Pharmacon
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
Articles
10 Documents
Search results for
, issue
"Vol 15, No 1 (2018)"
:
10 Documents
clear
<![CDATA[Pengaruh Ekstrak Etanol Daun Murbei (Morus Alba L.) dengan Glibenklamid Terhadap Ekspresi Gen CYP3A4 pada Kultur Sel HepG2 ]]>
<![CDATA[Nuralih, Nuralih]]>;
<![CDATA[Churiyah, Churiyah]]>;
<![CDATA[Pambudi, Sabar]]>;
<![CDATA[Tamat, Swasono R.]]>;
<![CDATA[Meila, Okpri]]>
<![CDATA[ Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.23917/pharmacon.v15i1.5766
<![CDATA[Mulberry leaf is a traditional herb and predicted has ecdysteronecompound which act as antihyperglicemid. Glybenclamide is a synthetic medicine used to cure diabetes mellitus type 2. The leaf reported as competitive inhibitor of CYP3A4 enzyme, which metabolizingglibenclamide. However, in many cases, combination of herbs with synthesis drugs causes interaction if used at the same time. This research aimed to see interaction of ethanol mulberry leaf extract with glibenclamide through CYP3A4 gene expression in HepG2 cell culture.Sample of mulberry extract, glibenclamide, and combination both sample were tested into cell HepG2 culture. Then RNA were isolated and purification using real time PCR to see the gene CYP3A4 expression. As a result, mulberry extract acts as inhibitor enzyme CYP3A4, while glibenclamide is enzyme substrate.The combination of mulberry and glibenclamide showed increased of expression of CYP3A4 gene, means greater enzyme produced, and lower medicine on blood plasma.]]>
<![CDATA[Willingness to Pay Pelayanan Konseling Apoteker di Apotek di Kecamatan Polokarto Tahun 2016 ]]>
<![CDATA[Harlianti, Mariska Sri]]>;
<![CDATA[Andayani, Tri Murti]]>;
<![CDATA[Puspandari, Diah Ayu]]>
<![CDATA[ Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.23917/pharmacon.v15i1.7247
<![CDATA[Counseling is one part of the clinical pharmacy service at the pharmacy that is the responsibility of the pharmacist to achieve therapeutic goal. Community needs for counseling have increased so that the active participation of pharmacists is needed through the provision of professional services. This research needs to be done to find out the amount of counseling services by pharmacists who are willing to be paid by patients with a WTP (Willingness to Pay) value parameter. In addition, the value of WTP can also describe the indirect benefits felt by the community towards counseling services by pharmacists at the pharmacy. This research is a descriptive observational research through a survey. The study was conducted at the pharmacy in the Polokarto sub-district of Sukoharjo regency in January – February 2016 with pharmacy visitor respondents who received counseling services by pharmacists. A total of 82 patients participated in this study. The amount of WTP is determined based on the average WTP value chosen by the patients with the payment card method. The result showed that the average WTP value of pharmacist counseling services at pharmacies in Sukoharjo regency was Rp. 15,892. ]]>
<![CDATA[Utilization of Secang (Caesalpinia Sappan L) Wood Extract in Optimization of Liquid Soap Formulation ]]>
<![CDATA[Saryanti, Dwi]]>;
<![CDATA[Setiawan, Iwan]]>
<![CDATA[ Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.23917/pharmacon.v15i1.5702
<![CDATA[One of the plants used in traditional medicine is secang (Caesalpinia sappan L.). Liquid soap is now widely produced because of its practical use and better appearance. The use of anionic surfactants can cause irritation and dry skin due to strong binding of skin proteins. Cocamid DEA is used as nonionic surfactant in the liquid soap formulation to reduce the irritation caused by the anionic surfactant. The determination of optimal formula of secang wood extract liquid soap used D-optimal method by using parameter of pH test, viscosity, density and antibacterial activity. The organoleptic, pH, viscosity, density, antibacterial activity, foam stability, and physical stability of optimal formula were tested by cycling test. The ratio of sodium lauryl sulfate:cocamid DEA in optimal formula of secang wood extract liquid soap was (98.95: 1.05). The optimal formula of liquid soap has pH 4.6, viscosity 51.67 dPas, density 1.06 g / mL, antibacterial activity of Staphylococcus aureus 16.2 mm and foam stability 96.67%.]]>
<![CDATA[Skrining Aktivitas Antibakteri Ekstrak Etanol 70% Sepuluh Daun Tanaman Terhadap Klebsiella Pneumoniae ]]>
<![CDATA[Qolbi, Nurul]]>;
<![CDATA[Yuliani, Ratna]]>
<![CDATA[ Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.23917/pharmacon.v15i1.6169
