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INDONESIA
Berkala Kedokteran
Published by Universitas Lambung Mangkurat
ISSN : 14120550     EISSN : 25485660     DOI : http://dx.doi.org/10.20527
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol 18, No 1 (2022)" : 15 Documents clear
IMPACT OF HEAVY METALS ON HEXOKINASE ISOFORMS: AN IN SILICO STUDY Ellen Ayuningtyas Pratidina; Eko Suhartono; Bambang Setiawan
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.505 KB) | DOI: 10.20527/jbk.v18i1.12801

Abstract

Abstract: Coal mining activities in South Kalimantan produce waste that is very dangerous if not processed wisely. Coal waste produces heavy metals cadmium and mercury that can pollute the environment. Heavy metals that enter the human body will cause negative impacts in the field of health such as the disruption of the glycolysis process in humans. The purpose of this study was determine the interaction of heavy metals which is cadmium and mercury against hexokinase enzymes using hexokinase enzymes type I, II, III with PDB ID : 4F9O, 2NZT, 3HM8 taken from Protein Data Bank and using the molecular docking website MIB: Metal Ion Binding Site Prediction and Docking server. Docking results will be visualized using chimera app version 1.15. Molecular docking of the heavy metals cadmium and mercury can interact with all three types of hexokinase enzymes. Cadmium metal ions bind hydrophobicly to amino acid residues of hexokinase enzymes type I, II, and III, while mercury metal ions bind covalently coordinate with amino acid residues of hexokinase enzymes type I and III. Mercury metal ions bind more strongly than cadmium metal ions. Of the three types of hexokinase enzymes, mercury metal ions bind most strongly with hexokinase enzyme type II because mercury ions bind to the active site of the three amino acid residues of hexokinase enzymes type II.Keywords: Cadmium ; hexokinase enzyme ; mercury ; molecular docking
EOSINOPHILS PROFILE AND LUND-MACKAY SCORE OF NASAL POLYPS IN ARIFIN ACHMAD HOSPITAL, RIAU PROVINCE Yolazenia Yolazenia; Inayah Inayah; Febri Romaito Romaito; Retni Tri Handayani; Novisa Dwi Utami
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.457 KB) | DOI: 10.20527/jbk.v18i1.12820

Abstract

Abstract: Theories suggest that nasal polyps occur as a result of chronic inflammation of the nasal and sinus mucosa. Eosinophils are the main inflammatory cells found in nasal polyp tissue. The severity of nasal polyps can be seen from the CT Scan of the Paranasal Sinus (PNS) using the Lund-Mackay score. The purpose of this study was to determine the description of the eosinophil count of nasal polyp tissue and the Lund-Mackay score of CT Scan PNS of nasal polyps patients in Arifin Achmad Hospital, Riau Province. Examination of the eosinophil count was carried out microscopically using histopathological preparations of nasal polyp tissue with semiquantitative assessment, and Lund-Mackay score was assessed from the CT Scan of the PNS. From the 14 samples collected, there were 8 men (57.1%) more than 6 women (42.9%) with an average age of 30.43 ± 17.36 years old. Eosinophil counts were obtained in 5  (35,7%) samples 1/2+,  5 (35.7%) samples 1+, and negative in 4 samples (28,6%). While the Lund-Mackay score obtained an average value of 10.21 ± 6.87 with a low category in 11 (78.6%) and high in 3 (21.4%) samples. Patients with high Lund-Mackay scores tend to have higher eosinophil counts which reflect a more severe degree of disease severity in nasal polyps.Keywords: Eosinophil; Lund-Mackay Score; Nasal polyp; Paranasal sinus
EFFECTS OF FAC CHEMOTHERAPY ON ANTI MULLERIAN HORMONE IN PREMENOPAUSAL BREAST CARCINOMA Winardi Budiwinata; Abdurahman Maman; Azhar Raden Yohana
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.016 KB) | DOI: 10.20527/jbk.v18i1.12863

