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All Journal AL KAUNIYAH Jurnal Farmasi Sains dan Komunitas Jurnal Abdimas Indonesia : Jurnal Abdimas Indonesia Jurnal Medika: Medika Biodiversitas Journal of Biological Diversity
Riska Ayu Febrianti
Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Bacteriophage-Based Wound Care Formulation for Diabetic Ulcers as A Growth Inhibitor of Alcaligenes faecalis Kiswara, Nur Hanifah Alim; Ludfillah, Rayyan Zhafir; Febrianti, Riska Ayu; Narulita, Erlia; Winarti, Lina
Al-Kauniyah: Jurnal Biologi Vol. 19 No. 1 (2026): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v19i1.44082

Abstract

Diabetic ulcers are frequently complicated by infections from multidrug-resistant bacteria such as Alcaligenes faecalis, necessitating the development of alternative therapeutic strategies. Bacteriophage therapy presents a promising approach due to its specificity and efficacy against antibiotic-resistant pathogens. This study aimed to formulate and evaluate a bacteriophage-based topical cleanser using the phage ϕAFaV1 for treating A. faecalis infections, focusing on high antibacterial efficacy and low dermal toxicity. Three suspension formulas (F1, F2, F3) were prepared with varying chitosan concentrations (0.5; 0.75, and 1.0%) as a suspending agent. These formulations underwent physical stability testing over 28 days, including assessments of viscosity, pH, zeta potential, and homogeneity. Antibacterial efficacy was determined through inhibition zone assays. All three formulations effectively inhibited bacterial growth, forming clear zones. The F2 formula (0.75% chitosan), containing 200 µL of active phage ingredient, was identified as the optimum formulation. It demonstrated superior physical stability and the most effective bactericidal activity against A. faecalis, as confirmed by statistical analysis. These results indicate that a bacteriophage suspension stabilized with 0.75% chitosan is a highly promising and stable topical agent for combating multidrug-resistant A. faecalis in diabetic wound care.
Edukasi Sanitasi Pangan Sebagai Upaya Peningkatan Keamanan Pangan Tingkat Rumah Tangga di Desa Kemuning Lor, Arjasa, Jember Ani Rosa Putri Ayu Mujayanah; Eko Priyantono; Intan Ria Neliana; Brihatsama Brihatsama; Riska Ayu Febrianti; Lituhayu Supartiningrum
Jurnal Abdimas Indonesia Vol. 5 No. 4 (2025)
Publisher : Perkumpulan Dosen Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34697/jai.v5i4.2188

Abstract

Kegiatan pengabdian masyarakat dilaksanakan di Desa Kemuning Lor, Kecamatan Arjasa, Kabupaten Jember bertujuan meningkatkan pengetahuan dan kesadaran masyarakat tentang sanitasi pangan rumah tangga. Edukasi difokuskan pada teknik sanitasi sesuai standar serta pentingnya penerapan sanitasi dalam keluarga. Metode yang digunakan meliputi ceramah, diskusi interaktif, demonstrasi, dan pembagian modul panduan. Peserta berjumlah 20 orang yang terdiri atas ibu rumah tangga dan kader desa. Hasil evaluasi menunjukkan peningkatan pengetahuan yang signifikan, ditunjukkan oleh rata-rata nilai pre-test 57,3 meningkat menjadi 84,1 pada post-test atau naik sebesar 46,7%. Peserta juga antusias dalam diskusi, mengaitkan materi dengan permasalahan sehari-hari, seperti teknik mencuci tangan maupun penyimpanan bahan pangan. Selain itu, keterampilan praktis berhasil dikuasai dan materi dapat langsung diterapkan di rumah tangga. Kesimpulannya, program edukasi ini efektif meningkatkan pemahaman dan kesadaran masyarakat tentang sanitasi pangan sekaligus memperkuat keterlibatan kelompok lokal, sehingga berpotensi menjadi model pengembangan berkelanjutan dalam menjaga keamanan pangan rumah tangga.
W/O/W Emulsions Formula of Bacteriophages ϕPT1b As a Fruit Wash to Inhibit Pathogenic Escherichia coli Contamination Icha Khairunnisa; Erlia Narulita; Lina Winarti; Riska Ayu Febrianti; Kuswati Kuswati; Ria Yulian
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007143

