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Labu Kuning (Cucurbita moschata Durch.) untuk Penurunan Kadar Glukosa Darah Puasa pada Tikus Model Diabetik Fathonah, Rahmi; Indriyanti, Anita; Kharisma, Yuktiana
Global Medical & Health Communication (GMHC) Vol 2, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstrak Â Diabetes melitus didefinisikan sebagai penyakit metabolik yang ditandai dengan hiperglikemia akibat defisiensi insulin atau penurunan efektivitas insulin dan dapat menimbulkan berbagai komplikasi akut maupun kronik. Salah satu obat tradisional yang mempunyai efek anti diabetik adalah labu kuning (Cucurbita moschata Durch.) yang mengandung flavonoid, beta-karoten, vitamin C, dan vitamin E. Tujuan penelitian ini adalah untuk mengetahui efek dan rentang dosis efektif ekstrak air labu kuning terhadap penurunan kadar glukosa darah puasa pada tikus model diabetik. Penelitian ini bersifat eksperimental laboratorik dengan menggunakan disain rancangan acak lengkap terhadap 28 ekor tikus putih jantan galur Wistar yang terbagi dalam empat kelompok yaitu kelompok I (diet biasa, induksi aloksan), kelompok II (diet biasa, induksi aloksan, ekstrak air labu kuning dosis 56 mg/200grBB/hari per oral), kelompok III (diet biasa, induksi aloksan, ekstrak air labu kuning dosis 112 mg/200grBB/hari per oral), dan kelompok IV (diet biasa, induksi aloksan, ekstrak air labu kuning dosis 224 mg/200grBB/hari per oral). Pengukuran kadar glukosa darah puasa dilakukan setelah masa adaptasi, setelah diinduksi aloksan, hari ke-7 dan hari ke-14 perlakuan. Data dianalisis dengan menggunakan uji repeated analysis of varians (ANOVA) lalu dilanjutkan dengan uji post-hoc Tamhaneâs T2. Hasil penelitian menunjukan bahwa pemberian ekstrak air labu kuning dengan rentang dosis 56 mg/200grBB/ hari per oral sampai 112 mg/200grBB/hari per oral selama 14 hari dapat menurunkan kadar glukosa darah puasa dengan bermakna. Penurunan kadar glukosa darah puasa diduga karena labu kuning mengandung flavonoid, beta-karoten, vitamin C dan vitamin E. Â Kata kunci : Diabetes melitus,ekstrak air labu kuning, glukosa darah puasaÂ Pumpkin (Curcubita moschata Durch) to Decline of Blood Glucose Fasting Levels in Diabetic Mice Â Abstract Â Diabetes mellitus defined as syndrome of metabolic diseases characterized by hyperglycemia due to insulin deficiency or decreased effectiveness of insulin that cause various acute and chronic complications. One of the traditional medicines which have anti-diabetic effect is pumpkin (Cucurbita moschata Durch) which contains flavonoids, beta-carotene, vitamin C, and vitamin E. The purpose of this study is to determine the effects and the effective dose range of pumpkin water extracts to the decline of blood glucose fasting levels in diabetic mice. This study was an Â experimental research with complete randomized design using 28 white male wistar mice divided into four groups i.e. group I (normal diet, alloxan induce), group II (normal diet, alloxan induce, water extract of pumpkin at the dose 56 mg/200grBW/day orally), group III (normal diet, alloxan induce,Â pumpkin water extract with the dose of 112 mg/200grBW/day orally), and group IV (normal diet, alloxan induce, pumpkin water extract orally with the dose of 224 mg/200grBW/day). Measurement of blood glucose fasting levels done after the adaptation period, after alloxan induced, on day 7th and day 14th of treatment. Data was analyzed using repeated ANOVA test followed by post-hoc test. The results showed that administration of pumpkin water extract with dose ranges of 56 mg/200grBB/day orally to 112 mg/200grBB/day orally for 14 days can lower blood glucose fasting levels. The decrease in blood glucose fasting levels presumably was because pumpkin contains flavonoid, beta-carotene, vitamin C and vitamin E which known to have those effects. Â Key words : Blood glucose fasting level, diabetes mellitus,pumpkin water extractÂ

