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All Journal Majalah Kedokteran Contagion: Scientific Periodical Journal of Public Health and Coastal Health Indonesian Journal of Global Health research KESANS : International Journal of Health and Science International Journal of Community Service (IJCS) Indonesian Journal of Advanced Research (IJAR)
Marliana Nurprilinda
Universitas Kristen Indonesia
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Immunohistochemical Profile of Er, Pr, Her2, and Ki-67 In Breast Cancer Patients Marliana Nurprilinda; Erida Manalu; Tiroy Sari B. Simanjuntak; Reinhard Christovel Andreas
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25681

Abstract

Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide, with hormonal factors playing a critical role in tumor development and progression. This study aims to describe the immunohistochemical profile of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 in breast cancer patients at MRCCC Siloam Semanggi Hospital in 2022. A retrospective descriptive study was conducted using a total sampling of anatomical pathology archives, comprising 316 breast cancer cases. The most common age group was 40-49 years. ER positivity was observed in 229 patients (72.5%), while PR positivity was found in 183 patients (57.9%). HER2 overexpression (3+) was identified in 75 patients (23.7%); cases with equivocal HER2 (2+) required confirmation by in situ hybridization. High proliferative activity, indicated by Ki-67 ≥20%, was present in 262 patients (82.9%). These findings indicate a predominance of hormone receptor-positive tumors with high proliferative indices, highlighting the importance of immunohistochemical profiling in guiding prognosis assessment, therapeutic decision-making, and selection of targeted and systemic treatments in breast cancer management. Keywords: Breast Cancer, Immunohistochemistry, Estrogen Receptor (ER), HER2, Ki-67
Profil Pasien Kanker Serviks di RS Awal Bros Batam Tahun 2020–2022 Debora Jenifer; Devy Serevina; Marliana Nurprilinda
Majalah Kedokteran Vol. 39 No. 2 (2023): MEI - AGUSTUS
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mk.v39i2.5898

Abstract

Kanker serviks adalah keganasan leher rahim yang disebabkan oleh Human Papilomavirus tipe 16 dan 18 dan ditularkan melalui hubungan seksual. Indonesia merupakan negara dengan kasus kanker serviks terbanyak di Asia Tenggara. Tujuan penelitian ini untuk mengetahui profil pasien kanker serviks di RS Awal Bros Batam tahun 2020-2022. Penelitian ini bersifat retrospektif dengan mengambil data rekam medis pasien kanker serviks. Sebanyak 97 orang subjek yang diteliti memiliki rentang umur 36-50 tahun (55,7%), menikah (99%), paritas 3-4´ (52,6%), berpendidikan SMA (50,5%), ibu rumah tangga (74,2%). Keluhan utama adalah perdarahan yang ditemukan pada 52 subjek dengan gambaran histopatologi karsinoma sel skuamosa (72,2%) dengan diferensiasi baik (44,3%). Kata kunci: Human Papilomavirus, karsinoma sel skuamosa, paritas, derajat diferensiasi Cervical cancer is a malignancy of the cervix caused by Human Papillomavirus types 16 and 18 and is transmitted through sexual contact. Indonesia is the country with the most cases of cervical cancer in Southeast Asia. The aim of this research is to determine the profile of cervical cancer patients at Awal Bros Hospital, Batam in 2020-2022. This research is retrospective in nature by taking medical record data from cervical cancer patients. A total of 97 subjects studied had an age range of 36-50 years (55.7%), married (99%), parity 3-4 times (52.6%), high school education (50.5%), housewives (74.2%). The main complaint was bleeding which was found in 52 subjects with histopathological features of squamous cell carcinoma (72.2%) with good differentiation (44.3%). Keywords: Human Papiloma Virus, squamous cell carcinoma, parity, degree of differentiation
Morphology Profile and PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Patients Marliana Nurprilinda; Silphia Novelyn; Sonya Trinur Veronika Siahaan; Frisca Angreni
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6167