Abstract

Pathogenic Escherichia coli infect fruit through irrigation contaminated water. Bacteriophage ϕPT1b has ability to infect E. coli and act as food security. Bacteriophage formulations as emulsion preparations increase the efficiency of application and the stability of long-term storage, one of it is W/O/W emulsions. The objective of this study was to examine the effect of cremophor RH 40, span 80 and their interaction on viscosity, droplet size and inhibition of bacteriophage ϕPT1b W/O/W emulsions against pathogenic E. coli. Factorial design method was used to get the optimum formula. The results showed that the cremophor RH 40, span 80, and their interactions increased the viscosity response, decreased the emulsion droplet size, and increased the inhibition against E. coli. FB is the optimum formula for ϕPT1b W/O/W emulsions which has 1% cremophor RH 40 and 4.5% span 80. The formula produced a viscosity of 29 dPas, an average emulsion droplet diameter size of 10.483, and an inhibition against E. coli of 8.65 m. The desirability index value of 0.905 indicates that FB meets 90.5% of the specified criteria.
Improving Tuna Chili Product Quality at KWT Larasati through Food Safety Education Riska Ayu Febrianti; Ani Rosa Putri Ayu Mujayanah; Akbar Pandu Segara; Erlia Narulita; Intan Ria Neliana; Moh Dliyauddin
Jurnal Medika: Medika in progres
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/smsftw11

Abstract

Food safety is a crucial aspect of small-scale processed food production, particularly for fish-based products such as tuna chili sauce, which are highly susceptible to contamination and quality deterioration. This community service program aimed to improve the knowledge and awareness of members of Kelompok Wanita Tani (KWT) Larasati regarding the application of food safety principles in tuna chili sauce production. The program was conducted in 2025 at the KWT Larasati production site using an educational and participatory approach, including food safety counseling, interactive discussions, and on-site mentoring and observation. The effectiveness of the program was evaluated using pre-test and post-test instruments to assess changes in participants’ knowledge levels, as well as an observation checklist based on Good Manufacturing Practices for small and micro food enterprises (Cara Produksi Pangan Olahan yang Baik/CPPOB) to evaluate hygiene and sanitation practices. Data were analyzed using descriptive quantitative methods by comparing mean pre-test and post-test scores, and qualitative descriptive analysis of field observations. The results showed a substantial increase in the average food safety knowledge score from 48 to 85 after the educational intervention. Initial improvements were also observed in several food safety practices, including workers’ personal hygiene, equipment cleanliness, production flow arrangement to reduce the risk of cross-contamination, and the completeness of basic product labeling information. Although the implementation of food safety principles has not yet been fully consistent, this program proved effective as an initial step in enhancing food safety awareness and encouraging improvements in production practices. This community service program is expected to serve as a foundation for strengthening the sustainable implementation of CPPOB to improve the quality, safety, and competitiveness of tuna chili products in small-scale food enterprises.
Genome analysis of novel Salmonella-infecting bacteriophage ?Sen-NF RISKA AYU FEBRIANTI; ERLIA NARULITA; FADHILAH AYU SAVITRI; AGUNG HARIS WIDIANTO; HARDIAN SUSILO ADDY; ERMA SULISTYANINGSIH; KUSWATI KUSWATI; BINAR RAHMA UTAMI
Biodiversitas Journal of Biological Diversity Vol. 26 No. 4 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260450