Abstract

Abstrak: Breast cancer is the most common carcinoma in women in the world. Anti-Mullerian Hormone (AMH) is a hormone secreted by primary, secondary, and small antral ovarian follicles of <4mm. The chemotherapy regimen toxic to ovarian follicles is 5-fluorouracil-doxorubicin-cyclophosphamide (FAC). In Indonesia, there had been no study on the effect of FAC chemotherapy on AMH in premenopausal breast carcinoma patients. This study aims to determine the effect of FAC chemotherapy on AMH in premenopausal breast carcinoma patients. This study employed a prospective cohort study design. Inclusion criteria were breast carcinoma, premenopausal, and history of chemotherapy (-). Exclusion criteria were history of ovarian surgery, pelvic radiation, GnRH-agonist therapy, smoking for ≥10 years, obesity, and chemotherapy dropout. Subjects were examined for AMH before the 1st chemotherapy and after the 4th chemotherapy. Statistical test was done with Wilcoxon test, significant if p≤0.05. The average AMH level before FAC chemotherapy was 1.51±1.957; the average AMH level after the 4th FAC chemotherapy was 0.24±0.587. The result of the Wilcoxon test comparing AMH levels before and after 4th FAC chemotherapy was p<0.0001. FAC chemotherapy reduces AMH patients with premenopausal breast carcinoma.Keywords: Breast carcinoma, chemotherapy, AMH.
MENTAL EMOTIONAL DISORDERS IN INTERSTITIAL CYSTITIS PATIENTS Fajar Gemilang Ramadani; Noor Riza Perdana; Anidiah Novy Hasdi; Dina Aulia Fakhrina
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.292 KB) | DOI: 10.20527/jbk.v18i1.12802

Abstract

Abstract: Interstitial cystitis is a chronic pain condition with unclear underlying etiology. Interstitial cystitis has a relation with psychological disorders. There has been an increase in visit patients diagnosed with interstitial cystitis at the urology clinic at Dr. H. Moch. Ansari Saleh Hospital since October 2020. The objectives of this study are to compare mental emotional disorder events in interstitial cystitis patients and control subjects and to determine the relationship between interstitial cystitis and the incidence of mental emotional disorders. included 62 subjects, classified into 2 groups, namely: patients diagnosed with interstitial cystitis based on medical records data at the Urology Clinic, Dr. H. Moch. Ansari Saleh Hospital, and control subjects who had never been diagnosed with interstitial cystitis and had no symptoms and complaints of interstitial cystitis. Both groups completed the Self Reporting Questionnaire SRQ-20 to assess the presence of mental emotional disorders. The incidence of mental emotional disorders in interstitial cystitis patients and controls were compared, and the odds ratios (OR) for the presence of a mental emotional disorder were determined. A total of 32 patients with interstitial cystitis and 30 controls were included in this study. There were 14 interstitial cystitis patients and 4 control subjects who had mental emotional disorders, respectively, and the difference was significant (p = 0.008). Patients with interstitial cystitis were 5 times more at risk of experiencing mental emotional disorders than the control group (OR = 5,056). Patients with interstitial cystitis have a significantly higher risk of experiencing mental emotional disorders compared to those without interstitial cystitis. Screening might be beneficial to assess their mental emotional health. It may be necessary to collaborate with a psychiatrist to treat these patients holistically.Keywords: Interstitial cystitis; Mental emosional disorder
THE EFFECT OF LONG EXPOSURE OF UV RADIATION ON ERYTHEMA AND MELANIN INDEX Isnaini Isnaini; Ika Kustiyah Oktaviyanti; Eko Suhartono
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.725 KB) | DOI: 10.20527/jbk.v18i1.11829

Abstract

UV radiation are divided into 3, namely UV A (400 – 315 nm), UV B (315-280 nm), UV C (280 – 100 nm). UV C radiation have the greatest effect on skin damage compared to UV A and UV B. UV radiation can reach the earth's surface, that can cause burning of the skin with signs such as redness of the skin (erythema), pain, blistering and peeling of the skin. Until now there has been no research on the effect of long exposure of UV C radiation on the erythema and melanin index, so aim this research is know about the effect of long exposure of UV C radiation on the erythema and melanine index. This research was conducted by giving exposure to rat that had been shaved with variations in exposure time, namely 5 minutes, 10 minutes, 15 minutes and 20 minutes. The skin that has been exposed with UV radiation will be photographed for color analysis using a chromometer. The results showed that exposure of UV radiation for 10 minutes caused the greatest increase in the melanin and erythema index

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