Abstract

Lung cancer cases in Indonesia became the second highest with the highest mortality rate in 2022. Various advanced examinations such as histopathology and immunohistochemistry are performed to identify the morphological types of lung cancer. Histopathologically, lung cancer classified into two types are Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC). After histopathological examination, further immunohistochemical testing is required to help classify the subtype and identify therapeutic markers. One of the markers is the expression of Programmed Death Ligand 1 (PD-L1). Patients with this marker can receive anti-PD-L1 immunotherapy according to the specified criteria. This study determined the morphological profile and PD-L1 expression in patients with Non-Small Cell Lung Cancer (NSCLC) at Siloam MRCCC Semanggi Hospital between 2020 and 2022. The method used was descriptive with a retrospective approach by collecting data from the archives of the Anatomical Pathology Laboratory at Siloam MRCCC Semanggi Hospital. The population in this study comprised all patients diagnosed with NSCLC who underwent PD-L1 IHC testing at Siloam MRCCC Semanggi Hospital between 2020 and 2022. Data collection was conducted using a total sampling method, including all individuals who met the predefined inclusion and exclusion criteria. The final sample consisted of 91 patients diagnosed with NSCLC who had undergone PD-L1 IHC examination during the 2020–2022 period. A total of 91 patients including the inclusion and exclusion criteria were included in the data and analyzed. The analysis revealed that the age group 60-69 years accounted for 39.5% of cases, 54.9% of cases were male, 73.6% of cases had an adenocarcinoma morphology, and 54.9% of cases had a negative PD-L1. The incidence of NSCLC patients who underwent PD-L1 IHK examination based on age was dominated by the 60-69 year age group, and most of them were male with the most common diagnosis being adenocarcinoma morphology type and PD-L1 expression with negative values.
Overview of Risk Factors for the Incidence of Pediculosis Capitis in Children Marliana Nurprilinda; Eva Silvia F Sitanggang; Mulyadi Djojosaputro; Dartri Cahyawari
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6907

Abstract

Pediculosis capitis (head lice) is a global health issue, particularly among school-aged children, caused by Pediculus humanus capitis. This condition can be transmitted both directly or indirectly via fomites. Symptoms commonly associated with Pediculosis capitis include itching of the scalp, sleep disturbances, and discomfort. Several factors generally influence the prevalence, including age, gender, frequency of hair washing, hair type, level of knowledge, personal hygiene, living conditions, and shared use of bedding or pillows. Research purposes to identify the risk factors associated with Pediculosis capitis among students at SDN Cawang 04 and SDN Cawang 12 in East Jakarta. This research is an analytical study with a cross-sectional approach. The research method employed is quantitative, utilizing questionnaires as research instruments and visual inspection to diagnose infestation, which is confirmed if eggs, nymphs, or adult lice are found in the hair. The sample was selected through random sampling from students in grades 3,4, and 5, with a total of 180 respondents determined using the Slovin formula. Data collection in this study used primary data collected through head lice or nit examinations and questionnaires. The research instruments used were a questionnaire regarding sociodemographic characteristics and questions to determine the number and risk factors for head lice. Data were analyzed using univariate analysis in SPSS. The results show that out of 180 respondents, 100 people (55.6%) were positive for Pediculosis capitis, with a higher infestation rate among female students (76, 42.2%) compared to male students (24, 13.3%). Based on respondent characteristics, the most common age was 9 years old, namely 39 people (21.6%), and grade IV, 37 people (20.5%). Dominant risk factors include age, gender, having long hair, a family size of more than four members, and parents' highest education level being high school. This study indicates that the incidence of Pediculosis capitis remains relatively high.
Pap Smear Examination as a Strategy for Prevention and Early Detection of Cervical Cancer at the HKBP Jatisampurna Church, Bekasi Marliana Nurprilinda; Frisca Ronauli Batubara; Fajar Lamhot Gultom; Abitmer Gultom
International Journal of Community Service (IJCS) Vol. 5 No. 1 (2026): January-June
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijcs.v5i1.1775

