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All Journal Wellness And Healthy Magazine Indonesian Journal of Global Health research Bioscientia Medicina : Journal of Biomedicine and Translational Research KESANS : International Journal of Health and Science International Journal of Health and Pharmaceutical (IJHP) Indonesian Journal of Advanced Research (IJAR) Synthesis Global Health Journal Indonesian Journal of Global Health Research
Salutondok, Welly
Universitas Kristen Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Hipertiroidisme: Sebuah Studi Laporan Kasus Saraswati, Niluh Ayu Sri; Salutondok, Welly
Wellness And Healthy Magazine Vol 4, No 1 (2022): February
Publisher : Universitas Aisyah Pringsewu (UAP) Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/well.183412022

Abstract

Introduction: Hyperthyroidism, an excessive concentration of thyroid hormones in tissue, is one of the major thyroid diseases in Indonesia. In 2007, the prevalence of hyperthyroidism in Indonesia is higher in women (14.7%) than men (12.8%) and stands at 6.9%, with TSH cut-off level less than 0.55 µIU/mL. Clinical signs and symptoms may vary according to the patient’s age, duration of illness, the magnitude of hormone excess, and presence of comorbid conditions. Methods: We present a case of diagnosis and treatment of hyperthyroidism in our health care unit. Complimentary databases were collected from PubMed and Google Scholar. Results: A 33 years old male patient presented with fatigue, palpitation, weight loss, a month before being admitted to the hospital. We suspected the patient is having a hyperthyroidism condition and used Wayne’s index to evaluate the score. More information such as the preference for cold, an increase of appetite, and hyperhydration was dug. The total score is 20 which signaling hyperthyroidism. The patient undergoes other examinations such as ECG (sinus tachycardia, rate 104 bpm), thyroid function (TSH 0.0039 µIU/mL, FT4 3.26 ng/dL), liver function (OT 31 U/L, PT 49 U/L), and electrolyte (Na 142 mEq/L, K 3.67 mEq/L). The patient has been treated with PTU 100 mg (3 times a day), propranolol 10 mg (2 times a day), and Curcuma 1 tablet (3 times a day). Discussion: Diagnosing hyperthyroidism begins with digging clinical information, counting Wayne’s index, and checking specific laboratory examinations. Treatment may vary according to symptoms and laboratory results.  Abstrak Pendahuluan: Hipertiroidisme, sebuah kondisi peningkatan hormon tiroid pada tubuh, merupakan salah satu masalah tiroid terbesar di Indonesia. Pada tahun 2007, prevalensi hipertiroidisme di Indonesia pada wanita (14.7%) lebih besar dibanding pria (12.8%), dan berada pada angka 6.9%, dengan nilai TSH kurang dari 0.55 µIU/mL. Tanda dan gejala klinis dapat bervariasi sesuai dengan usia pasien, durasi sakit, kadar hormon, dan kondisi komorbid. Metode: Laporan kasus ini akan memaparkan diagnosis dan terapi pada sebuah kasus hipertiroidisme yang ditemukan pada fasilitas layanan kesehatan tempat kami bekerja. Data penunjang didapatkan dari PubMed dan Google Cendekia. Hasil: Pasien merupakan seorang pria berusia 33 tahun dengan keluhan mudah lelah, berdebar, dan penurunan berat badan dalam 1 bulan terakhir. Kami mencurigai pasien dengan hipertiroidisme dan menggunakan indeks Wayne untuk mengevaluasi skor. Keluhan lain yang dialami oleh pasien yakni tidak tahan panas, peningkatan nafsu makan, dan mudah berkeringat. Skor total yang didapatkan ialah 20 yang menandakan pasien mengalami kondisi hipertiroidsme. Dilakukan pemeriksaan penunjang lain pada pasien berupa EKG (sinus takikardia, Nadi 104x/menit), fungsi tiroid (TSH 0.0039 µIU/mL, FT4 3.26 ng/dL), fungsi liver (OT 31 U/L, PT 49 U/L), dan elektrolit (Na 142 mEq/L, K 3.67 mEq/L). Pasien diterapi dengan PTU 3 x 100mg, propranolol 2 x 10mg, dan curcuma 3 x 1 tablet. Simpulan: Mendiagnosis hipertirodisme dimulai dengan penggalian informasi keluhan pasien, penghitungan indeks Wayna, dan pemeriksaan penunjang spesifik lainnya. Terapi dapat berbeda sesuai dengan kondisi dan hasil pemeriksaan laboratoris pasien.
The Role of Serum Omega 3 Levels on Muscle Mass, Muscle Strength, and Physical Performance in the Elderly Community Welly Salutondok; Nur Riviati; Yulianto kusnadi; Erial Bahar; Nova Kuniati; Syamsu Indra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 3 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i3.220

