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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal ABDIMAS-HIP Pengabdian Kepada Masyarakat Journal of Innovative and Creativity Journal of Pharmacopoeia Journal of Pharmacopoeia
Elisa Issusilaningtyas
Universitas Al-Irsyad Cilacap
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Health Professions Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Effectiveness of Soursop Leaf Extract in Reducing Glucose Levels in Diabetes Mellitus Patients: Literature Study Elisa Issusilaningtyas; Nikmah Nuur Rochmah
Journal of Pharmacopoeia Vol. 1 No. 2 (2024): SEPTEMBER-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/36x6v823

Abstract

Alternative treatment for lowering sugar levels can be done through the use of herbal plants such as soursop leaves. This study aims to evaluate the effectiveness of soursop leaf extract (Annona muricata L.) in reducing blood glucose levels in Diabetes Mellitus (DM) patients. This research uses a literature study method, with data taken from scientific articles or journals within the last five years. Data was collected using the Google Scholar search engine with the keywords "diabetes mellitus," "soursop leaf extract," and "reducing sugar levels". Research shows that soursop leaf extract (Annona muricata L.) contains flavonoids, tannins, alkaloids, and saponins which are effective in lowering blood glucose levels through various mechanisms, including inhibiting sugar absorption, increasing glucose tolerance, stimulating insulin release, and regulating carbohydrate metabolism enzymes. The results of clinical and in silico trials support the effectiveness of this extract, making it a potential herbal treatment alternative amidst the current high costs of diabetes care. This research encourages the use of soursop leaves as a promising therapy and recommends further research to optimize its benefits.
Effectiveness of Soursop Leaf Extract in Reducing Glucose Levels in Diabetes Mellitus Patients: Literature Study Elisa Issusilaningtyas; Nikmah Nuur Rochmah
Journal of Pharmacopoeia Vol. 1 No. 2 (2024): SEPTEMBER-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/36x6v823

Abstract

Alternative treatment for lowering sugar levels can be done through the use of herbal plants such as soursop leaves. This study aims to evaluate the effectiveness of soursop leaf extract (Annona muricata L.) in reducing blood glucose levels in Diabetes Mellitus (DM) patients. This research uses a literature study method, with data taken from scientific articles or journals within the last five years. Data was collected using the Google Scholar search engine with the keywords "diabetes mellitus," "soursop leaf extract," and "reducing sugar levels". Research shows that soursop leaf extract (Annona muricata L.) contains flavonoids, tannins, alkaloids, and saponins which are effective in lowering blood glucose levels through various mechanisms, including inhibiting sugar absorption, increasing glucose tolerance, stimulating insulin release, and regulating carbohydrate metabolism enzymes. The results of clinical and in silico trials support the effectiveness of this extract, making it a potential herbal treatment alternative amidst the current high costs of diabetes care. This research encourages the use of soursop leaves as a promising therapy and recommends further research to optimize its benefits.
Analisis Bibliometrik Bit Merah (Beta vulgaris L.) sebagai Antidiabetes Nikmah Nuur Rochmah; Elisa Issusilaningtyas; Rizki Azmi Nurmajid
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.8118

