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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal ABDIMAS-HIP Pengabdian Kepada Masyarakat Jurnal Impresi Indonesia Indonesian Journal of Innovation Multidisipliner Research Indonesian Journal of Innovation Multidisipliner Research
Ajeng Puspo Aji
Universitas Al-Irsyad Cilacap
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Physics Public Health Social Sciences Other

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Subchronic Toxicity Test of Burdock Root (Arctium Lappa L.) Nanoemulsion Based on Histopathology on The Albino Rat Rattus noverticus (Wistar strain): Uji Toksisitas Subkronik Nanoemulsi Akar Burdock (Arctium Lappa L.) Berdasarkan Histopatologi pada Tikus Albino Rattus noverticus (strain Wistar) Imam Agus Faizal; Dini Puspodewi; Ajeng Puspo Aji
Indonesian Journal of Innovation Multidisipliner Research Vol. 2 No. 2 (2024): April - Juni
Publisher : Institute of Advanced Knowledge and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69693/ijim.v2i2.140

Abstract

Tanaman burdock (Arctium lappa L.) merupakan tanaman herbal yang berkhasiat sebagai penambah darah (hemoglobin dan hematokrit) pada penderita anemia defisiensi besi. Sebanyak 15 ekor tikus (Rattus norvegicus) strain Wistar, jantan dan betina dibagi menjadi 3 kelompok secara random sampling yaitu Kelompok 1 Kontrol negatif (KN) tidak diberi A. lappa L. nanoemulsion. Kelompok Dosis 1 (KD1) diberi A. lappa L. nanoemulsion dengan dosis 150 mg/kgBB/hari. Kelompok Dosis 2 (KD2) diberikan A. lappa L. nanoemulsion dengan dosis 450 mg/kgBB/hari (selama 14 hari dimulai hari ke 8). Indikator penelitian ini dilihat kadar pemeriksaan biokimia kadar darah. Organ hati dan ginjal dinilai menggunakan Hematoxylin-Eosin (HE). Hasil pemeriksaan biokimia darah relatif normal. Sedangkan pewarnaan HE pada kelompok KD1 dan KD2 terjadi perubahan pada sel organ ginjal dan hati, menunjukkan bahwa sediaan nanoemulsi akar burdock bersifat toksik, namun terdapat faktor pengganggu yaitu ditemukan cacing parasit Taenia taeniaeformis, sehingga interpretasi hasilnya terganggu.
Subchronic Toxicity Test of Burdock Root (Arctium Lappa L.) Nanoemulsion Based on Histopathology on The Albino Rat Rattus noverticus (Wistar strain): Uji Toksisitas Subkronik Nanoemulsi Akar Burdock (Arctium Lappa L.) Berdasarkan Histopatologi pada Tikus Albino Rattus noverticus (strain Wistar) Imam Agus Faizal; Dini Puspodewi; Ajeng Puspo Aji
Indonesian Journal of Innovation Multidisipliner Research Vol. 2 No. 2 (2024): April - Juni
Publisher : Institute of Advanced Knowledge and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69693/ijim.v2i2.140

Abstract

Tanaman burdock (Arctium lappa L.) merupakan tanaman herbal yang berkhasiat sebagai penambah darah (hemoglobin dan hematokrit) pada penderita anemia defisiensi besi. Sebanyak 15 ekor tikus (Rattus norvegicus) strain Wistar, jantan dan betina dibagi menjadi 3 kelompok secara random sampling yaitu Kelompok 1 Kontrol negatif (KN) tidak diberi A. lappa L. nanoemulsion. Kelompok Dosis 1 (KD1) diberi A. lappa L. nanoemulsion dengan dosis 150 mg/kgBB/hari. Kelompok Dosis 2 (KD2) diberikan A. lappa L. nanoemulsion dengan dosis 450 mg/kgBB/hari (selama 14 hari dimulai hari ke 8). Indikator penelitian ini dilihat kadar pemeriksaan biokimia kadar darah. Organ hati dan ginjal dinilai menggunakan Hematoxylin-Eosin (HE). Hasil pemeriksaan biokimia darah relatif normal. Sedangkan pewarnaan HE pada kelompok KD1 dan KD2 terjadi perubahan pada sel organ ginjal dan hati, menunjukkan bahwa sediaan nanoemulsi akar burdock bersifat toksik, namun terdapat faktor pengganggu yaitu ditemukan cacing parasit Taenia taeniaeformis, sehingga interpretasi hasilnya terganggu.
Formula Optimization of Propolis Transfersome Gel, Aloe Vera, Gotu Extract: Formula Design, Formulation Evaluation and Cell Regeneration Test in Diabetic Wounds Ajeng Puspo Aji; Rochany Septiyaningsih; Septiana Indratmoko; Elisa Issusilaningtyas; Solikhatun Nasikha
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.9283