Abstract

Abstract. Febrianti RA, Narulita E, Savitri FA, Widianto AH, Addy HS, Sulistyaningsih E, Kuswati K, Utami BR. 2025. Genome analysis of novel Salmonella-infecting bacteriophage ?Sen-NF. Biodiversitas 26: 2011-2019. Genome mapping of bacteriophages that infect Salmonella is an important step in understanding the interactions between these pathogenic bacteria and viruses. Salmonella is one of the leading causes of food poisoning worldwide, with multiple serotypes that can cause serious infections in humans. This study aimed to identify and analyze bacteriophage genomes that can be used as therapeutic agents to control Salmonella infections. The study began with isolating bacteriophages from food samples, followed by morphological characterization, molecular and genomic analysis, and phylogenetics. The successfully isolated bacteriophage ?Sen-NF can only infect Salmonella enterica ser. Typhi, which has a diameter of ±1mm with a clear plaque. Bacteriophage ?Sen-NF, which infects Salmonella, is a linear double-stranded DNA virus with a genome size of 108,537 base pairs and a G+C content of 46.8%. Comparative genomic analysis revealed similarities with Myoviridae, such as ?SE24 and ?Sw2. Phylogenetic reconstruction showed a close evolutionary relationship with phages such as ?SE24 and ?Sw2. The results from this study are expected to make significant contributions to the development of new strategies to address food poisoning caused by Salmonella, as well as improve overall food safety.
Genomic and evolutionary perspectives on bacteriophage ΦAfa-NA1 targeting MDR Gram-negative bacteria in diabetic ulcer ERLIA NARULITA; DHIVA AULIA WINDA UTAMI; LAILI IZZATURROHMAH; HALIZA INAYAH ARRACHMI; RISKA AYU FEBRIANTI; RAYYAN ZHAFIR LUDFILLAH; AGUNG HARIS WIDIANTO; HARDIAN SUSILO ADDY; BINAR RAHMA UTAMI; KUSWATI KUSWATI; KAMALIA FIKRI
Biodiversitas Journal of Biological Diversity Vol. 26 No. 12 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d261205

Abstract

Abstract. Narulita E, Utami DAW, Izzaturrohmah L, Arrachmi HI, Febrianti RA, Ludfillah RZ, Widianto AH, Addy HS, Utami BR, Kuswati, Fikri K. 2025. Genomic and evolutionary perspectives on bacteriophage ?Afa-NA1 targeting MDR Gram-negative bacteria in diabetic ulcer. Biodiversitas 26: 6014-6024. The rise of Multidrug-Resistant (MDR) bacterial infections poses a significant challenge in clinical settings, particularly for diabetic ulcer patients who are highly susceptible to persistent infections. This study reports the isolation, characterization, and genomic analysis of a novel lytic bacteriophage, ?Afa-NA1, specifically targeting MDR Gram-negative bacteria associated with diabetic ulcers in Indonesia. The bacteriophage was isolated from wound dressings and tested against four clinical isolates: Alcaligenes faecalis T17, Pseudomonas sp. FP1911, and the Gram-positive control Streptomyces violaceoruber S21. ?Afa-NA1 exhibited strong lytic activity against three Gram-negative isolates but none against the Gram-positive control, confirming host specificity. ?Afa-NA1 produced clear plaques with an average diameter of 3.0±0.5 mm on Alcaligenes faecalis T17, indicative of its potent lytic activity. Stability tests showed the phage retained >90% infective titer after 24 hours at -20°C and 4°C, and exhibited robust stability across a wide pH range (pH 6 to 11). One-step growth analysis revealed a short latent period of 21.7±8.1 minutes and a burst size of 27.7±1.5 PFU per infected cell. Genomic analysis showed ?Afa-NA1 possesses a 78,105 bp double-stranded DNA genome with 45.8% G+C content encoding 83 predicted open reading frames. Comparative genomics and phylogenetic reconstruction confirmed its placement among T7-like Podoviruses, consistent with its obligate lytic lifecycle and genomic architecture. However, the potential for therapeutic application remains preliminary, as host range testing was conducted on a limited panel of single clinical isolates, and all assays were performed in vitro.
Co-Authors AGUNG HARIS WIDIANTO Akbar Pandu Segara Ani Rosa Putri Ayu Mujayanah Ani Rosa Putri Ayu Mujayanah BINAR RAHMA UTAMI Brihatsama Brihatsama DHIVA AULIA WINDA UTAMI Eko Priyantono ERLIA NARULITA ERLIA NARULITA Erlia Narulita ERMA SULISTYANINGSIH FADHILAH AYU SAVITRI HALIZA INAYAH ARRACHMI HARDIAN SUSILO ADDY HARDIAN SUSILO ADDY Icha Khairunnisa Intan Ria Neliana Intan Ria Neliana KAMALIA FIKRI Kiswara, Nur Hanifah Alim KUSWATI KUSWATI Kuswati Kuswati KUSWATI KUSWATI LAILI IZZATURROHMAH Lina Winarti Lina Winarti Lituhayu Supartiningrum Ludfillah, Rayyan Zhafir Moh Dliyauddin RAYYAN ZHAFIR LUDFILLAH Ria Yulian