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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 7 Documents

Search results for , issue "Vol 18 No 2, 2007" : 7 Documents clear

Co-chemotherapy of sambung nyawa (Gynura procumbens (Lour.) Merr.) leaves ethanolic extract and Doxorubicin on breast cancer cell Edy Meiyanto; Riris Istighfari Jenie
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Chemotherapy combination attracted high attention in recent years to cure cancer. This method combines between non-toxic or less toxic phytochemicals and chemotherapeutic agents to sensitize cancer cell, to enhance the efficacy of chemotherapeutic agents as well as to reduce its toxicity to normal tissues. The aim of the present research was to examine whether ethanolic extract of Sambung Nyawa leaves (SNE) or Gynura procumbens (Lour.) Merr. synergizes the therapeutic potential of doxorubicin (Dox) on breast cancer cell line T47D.MTT assay was used to measure the effect of growth inhibitory of the combination therapy on T47D cells. SNE (25-500 μg/mL) treatment of cell resulted in 12-97.% growth inhibition in a dose dependent manner (IC50 90 μg/mL), while Dox (1.8-90 nM) treatment showed inhibitory effect of 16-83.% (IC50 50 nM). The combinations of SNE with Dox (1.8-18 nM) showed synergistic effect (CI<1). These results demonstrate a strong possibility of synergistic efficacy of SNE and Dox combination for breast cancer treatment.Key words: Sambung Nyawa leaves ethanolic extract, doxorubicin, cochemotherapy, T47D human mammary cancer cell.

Analysis of Derivate Compound Between Sodium Alendronat with Chloride by High Performance Liquid Chromatography Yahdiana Harahap; Hayun .; Meriska Sukandar
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Sodium alendronate is one of biphosphonate group drugs for the treatment of osteoporosis,. The aim of this research was to obtain the optimum condition for forming derivative of sodium alendronate with dansyl chloride. By adding 270 μL dansyl chloride to 0.1 M sodium carbonate buffer at pH 10.0 mixing with thermomixer at 50.oC for 50 minutes, resulted in a stable derivative within 30 minutes. The compound was analysed by high performance liquid chromatography method using C18 column acetonitrilemethanol-buffer (25 mM KH2PO4 and 25 mM citric acid) (20:15:65;v/v) as mobile phase at a flow rate of 1.0 mL/minute; (detected at wavelength of excitation 320 nm and emission 495 nm). The retention time of the derivative was 19.758 minutes, the calibration’s curve was linear at concentration range of 0.2-1 μg/mL with coefficient of correlation (r) 0.9995 and limit of quantitation 0.114 μg/mL.Key word : HPLC, sodium alendronat, dansyl chloride, fluorescence

Performance evaluation of pharmacy x in Yogyakarta using balanced scorecard approach ., Satibi; Furdiyanti, Nova Hasani; Rahmawati, Maya
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The research to evaluate the performance of Pharmacy X in Yogyakarta using balanced scorecard approach has been performed. The goal of the present work was to find out the performance of the Pharmacy, evaluated by four perspectives, i.e. finance, customer, internal business process, and learning and growth.This research implemented non experiment at design by evaluative descriptive approach. Data consist of primary and secondary data. The primary data was obtained from observation of prescribing service process, i.e. average of dispensing time drug information service, drug available, identification of Drug Related Problem (DRP), customer satisfaction, and interview. Secondary data is taken from pharmacy documents, i.e. pharmacy finance report, pharmacy labor, and the patients-prescription in 2003-2005.The results show that pharmacy X condition is not good. The performance of finance perspective indicated the Return on Investment in 2003-2005 was bellow the average (1,45.%, 0.% and 0.%).Net profit margin (0,80.%, 0.% and 0.%) and turn over ratio (4,86 x, 4,48 x and 3,85 x). Performance of customer perspective indicates good customer satisfaction, but the number of prescription decreased. Learn – growth perspective analysis indicated a high level of employee motivation and productivity; Performance in internal business process perspective showed: level of drug availability 86,21%, average of dispensing time 16,97 minutes (for compounding drugs) and 4,78 minutes (for non compounding drugs), drugs information weren’t appropriate with standard of Kepmenkes No.1027/MENKES/SK/IX/2004. Drug Related Problems identified were prescription under dose (29.%), over dose (7.%), and drugs interaction (64.%).Key words : pharmacy X, performance, balanced scorecard