Pengaruh Ekstrak Etanol Buah Mahkota Dewa {Phaleria macrocarpa (Scheff) Boerl} per Oral terhadap Kontraktilitas Uterus Mencit Model Gravida Raden Anita Indriyanti; M. Sujatno; A. W. Soekandar
Global Medical & Health Communication (GMHC) Vol 4, No 1 (2016)
Publisher : Universitas Islam Bandung

Tanaman mahkota dewa {Phaleria macrocarpa (Scheff) Boerl} adalah tanaman yang tumbuh dan dimanfaatkan sebagai obat alternatif karena memiliki kandungan zat aktif yang dapat menyembuhkan berbagai penyakit. Penggunaan mahkota dewa ini tidak boleh dikonsumsi oleh wanita hamil karena dapat meningkatkan kontraksi uterus sehingga dapat menyebabkan abortus. Tujuan penelitian membandingkan efek pemberian ekstrak buah mahkota dewa dengan oksitosin terhadap kontraktilitas uterus. Penelitian eksperimental laboratorik dilakukan di Laboratorium Faal dan Farmakologi Klinik Fakultas Kedokteran Unpad Jatinangor Bandung periode Juli–November 2005 dengan memakai 27 ekor mencit gravida galur Swiss-Webster dalam 3 kelompok. Kelompok I sebagai kontrol negatif, kelompok II diberi suntikan oksitosin 0,045 mL/mnt (0,45 mU) intravena, dan kelompok III diberi ekstrak buah mahkota dewa kadar 6,25% sebanyak 0,5 mL per oral. Tiap-tiap kelompok diukur kontraktilitas uterusnya. Hasil perhitungan diolah dengan analisis varians (ANOVA) dilanjutkan dengan Uji Duncan. Pada kelompok mahkota dewa menggambarkan kontraksi yang bersifat ritmis dengan amplitudo kecil dan nilai frekuensi kontraksi tertinggi (119x/30 menit) dan perbedaan yang sangat signifikan versus kelompok kontrol tanpa perlakuan (16x/30 menit) dan kelompok oksitosin (23x/30menit). Kekuatan kontraksi pada pemberian ekstrak etanol buah mahkota dewa lebih rendah (1,2 cm) daripada kelompok kontrol tanpa perlakuan (1,6 cm), sedangkan kelompok yang diberi oksitosin menghasilkan kekuatan kontraksi paling kuat (2,6 cm). Simpulan, pemberian ekstrak etanol buah mahkota dewa menggambarkan kontraksi yang bersifat ritmis dengan amplitudo kecil serta menghasilkan frekuensi kontraksi tertinggi dan amplitudo terendah dibanding dengan kelompok kontrol dan kelompok oksitosin intravena. THE EFFECT OF MAHKOTA DEWA {PHALERIA MACROCARPA (SCHEFF) BOERL} FRUIT ETHANOL EXTRACTS PER ORAL TO UTERINE CONTRACTION OF GRAVIDA TYPE MICEMahkota dewa {Phaleria macrocarpa (Scheff) Boerl} known as a plant that used as an alternative medicine. Because of its rich active substances, it is believed to heal many diseases. Caution for this plant is that it must not be consumed by pregnant women, because it may increase the uterine contraction and cause an abortion. The aim of strudy was to compare the effect of Phaleria macrocarpa (Scheff) Boerl fruit extracts and oxytocin to uterine contraction. The experimental study with complete randomized had been conducted to 27 pregnant Swiss-Webster mouses in Laboratorium Faal and Farmakologi Klinik Fakultas Kedokteran Unpad Jatinangor Bandung periode July–November 2005 that devided in 3 groups. Group I served as a negative control, group II was given oxytocin 0.045 mL/mnt (0.045 mU) intravenous, and group III was given mahkota dewa ethanol extract 6.25% for 0.5 mL orally. The measurement for each group’s uterine contractility consisted of the number of frequency and level of contraction strength. The result analyzed using variant analysis (ANOVA) and Duncan test. Result showed that in mahkota dewa group, a rhythmical contraction with low amplitudo with the highest point (119x/30 mnt) for contraction frequency, compared to control group(16x/30 mnt) and oxytocin group (23x/30 mnt). It showed that in group given mahkota dewa ethanol extract the level of contraction strength was lower (1.2 cm) than control group (1.6 cm). While group given oxytocin intravenously had the highest level of contraction strength (2.6 cm). In conclusion mahkota dewa ethanol extract performed a rhythmical contraction with low amplitudo and has the highest point for contraction frequency, and the lowest level of contraction strength compared to those in control group and oxytocin group.