Abstract

A B S T R A C TIntroduction. Old age is related to geriatric syndrome where there are several healthproblems that often occur related to a decrease in body function and an increase inthe inflammatory process. Decrease in muscle mass, muscle strength and physicalperformance will lead to a condition of sarcopenia and frailty syndrome in the elderly.The importance of prevention so that sarcopenia does not occur in the elderly byevaluating the factors that can cause it, one of which is controlling nutritional factors(macro and micro nutrients), such as in research, namely omega-3 macronutrients.The purpose of this study was to determine the correlation between serum omega-3levels with muscle mass, muscle strength, and physical performance in the elderlycommunity at Moehammad Hoesin Hospital Palembang. Methods. This research isan observational analytic study with a cross-sectional approach which wasconducted at the Integrated Geriatric Clinic Internal Medicine RSMH Palembangfrom November 2019 to November 2020. A sample of 21 people aged> 60 years wasexamined for muscle mass, muscle strength, physical performance and omega-levels. 3 serums. All data processing and analysis in this study used SPSS version25 for Windows. Results. Of the 21 subjects, it was found that women were 19people (90.5%) and 2 men (9.5%). The mean value of muscle mass was 37.65 ± 5.7,hand grip strength was 24.04 ± 5 kg, and walking speed was 6.72 ± 1.8 seconds per6 meters. There were 11 subjects with low serum omega-3 levels of 485.25 ± 110.19mg. There was a significant relationship between serum omega-3 levels and musclemass (p = 0.041) with moderate correlation strength (r = 0.448). Conclusion: Musclemass has a significant relationship with serum omega-3 levels in the elderly withmoderate strength. Meanwhile, muscle strength and physical performance did nothave a significant relationship.
Description of Characteristics, Knowledge, and Behavior Towards the Hazards of Conventional Tobacco Cigarettes Among Cleaning Service and Security Workers Who Smoke Situmorang, Daniel Reinaldo Parsaoran; Salutondok, Welly; Simarmata, Vidi Posdo A.
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 3 (2025): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i3.520

Abstract

Introduction: Conventional tobacco cigarette smoking remains a major public health concern, particularly among occupational groups exposed to high work-related stress, such as cleaning service and security workers. Limited awareness of smoking-related health risks may contribute to continued smoking behavior and increased disease burden. Objective: This study aimed to describe the characteristics, knowledge levels, and smoking behaviors related to the dangers of conventional tobacco cigarettes among cleaning service and security workers at the Faculty of Medicine, University X, Jakarta. Method: This descriptive cross-sectional study was conducted in July 2023 among cleaning service and security personnel who were active smokers. Data were collected using a structured questionnaire covering demographic characteristics, knowledge of smoking hazards, and smoking behaviors. Data were analyzed using descriptive statistics. Result and Discussion: The results showed that 62% (31 respondents) had good knowledge regarding the dangers of conventional tobacco cigarettes, while 38% (19 respondents) had sufficient knowledge, and none had poor knowledge. In terms of smoking behavior, 38% of respondents always smoked, 24% often smoked, 34% sometimes smoked, and 4% never smoked in certain situations. Despite relatively adequate knowledge, risky smoking behaviors remained common. Conclusion: Although respondents generally had adequate knowledge, risky smoking behaviors persisted, indicating the need for targeted health education and smoking cessation programs for this occupational group
Profile of Hypertension Patients Receiving Outpatient Care Welly Salutondok; Syalomo Excellens Sangga Malole Ballo; Vidi Posdo A. Simarmata
International Journal of Health and Pharmaceutical (IJHP) Vol. 6 No. 2 (2026): May 2026
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v6i2.531

