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Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 51 Documents
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Search results for , issue "Vol 12, No 1 (2023)" : 51 Documents clear
Ethnobotanical Survey on the Plants Used in the Control of Nematodes in the Zone of Niayes of Thies/Senegal El Hadji Gorgui Diouf; Doudou Diop; Abdoulaye Gueye; Talibouya Ndior; Mamadou Latyr Ndour; Adama Faye; Mamadou
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.335-341

Abstract

Crop losses in vegetable crops due to nematodes are a concern in a country like Senegal where food demand is increasingly high. The use of chemical pesticides has made great progress in increasing harvests in Senegal. But these pesticides have negative effects on the environment and on human health. Crops are often contaminated as well as groundwater. The use of natural products to remedy this phenomenon is very important, especially in areas such as the Niayes zone where the climate and soil are very favorable for market gardening and where water contamination is very sensitive. The aim of our study is to identify the plants used to control nematodes in the Niayes area of This. To this end, we conducted an ethnobotanical survey of 100 people of different ages and sexes in this area. The results showed 17 plant species used to control nematodes in 12 families. Among these species, the most cited were Azadirachta indica A. Juss. Juss, Calotropis procera (Ait.) F. and Cassia Occidentalis L. Leaves (71%) are mostly used. The sample is often dried and ground (45%) or fresh (case of hydrodistillation) (53%) before preparation. Water (92%) is the most used solvent for extraction. Maceration (85%) and infusion are the most common preparation methods. The application of these preparations by systemic action (94%) is more adopted than fumigation. Local people find these preparations rather effective (78%), which is very encouraging. The present study constitutes a database for further studies in the field of Senegalese pharmacopeia. In addition, scientific research on bionematicidal substances may be conducted in the future to evaluate the effectiveness of these plants identified in the Niayes area of This for the protection of vegetable crops against nematodes.
Effect of Quarry Activities on Some Morphological Parameters of Two Maize Varieties (SWAN 1 and SAMMAZ 52) Odiyi, Bridget; Maku, Olubukola; Ologundudu, Foluso Akinbode; Abiya, Sylvanus Efetobor
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.295-303

Abstract

The effect of quarry activities on some morphological parameters of two maize varieties (swan 1 and sammaz 52) was investigated with the aim of determining the impact of quarry activities on some growth parameters of the maize varieties under study. The seeds were collected from the Seed Bank Department of the Ondo State Ministry of Agriculture, Akure, Ondo State. They were authenticated at the Herbarium unit of the Federal University of Technology, Akure, and the voucher was deposited. Soil samples were collected at 50m, 100m, 150m, 200m, and 250m from the quarry site and transferred to the laboratory for analysis. A screen house experiment was set up to house the pots. Seeds of SWAN 1 and SAMMAZ 52 were sown into perforated plastic pots (30 cm diameter and 33 cm depth) filled with 10 kg of quarry soil. The following morphological parameters were determined; shoot height, leaf area, plant dry weight, shoot dry weight, root dry weight, root-shoot ratio, leaf area, and determination of photosynthetic parameters especially chlorophylls a and b. The result revealed that at 50 meters from the quarry site, SAMMAZ 52, one of the maize varieties grown in soil taken from the site, had the highest shoot height (94 cm). which showed that plants growing in higher concentrations of dust pollution respond to nutrient stress by devoting more of their available carbon to shoot growth, resulting in elongated stems, were consistent with the observed higher shoot height in SAMMAZ 52, daily variations in photosynthetic activity and the rate of nitrogen uptake are to blame for these alterations in plant behavior. The efficiency with which plants use the available nutrients determines whether they will survive in an area where there is quarry dust. The observed higher biomass (3.84g) under SAMMAZ 52's management regime can be attributed to the best possible rates of photosynthesis and nutrient assimilation, as well as to the presence of more chlorophyll and larger leaf surfaces.
Fiber Concentration on Fermentation of Cleome Gynandra L Based on Storage Time and Solvent Change Lily Restusari; Ayu Komala Dewi; Alinea Dwi Elisanti
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.363-369

