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INDONESIA
MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol 1, No 1 (2015): January" : 7 Documents clear
INTRACELLULAR Ca2+ HOMEOSTASIS Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (941.79 KB) | DOI: 10.21776/ub.mnj.2015.001.01.7

Abstract

Ca2+ signaling functions to regulate many cellular processes. Dynamics of Ca2+ signaling or homeostasis is regulated by the interaction between ON and OFF reactions that control Ca2+ flux in both the plasma membrane and internal organelles such as the endoplasmic reticulum (ER) and mitochondria. External stimuli activate the ON reactions, which include Ca2+ into the cytoplasm either through channels in the plasma membrane or from internal storage like in ER. Most of the cells utilize both channels/sources, but there area few cells using an external or internal source to control certain processes. Most of the Ca entering the cytoplasm adsorbed to the buffer, while a smaller part activate effect or to stimulate cellular processes. Reaction OFF is pumping of cytoplasmic Ca2+ using a combination mechanism of mitochondrial and others. Changes in Ca2+ signal has been detected in various tissues isolated from animals induced into diabetes as well as patients with diabetes. Ca2+ signal interference is also found in sensory neurons of experimental animals with diabetes. Ca2+ signaling is one of the main signaling systems in the cell.
MANIFESTATIONS OF HIV AIDS IN CASE NEUROLOGY: EPIDEMIOLOGY STUDY AT SAIFUL ANWAR HOSPITAL YEAR 2013-2014 Munir, Badrul; Candradikusuma, Didi
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (438.163 KB) | DOI: 10.21776/ub.mnj.2015.001.01.2

Abstract

Background. Complications of HIV-AIDS cases neurological disorders are quite high and also very high mortality, but so far the data on disease epidemiology in Indonesia is still very limited.Objective. To determine the pattern of HIV-AIDS disease involving the nervous system in patients admitted to Saiful Anwar hospital.Methods. This prospective cohort study with a record of all patients with HIV-AIDS didagnosis manifest neurological disorders treated in an isolation room for HIV-AIDS Saiful Anwar Hospital for 1 year (September 2013- August 2014).Results. During 12 months acquired HIV-AIDS with neurological disorders as many as 23 patients (38.3% of all patients with an infection of the nervous system) with an average age of 48 years. Male gender 47.83%) and 52.17% of women. Number of CD4+ average of 24 / microliter, while the average number of leucocytes 9675/uL, while the most common sequence of disease; 39.1% of cerebral toxoplasmosis, tuberculosis meningoencephalitis 21.7%, 17.4% viral encephalitis, bacterial meningoencephalitis 13%, 4.3% dementia, cerebral abscess 4.3%. The mortality rate is still high, ranging from 57.6%.Conclusion. Manifestations of HIV AIDS in the field of neurology are very high, cerebral toxoplasmosis is the most common diagnosis, and correlated with the levels of CD4+. The mortality rate of HIV-AIDS cases manifesting high neurology.
NEURAL PAIN PATHWAY TRACING OF RABBIT ISCHEMIC HEART BY DOUBLE-RETROGRADE NEUROTRACING Dapamede, Theodorus; Paundralingga, Obed Trinurcahyo Kinantyo; Rahayu, Masruroh; Soemantri, Bambang
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.297 KB) | DOI: 10.21776/ub.mnj.2015.001.01.3

Abstract

Background. Myocardial ischaemia leads to angina pectoris or referred pain, whichhappens because of the inability of the brain to distinguish the visceral afferent inputs from the somatic afferent inputs since they run along a common pathway via the dorsal root ganglia.Objective. To distinguish specific areas of the rabbit heart that are projected to specific dorsal root ganglia, which then associates to its specific dermatomes.Methods. A double-retrograde neurotracing method was used, with True Blue and Nuclear Yellow as the neurotracers. Rabbits were divided into 3 groups, which the first and second groups were ligated at the left anterior descending artery and at the left circumflex artery, respectively.The third group acted as the control group, without ligation.Results. There is significant association between the site of ligation to the projection of the neurotracers at specific dorsal root ganglia (p<0.05). The first group showed high tendency to be projected to T2 and the second group showed a high tendency to project to T1.Conclusion. This study shows that the rabbit heart can be specifically projected neuronally to specific dorsal root ganglia, following coronary artery ligation.
THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE INCREASE OF THE NUMBER OF BRAIN CELLS IN SUBSTANTIA NIGRA BRAIN OF PARKINSON’S WISTAR STRAIN RAT (RATTUS NORVEGICUS) MODEL INDUCED WITH ROTENONE Rahayu, Masruroh; Kurniawan, Shahdevi Nandar; Anggraini, Dini Jatiya
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (611.994 KB) | DOI: 10.21776/ub.mnj.2015.001.01.4

