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Journal Pharmaceutical Science and Application (JPSA)

jpsa
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Published by Universitas Udayana

ISSN : 23017694 EISSN : 23017708 DOI : https://doi.org/10.24843/JPSA.2020.v02.i01

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Journal of Pharmaceutical Sciences and Applications (JPSA) is an online and print out Journal. This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmaceutical sciences and applications. Pharmaceutical Technology Pharmacognosy Natural Product Research Pharmaceutics Novel Drug Delivery Biopharmaceutics Pharmacokinetics Pharmaceutical/Medicinal Chemistry Computational Chemistry and Molecular Drug Design Pharmacology and Toxicology Pharmaceutical Analysis Pharmacy Practice Clinical and Hospital Pharmacy Community Pharmacy Cell Biology Genomics and Proteomics Pharmacogenomics Bioinformatics and Biotechnology The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal. Journal of Pharmaceutical Scince and Application (JPSA), a half yearly publication, serves the need of different scientists and others involved in Pharmaceutical science research and application. All contribution to JPSA are reviewed by peer review process and copy editing process with the understanding that they have not been published previously and are not under consideration for publication elsewhere.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 5 Documents

Search results for , issue "Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application" : 5 Documents clear

THE EFFECT OF LAVENDER AROMATHERAPY ON DYSMENORRHOEA STUDENTS IN INSTITUTE OF HEALTH SCIENCE MEDICA PERSADA BALI AA Sg Dewi Pradnya Pramita; IA Manik Partha Sutema; Dhiancinantyan Windydaca Brata Putri
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Background: Menstrual pain (dysmenorrhoea) is a symptom characterized by discomfort in the abdomen during menstruation. Lavender aromatherapy is beginning to be sought as one of the non-pharmacological therapies because the use of NSAIDs is reported to cause many side effects. The main components of lavender, linalool (35%) and linalyl acetate (51%) are efficacious as analgesics and maximally absorbed through the skin. Objective: This study aims to determine the effect of lavender aromatherapy on the menstrual pain of female college students at the Persada Medika Institute of Bali. Methods: Quasy experimental with one group pre-posttest design. The study was followed by 38 female students with moderate to severe pain using the random sampling technique. Data were analyzed using the non-parametric Wilcoxon test with p <0.05. Results: The results prior to lavender aromatherapy showed moderate pain at 73.7% and severe pain 26.3%. After lavender aromatherapy was administered, they showed moderate pain at 21% and mild pain at 79%. The Wilcoxon test indicated that the value of p = 0,000, where p <0.05. Conclusion: There is an effect of lavender aromatherapy to decrease menstrual pain (dysmenorrhoea) of female college students at the Persada Bali Institute of Health Sciences. Keywords: Aromatherapy Lavender, Dysmenorrhoea, Pain Scale, Linalool, Linalyl Acetate

EFFECTIVENESS OF BRONCHODILATOR AND CORTICOSTEROID TREATMENT IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) Putu Rika Veryanti; Ainun Wulandari
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic airway disease which is characterized by progressive airway obstruction. Bronchodilators and corticosteroids are the first choices of therapy in COPD patients. The goal therapy of COPD patients is to prevent respiratory failure, which can impact on death. But nowadays, the mortality rate due to COPD continues to increase. WHO predicts mortality from COPD in the year 2030 will be ranked third in the world. This high mortality can be caused by the ineffectiveness of therapy given. Objective: The aim of this study is to find out the effectiveness of bronchodilator and corticosteroid treatments in COPD patients. Methods: An observational study conducted retrospectively in the 2018 period at Fatmawati Central General Hospital. The effectiveness of therapy was assessed from the patient's clinical condition, blood gas values (PaO2 & PaCO2) and the average length of stay (AvLOS). Results: COPD was mostly suffered by males (83,33%), and the highest age for COPD was in the range of 45 years and above (90%). Bronchodilator that commonly prescribed were albuterol (30.08%), ipratropium bromide (12.2%), fenoterol hydrobromide (10.57%), terbutaline sulfate (8.13%), theophylline (1.63%) and aminophylline (5.69%), while the corticosteroids were budesonide (17.07%), methylprednisolone (9.76%) and dexamethasone (4.88%). Bronchodilator and corticosteroid had improved patient's clinical condition (96.67% patients) and also improved PaO2 & PaCO2 values patients. There was a significant improvement in PaO2 and PaCO2 value in COPD patients (p <0.05). Conclusion: Bronchodilator and corticosteroid in COPD patients had improved patient's clinical condition and PaO2 & PaCO2 values, but the average length of stay exceeds the standard (6-9 days). Keywords: Bronchodilator, Corticosteroid, COPD, Blood Gas Analysis, Average Length of Stay

STABILITY COMPARISON OF TULASI (Ocimum tenuiflorum L.) LEAF GEL HAND SANITIZER USING 0.5% AND 1% CMC-Na Dewa Ayu Made Adnya Swari; Ni Putu Udayana A; Ni Made Dharma Shantini S
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Background: Hand sanitizers contain 62% alcohol, softener and moisturizer. High alcohol content is able to irritate and make hands dry. A suitable moisturizer is needed for this preparation. Objective: The aim of this study is to evaluate the physical quality of gel hand sanitizer formulation of Ocimum tenuiflorum with CMC-Na as a gelling agent at a concentration of 0.5% and 1% CMC-Na. Methods: Data were collected at week-0,1,2,3,4, and replication is performed three times at each concentration of each measurement. The test results of the spread and adhesion data analysis using SPSS with a 95% confidence level. Results: Dispersive power and adhesion showed no significant difference (p <0.05) at week 0 and week 4 means second-hand sanitizer gel formulation concentration is not stable. Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) at a concentration of 1% CMC-Na stable from week 0 to week 3, while the concentration of 0.5% CMC-Na change at week 2. Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) with a gelling agent CMC-Na should need to be titrated. Conclusion: Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) that use concentrations of 1% CMC-Na as a gelling agent have a physical quality that is more stable than the organoleptic test concentration of 0.5% CMC-Na. Keywords: Hand sanitizer, Ocimum tenuiflorum L., CMC-Na, Physical quality evaluation

