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All Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Medika Hutama
Esa, Tenri
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Soluble Suppression of Tumorigenicity-2 Levels As Prognostic Marker in Non-ST-segment Elevation Myocardial Infarction Sherly Purnamawaty; Tenri Esa; Ibrahim Abd Samad
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1533

Abstract

Acute Myocardial Infarction (IMA) is the most severe manifestation of coronary arterial disease, and about 60%-75% of IMA is NSTEMI. It is known that complications are associated with high mortality rates; therefore, predicting the development of complications in NSTEMI will help physicians improve risk stratification and determine optimal treatment. Suppression of tumorigenicity-2 (ST2) is a family of interleukin-1 (IL-1) receptors. Ischemia, injury, and myocardial infarction will cause cardiomyocytes to release sST2 associated with a worse prognosis. This study aimed to analyze sST2 levels in NSTEMI patients as a prognostic marker. This study used a prospective cohort method performed on NSTEMI patients treated at Pusat Jantung Terpadu of Dr. Wahidin Sudirohusodo Hospital during March 2019. Forty-two patients were involved as samples. All patients were tested for sST2 levels by immunochromatography and followed up during hospitalization. Data on the development of heart failure, arrhythmia, cardiogenic shock, sudden cardiac arrest, length of stay, and outcome were recorded during follow-up. Data were statistically analyzed with Mann-Whitney and Spearman test.The results of the sST2 level in NSTEMI with and without heart failure were 114.09±92.01 ng/mL and 58.94±57.75 ng/mL (p=0.014), respectively. There was no significant difference between sST2 levels in NSTEMI with complications of arrhythmias, cardiogenic shock, and sudden cardiac arrest compared and patients without those complications (p>0.05). The level of sST2 was significantly higher in NSTEMI patients who passed away (164.05±77.35 ng/mL) than those who survived (72.55±73.15 (p=0.027). There was no correlation between sST2 levels and length of stay (p=0.947). It was concluded that sST2 levels could be a prognostic marker for NSTEMI, particularly heart failure and outcome. 
Omentin-1 Levels in Obesity Putri Hidayasyah Purnama Lestari; Nurahmi Nurahmi; Tenri Esa; Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 1 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i1.1737

Abstract

Omentin-1 is an anti-inflammatory adipokine secreted by stromal vascular cells. Inflammation and apoptosis of adipocyte tissue in obesity lead to decreased production of omentin-1. This study aims to find the difference in omentin-1 levels in the obese and non-obese groups and the correlation between levels of omentin-1 with BMI and waist circumference. This study was a cross-sectional study involving 70 subjects with 37 people in the obese group and 33 people in the non-obese group. Anthropometric data including weight, height, waist circumference, and BMI were measured. Serum omentin-1 levels were measured by ELISA. The statistical tests used were Chi-square, T-test, Mann-Whitney test, and Spearman test. Test results were significant if p-value < 0.05. Significant difference was observed in serum omentin-1 levels between obese and non-obese group (median 140,31 range (88.08 – 382.76) vs. 210,97 range (124,44–577,96) ng/mL), respectively; p < 0.001). Serum omentin-1 correlated negatively with BMI (p=0.001, r = - 0.398) and waist circumference (p=0.017, r = - 0.286). Obesity causes inflammation and increased death of adipocyte tissues due to apoptosis, autophagy, and fibrosis resulting in decreased production of omentin-1 by stromal vascular cells. Anthropometric parameters of waist circumference and BMI describe the distribution of adipocyte tissue and affect the secretion of omentin-1. Omentin-1 levels in the obese group were lower than in the non-obese group. The higher the BMI and waist circumference, the lower the omentin-1 level.
Analysis of Neutrophil Lymphocyte Ratio and Absolute Lymphocyte Count as Predictors of Severity of COVID-19 Patients Yunianingsih Selanno; Yuyun Widaningsih; Tenri Esa; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1738

