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All Journal Jurnal Sains dan Kesehatan Indonesian Journal of Global Health Research
Adryan Fristiohady Lubis
Universitas Halu Oleo
Health Professions Medicine & Pharmacology Nursing Public Health

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Analisis Sistem Pelaporan Monitoring Efek Samping Obat (Meso) Oleh Tenaga Farmasi Di Puskesmas Kota Kendari Wa Ode Sitti Nurrokhmadani; Adryan Fristiohady Lubis; Devi Savitri Effendy
Jurnal Sains & Kesehatan Vol 4 No 2 (2025): Jurnal Sains dan Kesehatan
Publisher : Politeknik Baubau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57151/jsika.v4i2.1558

Abstract

The extensive use of medicines in healthcare services carries the risk of adverse drug reactions (ADRs) that are not always detected during pre-marketing clinical trials. Therefore, a Monitoring of Adverse Drug Reactions (MESO) reporting system is required in healthcare facilities. This study aims to analyze the influence of knowledge, attitudes, barriers, and facilities on the implementation of MESO reporting by pharmacy personnel at primary health centers (Puskesmas) in Kendari City. The study employed an analytic quantitative cross-sectional design involving 68 pharmacy staff respondents and utilized bivariate chi-square and logistic regression analyses. The results showed that knowledge was not significantly associated with MESO reporting implementation (p=0.147), whereas attitude (p=0.027) and reporting barriers (p=0.004) demonstrated significant associations. Reporting facilities did not have a significant effect (p=0.188). Barriers such as workload and a complicated reporting system emerged as the main issues. In conclusion, optimizing MESO reporting requires strengthening positive attitudes, eliminating key barriers, and developing an integrated system to support sustainable reporting and improve the quality of healthcare services in primary health centers.
Optimization of Anti-Bacterial Gel from Ethyl Acetate Fraction of Purple Sweet Potato Leaves (Ipomoea Batatas L.) Using Hydroxy Propyl Methyl Cellulose (HPMC) and Testing Its Activity Against Staphylococcus Epidermidis Bacteria Muhamad Luthfid Anando Aly Roza; Fery Indradewi Armadany; Wahyuni Wahyuni; Ruslin Ruslin; Adryan Fristiohady Lubis; Nur Illiyyin Akib
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2075

Abstract

Bacterial infections are a significant global health challenge because they can attack various body tissues and cause illnesses ranging from mild to severe. Staphylococcus epidermidis is a bacterium that often causes various infections. Infection by Staphylococcus epidermidis can slow down the wound healing process and carry the risk of serious complications if not properly managed. This study aims to formulate and optimise an antibacterial gel from the ethyl acetate fraction of purple sweet potato leaves (Ipomoea batatas L.) as a natural alternative for treating skin infections caused by the bacterium Staphylococcus epidermidis. Using the I-optimal mixture design method in Design-Expert software, the optimization analysis was performed by evaluating several responses, including pH, viscosity, spreadability, and adhesion of the gel formulation. The experimental data were fitted to an appropriate polynomial model and analyzed using ANOVA to determine the significance of the model and mixture components. Numerical optimization was then carried out by setting the desired criteria for each response to obtain the optimum formulation. The optimal formulation consisted of 2% HPMC and 13% propylene glycol, with a desirability value of 0.964. The results showed that this formulation met all the criteria for a good and stable gel, including organoleptic properties (semi-solid, brownish-green, characteristic odour, homogeneous), pH (5.81), viscosity (2316.52 cPs), spreadability (6.4 cm), and adhesion time (2.18 seconds). The optimal formulation for an antibacterial gel containing the ethyl acetate fraction of purple sweet potato leaves (Ipomoea batatas L.) was achieved using a 2% HPMC concentration and 13% propylene glycol, with a desirability value of 0.964, , this gel formulation is also effective and falls into the category of being highly potent in inhibiting the growth of Staphylococcus epidermidis, as evidenced by the formation of an inhibition zone of 23 mm.
Co-Authors Devi Savitri Effendy Fery Indradewi Armadany Muhamad Luthfid Anando Aly Roza Nur Illiyyin Akib Ruslin Ruslin Wa Ode Sitti Nurrokhmadani Wahyuni Wahyuni