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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 6 Documents
 1 
Search results for , issue "Vol 5, No 1 (2019)" : 6 Documents clear
RELATIONSHIP OF SNP (RS867500) STX1A EXON 10 GENE WITH INTELLECTUAL INTELLIGENCE LEVEL Qur'andini, Dalinur; Yuwono, Yuwono; Triwani, Triwani
Biomedical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i1.7975

Abstract

The purpose of this study was to determine the relationship of SNP (rs867500) on the STX1A Exon 10 gene with the level of intellectual intelligence. This study was an observational analytic study with a cross sectional study design with a population of 368 and a sample of 36 which was divided into two groups, namely the above average IQ group and the average IQ group. To find out the relationship of SNP (rs867500) STX1A Exon 10 gene with intelligence level used X2 test (Chi-square). The results showed no SNPs were found in the STX1A exon 10 gene. The STX1A gene can be said to contribute to intelligence along with other genes, namely IGFR2 and FNBPL1 genes, although there is no polymorphism in the exon 10 STX1A gene.
EFFECT OF HIBISCUS ROSA-SINENSIS LINN. EXTRACTS ON THE AMOUNT, MOTILITY, MORPHOLOGY, VABILITY OF SPERMATOZOA OF MALE RATS (RATTUS NORVEGICUS) Julia, Dina; Salni, salni; Nita, Sri
Biomedical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i1.7976

Abstract

The participation of men in family planning is still relatively low when compared to the participation of women. One of the traditional medicinal plants used is antifertility hibiscus flowers. This study aims to examine the effect of hibiscus flower extract on the number, motility, morphology and viability of spermatozoa of male rats (Rattus norvegicus). This research is an experimental study using a completely randomized design (CRD). The sample in this study used 25 male Sprague Dawley strains aged 60-70 days with a body weight of 200-210 grams. Duration of treatment for 30 days at a dose of 200 mg / kg, 300 mg / kg, 400 mg / kg. Data is presented in the form of tables and diagrams and narration to interpret the data. The results of this study indicate a decrease in sperm count in the treatment group compared to the control group (p = 0,000), a decrease in sperm motility (p = 0.001), an abnormal morphological increase (p = 0,000), and a decrease in spermatozoa viability between the treatment groups compared to the group control (p = 0,000). It can be concluded that there is a significant difference in the effect of hibiscus flower extract on the number, motility, morphology, viability of spermatozoa.
EFFECT OF HIBISCUS FLOWERS (HIBISCUS ROSA-SINENSIS LINN.) ON EPIDIDYMIS, PROSTATE AND SEMINAL VESICLES Carolin, Bunga Tiara; Salni, Salni; Nita, Sri
Biomedical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i1.7972

Abstract

Hibiscus rosa-sinensis Linn. is one of the medicinal plants in Indonesia which is used as male contraception. Hibiscus flowers contain flavonoids which can reduce testosterone. The purpose of this study was to determine the effect of hibiscus flower extract on epididymal weight, cauda epididymal epithelial thickness, prostate weight and seminal vesicle of male rats. This research is an experimental study using a completely randomized design (CRD). The sample in this study used 25 male Sprague Dawley® strains aged 60-70 days with a body weight of 200-210 grams. The treatment dose is 200 mg / kg, 300 mg / kg, 400 mg / kg, 500 mg / kg for 30 days. The data is presented in tabular form and narrative to interpret the data. The results showed a decrease in epididymal weight in the treatment group compared to the control group (p = 0,000), there was also a thick shrinkage of the cauda epididymal epithelium (p = 0.021), a decrease in prostate weight and seminal vesicles between the treatment group versus the control group (p = 0.001). It can be concluded that there is an effect of hibiscus flower extract on the epididymis, prostate and seminal vesicles. The influence is likely due to the chemical content that is in hibiscus flowers that are antifertility.
RELATIONSHIP BETWEEN LUNG FUNCTION AND INTERLEUKIN-6 (IL-6) LEVELS IN THE POPULATION IN THE VICINITY OF THE GANDUS RUBBER FACTORY AND THE SUKAWINATAN WASTE DISPOSAL SITE IN PALEMBANG Adela, Novita; Zulkarnain, Mohammad; Flora, Rostika
Biomedical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i1.7977