ANTIFUNGAL ACTIVITIES OF ETHANOL EXTRACT OF ROSEMARY LEAF (Rosemarinus officinalis L.) AGAINST Candida albicans Dewa Ayu Made Adnya Swari; I Wayan Martadi Santika; I Gusti Made Aman
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Background: This study was a preliminary study aimed to investigating the in vitro activity of rosmarinic acid contained on Rosemary leaves (Rosemarinus officinalis L.) on the Candida albicans. Rosmarinic acid can be an inhibitor of the RTPase enzyme in the fungus Candida albicans. Objective: This study is expected to provide information in the development of science about the antifungal activity of ethanol extract of Rosemary leave (Rosmarinus officinalis L.) againsts C.albicans. The recent research was an laboratory experimental. Experiments on an ethanol extract of Rosemary leaves (Rosemarinus officinalis L.) and post-test design of the control group. Methods: The extraction method used in this study was a multilevel extraction method. The antifungal activity testing method uses discs and MIC methods. Replication was done six times at two concentration namely, 80% (b/v) and 100% for each measurement. Results: The data analysis was carried out using SPSS with 95% of confidence level with the Kruskal Wallis analysis then completed with the Mann Whitney U test. The results of the MIC experiment showed all the various concentrations of ethanol extract performed Candida albicans growth on the surface of the media. Extract with 80% (b/v) concentration showed greater antifungal activity. Furthermore the MIC was shown by 80% (b/v) concentration of the ethanol extract of Rosemary leaves against Candida albicans. The test results of the antifungal activity of the Rosemary leaf ethanol extract showed the presence of inhibitory diameter in the ethanol extract of the Rosemary leaf concentration of 80% (b/v) with a mean ± SD of 10.6 ± 0.57735 and RSD of 5.774%. Conclusion: The ethanol extract of Rosemary leaves (Rosmarinus officinalis L.) has an inhibitory effect on the fungus Candida albicans at a concentration of 80% (b / v) Keywords: Antifungal activity, Candida albicans, Rosemary, RTPase, ethanol extract

IDENTIFICATION OF THERAPY PROFILE AND FACTORS RELATED TO INCIDENCE OF PULMONARY TUBERCULOSIS IN DENPASAR-BALI Anisa Hanum; Made Krisna Adi Jaya; I Made Bakta
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Background: Tuberculosis is a problem for millions of people around the world. Indonesia as the second biggest country with the highest number of Pulmonary Tuberculosis that treatment has improved gradually. Denpasar is a city with the highest sufferers in Bali. It’s caused by the high rate of population, dense human settlement, and other related factors. Objective: Profiling incident and pulmonary tuberculosis treatment in Denpasar City primary health care. Methods: Observational study with cross-sectional analytic approaches. Forty pulmonary tuberculosis patients and One hundred twenty non-tuberculosis patients were observed in this study. Those were taken by multistage random sampling. Data were collected from medical records and questionnaires. A Chi-Square test was used for analyzing data. Results: Pulmonary tuberculosis sufferers are in productive ages which 65% were men. The treatment profile was excellently seen from the final treatment results of 31 people recovered and 9 people with complete treatment. Factors that have a statistical relation with pulmonary tuberculosis were occupation (p=0,012), income (p=0.003), smoking behavior (p=0.001), and contact history (p=0.001). The other factors with no relationship were education (p=0.270) and occupancy density (p=0.540). Conclusion: Pay attention to the caused factors of tuberculosis infection; society is suggested to implement a healthy lifestyle, maintain home sanitation, and environment. Keywords: Factor Related, Pulmonary, Tuberculosis, Primary Health Care, Denpasar City

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Made Krisna Adi Jaya

Contact Email
krisnaadijaya598@gmail.com

Phone
+6281293208990

Journal Mail Official
jpsa@unud.ac.id

Editorial Address
Gedung AF Jalan Kampus Udayana, Bukit Jimbaran Badung - Bali Indonesia 80239 Phone: +62 361 4747 770

Location
Kota denpasar,

Bali

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Made Krisna Adi Jaya

Contact Email krisnaadijaya598@gmail.com

Phone +6281293208990

Journal Mail Official jpsa@unud.ac.id

Editorial Address Gedung AF Jalan Kampus Udayana, Bukit Jimbaran Badung - Bali Indonesia 80239 Phone: +62 361 4747 770

Location Kota denpasar, Bali INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Made Krisna Adi Jaya

Contact Email
krisnaadijaya598@gmail.com

Phone
+6281293208990

Journal Mail Official
jpsa@unud.ac.id

Editorial Address
Gedung AF Jalan Kampus Udayana, Bukit Jimbaran Badung - Bali Indonesia 80239 Phone: +62 361 4747 770

Location
Kota denpasar,

Bali

INDONESIA