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All Journal NUSANTARA : Jurnal Ilmu Pengetahuan Sosial Indonesian Journal of Health Science Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Varda Arianti
Institut Kesehatan Hermina
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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EVALUASI FORMULASI SEDIAAN ANTISEPTIK SPRAY EKSTRAK CAIR UMBI RUMPUT TEKI (CYPERUS ROTUNDUS L.) Tisnawan Tisnawan; Dimas Adrianto; Amalina Fakhriah; Varda Arianti
NUSANTARA : Jurnal Ilmu Pengetahuan Sosial Vol 13, No 2 (2026): NUSANTARA : JURNAL ILMU PENGETAHUAN SOSIAL
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jips.v13i2.2026.544-547

Abstract

Umbi rumput teki diketahui mengandung senyawa aktif seperti flavonoid, saponin, tanin, dan terpenoid, yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak cair umbi rumput teki (Cyperus rotundus Linn) dan mengevaluasi sediaan antiseptik spray berbahan aktif ekstrak cair umbi rumput teki. Penelitian dilakukan secara eksperimental dengan formula F0 yang tidak mengandung ekstrak cair umbi rumput teki, sedangkan F1 dan F2 masingmasing mengandung ekstrak cair umbi rumput teki dengan konsentrasi sebesar 10% dan 20%. Ekstrak umbi rumput teki dibuat melalui metode maserasi berulang, kemudian diformulasikan dalam bentuk spray dan diuji melalui uji fisik-kimia (organoleptik, homogenitas, pH, stabilitas) Hasil penelitian menunjukkan bahwa formulasi antiseptik spray dengan ekstrak cair umbi rumput teki menunjukkan stabilitas yang baik, ekstrak cair umbi rumput teki berpotensi dikembangkan sebagai bahan aktif alami dalam sediaan antiseptik spray.
Phytochemical screening and standardization of ethanol extract of Guava Leaves (Psidium guajava L.) with specific and non-spesific parameters Sukma Dwyastati Biadi; Varda Arianti; Dimas Adrianto; Devi Maulina
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1837

Abstract

This study aims to conduct phytochemical screening and standardization of guava leaf ethanol extract (Psidium guajava L.) originating from Gunung Putri, Bogor Regency, West Java. The extract was derived by means of maceration procedure utilizing 96% ethanol as the extraction medium, and phytochemical analysis confirmed the presence of flavonoids, alkaloids, tannins, saponins, terpenoid/steroid compounds, as well as glycosides. Quality evaluation based on specific and non-specific parameters showed results that met the standards: drying loss of  (<10%), total ash content of (<8,4%), specific gravity of 0.99 g/mL, water content of 5.2% (<10%), and negative heavy metal contamination. These results indicate that guava leaves from the Gunung Putri area have a phytochemical profile and extract quality that are suitable for the development of standardized herbal preparation raw materials. Geographical aspects also contribute to the validity of the results and can be a reference for standardization based on plant growing areas.
Level of knowledge of the Menteng community RT 010 RW 009 Menteng Village regarding the use of mefenamic acid tablets as an NSAID analgesic Azrizah Rahmadani; Amalina Fakhriah; Varda Arianti; Devi Maulina
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1969

Abstract

Mefenamic acid, a meclofenamate derivative, is a type of NSAID that inhibits the formation of the cyclooxygenase enzyme. This cyclooxygenase enzyme converts arachidonic acid into prostaglandins. Therefore, if this drug is given as a pain reliever to children or adolescents during their growth period, it will disrupt the longitudinal growth process of their bones. This study aims to evaluate the level of public knowledge in RT 010 RW 009, Menteng Village, Central Jakarta, regarding the use of mefenamic acid tablets as an NSAID analgesic. The method used is descriptive with a quantitative approach and involved 64 respondents selected based on inclusion criteria. The results show that the average level of public knowledge is in the sufficient category (63,20%). Respondents are predominantly in the 17–25 year age group with a vocational high school education level. Only 35.90% of respondents have received direct education from health workers. This finding emphasizes the importance of more intensive educational interventions from health institutions so that the public uses drugs appropriately and wisely.
The effect of ethanol extract of Wuru Ketek Leaves (Myrica javanica Reinw. ex Bl.) on the relative weight of organs in Male White Mice (Mus musculus L.) with alloxan-induced diabetes. Anna Uswatun Hasanah Rochjana; Varda Arianti; Devi Maulina; Fani Aprilia
Indonesian Journal of Health Science Vol 6 No 2 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i2.2151