Labu Kuning (Cucurbita moschata Durch.) untuk Penurunan Kadar Glukosa Darah Puasa pada Tikus Model Diabetik Rahmi Fathonah; Anita Indriyanti; Yuktiana Kharisma
Global Medical & Health Communication (GMHC) Vol 2, No 1 (2014)
Publisher : Universitas Islam Bandung

Diabetes melitus didefinisikan sebagai penyakit metabolik yang ditandai dengan hiperglikemia akibat defisiensi insulin atau penurunan efektivitas insulin dan dapat menimbulkan berbagai komplikasi akut maupun kronik. Salah satu obat tradisional yang mempunyai efek anti diabetik adalah labu kuning (Cucurbita moschata Durch.) yang mengandung flavonoid, beta-karoten, vitamin C, dan vitamin E. Tujuan penelitian ini adalah untuk mengetahui efek dan rentang dosis efektif ekstrak air labu kuning terhadap penurunan kadar glukosa darah puasa pada tikus model diabetik. Penelitian ini bersifat eksperimental laboratorik dengan menggunakan disain rancangan acak lengkap terhadap 28 ekor tikus putih jantan galur Wistar yang terbagi dalam empat kelompok yaitu kelompok I (diet biasa, induksi aloksan), kelompok II (diet biasa, induksi aloksan, ekstrak air labu kuning dosis 56 mg/200 gBB/hari per oral), kelompok III (diet biasa, induksi aloksan, ekstrak air labu kuning dosis 112 mg/200 gBB/hari per oral), dan kelompok IV (diet biasa, induksi aloksan, ekstrak air labu kuning dosis 224 mg/200 gBB/hari per oral). Pengukuran kadar glukosa darah puasa dilakukan setelah masa adaptasi, setelah diinduksi aloksan, hari ke-7, dan hari ke-14 perlakuan. Data dianalisis dengan menggunakan uji repeated analysis of varians (ANOVA) lalu dilanjutkan dengan uji post-hoc Tamhane’s T2. Hasil penelitian menunjukan bahwa pemberian ekstrak air labu kuning dengan rentang dosis 56 mg/200 gBB/ hari per oral sampai 112 mg/200 gBB/hari per oral selama 14 hari dapat menurunkan kadar glukosa darah puasa dengan bermakna. Penurunan kadar glukosa darah puasa diduga karena labu kuning mengandung flavonoid, beta-karoten, vitamin C dan vitamin E. PUMPKIN (CURCUBITA MOSCHATA DURCH.) TO DECLINE OF BLOOD GLUCOSE FASTING LEVELS IN DIABETIC MICEDiabetes mellitus defined as syndrome of metabolic diseases characterized by hyperglycemia due to insulin deficiency or decreased effectiveness of insulin that cause various acute and chronic complications. One of the traditional medicines which have anti-diabetic effect is pumpkin (Cucurbita moschata Durch.) which contains flavonoids, beta-carotene, vitamin C, and vitamin E. The purpose of this study is to determine the effects and the effective dose range of pumpkin water extracts to the decline of blood glucose fasting levels in diabetic mice. This study was an experimental research with complete randomized design using 28 white male wistar mice divided into four groups i.e. group I (normal diet, alloxan induce), group II (normal diet, alloxan induce, water extract of pumpkin at the dose 56 mg/200 gBW/day orally), group III (normal diet, alloxan induce, pumpkin water extract with the dose of 112 mg/200 gBW/day orally), and group IV (normal diet, alloxan induce, pumpkin water extract orally with the dose of 224 mg/200 gBW/day). Measurement of blood glucose fasting levels done after the adaptation period, after alloxan induced, on day 7th and day 14th of treatment. Data was analyzed using repeated ANOVA test followed by post-hoc test. The results showed that administration of pumpkin water extract with dose ranges of 56 mg/200 gBB/day orally to 112 mg/200 gBB/day orally for 14 days can lower blood glucose fasting levels. The decrease in blood glucose fasting levels presumably was because pumpkin contains flavonoid, beta-carotene, vitamin C and vitamin E which known to have those effects.

