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INDONESIA
Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 9 Documents
 1 
Search results for , issue "Vol 9, No 1 (2020)" : 9 Documents clear
Antioxidant Activities of the Leaf Extract and Fractions of Dryopteris filix-mas (L.) Schott could be Attributed to The Abundance of Polyphenol Compounds Earnest Oghenesuvwe Erhirhie; Emmanuel Emeka Ilodigwe; Daniel Lotanna Ajaghaku; Blessing Ogechukwu Umeokoli; Peter Maduabuchi Eze; Festus Basden Chiedu Okoye
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.1-6

Abstract

Dryopteris filix mas (D filix-mas) is wildly used in ethnomedicine for the management of rheumatoid arthritis, wounds and other diseases. We investigated the anti-oxidant activities of its leaf extract, and chromatographic fractions. The ethanol leaf extract was partitioned into four fractions; n-hexane, ethyl acetate, n-butanol and water. Ferric reducing anti-oxidant power (FRAP), 1, 1-diphenyl-2-picrylhydrazil (DPPH) and nitric oxide (NO) scavenging in vitro assays were carried out on the extract and fractions at 6.25, 12.5, 25, 50, 100, 200, 400 and 800 µg/mL. The most active fraction (ethyl acetate fraction) was further purified using chromatographic techniques to isolate its major compound whose structure was elucidated using ID nuclear magnetic resonance (NMR) and mass spectrometry. The ethyl acetate fraction produced the highest free radical scavenging activity among the other fractions. The fraction (VLC-E7) from which the bioactive compound, quercetin-3-O-αL-rhamnopyranoside, was isolated had the best FRAP and DPPH scavenging activities with EC50 and IC50 values of 88.81 ± 3.41 and 26.87 ± 0.24 respectively more than the ethyl acetate fraction. This study revealed that the polyphenol flavonoid, quercetin-3-O-αL-rhamnopyranoside could be responsible for antioxidant activity of ethno-medicinal property of D filix-mas leaf.
The Effect of Cassava Peel Starch Addition to Bioplastic Biodegradation Based On Chitosan On Soil and River Water Media Mahfud Syuhada; Sintia Ainus Sofa; Endaruji Sedyadi
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.7-13

Abstract

The study of the relationship between starch addition to biodegradation of bioplastics has been carried out. This study aims to understand the biodegradability of chitosan-based bioplastics with additional cassava peel starch on soil and river water media. This research was conducted through four stages, namely making starch from cassava peel waste, making bioplastics using the blending and castingwet processes method with variations of starch 5, 10, 15 and 20 ml. Testing physical mechanical properties including water resistance, thickness, tensile strength, elongation, and modulus young. Testing the characteristics of bioplastics functional groups was carried out using FTIR (Fourier Transform Infrared) and biodegradation testing of bioplastics carried out on soil and river water media. The results of bioplastics research with variation 5 ml produce good mechanical physical properties. Bioplastics produced water resistance value of 45.03%, thickness of 0.0190 mm, tensile strength of 49.93 MPa, elongation of 3.068% and Young modulus of 1627.63 MPa. Bioplastics biodegradation test was observed by measuring the decrease in sample mass. The biodegradation test results in soil and river water media respectively showed a decrease in bioplastic mass up to 63% and 54%. The biodegradation rate of the calculation results on soil media is −0,1502 and in river water media is −0,0948.
A Mathematical Model of the Covid-19 Cases in Indonesia (Under and Without Lockdown Enforcement) Sugiyanto Sugiyanto; Muchammad Abrori
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.15-19

Abstract

COVID-19 stands for Corona (CO), Virus (VI), Disease (D) and year 2019 (19), which is COVID-19 first appeared in 2019. Mathematical model of covid deployment in Indonesia under and without lockdown case uses the SIRV model, such as Susceptible, Infected, Recovery, and Virus. The results of this model state that under lockdown the spread of COVID-19 could be stopped. If it were not under lockdown it can multiply 1,276 times higher over two months.
Analysis of Body Posture using Rapid Entire Body Assessment (REBA) and Rapid Upper Limb Assessment (RULA) to Improve the Posture of Sand Paper Machine Operators and Reduce the Risk of Low Back Pain Trio Yonathan Teja Kusuma
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.21-25

Abstract

The metal casting industry, Nitikan is a micro business whose production process is carried out manually. The equipment used is simple and without considering the user's health. This can be seen in the product finishing process that uses a sanding machine. The equipment is not designed according to the user's posture so the operator bends in doing work movements, of course this is very risky to experience lower back pain injuries. This study aims to analyze the work activities of the finishing process using the Rapid Entire Body Assessment (REBA) and Rapid Upper Limb Assessment (RULA) approach and design work tools that can be applied to improve work posture. The results of data processing and analysis obtained a Rapid Entire Body Assessment score on a sandpaper machine single head of 5 and a Rapid Upper Limb Assessment score of 4, the score indicates that the work position has the potential to experience a risk of low back pain, so there must be an improvement in work posture. Work posture improvement is done by designing a tool in the form of a sandpaper machine that takes into account ergonomic dimensions to reduce the risk of lower back injury. The final result after the improvement is obtained Rapid Entire Body Assessment score of 3 and Rapid Upper Limb Assessment score of 4. This shows that the risk of lower back injuries can be minimized.
The Potential of Chrysin of Oroxylum indicum L. to Induce Carbonic Anhydrase (CA) to Improve Cattle Fertility Amin, Mohamad; Fahmi, Muhammad Najib; Ridho, Muhammad Andi Ali; Fitri, Nurul; Lestari, Umie; Maulina, Dina; Amin, Ihya Fakhrurizal
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.27-32

