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All Journal Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL
Kumala Sari Poespita Dewi Wahyuni
Institut Ilmu Kesehatan Bhakti Wiyata
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Evaluation of Dose Appropriateness in Patients Congestive Heart Failure and Comorbid Chronic Kidney Disease at RSUD Kabupaten Kediri Ela Agustin; Shofiatul Fajriyah; Esti Ambar Widyaningrum; Adinda Sheisella Putri; Kumala Sari Poespita Dewi Wahyuni
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9346

Abstract

Congestive heart failure (CHF) is a chronic condition requiring long-term therapy. Patients with heart failure accompanied by comorbid chronic kidney disease (CKD) require dose adjustment to prevent drug toxicity. This study aimed to determine the therapeutic profile and dosing appropriateness among patients with congestive heart failure and comorbid CKD hospitalized at RSUD Kabupaten Kediri during the January–December 2022 period. This study employed a retrospective observational design using medical record data with a total sampling technique, resulting in 72 eligible patients. Dose appropriateness was evaluated based on estimated glomerular filtration rate (eGFR) calculated using the Cockcroft–Gault equation and compared with recommendations from The Renal Drug Handbook. The results indicate that the majority of samples in this study were female (54.17%) and aged 45–54 years (41.67%). Most patients had additional comorbidities (80.56%), with anaemia being the most prevalent concomitant condition. Based on CKD staging, the majority of patients were classified as stage 5 CKD (77.78%). Combination therapy involving two medications was the most common treatment pattern (30.57%), with a diuretic plus ARB combination being the most frequently prescribed regimen. The evaluation of dosing appropriateness demonstrated that 69 patients (95.83%) received doses adjusted appropriately to their renal function, while 3 patients (4.17%) received inappropriate dosing. Inappropriate use was identified in prescriptions of spironolactone and acarbose, which should be avoided in patients with low eGFR values. In conclusion, most patients with congestive heart failure and comorbid CKD received therapy with doses appropriately adjusted to renal function. However, cases of inappropriate dosing were still identified, which may increase the risk of adverse effects.
Analisis Faktor Kepatuhan Minum Obat Antituberkulosis Pasien Rawat Jalan Pada Layanan Kesehatan Primer : Studi Cross-sectional Di Puskesmas Ngasem Kabupaten Kediri Eko Yudha Prasetyo; Dyah Ayu Kusumaratni; Hariyani Hariyani; Kumala Sari Poespita Dewi Wahyuni; Dwi Evi Dian Sari
Jurnal Ilmiah JOPHUS : Journal Of Pharmacy UMUS Vol. 8 No. 1 (2026): Agustus
Publisher : Program Studi Farmasi, Universitas Muhadi Setiabudi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46772/jophus.v8i1.1953

Abstract

Pengobatan TB melibatkan banyak obat dan durasi terapi yang panjang. Keberhasilan pengobatan sangat dipengaruhi oleh kepatuhan pasien dalam mengonsumsi Obat Anti Tuberkulosis secara teratur. Penelitian ini bertujuan mengetahui tingkat kepatuhan minum Obat Anti Tuberkulosis serta menganalisis faktor-faktor yang mempengaruhinya pada penderita tuberkulosis di Puskesmas Ngasem Kabupaten Kediri. Penelitian menggunakan desain kuantitatif dengan metode survei analitik dan pendekatan prospektif pada Februari–April 2026. Sampel penelitian berjumlah 40 pasien yang dipilih menggunakan teknik total sampling. Tingkat kepatuhan diukur menggunakan metode pill count, sedangkan faktor-faktor yang mempengaruhi kepatuhan diidentifikasi melalui kuesioner yang telah diuji validitas dan reliabilitasnya. Analisis data menggunakan uji Fisher’s Exact Test. Hasil penelitian menunjukkan bahwa 92,5% responden termasuk kategori patuh. Pengetahuan, sikap, efek samping obat, dukungan tenaga kesehatan, dan dukungan keluarga berhubungan signifikan dengan kepatuhan minum obat, sedangkan akses fasilitas kesehatan tidak menunjukkan hubungan yang signifikan. Disimpulkan bahwa peningkatan edukasi, konseling, dan dukungan keluarga serta tenaga kesehatan perlu dipertahankan untuk meningkatkan keberhasilan pengobatan tuberkulosis.
Co-Authors Adinda Sheisella Putri Dwi Evi Dian Sari Eko Yudha Prasetyo Ela Agustin Esti Ambar Widyaningrum Hariyani Hariyani Kusumaratni, Dyah Ayu Shofiatul Fajriyah