Fenomena Dose Dependent Manner Efek Jahe Gajah terhadap Cedera Jaringan Hati pada Sindrom Metabolik Agista Rohani; Noormartany Noormartany; Arief Budi Yulianti; Anita Indriyanti; Maya Tejasari
Jurnal Integrasi Kesehatan dan Sains Vol 1, No 2 (2019): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v1i2.4332

Sindrom metabolik merupakan kelainan metabolik kompleks yang memiliki komponen utama obesitas, resistensi insulin, dislipidemia, dan hipertensi. Penyakit ini dapat berlanjut menjadi penyakit perlemakan hati non-alkoholik yang ditandai dengan cedera jaringan hati. Parameter yang dapat menandakan cedera jaringan hati adalah peningkatan kadar AST dan ALT. Peningkatan stres oksidatif mendasari terjadi penyakit ini sehingga untuk mengatasinya dapat menggunakan antioksidan, salah satunya adalah jahe. Penelitian ini bertujuan mengetahui pengaruh pemberian fraksi etil asetat jahe gajah terhadap kadar AST dan ALT pada mencit sindrom metabolik. Penelitian ini merupakan penelitian eksperimental in vivo menggunakan mencit galur Swiss Webster yang terbagi dalam empat kelompok, yaitu kelompok kontrol yang tidak diberikan perlakuan dan tiga kelompok perlakuan yang diberi fraksi etil asetat jahe gajah dengan konsentrasi 0,78 mg/kgBB/hari, 1,56 mg/kgBB/hari, dan 3,12/kgBB/ hari. Hasil penelitian menunjukkan kelompok perlakuan 1 memiliki kadar AST dan ALT lebih rendah dibanding kelompok kontrol, sedangkan kelompok perlakuan 2 dan 3 lebih tinggi dibanding dengan kelompok kontrol. Hal ini menunjukan bahwa pada kelompok perlakuan satu, fraksi jahe dapat mencegah cedera jaringan hati, sedangkan pada kelompok perlakuan dua dan tiga justru merusak jaringan hati. Simpulan fraksi etil asetat jahe gajah memengaruhi cedera jaringan hati pada mencit model sindrom metabolik secara dose dependent manner. DOSE DEPENDENT MANNER PHENOMENON OF GINGER EFFECTS IN METABOLIC SYNDROME LIVER INJURYMetabolic syndrome is a complex metabolic disorder that has a major component are obesity, insulin resistance, dyslipidemia, and hypertension. This disease can progress to non-alcoholic fatty liver disease characterized by liver injury. Parameters that can indicate liver tissue injury are an increase in AST and ALT levels. Increased oxidative stress underlies the occurrence of this disease, so to overcome it can use antioxidants, one of which is ginger. This study aims to determine the effect of ethyl acetate fraction ginger on AST and ALT levels in mice of metabolic syndrome. This study was an experimental study in vivo using Swiss Webster mice models divided into four groups: untreated control group and three treatment groups given ethyl acetate fraction ginger with concentration 0.78 mg/ kgBW/day, 1.56 mg/kgBW/day, 3.12/kgBW/day. The results showed that the treatment group 1 had AST and ALT levels lower than the control group, while the 2 and 3 treatment groups were higher than the control group. This suggests that in the treatment group one, the ginger fraction can prevent liver injury while in the treatment group two and three actually damage the liver tissue. It can be concluded that the elephant glycol ethyl acetate fraction affects liver injury in metabolic syndrome mice model by dose dependent manner.