Abstract

Wuru Ketek (Myrica javanica Reinw. ex Bl.) plant is known to contain flavonoids and tannins that have the potential as antidiabetics. This study aims to evaluate the effect of ethanol extract of wuru ketek leaves (Myrica javanica Reinw. ex Bl.) on the relative weight of the liver, kidneys, and heart of alloxan-induced diabetic male mice. A total of 30 mice were divided into six groups: normal group, negative control, positive control (glibenclamide), and three treatment groups with doses of 100, 200, and 300 mg/kgBW for 12 days orally. The organs were weighed and analyzed statistically. The results showed no significant difference in relative organ weight (p>0.05) between the treatment group and the normal group. These findings indicate that the ethanol extract of wuru ketek leaves (Myrica javanica Reinw. Ex Bl.) does not show toxic effects on target organs in the short term. Further studies are needed to assess long-term safety and other biochemical parameters.
Prescribing profile of long-acting insulin in outpatients with type 2 diabetes mellitus at the BPJS clinic of Hermina Kemayoran Hospital Yuni Agustin; Varda Arianti; Amalina Fakhriah
Indonesian Journal of Health Science Vol 6 No 5 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i5.2409

Abstract

Type 2 diabetes mellitus is a chronic metabolic disease with a rising prevalence; some patients require insulin therapy to reach optimal glycemic control. Long-acting insulin, particularly insulin glargine and insulin detemir, serves as basal therapy. This study describes the prescribing profile of long-acting insulin among BPJS outpatients with type 2 diabetes mellitus at Hermina Kemayoran Hospital during October-December 2025. The study used a descriptive design with a retrospective approach. The population comprised 1,868 outpatients with type 2 diabetes mellitus. Samples were selected through purposive sampling based on inclusion criteria, and all eligible records were then included using total sampling. A total of 204 patients met the eligibility criteria. Data were collected from medical records and prescription data, covering sex, age, HbA1c results, and the type of long-acting insulin prescribed, then analyzed univariately and presented as frequencies and percentages. Female patients outnumbered male patients throughout the study period. Long-acting insulin use was concentrated among patients aged 46-65 years and older than 65 years. Insulin glargine was the most frequently prescribed type, accounting for 91.46% in October, 90.74% in November, and 94.12% in December, while insulin detemir was prescribed less often. The prescribing profile of long-acting insulin was dominated by female patients, older age groups, and insulin glargine use. These findings can serve as baseline data for evaluating insulin utilization and planning pharmaceutical care services.
Comparative Standardization of Moringa oleifera L. Leaf Extracts: Evaluation of Maceration vs. Infusion Using Aqueous Solvent Amalina Fakhriah; Varda Arianti; Yolanda Ongkowidjaya Kuswanda; Ika Aulia Rahmi
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.174

Abstract

Herbal plants traditionally used to treat various diseases and serves as basis for modern drug development. The traditional medicines in Indonesia must meet safety, quality, and efficacy standards, including extract standardization and screening phytochemical. Pharmaceutical industry activities are closely related to implementation of standardization, from raw materials to finished product, in order to ensure efficacy, batch-to-batch consistency, stability, and safety. This study aims to support the utilization of Indonesia herbal plants, particularly moringa leaf. The extract evaluation must be qualified through phytochemical screening and standardization tests. The screening phytochemical result showed both methods contained alkaloids, flavonoids, tannins, saponins, terpenoids, and glycosides. Organoleptically, both extract exhibited similar characteristics besides infusion extract showing a more intense color. The water-soluble extractive values of maceration and infusion methods were 63.95% and 64%. Most non-specific parameters were within the specified limits, including loss on drying (9,07% and 10,23%), specific gravity (1,017 g/mL and 1,007g/mL), total ash content (6,08% and 7,1%), moisture content (9,40% and 10,82%), heavy metal contaminations were negative, while microbial contaminations were at 1,2 x 105 CFU/mL and 3,35 x 102 CFU/mL. Overall, both maceration and infusion methods produced M. oleifera extracts with similar phytochemical profiles and fulfilled most of the evaluated standardization parameters. Infusion produced a higher extraction yield and lower microbial contamination, whereas maceration showes lower moisture content and loss on drying values. However, neither method met all quality requirements nor considered superior overall based on the parameters evaluated, and further optimization is required to obtain a better extract standardization result.
Co-Authors Amalina Fakhriah Anna Uswatun Hasanah Rochjana Azrizah Rahmadani Devi Maulina Dimas Adrianto Fani Aprilia Ika Aulia Rahmi Sukma Dwyastati Biadi Tisnawan Tisnawan Yolanda Ongkowidjaya Kuswanda Yuni Agustin