Abstract

The study was conducted to determine the optimal formula of transfersome propolis gel, aloe vera extract and gotu gotu leaf extract and test it against diabetic wounds in male white rats (Rattus norvegicus). The gel was created with an optimal formulation resulting from the application of a Design Expert with Cutimed as a positive control of burns on the backs of male white rats (Rattus norvegicus). Formula optimization was carried out using a Simple Lattice Design with variations of carbopol, TEA and glycerin. Activity tests of propolis transferosome gel, aloe vera extract and gotu gotu extract were conducted on 20 rats. The data results were statistically analyzed using the SPSS One Way ANOVA method. Phytochemical screening on aloe vera and gotu gotu showed the presence of flavonoid compounds, tannins and saponins. Transfersome propolis has a particle size of 88.55 nm and a zeta potential of -24.13 mV. The optimal formula produces a clear preparation in white, a distinctive odour, a stable viscosity of 19980 cps, dispersion power of 6.67 cm, adhesion of 4.07 seconds and pH of 6.45. The burn activity test had the fastest effectiveness on day 12 but did not differ significantly from the customized control.
Pengabdian Donor Darah pada Masyarakat Sidanegara Cilacap: Blood Donation Service to The Sidanegara Cilacap Community Elisa Issusilaningtyas; Yuniariana Pertiwi; Nikmah Nuur Rochmah; Ajeng Puspo Aji; Asep Nurrahman Yulianto; Nursanti Dwi Yogawati; Anita Ratna Faoziyah; Tri Kusuma Wardani
Jurnal ABDIMAS-HIP Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2024): Jurnal ABDIMAS-HIP Pengabdian Kepada Masyarakat
Publisher : LPPM Akbid Harapan Ibu Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37402/abdimaship.vol5.iss2.309

Abstract

The scarcity of blood is assumed to be caused by a lack of public knowledge about blood donation. Donor health advantages can minimize the danger of cancer, help with weight loss, make the body psychologically better and prolong life, reduce the risk of heart and blood vessel disease, and detect major disorders. Aside from carrying out the Tri Dharma of Higher Education, community service activities seek to encourage local residents to donate blood for the safety of others, hence raising people's desire and willingness to contribute. PMI Cilacap supports this program by sending numerous medical personnel to perform blood draws. The service team distributed information about the benefits of blood donation during this activity. There were 62 registered blood donors, with 43 (69.35%) passing the health check and donating blood, and 19 (30.65%) failing (not passing) the health check and so unable to donate blood.
Perkembangan Sintesis Green Nanopartikel Centella Asiatica Sebagai Antioksidan Ghalathea Geraldine; Asep Nurrahman Y; Ajeng Puspo Aji
Jurnal Impresi Indonesia Vol. 5 No. 3 (2026): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v5i3.7567

Abstract

Sintesis nanopartikel berbasis green synthesis berkembang pesat sebagai alternatif ramah lingkungan terhadap metode konvensional yang menggunakan bahan kimia toksik. Centella asiatica (CA) mengandung triterpenoid, flavonoid, dan senyawa fenolik yang berpotensi berfungsi sebagai agen pereduksi dan penstabil alami dalam pembentukan nanopartikel. Review ini bertujuan untuk menganalisis perkembangan metode sintesis green nanopartikel berbasis Centella asiatica, karakteristik nanopartikel yang dihasilkan, serta potensi aktivitas antioksidannya dalam bidang farmasi dan kosmetik. Metode yang digunakan adalah Systematic Literature Review (SLR) dengan pedoman PRISMA 2020. Pencarian artikel dilakukan melalui basis data Scopus pada periode 2016–2025 menggunakan kata kunci terkait green synthesis, nanopartikel, Centella asiatica, dan antioksidan. Dari 65 artikel yang teridentifikasi, 15 artikel memenuhi kriteria inklusi dan dianalisis secara kritis. Hasil kajian menunjukkan bahwa Centella asiatica telah diaplikasikan dalam berbagai sistem nano, termasuk nanopartikel logam, polimerik, lipid, karbon, dan nanokomposit. Sebagian besar penelitian melaporkan peningkatan aktivitas antioksidan melalui penurunan ROS, peningkatan aktivitas penangkal radikal bebas, serta aktivasi jalur pertahanan seluler. Namun, mayoritas studi masih terbatas pada uji in vitro. Green nanopartikel berbasis Centella asiatica berpotensi sebagai sumber antioksidan yang biokompatibel dan berkelanjutan, namun diperlukan penelitian lanjutan berbasis in vivo dan klinis.
Formulation of Nutraceutical Products Based on Multigrain and Moringa Leaves (Moringa oleifera L.) as Antistunting Innovations Rochany Septiyaningsih; Ajeng Puspo Aji; Meyra Alfiah Ananda; Septiana Indratmoko
Jurnal Penelitian Pendidikan IPA Vol 12 No 7 (2026): In Progress
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i7.15843

Abstract

Stunting is a nutritional problem that requires innovation in functional food products made from natural ingredients that are nutritious and easy to consume. This study aimed to formulate an anti-stunting nutraceutical product based on multigrain ingredients and moringa leaves (Moringa oleifera L.) in the form of a cereal-like health drink. Product evaluation was conducted through organoleptic testing, pH stability testing, proximate analysis, and hedonic testing. The organoleptic results showed that the three formulations had relatively similar color, taste, aroma, and texture characteristics and remained stable during one month of storage. The pH values were also stable, indicating good chemical stability of the product. Proximate analysis showed that the protein content of 8.14-9.13%, ash content of 1.36-1.74%, and carbohydrate content of 75.15-77.88% met the requirements of SNI 01-4270-1996. However, the moisture content of 7.56-8.01% still exceeded the maximum limit, while the fat content of 4.49-6.19% remained below the standard. The hedonic test results showed that all formulations were accepted and preferred by the panelists, with an average score exceeding 4. Formulation 3 showed superiority in the color parameter, while Formulation 2 was more preferred in terms of taste. Overall, this product has the potential to be developed as an anti-stunting nutraceutical innovation. However, further optimization of the drying process and the composition of fat-source ingredients is still required.
Co-Authors Anita Ratna Faoziyah Asep Nurrahman Y Asep Nurrahman Yulianto Dini Puspodewi Elisa Issusilaningtyas Ghalathea Geraldine Imam Agus Faizal Meyra Alfiah Ananda Nikmah Nuur Rochmah Rochany Septiyaningsih Solikhatun Nasikha Tri Kusuma Wardani Yogawati, Nursanti Dwi Yuniariana Pertiwi