Perbandingan Efek Getah Tanaman Jarak Pagar (Jatropha Curcas L) dengan Lendir Bekicot (Achantina Fulica) terhadap Lama Penyembuhan Luka pada Mencit Jantan Galur Swiss Webster Wiwit Kesumaningrum; R. Anita Indriyanti
Jurnal Riset Kedokteran Volume 1, No.1, Juli 2021, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Abstract. A wound is a break in body tissue from the epithelial layer of the skin to the inner layer, such as subcutaneous tissue, fat, muscle, and bone. Jatropha sap and snail slime are natural ingredients that can be used in the treatment of wounds. Jatropha sap contains tannins, alkaloids, and flavonoids which function as anti-inflammatory, while snail mucus contains achantin isolate which has anti-bacterial and anti-inflammatory effects. The purpose of this study was to compare the effect of jatropha (Jatropha Curcas L) and snail slime (Achantina fulica) on the duration of wound healing in Swiss Webster male mice. This study was a laboratory experimental study with a completely randomized design method on 24 male white mice strains. Swiss Webster. An incision was made on each mouse 1.5 cm long and 2 mm deep. The experimental animals were divided into 4 groups, namely the negative control group which was not given any treatment, the positive control group was given 10% povidone iodine, group I was given jatropha plant sap at a dose of 2 times per day with 2 drops of Pasteur pipette and group II snail mucus 2 times per day with 2 drops of Pasteur pipette. The wound observer was carried out for 14 consecutive days starting one day after the treatment. All mice in the positive control and negative control experienced healing (100%) and only a part of the mice (50%) in the group given karak plant sap and snail mucus who experienced healing. In the treatment of jatropha sap has no effect on wound healing time, as well as snail mucus there is no effect in the duration of healing wounds, but wounds heal faster using castor plant sap. Abstrak. Getah tanaman jarak pagar dan lendir bekicot merupakan salah satu bahan alam yang dapat digunakan dalam pengobatan luka. Getah tanaman jarak pagar mengandung tanin,alkaloid, serta flavonoid yang berfungsi sebagai antiinflamasi, sedangkan lendir bekicot mengandung isolat achantin yang memiliki efek anti bakteri dan anti inflamasi, sehingga membantu untuk mempercepat penyembuhan luka. Tujuan penelitian ini untuk membandingkan efek getah tanaman jarak pagar (Jatropha Curcas L) dengan lendir bekicot (Achantina fulica) terhadap lama penyembuhan luka pada mencit jantan galur Swiss Webster. Penelitian ini merupakan penelitian eksperimental laboratoris dengan pendekatan acak lengkap terhadap 24 ekor mencit putih jantan galur Swiss Webster. Luka secara insisi dibuat pada masing-masing mencit sepanjang 1.5 cm dengan kedalaman 2 mm. Hewan coba dibagi menjadi 4 kelompok yaitu kelompok kontrol negatif yang tidak diberikan perlakuan apapun, kelompok kontrol positif yang diberikan povidon iodin 10%, kelompok I diberi getah tanaman jarak dengan dosis 2x/hari sebanyak 2 tetes dan kelompok II lendir bekicot 2x/hari sebanyak 2 tetes. Pengamatam ukuran luka dilakukan selama 14 hari berturut-turut yang dimulai satu hari setelah pemberian perlakuan. Luka diamati selama 14 hari berturu-turut. Seluruh mencit pada kontrol positif dan kontrol negatif mengalami penyembuhan luka (100%) dan hanya sebagian mencit (50%) pada kelompok yang diberikan getah tanaman karak dan lendir bekicot yang mengalami penyembuhan. Pada perlakuan getah tanaman jarak tidak memiliki efek terhadap lama penyembuhan luka, begitu juga dengan lendir bekicotpun tidak terdapat efek dalam lama penyebuhan luka, namun luka lebih cepat mengalami penyembuhan dengan menggunakan getah tanaman jarak. Hasil menunjukkan bahwa tidak terdapat perbedaan bermakna antara pemberian getah tanaman jarak terhadap penyembuhan luka (p=0,125). Karena nilai sig nya > 0,05 artinya tidak terdapat perbedaan antara Kontrol negative, Kontrol positif, Kelompok 1 (Getah tanaman jarak), dan Kelompok 2 (Lendir bekicot). Pemberian getah tanaman jarak pagar dan lendir bekicot tidak memiliki efek terhadap lama penyembuhan luka pada mencit jantan galur Swiss Webster tetapi pemberian getah tanaman jarak pagar lebih baik dari pada lendir bekicot.