Abstract

Exposure to air pollution can interfere with the capacity of lung function and the body's immune system. Lung function capacity is the sum of two or more lung volumes. Interleukin-6 (IL-6) is an inflammatory mediator in respiratory pathogenesis. This study aims to determine the relationship between lung function and Interleukin-6 (IL-6) levels in the population around the Gandus Rubber Factory and Sukawinatan Landfill Palembang. The research design used is the type of correlation or explanatory that is examining the relationship between variables. A total of 72 samples were divided into 2 groups: groups in the Gandus Rubber Factory area and groups in the Sukawinatan Waste Disposal Site (Palembang). Lung function tests were measured using spirometry and Interleukin-6 levels were measured using ELISA examination. Chi square test results showed that there was no significant relationship (p value = 0.001) between lung function in the population around the Gandus Rubber Factory and Sukawinatan Waste Landfill. And there is no significant relationship (p value = 0.337) between Interleukin-6 (IL-6) levels in the population around the Gandus Rubber Factory and Sukawinatan Waste Landfill. Chi Square test results showed that there was no significant relationship (p value = 0.626) between lung function and Interleukin-6 (IL-6) levels in the population around the Gandus Rubber Factory. Chi Square test results showed that there was no significant relationship (p value = 1,000) between lung function and Interleukin-6 (IL-6) levels in the population around the Palembang Sukawinatan Landfill. Conclusions from the results of the study that there is no significant relationship (p <0.05) between levels of Interleukin-6 and Lung Function in the population around the Gandus Rubber Factory and Sukawinatan Landfill Palembang.
WEIGHT CHANGES AND HISTOLOGY OF TESTES OF MALE WHITE RATS (RATTUS NORVEGICUS) DUE TO PROVISION OF RED GUAVA LEAF (PSIDIUM GUAJAVA L.) LEAVES Sripratiwi, Chessy
Biomedical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i1.7973

Abstract

Red Guava Leaf (Psidium guajava L.) is a plant that grows in Indonesia. Chemical content contained in red guava leaves are alkaloids, flavonoids, tannins, essential oils and beta-sitosterol which are thought to be antifertility. As the population increase is very high at 1.49% per year, it is necessary to develop a contraceptive method in men that is safe, effective and high reversibility. The aim of this study was to analyze the changes in testicular weight and histology of male white rats (Rattus norvegicus) due to the administration of red guava leaf fraction. The research method used was true experiment with post test control group design using 24 male rats divided into 4 treatment groups, each group consisting of 6 male rats. Each group was treated with n-hexane, ethyl acetate, methanol water as much as 80 mg / head / day for 48 days and for the control group was given 1% 2 ml CMC, administered by oral sonde. The results showed an average decrease in testicular weight, seminiferous tubule diameter, thickness of the seminiferous tubular epithelium and a decrease in the number of Leydig cells between the control group and the treatment group. Testicular weight and diameter of the seminiferous tubules in the post hoct test results between the control group and the treatment group obtained p value <0.05 means that there is a very significant difference in thickness of the seminiferous tubular epithelium between the control group and the treatment group. Likewise on the thickness of the seminiferous tubule epithelium and the number of Leydig cells, the results of the post hoct test showed a p value <0.05. From the results of this study it can be concluded that the fraction of red guava leaves can reduce the weight of the testes, the diameter of the seminiferous tubules, the epithelial seminiferous tubules and the number of Leydig cells.
COMPARISON BETWEEN BELUNTAS (PLUCHEA INDICA LEES) FRACTION AND KETOCONAZOLE INVITRO ON CANDIDA ALBICANS Marsasi, Bina; Yuwono, Yuwono; Salni, Salni
Biomedical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i1.7974

Abstract

Beluntas leaves are useful as a treatment for flour albus and discharge caused by fungi. This study aims to find the anti-fungal activity of fraction of beluntas (Pluchea indica Lees) leaf extract against Candida albicans. This research is an in vitro experimental study using the Posttest-only Control Group Design study design. Methanol extract is obtained through maceration process while the fraction is through liquid-liquid fractionation. The most active fraction is determined by the antifungal activity test. The most active fractions with concentrations of 10%, 5%, 2.5%, 1.25%, 0.625% and the diameter of the inhibition zone 0.3125% were measured by the liquid dilution method. Equivalence with drugs is assessed through regression analysis, then the class of active compounds is determined through bioautographic testing using thin layer chromatography. The research results obtained methanol-fraction-water can inhibit the growth of Candida albicans while the methanol extract, n-hexane and ethyl acetate do not inhibit. The methanol fraction of water which has inhibition zone diameters starts at a concentration of 0.3125% with an average diameter of 7.34 mm and at a concentration of 10% the largest diameter of 17.10 mm is obtained. Through the diluent liquid and the KHM solid fraction from the methanol-water fraction is inhibited at a concentration of 0.3125%. Equivalence test shows that 1 mg / ml of ketoconazole is equivalent to 39,561 mg / ml of methanol-water fraction of beluntas leaves. Compounds that inhibit fungi are thought to be active groups of flavonoid and alkaloid compounds. The methanol-water fraction of beluntas leaves (Pluchea indica Lees) has antifungal activity against Candida albicans in vitro.

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