Abstract

Umbi bit merah (Beta vulgaris L.) sebagai kandidat terapi antidiabetes meningkat, didukung temuan aktivitas antioksidan–antiinflamasi, perbaikan sensitivitas insulin, serta penghambatan enzim α-glukosidase dan α-amilase. Namun, arah riset 2015–2025 (tren, jejaring kolaborasi, dan tema dominan) belum dipetakan secara komprehensif. Tujuan: Memetakan lanskap riset bit merah sebagai antidiabetes pada artikel Scopus dan jurnal nasional periode 2015–2025. Metode: Data Scopus dihimpun melalui strategi kata kunci terstruktur yang mengombinasikan istilah tanaman, diabetes/hiperglikemia, insulin, dan blood glucose; artikel disaring berdasarkan relevansi, bahasa, dan tipe dokumen. Metadata diekspor (CSV/BibTeX) lalu dianalisis dengan VOSviewer untuk pemetaan ko-occurrence kata kunci, ko-authorship, dan sitasi; artikel nasional dipakai sebagai triangulasi konteks metode in vivo/in vitro. Hasil dan pembahasan: Tren menunjukkan pertumbuhan publikasi dengan puncak produktivitas pada awal dekade 2020-an, serta dominasi artikel pra-klinik. Terbentuk beberapa klaster tema: (1) resistensi insulin, metabolisme glukosa, dan stres oksidatif; (2) betalain/polifenol dan jalur inflamasi; (3) fermentasi, nitrat–nitrit–NO, serta mikrobiota usus; dan (4) inhibisi enzim dan pendekatan in silico (docking). Studi nasional banyak menilai model tikus diabetik terinduksi aloksan/streptozotosin, parameter glukosa darah, dan histopatologi pankreas, namun heterogenitas dosis serta standardisasi ekstrak masih tinggi. Analisis jejaring memperlihatkan kolaborasi internasional terkonsentrasi pada kelompok peneliti nutrisi-farmakologi, dengan kontribusi dari negara produsen hortikultura dan pusat riset pangan fungsional. Celah utama meliputi minimnya uji klinik terkontrol, pelaporan biomarker glikemik (HbA1c), serta evaluasi interaksi dengan obat hipoglikemik dan kajian farmakokinetik komponen aktif. Kesimpulan: Riset bit merah sebagai antidiabetes berkembang dan semakin multidisipliner, tetapi masih terdapat kesenjangan translasi menuju uji klinik, standardisasi bahan, dan pelaporan keamanan jangka panjang.
Formula Optimization of Propolis Transfersome Gel, Aloe Vera, Gotu Extract: Formula Design, Formulation Evaluation and Cell Regeneration Test in Diabetic Wounds Ajeng Puspo Aji; Rochany Septiyaningsih; Septiana Indratmoko; Elisa Issusilaningtyas; Solikhatun Nasikha
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.9283

Abstract

The study was conducted to determine the optimal formula of transfersome propolis gel, aloe vera extract and gotu gotu leaf extract and test it against diabetic wounds in male white rats (Rattus norvegicus). The gel was created with an optimal formulation resulting from the application of a Design Expert with Cutimed as a positive control of burns on the backs of male white rats (Rattus norvegicus). Formula optimization was carried out using a Simple Lattice Design with variations of carbopol, TEA and glycerin. Activity tests of propolis transferosome gel, aloe vera extract and gotu gotu extract were conducted on 20 rats. The data results were statistically analyzed using the SPSS One Way ANOVA method. Phytochemical screening on aloe vera and gotu gotu showed the presence of flavonoid compounds, tannins and saponins. Transfersome propolis has a particle size of 88.55 nm and a zeta potential of -24.13 mV. The optimal formula produces a clear preparation in white, a distinctive odour, a stable viscosity of 19980 cps, dispersion power of 6.67 cm, adhesion of 4.07 seconds and pH of 6.45. The burn activity test had the fastest effectiveness on day 12 but did not differ significantly from the customized control.
Pengabdian Donor Darah pada Masyarakat Sidanegara Cilacap: Blood Donation Service to The Sidanegara Cilacap Community Elisa Issusilaningtyas; Yuniariana Pertiwi; Nikmah Nuur Rochmah; Ajeng Puspo Aji; Asep Nurrahman Yulianto; Nursanti Dwi Yogawati; Anita Ratna Faoziyah; Tri Kusuma Wardani
Jurnal ABDIMAS-HIP Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2024): Jurnal ABDIMAS-HIP Pengabdian Kepada Masyarakat
Publisher : LPPM Akbid Harapan Ibu Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37402/abdimaship.vol5.iss2.309

Abstract

The scarcity of blood is assumed to be caused by a lack of public knowledge about blood donation. Donor health advantages can minimize the danger of cancer, help with weight loss, make the body psychologically better and prolong life, reduce the risk of heart and blood vessel disease, and detect major disorders. Aside from carrying out the Tri Dharma of Higher Education, community service activities seek to encourage local residents to donate blood for the safety of others, hence raising people's desire and willingness to contribute. PMI Cilacap supports this program by sending numerous medical personnel to perform blood draws. The service team distributed information about the benefits of blood donation during this activity. There were 62 registered blood donors, with 43 (69.35%) passing the health check and donating blood, and 19 (30.65%) failing (not passing) the health check and so unable to donate blood.
Co-Authors Ajeng Puspo Aji Anita Ratna Faoziyah Asep Nurrahman Yulianto Nikmah Nuur Rochmah Rizki Azmi Nurmajid Rochany Septiyaningsih Solikhatun Nasikha Tri Kusuma Wardani Yogawati, Nursanti Dwi Yuniariana Pertiwi