Identification of physical interaction between levodopa–benzerazide hydrochloride Ilma Nugrahani; Sukmadjaja Asyarie; Sundani Noerono Soewandhi; Slamet Ibrahim
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of this research was to investigate the possibility physical interaction occurred between of levodopa and benzerazide hydrochloride, which known as compounds used in combination for the the antiparkinson. The “cold contact methods” was used which was developed from Kofler contact method’s (hot stage methods). Thermograms Differential Scanning Calorimetry and difractograms X-Ray indicated that levodopa – benzerazide hydrochloride tent to form a peritecticum-molecular compound physical interaction with eutectics point at 4:6 and 9:1 molar ratios.Key words: benzerazide hydrochloride, cold contact method, levodopa, physical interaction.

8-Methoxycapnolactone and stigmasterol From Micromelum minutum Ratna Asmah Susidarti; Marwadi Rahmani; Abdul Manaf Ali; M. Aspollah Sukari; Hazar B.M. Ismail; Julius Kulip; Peter G. Waterman
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The coumarin, 8-methoxycapnolactone and stigmasterol were isolated from the leaves of Micromelum minutum (Rutaceae) which collected from Sepilok, Sabah, Malaysia and their structures were characterized by spectroscopic methods.Key words: Micromelum minutum; Coumarin; 8-Methoxycapnolactone, Stigmasterol

Active cutaneous anaphylaxis-inhibitory activity of Gamavuton-0 potassium (K-GVT-0) Agung Endro Nugroho; Nunung Yuniarti; Enade Perdana Istyastono; Supardjan .; Lukman Hakim
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Potassium Gamavuton-0 is a salt form of 1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,6-heptadiene-3,5 dione or gamavuton-0. Structure modification to a salt form is expected to result in a soluble compound which should have a better bioavailability. The purpose of this experimental study was to evaluate the inhibitory effects of potassium gamavuton-0 on active cutaneous anaphylaxis reaction induced by ovalbumin as an antigen.The study was performed using an active cutaneous anaphylaxis method followed by histopathological observation. The rats were subcutaneously sensitised by ovalbumin (OVA) and Al(OH)3 twice on the days of 0 and 7, and finally were challenged by ovalbumin on the day of 14 to induce active cutaneous anaphylaxis reaction. In order to determine the mast cells on the inflammation tissues, the specimens were stained with 0.1 % Alcian Blue (pH 0.3) and nuclear fast red. Under light microscopy, mast cells were identified as blue granules against a pale red backgound.The results showed that potassium gamavuton-0 at the doses of 20 and 40 mg/kg BW could inhibit the pigmentation area of vascular permeability on rats dorsal skin. It indicated that this compound has the inhibitory effect on active cutaneous anaphylaxis reaction with ED30 value of 28.26 mg/kg BW. Nevertheless, inhibitory effect of potassium gamavuton-0 was still lower than that of cromolyn sodium, a mast cell degranulation inhibitory drug. Histopathologically, the mechanism of inhibitory effect of potassium gamavuton-0 on active cutaneous anaphylaxis reaction is suggested through the inhibition on mast cell degranulation process responsible for releasing inflammation mediators such as histamine, serotonin.Key words: Gamavuton-0 potassium, anaphylaxis, mast cell, ovalbumin

The thermodynamics of inclusion complex of phenobarbital with hydroxypropyl-Î²-cyclodextrin Martodihardjo, Suwaldi; Isadiartuti, Dewi
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Cyclodextrins are cyclic oligosaccharides which have been used extensively to improve the solubility in the formation of inclusion complex. The ability of cyclodextrin to form an inclusion complex has been attributed to factors including size of cyclodextrin cavity to the guest molecule and thermodynamics of their interactions.In this study, complex formation of phenobarbital and hidroxypropyl-Î²-cyclodextrin in the acetate buffer 0.01 M pH 4.4 and phosphate buffer 0.01 M pH 7.4 all with Î¼ =0.10 and at temperatures of 32.o, 37.o, and 42oÂ±0.5oC were determined.The results showed that phenobarbital formed inclusion complex with hidroxypropyl-Î²-cyclodextrin. The interaction shown a negative enthalphy (Î”H < 0 ), a spontaneous processes (Î”G < 0) and an increase in the entropy of the system (Î”S > 0).Key words : phenobarbital and hidroxypropyl-Î²-cyclodextrin, inclusion complex, thermodynamics

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