<![CDATA[Klebsiella pneumoniae causes several diseases such as chronic obstructive lung disease and community pneumonia. The antibiotics used for treating the infectious diseases cause several side effects. Therefore, alternative medicines which have minimal side effects are needed. This research aimed to investigate antibacterial activity of ten ethanolic extract of leaves against K. pneumoniae, identify compounds and active compounds in extract which has the highest antibacterial activity. Compounds in leaves were extracted using 70% ethanol with maceration method. The disk diffusion method was used for screening antibacterial activity against K. pneumoniae. The identification of group of compounds in extract with the largest inhibitory zone diameter was done using Thin Layer Chromatography (TLC) and bioautographic test was performed to determine the active compounds. The results of antibacterial activity screening tests showed that all extracts have antibacterial activity except bamboo leaf extract. Breadfruit extract (Artocarpus altilis) has the highest antibacterial activity with diameter of inhibition zone of 18,33 ± 5,57 mm. Breadfruit extract contains tannin, polyphenol, alkaloid, terpenoid, saponin, and the active antibacterial compounds were terpenoid and saponin.]]>
<![CDATA[Analisis Rasionalitas Penggunaan Antipsikotik pada Pasien Skizofrenia di Instalasi Rawat Inap RSJD Atma Husada Mahakam Samarinda Tahun 2016 ]]>
<![CDATA[Saputri, Rika Paramitha]]>;
<![CDATA[Sulistyawati, Elina Endang]]>;
<![CDATA[Untari, Meta Kartika]]>
<![CDATA[ Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.23917/pharmacon.v15i1.6180
<![CDATA[Schizophrenia is a chronic heterogeneous syndrome characterized by irregular mindset, delusion, hallucination, improper behavioral changes, and psychosocial dysfunction. The purpose of this research was to know the pattern of antipsychotic use and rationality of antipsychotic use in schizophrenia patient at Inpatient Installation of Atma Husada Mahakam Psychiatric Hospital Samarinda in 2016 based on right indication, right drug selection, right patient, and right dose. The study was use descriptive non-experimental method with retrospective data collection from medical record of patients with purposive sampling technique. The samples used was 94 patients who received antipsychotic with age range 17-55 years and had a complete medical history. The data obtained were analyzed according to Guideline Texas Medication Algorithm Project Procedural Manual of Schizophrenia Treatment Algorithms. Based on the results obtained data of single antipsychotic the most widely used was haloperidol as 39 prescriptions (53.42%). The use of the most commonly prescribed combination of two antipsychotic was combination of clozapine-haloperidol as 19 prescriptions (38,00%), while combination of three prescribed antipsychotic was combination of chlorpromazine-risperidone-clozapine and haloperidol-risperidone-clozapine each as 1 prescription (50,00%). The rationale of antipsychotic use obtained percentage of right indication was 100%, right drug selection 95,20%, right patient 100%, and right dose 100%.]]>
<![CDATA[Utilization of Secang (Caesalpinia Sappan L) Wood Extract in Optimization of Liquid Soap Formulation ]]>
<![CDATA[Dwi Saryanti]]>;
<![CDATA[Iwan Setiawan]]>
<![CDATA[ Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.23917/pharmacon.v15i1.5702
<![CDATA[One of the plants used in traditional medicine is secang (Caesalpinia sappan L.). Liquid soap is now widely produced because of its practical use and better appearance. The use of anionic surfactants can cause irritation and dry skin due to strong binding of skin proteins. Cocamid DEA is used as nonionic surfactant in the liquid soap formulation to reduce the irritation caused by the anionic surfactant. The determination of optimal formula of secang wood extract liquid soap used D-optimal method by using parameter of pH test, viscosity, density and antibacterial activity. The organoleptic, pH, viscosity, density, antibacterial activity, foam stability, and physical stability of optimal formula were tested by cycling test. The ratio of sodium lauryl sulfate:cocamid DEA in optimal formula of secang wood extract liquid soap was (98.95: 1.05). The optimal formula of liquid soap has pH 4.6, viscosity 51.67 dPas, density 1.06 g / mL, antibacterial activity of Staphylococcus aureus 16.2 mm and foam stability 96.67%.]]>
<![CDATA[Skrining Aktivitas Antibakteri Ekstrak Etanol 70% Sepuluh Daun Tanaman Terhadap Klebsiella Pneumoniae ]]>
<![CDATA[Nurul Qolbi]]>;
<![CDATA[Ratna Yuliani]]>
<![CDATA[ Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.23917/pharmacon.v15i1.6169
<![CDATA[Klebsiella pneumoniae causes several diseases such as chronic obstructive lung disease and community pneumonia. The antibiotics used for treating the infectious diseases cause several side effects. Therefore, alternative medicines which have minimal side effects are needed. This research aimed to investigate antibacterial activity of ten ethanolic extract of leaves against K. pneumoniae, identify compounds and active compounds in extract which has the highest antibacterial activity. Compounds in leaves were extracted using 70% ethanol with maceration method. The disk diffusion method was used for screening antibacterial activity against K. pneumoniae. The identification of group of compounds in extract with the largest inhibitory zone diameter was done using Thin Layer Chromatography (TLC) and bioautographic test was performed to determine the active compounds. The results of antibacterial activity screening tests showed that all extracts have antibacterial activity except bamboo leaf extract. Breadfruit extract (Artocarpus altilis) has the highest antibacterial activity with diameter of inhibition zone of 18,33 ± 5,57 mm. Breadfruit extract contains tannin, polyphenol, alkaloid, terpenoid, saponin, and the active antibacterial compounds were terpenoid and saponin.]]>