Abstract

Cleome gynandra L (CGL) or Maman plant, is the basic ingredient of Malay food in Riau Province, Indonesia. The young leaves and stems of CGL are processed into fermented food (Joruk Maman). It contains crude fiber and is useful for lowering blood cholesterol levels. However, effective storage of this CGL has not been carried out. This study wants to see the effect of storage time and solvent change on the fiber content of Joruk Maman. An experimental study applied a completely randomized design (CRD) using 5 groups and 2 repetitions. This sample of CGL leaves was taken from one seller in the Rokan Hilir market of Riau Province. The primary outcome was a difference to the number of fibers in Joruk Maman without solvent change (p =0.001) and with solvent change (p = 0.001) based on the day group and there was no difference base on the temperature group. Secondary outcome was the difference in duration time to produce the highest fiber content at room temperature with the solvent change and not. The highest fiber content occurred at 5 days of storage at room temperature without solvent changing. Meanwhile, by changing the solvent, the fiber content would be optimal for 1-day of storage.
Medicinal Biospecificity of Ginger and Its Efficacious Bioactive Compounds in the Context of Its Biological Activities Against Predominant Health Issues: Current Study and New Avenues Haseeba Shahzad; Shaifa Saleem; Waqas Hanif; Zareena Ali; Muhammad Zeeshan Ahmed; Haq Nawaz; Zelle Humma; Laraib Rana; Muhammad Qamar Farid; Hajira Kalsoom; Samavia Jaan
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.371-389

Abstract

There is a multitude of life-threatening and widespread health issues worldwide, regarding weak immunity, severe inflammation, viral infections, bacterial infections as well as antimicrobial resistance (AMR), high free radicals generation, and cancer. Ginger, a perennial plant of the Zingiberaceae family with several authentic nutritional and medicinal values used in many countries as traditional medicine. That is why, the study was designed to highlight recent studies about medicinally most efficacious bio-active compounds of ginger along their biological significance related to immuno-stimulatory, anti-inflammatory, anti-viral, anti-bacterial, anti-oxidant, and anti-cancer effects. Our study also recognized future gaps in research. The study included professional research data under duration from 2001-2022 appearing in books and scholarly journals, collected from scientific database platforms via PubMed, Web of Science, Google Scholar, Springer Nature, Science Direct and Scopus. The present study includes the medicinal effects of almost 44 most influential ginger compounds like phenolics, terpenoids, flavonoids, and vinyllyl ketonic compounds etc. Our results revealed the strong alleviating effects of gingerols, shogaols, paradols, and polyphenols. Moreover, the ginger essential oil has proven to be very effective both for antiviral and antibacterial activity. However, no data is available in previous literature for components of ginger involved in immuno-stimulatory, effects. There is also a need to explore components for antibacterial activity. However, research has been conducted on ginger for only a few viruses despite its strong alleviating effects. Besides this, more study is needed to comprehend the comprehensive mechanism of action (especially at the molecular level) regarding the anti-bacterial and anti-viral activity of ginger and its constituents.
Nanotechnology-Based Vaccines Mohamed Hussein; Madiha Mumtaz; Iqra Nasir; Anisa Abdullahi
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.343-361