Histopathology of Nephrotoxicity Associated with Administered Water Extract Purple Sweet Potato (Ipomoea batatas) in Mice (Mus musculus) in Stratified Phases of Dose Meta Maulida Damayanti; Raden Anita Indriyanti; Yuktiana Kharisma; Yuke Andriane; Uci Ari Lantika; Ratna Damailia; Meike Rachmawati
Global Medical & Health Communication (GMHC) Vol 10, No 3 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v10i3.9662

The main aim of the registered purple sweet potato (Ipomoea batatas) is to provide minimize the adverse chemical drugs, in addition to its anti-inflammatory, antioxidant, and antimicrobial effects. Potentially adverse effects may be observed in laboratory animals in particular, the extent to which this administration can cause toxicity. This study aimed to examine the histopathology of nephrotoxicity associated with administered water extracts of purple sweet potato in mice with stratified doses. The study was conducted at the Biomedical Laboratory, Faculty of Medicine, Universitas Islam Bandung on September 2019. Female mice (Mus musculus) strain Swiss Webster, aged between 6–8 weeks weighing 25 to 30 g, were obtained from Biopharma Laboratory, Bandung. The animal was acclimatized for seven days before being administered water extract purple sweet potato: eleven mice, one control group, and ten treatment groups underwent toxicity doses of purple sweet potato water extract administration. Purple sweet potato variant of Ayamurasaki prepared in various oral doses. The results show in the control group there were no histopathological changes, but in the group administered water extract purple sweet potato from the first phase seems in a mild grade of macrophage accumulation, mild vacuolization of tubular epithelial cells, mild vascular dilatation, and mild hydrophilic degeneration. In the second phase, macrophage accumulation was visible in moderate grades. The LD50 of purple sweet potato extract is greater than 5,000 mg/kgBW. The findings of this study indicate that registration of purple sweet potato extract in confirmatory doses is safe to administer and did not exhibit any mortality. The toxicity test of purple sweet potato water extracts in the kidney exhibits minimal chemical effects.

Prescription Writing Errors in Clinical Clerkship among Medical Students Indriyanti, Raden Anita; Yulianto, Fajar Awalia; Andriane, Yuke
Global Medical & Health Communication (GMHC) Vol 7, No 1 (2019)
Publisher : Universitas Islam Bandung

