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All Journal Health Research Journal of Indonesia Laboratory Journal of Infectious Diseases
Michael Vallery Loueis Tumbol
Poltekkes Kemenkes Manado
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The Relationship between Duration of Anti-Tuberculosis Treatment and Blood Urea Levels in Patients with Pulmonary Tuberculosis at Bakunase Community Helath Center Lidia Wulan Stevania Lapudo'oh; Ni Made Susilawati; Byantarsih Widyaningrum; Michael Vallery Loueis Tumbol
Laboratory Journal of Infectious Diseases Vol. 2 No. 1 (2026): Laboratory Journal of Infectious Diseases
Publisher : Poltekkes Kemenkes Kupang

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Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a prevalent pathogen requiring prolonged treatment, typically lasting six months. The kidneys, as the primary excretory organs, must intensively filter pharmaceutical compounds throughout this period. This extended regimen can strain renal function and potentially lead to kidney damage, particularly with rifampicin and streptomycin, which have the highest risk of nephrotoxic effects compared to other anti-tuberculosis drugs. This study aimed to determine the relationship between treatment duration and blood urea levels among pulmonary TB patients at the Bakunase Community Health Center using a quantitative observational approach with a cross-sectional design. Researchers collected data with questionnaires and measured urea levels using the BT15i device. The statistical analysis of 30 samples using the Spearman rank correlation test yielded a correlation coefficient of 0,302 (30,2%) and a significance value of 0,105 (p > 0,05). These results indicate no significant correlation between the duration of anti-tuberculosis therapy and blood urea levels. Consequently, the findings suggest that prolonged TB treatment does not lead to a direct increase in urea levels among patients in this clinical setting, indicating that renal filtration remains relatively stable during the standard course of therapy.
Karaktertistik Urine Dengan Pola Resistensi Bakteri Penyebab Infeksi Saluran Kemih Di Beberapa Rumah Sakit Kota Manado Michael Vallery Loueis Tumbol; Indra Elisabet Lalangpuling; Gabriella Lelengboto; Novri Lorens Nontah; Risti A.D Hasan; Vutry Osyania Sasauw
Health Research Journal of Indonesia Vol 4 No 5 (2026): Health Research Journal of Indonesia
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/hrji.v4i5.1222

Abstract

Di Indonesia prevalensi ISK berkisar antara 5-15 % dengan jumlah penderita mencapai 90-100 kasus per 100.000 penduduk per tahun. Bakteri menjadi penyebab ISK adalah Escherichia coli, Klebsiella, dan Staphylococcus sp. Pengobatan utama ISK adalah antibiotik, masalahnya sudah terjadi resistensi bakteri. Pemeriksaan laboratorium diawali dengan urinalysis dan menjadi petunjuk awal adanya ISK. Berdasarkan hal diatas, adalah bagaimana hubungan karakteristik urine dan pola resistensi bakteri ISK di beberapa rumah sakit di Kota Manado. Jenis penelitian studi cross-sectional bertujuan mengetahui karakteristik urine dan pola resistensi bakteri penyebab ISK di beberapa rumah sakit Kota Manado pada bulan Januari-Juni 2024. Karakteristik utama urine ISK adalah warna kuning cerah, bau amoniak, urine keruh, positif bakteri, pH 5.0 - 6.0, berat jenis 1,005 - 1,030, positif protein, eritrosit, dan leukosit esterase. Pola resistensi bakteri penyebab ISK pada penelitian ini adalah bakteri E.coli telah resisten terhadap Ampicillin (67%), ceftriaxone (63%), dan cefoxitin (50%); Enterobacter aerogenes dan Pseudomonas aeruginosa telah resisten terhadap Ampicillin (59%) dan cefoxitin (63%); Klebsiella pneumoniae telah resisten terhadap Ceftriaxone (50%) dan Staphylococcus aureus telah resisten terhadap Ampicillin (50%), Clindamycin (54%). Terdapat hubungan karakteristik warna urine, leukosit esterase dan jenis bakteri, dan tidak terdapat hubungan kejernihan urine, bau urine, pH urine, protein urine, eritrosit dalam urine dan berat jenis urine penderita ISK dengan pola resistensi antibiotika.
Co-Authors BYANTARSIH WIDYANINGRUM Gabriella Lelengboto Indra Elisabet Lalangpuling Lidia Wulan Stevania Lapudo'oh Ni Made Susilawati Novri Lorens Nontah Risti A.D Hasan Vutry Osyania Sasauw