Abstract

The Artificial Insemination (AI) aims to develop the potential of the cattle reproduction comprehensively. The success of AI results is highly dependent on the level of livestock fertility. Therefore, improv the quality and quantity of semen could be done by hormone induction. However, hormone prices are expensive. This problem could be overcome using alternative way with the natural compound containing chrysin which might has the same function. The purpose of the study was analyze the potential of chrysin compound from Bungli plant (Oroxylum indicum) as fertilizer of males through bioinformatics approach. Methods performed through data search by webserver with the following stages: (1) Pubchem, (2) Swiss (3) Target Prediction, (4) Uniprot, (5) Protein Data Bank and (6) docking software using PyRx, PyMOL and Discovery Studio. The results showed that the chrysin compound interact with carbonic anhydrase (CA) expressed from the testes of the cattle, through van der Waals and Pi-Alkyl bonds. Chrysin is effective as CA ligand inducers based on affinity bonds (-8.4 kcal/mole) and more negatively than flavonol as a control compound with binding affinity (-6.2 kcal/mol). This suggests that chrysin is an effective compound as a potential drug for improved livestock fertility.
Isolation and Characterization of Sesquiterpenes from Stem Bark of Warburgia ugandensis Sprague Teshome Gonfa Hordofa
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.39-46

Abstract

Warburgia ugandensis Sprague is one of the medicinal plants traditionally used to treat a number of diseases like asthma, cough, diarrhea, common cold, stomachache and toothache in Ethiopia. However, there is still insufficient information on the isolation and evaluation of bioactive compounds from this plant species. Extraction, purification and isolation of the stem bark of this plant by dichloromethane and chloroform as solvents afforded two sesquiterpenes; namely, WU-1 (ugandensidial) and WU-2 (cinnamolide-3β-acetate) respectively. The structural elucidations of these bioactive compounds were accomplished by using a variety of spectroscopic methods (IR, UV and NMR). The spectroscopic results compared with the reported data in the literature.
Toxicological Effects of Ethanolic Stem Bark Extract of Xylopia Aethiopica on Testicular Oxidative Stress Markers and Histology of Male Rats Elias Adikwu; Ben Ehigiator
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.33-37

Abstract

Impairment in testicular function can occur through perturbations in testicular oxidative stress markers and histology. Xylopia aethiopica (XE) is used to enhance fertility in males, but with information gap on its effect on testicular oxidative stress markers and histology. The present study assessed the effects of ethanolic stem bark extract of Xylopia aethiopica (EEXA) on testicular oxidative stress markers and histology of male albino rats. Sixty adult male albino rats (200g-250g) were randomly grouped into 4 (A-D) of 15 rats per group. The rats in the control group A (A1-A3) were administered per oral (p.o) with water (0.2 mL/day) for 15, 30 and 60 days respectively. The rats in groups B (B1-B3), C(C1-C3) and D (D1-D3) were administered p.o with EEXA (200, 400 and 800 mg/kg/day) for 15, 30 and 60 days respectively. The rats were anesthetized at the termination of EEXA administration and were dissected and testes removed. The testes were weighed and evaluated for oxidative stress markers and histology. Testicular weights were decreased in a dose and-time dependent fashion in EEXA-treated rats. Significant decreases in testicular superoxide dismutase, glutathione, catalase, and glutathione peroxidase levels with significant increases in malondialdehyde levels in a dose and time-dependent fashion were observed in rats administered with EEXA. Testicular histology showed cellular necrosis, degeneration and loss of interstitial tissues in rats administered with EEXA. This study observed that EEXA perturbed testicular oxidative markers and histology. Its use may impair testicular function.
Prevalence of Psychoactive Substance Use Among Nigerian Male Commercial Vehicle Drivers Selected from The Three Major Ethnic Groups in Nigeria Tochukwu Frank Egwuatu; Onyekachi Ogbonnaya Iroanya; Khalid Olajide Adekoya
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.47-55

Abstract

The use of psychoactive substances for several reasons by commercial vehicle drivers has been documented as a major cause of increased incidences of traffic accidents globally. The study aimed at determining the prevalence of psychoactive substance use among Nigerian male commercial vehicle drivers randomly selected from the three major ethnic groups in Nigeria (Igbo, Hausa and Yoruba). A structured questionnaire which included data on sociodemographic status and psychoactive drug use history was introduced to all participants. Generic Multi-Drug Urine Dip Card Test Kit and Shimadzu chromatograph system (Shimadzu Corporation, Kyoto, Japan) were used for toxicological analyses. Out of the 264 Nigerian male commercial vehicle drivers who participated in this study, 111(42.0 %) had used illicit drugs in recent times, 55(20.8 %) took drugs for improved energy and 90(34.1 %) felt high after using illicit drugs. Marijuana was the most abused substance; 77(29.2 %) followed by benzodiazepine; 34(12.9) across all ethnicities studied. Across all ethnicities, HPLC revealed that the Hausa drivers had the highest concentration of psychoactive substances in their urine samples. These findings, reiterates the need for the Nigerian anti-drug agency to develop new strategies in conducting a repressive drug war and extending the same to bus stations.
Cover, Editorial Board, Guidance for Authors, & Table of Contents | Vol. 9 No. 1 April 2020 Muhammad Ja’far Luthfi
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.%p

Abstract

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