Abstract

Hypertension is a non-communicable disease with high prevalence and a major risk factor for cardiovascular disease, stroke, and kidney disorders. This condition is often asymptomatic, leading many patients to be diagnosed only after complications arise. Therefore, information on the profile of hypertensive patients is essential for healthcare planning and complication prevention. This study aimed to identify the profile of hypertensive patients at RSUD Naibonat during 2023-2024. A retrospective descriptive design was employed. Data were obtained from medical records of outpatient hypertensive patients at RSUD Naibonat during the study period. Total sampling was applied, including 152 patients meeting inclusion criteria. Variables analyzed included age, sex, body mass index, and blood pressure grade according to the Indonesian Society of Hypertension. Data were analyzed descriptively and presented as frequency distributions and percentages. Most hypertensive patients were elderly, particularly aged 67-76 years. Female patients outnumbered males. The majority had above-normal body mass index, predominantly type 2 obesity. Regarding blood pressure grade, grade 1 hypertension was most common, followed by isolated systolic hypertension and grade 2 hypertension. The profile of hypertensive patients at RSUD Naibonat during 2023-2024 was dominated by elderly individuals, females, and those with above-normal body mass index. These findings highlight the importance of early detection, risk factor management, and adoption of a healthy lifestyle to prevent hypertension progression and its complications.
The Role of Toll-Like Receptor-2 in the Pathogenesis of Pulmonary Tuberculosis Sudarto Sudarto; Zen Hafy; Irsan Saleh; Iche Andriyani Liberty; Zen Ahmad; Fadhyl Zuhry Lubis; Owen Hu; Welly Salutondok
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6797

Abstract

Pulmonary tuberculosis (PTB), primarily caused by Mycobacterium tuberculosis (M.tb), remains a major global health burden. Toll-like receptor 2 (TLR-2), a critical component of the innate immune system, plays a key role in the host-pathogen interaction by recognizing specific components of the mycobacterial cell wall and initiating downstream inflammatory pathways. However, the dual role of TLR-2 in both protective immunity and immune evasion by M.tb contributes to the complexity of TB pathogenesis. This study aims to investigate the role of Toll-Like Receptor-2 (TLR-2) in the pathogenesis of pulmonary tuberculosis, including its immunological mechanisms, relationships with disease severity, and the potential of TLR-2 as a diagnostic and therapeutic target. This literature review systematically analyzed molecular mechanisms involving TLR-2 signaling in pulmonary TB using peer-reviewed primary and secondary sources from experimental and clinical studies. Emphasis was placed on signal transduction (NF-κB and MAPK), cytokine profiles, antigen presentation, and the impact of TLR-2 gene polymorphisms on TB susceptibility. Activation of TLR-2 through ligands such as lipoproteins, lipoarabinomannan (LAM), and PE/PPE proteins initiates immune responses via MyD88-dependent pathways, leading to the release of proinflammatory cytokines (TNF-α, IL-6, IL-12). TLR-2 also enhances the function of macrophages and dendritic cells, promoting Th1-mediated immunity. However, chronic or excessive stimulation of TLR-2 can suppress antigen processing, promote IL-10 expression, inhibit phagolysosome fusion, and facilitate M. tb survival within host macrophages. Polymorphisms in the TLR-2 gene (e.g., rs3804099) have been associated with increased susceptibility and variable clinical outcomes in PTB. TLR-2 plays a paradoxical role in pulmonary tuberculosis by mediating both protective immunity and facilitating immune evasion by M.tb. Understanding the balance of TLR-2 signaling and genetic variation is crucial for developing immunomodulatory therapies and personalized interventions in TB management.
Navigating Tuberculosis Treatment Challenges of Genetic Perspectives and DNA-Based Detection: A Literature Review Rouly Pola Pasaribu; Zen Hafy; Ariesti Karmila; Nur Riviati; Zen Ahmad; Fadhyl Zuhry Lubis; Welly Salutondok
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1926

Abstract

Tuberculosis remains a major global health problem, particularly because of the increasing burden of drug-resistant tuberculosis (DR-TB), including MDR-TB and XDR-TB. Resistance in Mycobacterium tuberculosis is driven mainly by spontaneous genetic mutations, adaptive evolution, tolerance mechanisms, and host microenvironmental factors, which complicate both treatment and diagnosis. This review aimed to examine recent advances in the genetic mechanisms underlying antibiotic resistance in M. tuberculosis and to evaluate the progress of DNA-based detection technologies for tuberculosis diagnosis and management. This literature review analyzed 49 scientific articles published between 2012 and 2026 to examine the molecular and genetic basis of drug resistance in M. tuberculosis. The study focused on identifying target gene mutations, efflux pump mechanisms, compensatory evolution, and heteroresistance. Furthermore, it evaluated the clinical application of advanced DNA-based diagnostic tools, including GeneXpert, line probe assays, targeted next-generation sequencing (tNGS), whole-genome sequencing (WGS), droplet digital PCR, and CRISPR-based detection. Information was qualitatively synthesized to compare the efficacy and limitations of these modern diagnostic strategies in global tuberculosis management. Drug resistance was primarily associated with de novo mutations in genes such as rpoB, katG, inhA, pncA, gyrA/gyrB, and rrs/eis, as well as compensatory mutations that preserve bacterial fitness. In addition, non-genetic tolerance, dormancy, and efflux pump overexpression contributed to bacterial survival. DNA-based technologies enabled faster and more comprehensive resistance detection than conventional methods, although limitations remained in sensitivity, mutation coverage, cost, and infrastructure requirements. Genetic mutations, evolutionary adaptation, and tolerance mechanisms form the core basis of drug resistance in M. tuberculosis. Integrating DNA-based diagnostics into clinical practice is essential to improve early resistance detection, support personalised treatment, and reduce the spread of drug-resistant tuberculosis.
COMPARATIVE ANALYSIS OF THE EFFECTIVENESS OF OLD AND NEW TB DRUGS IN THE TREATMENT OF PULMONARY TUBERCULOSIS Romauli Lumbantobing; Linggom Kurniaty; Welly Salutondok; Tiroy Sari B. Simanjuntak
SYNTHESIS Global Health Journal Volume 3, Issue 2, 2025
Publisher : SYNTIFIC