Abstract

Several new infectious diseases have developed in recent years, and a few old ones that were formerly thought to pose no threat to humans have made a comeback. Millions of fatalities are attributed to these illnesses together, having a significant negative influence on the worldwide socioeconomic and healthcare sectors. The lack of appropriate medications for many of these disorders is one of the biggest obstacles to treating them. Yet, several of the most common diseases currently have no vaccinations that are reliable. The ideal vaccine should have several key characteristics, including safety, stability, and the capacity to induce a sufficient and long-lasting immune response with a minimal number of doses. To induce protective immunity against illnesses, different generation vaccines are employed, including attenuated or dead entire organisms (first generation), subunits (second generation), and RNA or DNA vaccines (third generation). To get beyond these obstacles, a reliable vaccination delivery mechanism is needed, one that not only gets the vaccine molecules to the target region where they can trigger long-lasting immune responses but also has few side effects and uses fewer doses. Only a few hundred atoms make up the majority of nanoparticles. Nanoparticles have a relatively significant surface area-to-volume ratio because of their extremely small size. Nanoparticles can have surprising optical, physical, and chemical properties due to this property. Nanotechnology has many benefits for the creation of vaccines for the next generation. A delivery strategy based on nanocarriers can shield vaccines from early deterioration, increase stability, have high adjuvant qualities, and can help with the targeted distribution of an immunogen. The researcher conducts an examination of articles that are in accordance with the issue to be studied. Articles used in the literature review are obtained through the database of international journal providers through PubMed, we investigated clinical studies and discussed what happened in these clinical studies and the extent of the effectiveness of Nanoparticle-Based Vaccines. In order to achieve effective vaccine distribution and generate the required host immunity against infectious diseases, this review article focuses on the applications of nanocarrier-based vaccine formulations and the methodologies utilized for functionalizing nanoparticles.
Analysis of Biological Activities of Two Novel Metal (II) Complexes of Andrographis Paniculata Crude Extract Mary Adelaide Oladipo; Ayodele Oluwabunmi Ojo; Kayode Taiwo Ishola
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.391-397

Abstract

Many diseases in nature have led to the death of many young and old. Many bacteria have developed resistance to the available antibiotics on the market. And many drugs employed in treating many diseases such as diabetes mellitus are expensive and are not locally available. Therefore, in order to search for more effective, inexpensive, and locally available drugs, this study synthesized and investigated the biological activities of Andrographis paniculata crude extract and its Co (II) and Ni (II) complexes. The crude extract and synthesized complexes were characterized using a solubility test, Infrared, and Ultraviolet-Visible spectroscopic analysis. Their antibacterial potentials were investigated against two gram-negative bacteria (Escherichia coli,Staphylococcus aureus) and three gram-negative bacteria (Proteus, Klebsiella, Pseudomonas) while their antidiabetic activities were examined against ?-amylase and ?-glucosidase enzymes. Acarbose was employed as a standard drug. The crude extract and its metal complexes showed different degrees of solubility in the employed solvents. Infrared analysis suggested coordination of the crude extract to the metal ions through the oxygen donor atom while the formation of the complexes was affirmed through the occurrence of d-d transitions in the visible region of the metal complexes. The metal complexes were found to display more antibacterial activity than the crude extract. Co (II) and Ni (II) complexes of the crude extract were found to exhibit better activities against ?-amylase and ?-glucosidase enzymes, respectively than the crude extract and acarbose. It is concluded that the metal complexes could be considered potential antibacterial and antidiabetic agents.
The Anticancer Properties of Guava Leaves (Psidium guajava L.) and Turmeric Rhizome (Curcuma longa L.) Against Breast Cancer: A Literature Study Angga Puja Asiandu; Widya Sari; Septi Widiya Sari; Alif Syahrul Abdul Majid
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.407-412

Abstract

Breast cancer, one of the most deadly diseases occurring in women, is caused by factors. In the healing process, the sufferer needs treatment, such as radiation techniques, surgery, and chemotherapy. But, these techniques have avoidable weaknesses that damage healthy cells. To date, natural sources can be utilized in medicine field. Guava (Psidium guajava L.) and turmeric (Curcuma longa L.) are two common plants obtaining compounds that inhibit the growth of cancer cells based on phytochemical properties. This study was written to review the potential both of plants as anticancer agents. Through the literature, guava leaf extract consists of flavonoids, tannins, alkaloids, saponins, terpenoids that inhibit the proliferation of cancer cells. Besides, turmeric also has tannins, alkaloids, terpenoids, flavonoids, glycosides, sterols, and curcumin. The presence of curcumin reduces histamine production which induce inflammation and decrease toxin. Because of curcumin, breast cancer cells have dehydration before apoptosis.
Peptide Fractions from Pepsin-digested Moringa oleifera Seed Proteins Inhibit Hemoglobin Glycation and Carbohydrate-hydrolyzing Enzymes Oluwafemi Emmanuel Ekun
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.413-422

