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All Journal Global Medical and Health Communication Jurnal Abdi Insani Jurnal Riset Kedokteran
Widiyanti, Alvira
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Impact of Propolis Administration on Osteocrin Expression and Osteoblast-to-Osteoclast Ratio in the Femurs of Rats Fed a High-fat Diet Widiyanti, Alvira; Tarawan, Vita Murniati; Lubis, Leonardo
Global Medical & Health Communication (GMHC) Vol 12, No 2 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i2.13833

Abstract

A high-fat diet (HFD) is associated with bone inflammatory processes that can affect bone remodeling balance. Osteocrin produced by periosteal osteoblasts correlates with osteoblast activity, is expressed on osteoblast-derived cells, and is localized in osteoblasts and young osteocytes. Propolis is an antioxidant and anti-inflammatory in bone remodeling by inhibiting proinflammatory factors NF-κB and COX-2, reducing inflammatory suppression of cytokines responsible for osteoclast differentiation and osteoblast apoptosis. The flavonoid content increases the production of nitric oxide and osteoprotegerin, which enhances osteoblastogenesis. This study determined the effect of propolis administration on bone formation and resorption in bone previously damaged by an HFD. This research was conducted in the Animal Laboratory of Postgraduate Building Dipati Ukur and Genetics and Molecular Laboratory Eycman Building, Faculty of Medicine, Universitas Padjadjaran. The research time was from January 2023–May 2024. Male Wistar rats were divided into four groups: normal chow diet (NCD), NCD with propolis administration, HFD, and HFD with propolis administration. The 12-week-old rats were given an HFD for 12 weeks and then treated with propolis at a 300 mg/kgBW dose for nine weeks. The administration of propolis increased the ratio of osteoblasts-osteoclast cells in the femur of the HFD rats but did not affect periosteal osteocrin expression.
PEMBERDAYAAN ALUMNI FK UNISBA WILAYAH PRIANGAN TIMUR SEBAGAI UPAYA KONTRIBUSI PEDULI PESANTREN SEHAT DI LINGKUNGANNYA Indriyanti, Raden Anita; Perdana, Rizki; Widiyanti, Alvira
Jurnal Abdi Insani Vol 12 No 2 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i2.2241

Abstract

Based on a preliminary survey, situational analysis and dialogue conducted by the FK Unisba service team and alumni at the Sabilunnajat Islamic boarding school, produced data that the need for information regarding health, especially clean and healthy living behavior, is still minimal. Seeing the high potential for medical graduates from Islamic educational institutions , it is appropriate to make various efforts by FK Unisba alumni to solve health problems in Islamic boarding schools. The aim of this activity is to make efforts to empower FK Unisba Alumni in improving the health of students at the Sabilunnajat Islamic boarding school through training healthy student cadres. The method of this activity consists of a preparatory stage in form of a Focused Group Discussion by FK UNISBA alumni to identify problems in the Islamic boarding school environment, followed by an implementation stage through health screening and therapy, provision of health facilities, counseling for santri and training for healthy santri cadres. The activity ended with the reporting stage to assess the success of the training of healthy santri cadres. The results of this PKM activity are a reduction in health problems, the availability of health facilities, and the formation of  health cadres  as an effort to overcome early stage health problems in the Sabilunnajat Islamic boarding school environment. The importance of the role of partnership and cooperation between various parties, especially the Islamic boarding school comittee, the UNISBA Medical Faculty, the contribution of alumni and authorities in policy making, is the key to the success in improving the level of health in the surrounding environment.
Implementasi Alur Klinis Sindrom Koroner Akut di Rumah Sakit Jantung Tasikmalaya Widiyanti, Alvira; Lestari, Rini; Zulmansyah
Jurnal Riset Kedokteran Volume 5, No.2, Desember 2025, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.v5i2.8854

Abstract

Abstract. The social security program is government effort to facilitate public health in Indonesia. The quality of health services accordance with the Minister of Health Regulation 2022 Number 30, one of them is compliance by clinical pathway (CP). Acute Coronary Syndrome (ACS) is the second highest cause of death in Indonesia after stroke at 12.9%. Several previous studies have shown that the implementation of ACS CP has the benefit of reducing the length of time and cost of patient care. Tasikmalaya Heart Hospital as a hospital with cardiac health services specialities in East Priangan area. This study aims to assess the implementation and effect of the implementation ACS CP on the length of time and cost of care. This study used Kolmogorov-Smirnov normality test, homogenity testing for multivariate test using Box's M-Test, and continued with MANOVA test. It found that the implementation of CP in ACS patients had been implemented 78.33%, with a length of treatment time of 71.7% in the low category, 45% treatment costs in the moderate category with a median of Rp 7.599.300,00  and the results of the MANOVA test found that the implementation of CP was significant to the length of time and cost of treatment. Abstrak. Program jaminan sosial adalah upaya pemerintah dalam memfasilitasi kesehatan masyarakat di Indonesia. Mutu Pelayanan Kesehatan di evaluasi menggunakan Indikator Mutu Nasional Rumah Sakit sesuai dengan Peraturan Menteri Kesehatan Nomor 30 Tahun 2022, salah satunya adalah kepatuhan terhadap alur klinis. Sindroma Koroner Akut (SKA) merupakan penyebab kematian tertinggi kedua di Indonesia setelah stroke sebesar 12.9%. Beberapa penelitian sebelumnya menunjukan bahwa penerapan Alur Klinis SKA memiki manfaat untuk menurunkan lama waktu dan biaya perawatan pasien. RS Jantung Tasikmalaya sebagai rumah sakit yang memiliki kekhususan pelayanan kesehatan jantung di daerah Priangan Timur diharapkan dapat menyediakan layanan kesehatan yang mumpuni. Penelitian ini bertujuan untuk menilai implementasi dan pengaruh implementasi alur klinis  SKA terhadap lama waktu dan biaya perawatan di RS Jantung Tasikmalaya. Penelitian ini menggunakan uji normalitas Kolmogorov-Smirnov, pengujian homogenitas untuk uji multivariate menggunakan Box’s M Test, dan dilanjutkan uji MANOVA. Pada penelitian ini didapatkan bahwa implementasi alur klinis pada pasien SKA di RS Jantung Tasikmalaya telah terlaksana 78,33%, dengan lama waktu perawatan 71,7% masuk ke dalam kategori rendah, biaya perawatan 45% masuk ke dalam kategori cukup dengan median Rp 7.599.300, serta hasil uji MANOVA didapatkan bahwa implementasi alur klinis bermakna secara signifikan terhadap lama waktu dan biaya perawatan.
Co-Authors Leonardo Lubis Perdana, Rizki Raden Anita Indriyanti Rini Lestari Vita Murniati Tarawan Zulmansyah