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INDONESIA
Indonesia Chimica Acta
Published by Universitas Hasanuddin
ISSN : 2085014X     EISSN : 26556049     DOI : -
Core Subject : Engineering,
Chemical Engineering, Chemistry & Bioengineering
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of chemistry. The result of research and development in the fields of chemistry in both experimental and theory/ computation, chemical-based technological innovations, and chemical applications in industrial fields. The journal publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Volume 18, No 1: June 2025" : 5 Documents clear
Determination of Total Flavonoid Content, Antioxidant and Antibacterial Activities of Yellow Root (Fibraurea tinctoria L.) Yansyah, Rudi
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 1: June 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i1.37088

Abstract

Abstract. Yellow root (F. tinctoria) is one of endemic plants from Kalimantan and commonly used by local society as a traditional medicine. Alkaloids are the main chemical constituent and has been reported widely. Unfortunately, other secondary metabolites such as flavonoids and terpenoids are scarce. Total flavonoid contents was determined by a spectrophotometric method, DPPH method was conducted for antioxidant activity, and antibacterial activity against Staphylococcus aureus and Escherichia coli was measured by the well diffusion method. The result showed that methanol fraction has the highest total flavonoid content with 52.23 ± 0.00781 mg QE/g extract. Methanol extract, fractions of methanol and ethyl acetate exhibited weak antioxidant activity with IC50 values of 472.5; 390.6; and 369.3 mg/L, respectively. The antibacterial activity of the three samples against Staphylococcus aureus at a concentration of 50 µg/µL showed a weak-medium category.
Pharmaceutic Production of Microcrystalline Cellulose (MCC) as Tablet Excipient from Sugarcane Bagasse Putri, Elisa
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 1: June 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i1.42631

Abstract

Waste from sugarcane ice milling in Langsa is abundant without processing, so it is necessary to think about its more useful utilization without causing environmental pollution. Sugarcane bagasse is one of the samples that is rich in cellulose, so it has the potential to be developed into cellulose microcrystals that can be used as a filling material in tablet making. The preparation of bagasse MCC was carried out in 2 (two) stages, namely the α-cellulose isolation stage (including delignification, swelling, and bleaching processes), and the second stage is the hydrolysis of α-cellulose using 2.5 N HCl solvent to obtain bagasse MCC. From the results of this study, the sugarcane bagasse MCC produced has physical characteristics in the form of hablur, white in color, odorless, and tasteless, has a moisture content of 3.78%, with a pH of 7, a permanganate content of 2.54% and a size of 33.843 μm. So it can be concluded that the sugarcane bagasse MCC produced has met the tablet excipient requirements as required by the Handbook of Pharmaceutical Excipients.
The Toxicity and Cytotoxicity Test of Anticancer Peptides Isolated from Symbiotic Bacteria Asmi, Nur; Ahmad, Ahyar; Natsir, Hasnah; Karim, Harningsih; Muhakim, Ali; Khairunnur, Siti
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 1: June 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i1.43925

Abstract

The purpose of this research was to evaluate the toxicity and cytotoxicity of the fragment peptide from symbiotic bacteria in the lung cancer LK-2 cell line, compared normal M5S cell line. Protein hydrolyzates were separated using Molecular Weight Cut Off (MWCO) to isolate peptide fragments. Fragments were categorized as ≤ 5 kDa, > 5-10 kDa, and > 10 kDa to evaluate their toxicity through the Brine Shrimp Lethality Test (BSLT) method and to study cytotoxicity effects and proliferation in LK-2 lung cancer cells against normal M5S cells. MTT assay was used to analyze the percentage of living cells and cell growth. The Selectivity Index (SI) equation was applied to determine selectivity. Findings indicated that the peptide fragment ≤ 5 kDa had the highest toxicity, with an LC50 of 8.15 µg/ml. The number of LK-2 cells that died increased when exposed to peptide fragments of sizes ≤ 5 kDa, > 5-10 kDa, and > 10 kDa over 16 hours. Moreover, cell growth in LK-2 cells decreased after 16 hours, while there was no significant decline (P < 0.05) in M5S cells compared to the controls. The peptide fragments with molecular weights ≤ 5 kDa and > 5-10 kDa demonstrated the highest selectivity, resulting in an SI value of 3. These results suggest that the selected peptide fragments may serve effectively as anticancer agents. This study highlights the potential of peptides from symbiotic bacteria as possible treatments for cancer, particularly lung cancer.
Effect of Activated Bentonite Concentration on the Characteristics of Virgin Coconut Oil (VCO) via Enzymatic Method Pratiwi, Ananda Elga
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 1: June 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i1.43944

Abstract

This study aimed to evaluate the effectiveness of activated bentonite in improving the quality of Virgin Coconut Oil (VCO). The quality of VCO is strongly influenced by moisture content, free fatty acids, and peroxide value. In this study, VCO was produced using an enzymatic method with papain and then purified using activated bentonite at concentrations of 3%, 5%, and 10%. The quality parameters analyzed included moisture content, free fatty acids (FFA), peroxide value, specific gravity, viscosity, and organoleptic attributes such as aroma, color, and taste. The results showed that 10% activated bentonite provided the best performance, with FFA at 0.174%, peroxide value at 0.99 mEq/kg, specific gravity at 0.4524 g/mL, moisture content at 0.0026%, and viscosity at 10.47 cP. Organoleptic tests indicated improvement in aroma, color, and taste. Therefore, the use of activated bentonite has been proven effective in enhancing the quality characteristics of VCO in accordance with the Indonesian National Standard (SNI).
Effectiveness of Kiambang Plant (Salvinia molesta) in Phytoremediation of Copper (Cu) Heavy Metal at Various Concentrations Awaluddin, Muhammad
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 1: June 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i1.43963

Abstract

This study aimed to determine the effectiveness of the kiambang plant (Salvinia molesta) in reducing copper (Cu) heavy metal concentrations in water bodies through phytoremediation. Copper concentrations of 3 ppm, 6 ppm, 9 ppm, 12 ppm, and 15 ppm were applied, and observations were conducted over seven days using a UV-Vis spectrophotometer at a wavelength of 445 nm. The results showed a significant effect of Cu concentration variation on the plant’s phytoremediation capacity, as indicated by the One Way ANOVA test (F-count 73.064 > F-table 3.05; p < 0.05). The highest remediation efficiency was observed at the 15 ppm concentration. Kiambang plants proved effective as phytoremediation agents in mitigating copper heavy metal pollution in aquatic environments.

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