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61543/syn.v3i2.148

Abstract

Background. The availability of effective drug regimens of Pulmonary tuberculosis (TB) poses a global health challenge. Traditional first-line therapies-isoniazid, rifampicin, pyrazinamide, and ethambutol-remain the cornerstone of TB management due to their accessibility and documented cure rates exceeding 85%. Nevertheless, limitations such as variable drug metabolism, patient non-adherence, and the emergence of multidrug-resistant strains have prompted evaluation of newer treatment combinations to optimize efficacy, safety, and duration. The purpose was to compare the effectiveness of older first-line tuberculosis (TB) drug regimens with newer therapeutic regimens in the treatment of pulmonary tuberculosis. Research Method. This narrative review synthesizes findings from five peer-reviewed studies comparing the effectiveness and safety profiles of conventional and novel TB drug regimens. The review focused on regimen composition, treatment duration, bacteriological clearance, hepatotoxicity, and patient adherence outcomes. Findings. The inclusion of pyrazinamide in six-month regimens significantly accelerated bacterial clearance without increasing hepatic toxicity compared to traditional nine-month isoniazid–rifampicin regimens. Additionally, shorter rifampin-based regimens for latent TB demonstrated higher treatment completion rates and fewer adverse effects than isoniazid monotherapy. Emerging regimens, such as fluoroquinolone-based HRM therapies and the novel BPaL combination (bedaquiline, pretomanid, and linezolid), yielded comparable or improved outcomes, with BPaL achieving success rates up to 93% in drug-resistant TB cases. Conclusion. Current evidence supports the strategic adaptation of TB therapy to balance efficacy, tolerability, and treatment duration. Incorporating newer drug combinations, particularly for drug-resistant TB, enhances adherence and clinical outcomes, underscoring the need for individualized treatment protocols aligned with evolving resistance patterns and patient profiles.
Clinical and Demographic Profile of Pulmonary Tuberculosis Patients Based on AFB Examination Results at UKI General Hospital, Jakarta Marliana Nurprilinda; Paskalia Eka Rosari Prima; Welly Salutondok
Indonesian Journal of Advanced Research Vol. 5 No. 9 (2026): September 2026
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijar.v5i9.17291

Abstract

Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major public health concern in Indonesia. This study described Acid-fast bacilli (AFB) examination results among pulmonary TB patients at Universitas Kristen Indonesia General Hospital from January to December 2023. A descriptive quantitative design was applied using medical records and total sampling of 41 patients. Univariate and bivariate analyses were conducted. Positive AFB results were found in 31 patients (75.6%), while 10 (24.4%) were negative. Most patients were aged 15–64 years (70.7%) and male (65.9%). AFB positivity was higher among males (81.5%) than females (64.3%). Overall, positive AFB results predominated, particularly among male and productive age patients.
Co-Authors Ariesti Karmila Daniel Reinaldo Parsaoran Situmorang Erial Bahar Fadhyl Zuhry Lubis Iche Andriyani Liberty, Iche Andriyani Linggom Kurniaty Marliana Nurprilinda Muhammad Irsan Saleh Nova Kuniati Nur Riviati Nur Riviati, Nur Owen Hu Paskalia Eka Rosari Prima Romauli Lumbantobing Rouly Pola Pasaribu Saraswati, Niluh Ayu Sri Simanjuntak, Tiroy Sari Bumi Simarmata, Vidi Posdo Sudarto Sudarto Syalomo Excellens Sangga Malole Ballo Syamsu Indra Vidi Posdo A. Simarmata Yulianto kusnadi Zen Ahmad Zen Ahmad Zen Hafy