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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) INTEGRITAS : Jurnal Pengabdian Narra J
Margalin, Brilliant
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Effector function and neutrophil cell death in the severity of sepsis with diabetes mellitus Margalin, Brilliant; Arfijanto, Muhammad V.; Hadi, Usman
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.532

Abstract

Sepsis, a life-threatening condition resulting from immune dysregulation, is typically triggered by bacterial infections and commonly coexists with diabetes mellitus. Neutrophils are the first responders to infection and require regulated activation to control pathogen and damage-associated molecular patterns. Dysregulation of neutrophil activation leads to uncontrolled inflammatory responses, often observed in both sepsis and diabetes patients. Neutrophil dysregulation, characterized by effector dysfunction and inadequate cell death processes, can serve as a biomarker for assessing sepsis severity, particularly in diabetic patients. This review article provides information on the relationship between effector function, neutrophil cell death, and the severity of sepsis in individuals with diabetes mellitus, aiming to shed light on the mechanisms underlying sepsis progression. Topics covered in the review include an overview of effector function of neutrophil cells, mechanisms of neutrophil cell death, and dysregulation of effectors and neutrophil cell death processes in sepsis severity with diabetes mellitus.
PENINGKATAN USAHA MELALUI DIGITALISASI PADA UMKM DAPUR ATHA Rodli, Achmad Fathoni; Lestari, Lilla Puji; Anam, Khairil; Setiawan, Setiawan; Margalin, Brilliant; Sari, Renny Nirwana; Aulia, Rizza Fatma; Ngibad, Khoirul
INTEGRITAS : Jurnal Pengabdian Vol 6 No 1 (2022): JANUARI - JULI
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat - Universitas Abdurachman Saleh Situbondo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36841/integritas.v6i1.1703

Abstract

UMKM (Usaha Mikro Kecil Menengah) “Dapur Atha” yang bergerak dibidang bisnis makanan selama ini penjualannya tidak mengalami peningkatan hal ini dikarenakan adanya proses pemasaran yang kurang meluas. Mitra hanya memasrkan produknya hanya di sekitar Wilayah Taman atau wilayah tempat produksi saja. Dengan adanya kondisi tersebut, maka diperlukan kemajuan teknologi dengan melakukan penjualan melalui pemasaran online dengan media Website Statis dan Pengembangan Pemasaran melalui E-Commerce Shopee. Tujuan program ini adalah melaksanakan sosialisasi dan pelatihan tentang pemasaran secara online bagi mitra. Adapun hasil kegiatan dari program ini adalah adanya peningkatan kunjungan dan penjualan baik dalam Website Statis dan E-Commerce Shopee.
RF AND ANTI-CCP POSITIF IN ANKYLOSING SPONDYLITIS(AS) PATIENT WITH RHEUMATOID ARTHRITIS(RA): TRUE OR FALSE POSITIVE? TRUE OR FALSE POSITIVE? Margalin, Brilliant; Aryati, Aryati; Yuliasih, Yuliasih; R Raharjo, Paulus
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2765

Abstract

Ankylosing Spondylitis (AS) and Rheumatoid Arthritis (RA) are different autoimmune arthritis diseases but have overlapping clinical manifestations. Rheumatoid Factor (RF) and Anti-Cyclic-Citrulinated-Peptide (anti-CCP) serological examinations have an important role because they are seropositive in RA and seronegative in AS. This case report is interesting because it discusses a patient with AS who was unexpectedly negative for HLA-B27, positive for RF and anti-CCP, raising doubts about clinical and laboratory discrepancies. Patients with AS and RA disease can occur simultaneously, although it is very rare. This case report analyzes the diagnostic role of RF and Anti-CCP examinations, whether they are true positive or false positive.
Co-Authors Arfijanto, Muhammad V. Aryati Aryati Aulia, Rizza Fatma Khairil Anam, Khairil Lilla Puji Lestari Ngibad, Khoirul R Raharjo, Paulus Rodli, Achmad Fathoni Sari, Renny Nirwana Setiawan Setiawan Usman Hadi Yuliasih