Abstract

The multidirectional abilities of peptide digests and fractions obtained from the hydrolysis of food-based proteins have been investigated in recent times. This study aims to evaluate the effects of pepsin-derived Moringa oleifera seed protein hydrolysates and fractions on hemoglobin glycation and the carbohydrases - ?-amylase and ?-glucosidase. Proteins were extracted from M. oleifera seeds and consequently digested using pepsin. The hydrolysates obtained were separated into fractions of <1 kD, 1-3 kD, and 3-5 kD ranges using size-exclusion chromatography and comparison with elution volumes of known standards. The activities of the hydrolysates and peptide fractions against both the non-enzymatic glycation of hemoglobin and the carbohydrases were determined in vitro. Results revealed that the hydrolysate and its peptide fractions demonstrated varying abilities against the glycation of hemoglobin, with the unfractionated hydrolysate showing better activities (78.230 0.774 % at a maximum concentration of 1.0 mg/ml) than its peptide fractions. Also, the hydrolysates and fractions demonstrated higher inhibitory effects on a-amylase (with all fractions displaying above 50% inhibition at a final concentration of 1.0 mg/mL) than against a-glucosidase. Kinetic analysis of a selected fraction showed that it inhibited ?-amylase via a mixed mechanism (Ki = 0.029 mg/mL) but displayed an uncompetitive mode for ?-glucosidase inhibition (Ki = 0.333 mg/mL). Therefore, it is inferred that M. oleifera seed proteins encode potentially therapeutic peptide sequences that could be further processed to formulate potential antidiabetic agents.
Cover, Editorial Board, Guidance for Authors, & Table of Contents | Vol. 12 No. 1 April 2023 Luthfi, Muhammad Ja'far
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.%p

Abstract

Weed Community Structure in Patia Village Rice Fields Patia Sub-District, Pandeglang Regency Ai Widiyawati; Hadi Susilo; Mu&#039;jijah Mu&#039;jijah; Suyamto Suyamto; Nurullah Asep Abdilah
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.423-430

Abstract

Rice is a very important type of food crop because it is a staple food source. Crop losses at the farmer level due to competition with weeds reach 10-1.5%. This study aims to determine the structure of rice weed communities in rice fields in Patia Village, Patia District, and Pandeglang Regency. The research method uses an observation method with the sampling technique used as a random method. The plot used was 2 m x 2 m. Weed sampling was carried out by recording the types of weed types and counting the number of individuals of each species. Measurements of environmental factors such as temperature, humidity, pH, and light intensity were measured. The data parameters measured include the Shannon-Wiener diversity index (H'), evenness index (J'), dominance index (D), wealth index (S), and abundance of rice weed species. The results of the study were that the types of rice weeds found in the rice fields of Patia Village, District, and Patia, Pandeglang Regency, namely Ludwigia octovalvis (Jacq) Raven, Commanded cylindricaL. Beauv, Spigelia anthelmia, Ageratum conyzoides, Spihemoclea zeylanica, Altemanthera sessillis, Eclipta prostate, Cypress deformed L., Digitaria sp. and Mimosa chaste L. The structure of the weed community in the rice fields of Patia Village, Patia District, Pandeglang Regency is the Shannon-Wiener Diversity Index (H') of 1.94; Evenness Index (J') of 0.884; Dominance Index (D) of 0.15.

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