<![CDATA[Pengaruh Ekstrak Etanol Daun Murbei (Morus Alba L.) dengan Glibenklamid Terhadap Ekspresi Gen CYP3A4 pada Kultur Sel HepG2 ]]>
<![CDATA[Nuralih Nuralih]]>;
<![CDATA[Churiyah Churiyah]]>;
<![CDATA[Sabar Pambudi]]>;
<![CDATA[Swasono R. Tamat]]>;
<![CDATA[Okpri Meila]]>
<![CDATA[ Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.23917/pharmacon.v15i1.5766
<![CDATA[Mulberry leaf is a traditional herb and predicted has ecdysteronecompound which act as antihyperglicemid. Glybenclamide is a synthetic medicine used to cure diabetes mellitus type 2. The leaf reported as competitive inhibitor of CYP3A4 enzyme, which metabolizingglibenclamide. However, in many cases, combination of herbs with synthesis drugs causes interaction if used at the same time. This research aimed to see interaction of ethanol mulberry leaf extract with glibenclamide through CYP3A4 gene expression in HepG2 cell culture.Sample of mulberry extract, glibenclamide, and combination both sample were tested into cell HepG2 culture. Then RNA were isolated and purification using real time PCR to see the gene CYP3A4 expression. As a result, mulberry extract acts as inhibitor enzyme CYP3A4, while glibenclamide is enzyme substrate.The combination of mulberry and glibenclamide showed increased of expression of CYP3A4 gene, means greater enzyme produced, and lower medicine on blood plasma.]]>
<![CDATA[Analisis Rasionalitas Penggunaan Antipsikotik pada Pasien Skizofrenia di Instalasi Rawat Inap RSJD Atma Husada Mahakam Samarinda Tahun 2016 ]]>
<![CDATA[Rika Paramitha Saputri]]>;
<![CDATA[Elina Endang Sulistyawati]]>;
<![CDATA[Meta Kartika Untari]]>
<![CDATA[ Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.23917/pharmacon.v15i1.6180
<![CDATA[Schizophrenia is a chronic heterogeneous syndrome characterized by irregular mindset, delusion, hallucination, improper behavioral changes, and psychosocial dysfunction. The purpose of this research was to know the pattern of antipsychotic use and rationality of antipsychotic use in schizophrenia patient at Inpatient Installation of Atma Husada Mahakam Psychiatric Hospital Samarinda in 2016 based on right indication, right drug selection, right patient, and right dose. The study was use descriptive non-experimental method with retrospective data collection from medical record of patients with purposive sampling technique. The samples used was 94 patients who received antipsychotic with age range 17-55 years and had a complete medical history. The data obtained were analyzed according to Guideline Texas Medication Algorithm Project Procedural Manual of Schizophrenia Treatment Algorithms. Based on the results obtained data of single antipsychotic the most widely used was haloperidol as 39 prescriptions (53.42%). The use of the most commonly prescribed combination of two antipsychotic was combination of clozapine-haloperidol as 19 prescriptions (38,00%), while combination of three prescribed antipsychotic was combination of chlorpromazine-risperidone-clozapine and haloperidol-risperidone-clozapine each as 1 prescription (50,00%). The rationale of antipsychotic use obtained percentage of right indication was 100%, right drug selection 95,20%, right patient 100%, and right dose 100%.]]>
<![CDATA[Willingness to Pay Pelayanan Konseling Apoteker di Apotek di Kecamatan Polokarto Tahun 2016 ]]>
<![CDATA[Mariska Sri Harlianti]]>;
<![CDATA[Tri Murti Andayani]]>;
<![CDATA[Diah Ayu Puspandari]]>
<![CDATA[ Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.23917/pharmacon.v15i1.7247
<![CDATA[Counseling is one part of the clinical pharmacy service at the pharmacy that is the responsibility of the pharmacist to achieve therapeutic goal. Community needs for counseling have increased so that the active participation of pharmacists is needed through the provision of professional services. This research needs to be done to find out the amount of counseling services by pharmacists who are willing to be paid by patients with a WTP (Willingness to Pay) value parameter. In addition, the value of WTP can also describe the indirect benefits felt by the community towards counseling services by pharmacists at the pharmacy. This research is a descriptive observational research through a survey. The study was conducted at the pharmacy in the Polokarto sub-district of Sukoharjo regency in January – February 2016 with pharmacy visitor respondents who received counseling services by pharmacists. A total of 82 patients participated in this study. The amount of WTP is determined based on the average WTP value chosen by the patients with the payment card method. The result showed that the average WTP value of pharmacist counseling services at pharmacies in Sukoharjo regency was Rp. 15,892. ]]>