Prescription is an instruction written by a medical practitioner to give a drug or device for a patient. The proper prescription will contribute to speedy recovery or healing process for the patient. Clinical clerkship must have an excellent competency to choose the right medication and prescribe the appropriate drugs or therapy. This study aims to analyze the common error in prescription's writing in clinical clerkship among medical students at their final examination to be a medical doctor. This study used the analytic method to 609 sheets of prescription from 180 clerkship students in their last try out on objective structured clinical examination (OSCE) at the Faculty of Medicine Universitas Islam Bandung in March 2018. Analyzed the component that every prescription should have, which consists of patient identity, superscription, inscription, subscription, and signatures. The result showed that more than half of the clerkship students made an error in subscription (50.25%) and signatures items (55.83%), while most of them had written down properly the patient identity (77.5%), superscription (83.74%), and inscription (78.98%). As a result, with more than half error in a prescription written in subscription and signature item, the failure of giving adequate therapy will cause a low recovery or healing process to the patients. Moreover, it may harm or cause death to the patients. In conclusion, more than half of medical students made common errors in prescription's writing. KESALAHAN PENULISAN RESEP PADA MAHASISWA KOASISTENSI FAKULTAS KEDOKTERANResep merupakan instruksi yang ditulis oleh tenaga medis untuk memberikan obat atau seperangkat alat kepada pasien. Peresepan yang tepat akan membawa proses pemulihan dan penyembuhan terhadap pasien. Mahasiswa kedokteran yang menjalankan masa koasisten harus memiliki kompetensi yang baik untuk memilih dan menuliskan terapi yang sesuai. Penelitian ini bertujuan menganalisis kesalahan umum dalam penulisan resep pada mahasiswa kedokteran yang akan menghadapi ujian akhir untuk menjadi seorang dokter. Penelitian ini menggunakan metode analitik terhadap 609 lembar resep dari 180 mahasiswa kedokteran yang sedang melaksanakan try out akhir objective structured clinical examination (OSCE) di Fakultas Kedokteran Universitas Islam Bandung pada Maret 2018. Dianalisis setiap komponen yang harus ada dalam penulisan resep, yaitu identitas pasien, superskripsi, inskripsi, subskripsi, dan signature. Hasil penelitian menunjukkan bahwa lebih dari setengah mahasiswa melakukan kesalahan pada item subskripsi (50,25%) dan signature (55,83%), sedangkan sebagian besar sudah menulis dengan baik pada item identitas pasien (77,5%), superskripsi (83,74%), dan inskripsi (78,98%). Akibatnya, dengan lebih dari setengah jumlah kesalahan dalam penulisan item subskripsi dan signature maka kegagalan dalam memberikan terapi yang adekuat dapat menyebabkan angka kesembuhan yang rendah, terlebih lagi dapat menimbulkan bahaya bahkan kematian terhadap pasien. Simpulan, lebih dari setengah mahasiswa kedokteran melakukan kesalahan umum dalam penulisan resep.

Nuclear Changes Features in Buccal Mucosa Smear of Adult Male Smokers Using Pappaniculou Staining Kharisma, Yuktiana; Indriyanti, Raden Anita; Yuniarti, Lelly; Noormartany, Noormartany; Nur, Ismet Muchtar; Yenolinsky, Yolanda
Althea Medical Journal Vol 12, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n1.3486

Background: Tobacco smoke contains a combination of chemicals that could be harmful to the buccal mucosa as the first part of the body that has been exposed. Damage to the buccal epithelial cells has the potential to become a malignant lesion. This study aimed to describe changes in the nuclear epithelial of the buccal mucosa using Pappaniculou staining as an indicator of mucosal damage in smokers.Methods: This was a descriptive analytical study, involving adult male participants from Bale Endah District, Bandung Regency, Indonesia aged >35 years, who had smoked for ≥10 years. Buccal mucosa smear was taken, and the features of nuclear epithelial changes were observed per 500 cells, each at 400x magnification with Pappaniculou stain to evaluate the features of micronucleus, broken egg, karyorrhexis, karyolysis. Those who did not smoke were recruited as a control group.Results: Smokers were mostly light active smokers or kretek cigarettes, with a smoking duration of ≥15 years. The frequency of micronucleus (p<0.001), broken eggs (p<0.001), karyorrhexis (p=0.001), karyolysis (p=0.003) in the buccal mucosal epithelial was significantly different between the smoker and non-smoker groups.Conclusions: All epithelial nuclear changes have shown significant differences between smoker and non-smoker groups. Nuclear epithelial features in smoker may be associated with future malignancies, therefore, smoking cessation programs are necessary to substantially reduce tobacco use, thus fostering a healthy lifestyle for everyone.

PEMBERDAYAAN ALUMNI FK UNISBA WILAYAH PRIANGAN TIMUR SEBAGAI UPAYA KONTRIBUSI PEDULI PESANTREN SEHAT DI LINGKUNGANNYA Indriyanti, Raden Anita; Perdana, Rizki; Widiyanti, Alvira
Jurnal Abdi Insani Vol 12 No 2 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i2.2241

