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All Journal Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal ABDIMAS-HIP Pengabdian Kepada Masyarakat Indonesian Journal of Pharmacy and Natural Product
Asep Nurrahman Yulianto
Universitas Al-Irsyad Cilacap
Humanities Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Public Health Social Sciences

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Sub-Chronic Toxicity Test of Solid Self Nanoemulsifying Drug Delivery System (S-Snedds) Hydrochlorothiazide in Male Rats Asep Nurrahman Yulianto; Wahyu Widyaningsih; Iis Wahyuningsih; Ilham Fadilah; Tatang Tajudin
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 02 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i02.4434

Abstract

Hydrochlorothiazide (HCT) is a diuretic thiazide that is commonly used in the treatment of hypertension, although it exhibits has low bioavailability. The development of the Solid Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) is expected to be able to increase the solubility and bioavailability orally administered of HCT. This study aims to evaluate the sub-chronic toxicity of S-SNEDDS HCT formulations by examining biochemical parameters (SGOT, SGPT, BUN, and creatinine), and histopathological analysis of liver, kidney, and heart in male Wistar strain rats. An experimental design with five distinct treatment groups was utilized: negative control (CMC-Na 0,5%), S-SNEDDS base (aerosil), positive control (pure HCT 25 mg/kg BW), S-SNEDDS HCT (25 mg/kg BW), and satellite group (S-SNEDDS HCT 50 mg/kg BW). The treatment spanned for 28-days, followed by a 14-days observation period with no treatment for the satellite group.  The results showed that SGPT, BUN, and creatinine remained normal across all groups, suggesting the absence of liver or kidney damage. Histopathology analysis shows structural changes in the form of degeneration, necrosis, and infiltration of inflammatory cells mainly in the pure HCT and S-SNEDDS HCT groups, however in the satellite group the damage may return to normal when administration is stopped.
Pengabdian Donor Darah pada Masyarakat Sidanegara Cilacap: Blood Donation Service to The Sidanegara Cilacap Community Elisa Issusilaningtyas; Yuniariana Pertiwi; Nikmah Nuur Rochmah; Ajeng Puspo Aji; Asep Nurrahman Yulianto; Nursanti Dwi Yogawati; Anita Ratna Faoziyah; Tri Kusuma Wardani
Jurnal ABDIMAS-HIP Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2024): Jurnal ABDIMAS-HIP Pengabdian Kepada Masyarakat
Publisher : LPPM Akbid Harapan Ibu Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37402/abdimaship.vol5.iss2.309

Abstract

The scarcity of blood is assumed to be caused by a lack of public knowledge about blood donation. Donor health advantages can minimize the danger of cancer, help with weight loss, make the body psychologically better and prolong life, reduce the risk of heart and blood vessel disease, and detect major disorders. Aside from carrying out the Tri Dharma of Higher Education, community service activities seek to encourage local residents to donate blood for the safety of others, hence raising people's desire and willingness to contribute. PMI Cilacap supports this program by sending numerous medical personnel to perform blood draws. The service team distributed information about the benefits of blood donation during this activity. There were 62 registered blood donors, with 43 (69.35%) passing the health check and donating blood, and 19 (30.65%) failing (not passing) the health check and so unable to donate blood.
Kerupuk Daun Mangrove: Inovasi Pangan Lokal bagi Perempuan Pesisir Kampung Laut Nikmah Nuur Rochmah; Elisa Issusilaningtyas; Nursanti Dwi Yogawati; Dede Yusuf; Asep Nurrahman Yulianto; Wahyunita Yulia Sari
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 7 No. 2 (2026): Edisi Mei - Agustus
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v7i2.9095

Abstract

Kampung Laut, Kabupaten Cilacap, memiliki sumber daya mangrove yang melimpah, tetapi daun mangrove belum dimanfaatkan secara optimal sebagai produk pangan bernilai tambah. Hasil observasi awal menunjukkan empat persoalan mitra, yaitu pengetahuan yang masih terbatas, kekhawatiran terhadap keamanan bahan, belum tersusunnya proses produksi yang higienis, serta lemahnya aspek pengemasan dan pemasaran. Kegiatan ini bertujuan memperkuat kapasitas ibu-ibu PKK dan kelompok perempuan produktif melalui pembuatan prototipe kerupuk daun mangrove. Program dilaksanakan pada 11 September 2025 di Balai Desa Ujunggagak melalui tahap persiapan dan pemetaan kebutuhan, edukasi, demonstrasi dan praktik, evaluasi formatif, serta penyusunan tindak lanjut. Evaluasi menggunakan tanya jawab terstruktur, observasi partisipasi, dan penilaian unjuk kerja pada tahapan pemilihan bahan, sanitasi, pengolahan adonan, pengukusan, pengeringan, penggorengan, dan pengemasan. Hasil kegiatan menunjukkan peserta mampu menjelaskan potensi dan kehati-hatian pemanfaatan daun mangrove, menyelesaikan seluruh tahapan produksi secara berkelompok, menghasilkan prototipe kerupuk, serta mengidentifikasi kebutuhan label, harga, dan pemasaran sederhana. Perubahan kapasitas dilaporkan secara kualitatif karena kegiatan belum menggunakan instrumen pretest-posttest terstandar. Program ini mengintegrasikan edukasi kesehatan, keterampilan produksi, sanitasi pangan, dan orientasi usaha rumah tangga. Keberlanjutan kegiatan memerlukan autentikasi spesies, pengujian keamanan, proksimat, mikrobiologi, dan sensori, standardisasi formula, pengurusan perizinan, serta pendampingan pemasaran.
Co-Authors Ajeng Puspo Aji Anita Ratna Faoziyah Dede Yusuf Elisa Issusilaningtyas Iis Wahyuningsih Ilham Fadilah Nikmah Nuur Rochmah Tatang Tajudin Tri Kusuma Wardani Wahyu Widyaningsih Wahyunita Yulia Sari Yogawati, Nursanti Dwi Yuniariana Pertiwi