitus (T2DM), dyslipidemia, LDL level, CHD complication

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