Abstract

Cervical cancer remains one of the leading causes of morbidity and mortality among women, particularly in developing countries, largely due to late diagnosis and low participation in early screening programs. Limited knowledge and awareness regarding cervical cancer and Pap smear examinations contribute significantly to delayed detection. This community service activity aimed to increase the knowledge and awareness of the congregation of HKBP Jatisampurna Church, Bekasi, regarding the importance of early detection of cervical cancer through Pap smear examinations. The activity was conducted using interactive educational counseling followed by free Pap smear examination services. Educational sessions covered cervical cancer risk factors, prevention strategies, and the procedures and benefits of Pap smear screening. A total of 50 female congregation members participated in the activity and voluntarily underwent Pap smear examinations. The results demonstrated an improvement in participants’ knowledge and understanding of cervical cancer and the importance of early detection through Pap smear screening. In addition, there was an increased willingness and participation of congregation members in undergoing Pap smear examinations, indicating positive behavioral changes toward preventive health practices. In conclusion, educational counseling combined with direct Pap smear services effectively increased awareness and participation in cervical cancer screening among the HKBP Jatisampurna Church congregation. This community service activity represents a strategic approach to cervical cancer prevention and early detection and highlights the importance of community-based interventions in promoting women’s reproductive health
Patient Characteristics and Histopathological Features of Breast Cancer Marliana Nurprilinda; Rayllion Zefza Gerald Londo; Silphia Novelyn
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 11 (2026): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i11.721

Abstract

Introduction: Breast cancer is a cause of morbidity and mortality among women. Histopathological features are important for tumor characterization. Objective: This study aimed to describe patient characteristics and histopathological features of breast cancer at MRCCC Siloam Semanggi Cancer Hospital in 2024. Method: This retrospective study used pathology records of patients diagnosed with primary breast cancer in 2024. A total of 243 of 281 patients met the inclusion criteria and were selected using purposive sampling. Variables included age, tumor location, histopathological type, and histopathological grade. Data were analyzed using univariate analysis and presented as frequencies and percentages. Result and Discussion: All patients were female (100%). The largest age group was 40–49 years, comprising 75 cases (30.9%), followed by 50–59 years (23.9%) and 60–69 years (20.2%). Tumors were located in the left breast (50.6%), followed by the right breast (47.7%) and bilateral breast (1.6%). Invasive ductal carcinoma of no special type was predominant (77.8%), while grade III was the most frequent grade (60.9%), indicating poorly differentiated tumors. Conclusions: Cases were most common among women aged 40–49 years, with left-sided tumors predominating. Invasive ductal carcinoma of no special type and grade III were predominant
Clinical and Demographic Profile of Pulmonary Tuberculosis Patients Based on AFB Examination Results at UKI General Hospital, Jakarta Marliana Nurprilinda; Paskalia Eka Rosari Prima; Welly Salutondok
Indonesian Journal of Advanced Research Vol. 5 No. 9 (2026): September 2026
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijar.v5i9.17291

Abstract

Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major public health concern in Indonesia. This study described Acid-fast bacilli (AFB) examination results among pulmonary TB patients at Universitas Kristen Indonesia General Hospital from January to December 2023. A descriptive quantitative design was applied using medical records and total sampling of 41 patients. Univariate and bivariate analyses were conducted. Positive AFB results were found in 31 patients (75.6%), while 10 (24.4%) were negative. Most patients were aged 15–64 years (70.7%) and male (65.9%). AFB positivity was higher among males (81.5%) than females (64.3%). Overall, positive AFB results predominated, particularly among male and productive age patients.
Co-Authors Abitmer Gultom Dartri Cahyawari Debora Jenifer Devy Serevina Erida Manalu Eva Silvia F Sitanggang Fajar Lamhot Gultom Frisca Angreni Frisca Ronauli Batubara Mulyadi Djojosaputro Paskalia Eka Rosari Prima Rayllion Zefza Gerald Londo Reinhard Christovel Andreas Salutondok, Welly Silphia Novelyn Simanjuntak, Tiroy Sari Bumi Sonya Trinur Veronika Siahaan