Based on a preliminary survey, situational analysis and dialogue conducted by the FK Unisba service team and alumni at the Sabilunnajat Islamic boarding school, produced data that the need for information regarding health, especially clean and healthy living behavior, is still minimal. Seeing the high potential for medical graduates from Islamic educational institutions , it is appropriate to make various efforts by FK Unisba alumni to solve health problems in Islamic boarding schools. The aim of this activity is to make efforts to empower FK Unisba Alumni in improving the health of students at the Sabilunnajat Islamic boarding school through training healthy student cadres. The method of this activity consists of a preparatory stage in form of a Focused Group Discussion by FK UNISBA alumni to identify problems in the Islamic boarding school environment, followed by an implementation stage through health screening and therapy, provision of health facilities, counseling for santri and training for healthy santri cadres. The activity ended with the reporting stage to assess the success of the training of healthy santri cadres. The results of this PKM activity are a reduction in health problems, the availability of health facilities, and the formation of health cadres as an effort to overcome early stage health problems in the Sabilunnajat Islamic boarding school environment. The importance of the role of partnership and cooperation between various parties, especially the Islamic boarding school comittee, the UNISBA Medical Faculty, the contribution of alumni and authorities in policy making, is the key to the success in improving the level of health in the surrounding environment.

Pendampingan kewaspadaan bencana alam longsor dan antisipasinya di Pesantren Sabilunnajat kecamatan Rancah kabupaten Ciamis Indriyanti, Raden Anita; Triyani, Yani
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 1 (2024): March
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i1.22259

AbstrakBencana alam longsor kabupaten Ciamis pada tahun 2021 mengakibatkan kerusakan asrama putra di pesantren Sabilunnajat. Berdasarkan hasil survey di pesantren Sabilunnajat, belum pernah ada pelatihan kewaspadaan terhadap bencana longsor di pesantren tersebut. Kegiatan pengabdian ini bertujuan memberikan solusi menjadikan kader santri siaga bencana, melalui pelatihan perwakilan santri sebagai kader kesehatan sesuai bimbingan BNPB dengan kolaborasi tim dokter yang tergabung dalam ikatan alumni FK Unisba. Metode yang dilakukan pada tahap awal adalah melakukan edukasi berupa sosialisasi kewaspadaan bencana alam longsor, dan perilaku hidup bersih dan sehat (PHBS) , selanjutnya pembentukan kader santri siaga bencana, serta pembentukan Pos Kesehatan Pesantren berkolaborasi dengan dokter alumni FK Unisba. Kegiatan dilakukan di Pesantren Sabilunnajat-Ciamis, bulan Juni–Agustus 2023. Hasil dari program pengabdian ini adalah didapatkan hasil secara statistik yang meningkat signifikan setelah pemberian penyuluhan, terbentuknya kader pesantren sehat, pembentukan sarana dan prasarana kamar mandi di lokasi aman longsor, berjalannya fasilitasi pelayanan kesehatan gratis melalui kerjasama dengan klinik dikelola oleh alumni Fakultas Kedokteran Unisba. Kata kunci: dokter alumni FK Unisba; kader santri; siaga bencana AbstractThe natural landslide disaster in Ciamis district in 2021 resulted in damage to the boys' dormitory at the Sabilunnajat Islamic boarding school. Based on the results of a survey at the Sabilunnajat Islamic boarding school, there has never been any landslide awareness training at the Islamic boarding school. This service activity aims to provide a solution to make students prepared for disasters through training student representatives as health cadres according to BNPB guidance with the collaboration of a team of doctors who are members of the FK Unisba alumni association. The method used in the initial stage was to provide education in the form of socializing awareness of landslide disasters, and clean and healthy living behavior (PHBS), followed by the formation of santri health cadres, as well as the establishment of Islamic boarding school health posts in collaboration with FK Unisba alumni doctors. Activities were carried out at the Sabilunnajat-Ciamis Islamic boarding school, June–August 2023. The results of this service program were that statistically significant results increased after providing counseling, the formation of healthy Islamic boarding school cadres, the establishment of bathroom facilities and infrastructure in landslide-safe locations, and ongoing facilitation. free health services in collaboration with clinics managed by alumni of the Unisba Faculty of Medicine. Keywords: FK Unisba alumni doctors, student cadres, disaster preparedness.

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