Abstract

Background. Beta glucan from Saccharomyces cerevisae is very potential to be used as a regenerative therapy of Parkinson's disease. Beta glucan can increase the mobilization of hematopoietic stem cells (HSCs) from the bone marrow into the damaged tissues.Objective. To find out the effects of the addition of Saccharomyces cerevisae toward the number of brain cells in substantia nigra Parkinson’s rat model.Methods. Experimental research in vivo using the draft of randomized post test only controlled group design.Results. Treatment Group 3 (72 mg/kgBB) was a group with the largest number of brain cells than the other treatment groups. Statistical data obtained showed that the average number of brain cells in negative control group was 192.00 cells; positive control amounted to 116.80 cells; Treatment 1 amounted to 135.40 cells; Treatment 2 amounted to 140.80 cells; and Treatment 3 amounted to 161.80 cells.Conclusion. The addition of Saccharomyces cerevisae with a dose of 18mg/kgBB, 36mg/kgBBdan 72mg/kgBB is able to increase the number of brain cells in the substantia nigra of the brain of Parkinson’s Strain Wistar rat model significantly.
INFECTION-ASSOCIATED DEMENTIA Harahap, Herpan Syafii; Rianawati, Sri Budhi
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (478.808 KB) | DOI: 10.21776/ub.mnj.2015.001.01.6

Abstract

Central nervous system infection may decrease cognitive function in broad spectrum, ranged from mild cognitive impairment to infection-associated dementia. Infection-associated dementia is a dementia which develops concomitantly or lately after central nervous system infection by any microorganism. Some study showed infection-associated dementia was likely developing as the secondary neuronal response to the activation of immune cell in the brain activated by infectious agent. Screening and formal neuropsyichological testing are the most important examination modalities for the diagnosis of infection associated dementia. The availability of functional radiological examination techniques are useful for identifying of brain function and visualizing the brain activities in vivo. The recent modality treatments for infection-associated dementia are insignificantly different with the modality treatments for other dementia. These treatment are consists of pharmacological and non-pharmacological treatments.
CORRELATION OF C-REACTIVE PROTEIN LEVELS WITH CLINICAL OUTCOME INTRACEREBRAL HEMORRHAGE STROKE PATIENTS Setianto, Catur Ari; Purnomo, Hari; Marhaendraputro, Eko Arisetijono; Santoso, Widodo Mardi
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (578.31 KB) | DOI: 10.21776/ub.mnj.2015.001.01.5

Abstract

Background. Increased levels of markers of inflammatory factors after hemorrhage stroke was able to predict poor clinical outcome. Until now, the role of C Reactive Protein (CRP) in the local inflammatory response and clinical determinants output remains unclear.Objective. To investigate the correlation of CRP level with poor clinical outcome as measured by Barthel Index. Methods. This study was an observasional cohort porspective study performed on haemorrhage stroke patients in Saiful Anwar General Hospital in Februari 2014 until April 2014.Results. There was significant correlation (p=0,01, r=0,613) between CRP levels to poor clinical outcome measured by Barthel Index.Conclusion. C Reactive Protein levels could predict poor clinical outcome as measured by Barthel Index in intracerebral hemorrhage patients.
THE PROFILE OF COGNITIVE FUNCTION OF PATIENTS HIV/AIDS IN Dr. SAIFUL ANWAR MALANG HOSPITAL Harahap, Herpan Syafii; Rianawati, Sri Budhi
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.037 KB) | DOI: 10.21776/ub.mnj.2015.001.01.1

Abstract

Background. HIV/AIDS caused cellular immunodeficiency (the depletion of CD4+). This, in turn, raised many complications, such as HIV-associated dementia (HIV-D).Objective. To know the profile of cognitive function of patients of HIV/AIDS tretaed in Dr. Saiful Anwar Malang Hospital.Methods. This was a descriptive study using cross-sectional design. This study was conducted to 41 patients of HIV/AIDS treated in Dr. Saiful Anwar Malang Hospital during January to February 2012 (n=41). The cognitive function was assessed by using Mini Mental State Examination (MMSE) and Clock Drawing Test (CDT) instruments.Results. In MMSE, Number of patients showing total score 0-16 were 9 (21.95%), those showing total score 17-23 were 25 (60.98%), and those showing total score 24-30 were 7 (17.07%) . In CDT, 37 patients showed decrease of cognitive function (CDT<4), the remainder showed normal cognitive function. All of patients showing total score of both MMSE and CDT below normal limit, showed low level of CD4 (< 200 sel/µL). Patients showing normal cognitive function on CDT, also showing the same result on MMSE.Conclusion. Most of patients in this study showed the decrease of cognitive function.

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