Abstract

It is important to predict the severity of COVID-19 during the pandemic. Both Neutrophil Lymphocyte Ratio (NLR) and Absolute Lymphocyte Count (ALC) are two easy, low-cost, and fast inflammatory markers, which positively correlate with the severity of COVID-19. The purpose of this research was to analyze the value of NLR and ALC as predictors of COVID-19 severity. This research was a retrospective study using medical record data of 376 COVID-19 patients during April-September 2020 at the Hasanuddin University Hospital and Makassar City Regional Hospital. Patients were classified into non-severe and severe COVID-19. Neutrophil lymphocyte ratio and ALC values were determined based on routine blood test (Sysmex XS-800i) results, statistical analysis using Independent T-test, while NLR and ALC diagnostic values were analyzed with Receiver Operating Characteristics (ROC) curve to obtain the cut-off value, p < 0.05 was significant. The samples consisted of 372 non-severe and 49 severe COVID-19 patients. Neutrophil lymphocyte ratio value in non-severe (4.02±5.22) was significantly different from severe COVID-19 (9.81±7.06) (p < 0.001), similar to ALC in non-severe (2.00±0.83x103/μL) and severe COVID-19 (1.22±0.78x103/μL) (p < 0.001). Receiver operating characteristics curve showed that NLR had a sensitivity of 91.8% and specificity of 66.4% with a cut-off ≥ 3.17 with Negative Predict Value (NPV) of 98.2% and Positive Predict Value (PPV) of 29.0%; while ALC had a sensitivity of 81.6% and specificity of 64.8% at cut-off ≤ 1.74x103/μL with NPV of 95.9% and PPV of 25.8%. Increased NLR and decreased ALC in severe COVID-19 patients occurred due to an increased inflammatory response resulting in a decreased cellular immunity. Receiver operating characteristics curve showed a cut-off for NLR of 3.17 and ALC of 1.74x103/μL, indicating an optimum sensitivity and specificity. It was concluded that NLR and ALC can be used as predictors of COVID-19 severity with a cut-off ≥ 3.17 and ≤ 1.74x103/μL, respectively.
D-dimer Analysis in COVID-19 Patients Abd. Rahim Mubarak; Tenri Esa; Yuyun Widaningsih; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 1 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i1.1812

Abstract

The COVID-19 incidence is increasing around the world. Some countries are experiencing worsening conditions, even deaths. One coagulation marker that noticeably increases in COVID-19 patients is D-dimer. This study aimed to analyze D-dimer levels of COVID-19 patients. Retrospective study using medical records of 84 COVID-19 patients, conducted from April to August 2020 at UNHAS Hospital. Patients were grouped based on the severity of the disease as non-severe and severe. D-dimer levels were measured using the Alere Triage® D-dimer with the fluorescent immunoassay method. The statistical test used was Mann-Whitney, D-dimer prognostic levels were calculated with ROC analysis to get the cut-off. Significant if the p < of 0.05. The sample consisted of 74 non-severe and ten severe COVID-19 patients, mostly in the 30-39 age group. D-dimer levels in non-severe (0.31±0.38 μg/L) significantly differ from severe group (3.09±2.56 μg/L) (p<0.001). The Receiver Operating Characteristics (ROC) curve showed D-dimer sensitivity and specificity of 90.0% and 89.2%, respectively at the ≥ 0.80 μg/L cut-off, Negative Predictive Value (NPV) of 98.5%, and Positive Predictive Value (PPV) of 52.9%. D-dimer levels increased in severe COVID-19 patients due to an increased inflammatory response resulting in excessive thrombin. The ROC D-dimer curve indicated a cut-off rate of 0.80 μg/L, providing optimal sensitivity and specificity. D-dimer has a significant difference in non-severe and severe COVID-19 patients and shows good value to determine the severity of COVID-19 disease with a cut-off value ≥ 0.80 μg /L.
MEMAHAMI INTERLEUKIN 1 BETA SEBAGAI SITOKIN PROINFLAMASI Andi Ita Maghfirah; Tenri Esa; Uleng Bahrun
Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Vol 5 No 3 (2023): December
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v5i3.134

Abstract

Interleukin-1 (IL-1) awalnya dijelaskan pada tahun 1940an sebagai protein pemicu demam yang dilepaskan oleh leukosit yang diaktifkan. Pada waktu itu disebut “pirexin” atau “pyrogen endogen”. Interleukin-1 adalah sebuah sitokin inflamasi yang dianggap memiliki beragam fungsi fisiologis dan signifikansi patologis dan memainkan peran penting dalam kesehatan dan penyakit. Studi awal ini dengan hati-hati mencirikan fungsi interleukin 1 yang masih sangat penting dibahas pada masa sekarang setelah >40 tahun kesimpulan mereka yang menggambarkan fungsi biologis utama dari sitokin IL-1β ini. Oleh sebab itu, makalah ini menjelaskan mengenai IL-1β, bagaimana perannya dalam proses inflamasi, dan apa aplikasi klinis terhadap sitokin ini.
Analysis of NLR, PLR, and Carcinoembryonic Antigen in Colorectal Cancer Patients Parabang, Budi; Esa, Tenri; Bahrun, Uleng
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2063

Abstract

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. The development and prognosis of CRC are affected by the tumor's appearance and the host's inflammatory response. A combination of several parameters, including the Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR), has been used as a cancer prognostic marker. Research needs to be performed to analyze its role in CRC. This study aimed to determine the differences in the NLR, PLR, and CEA values with the severity and site of CRC. Medical record data were collected from 246 CRC patients from January 2021 to June 2022 at Dr. Wahidin Sudirohusodo Hospital were used and grouped by severity (metastatic and non-metastatic) and site (left colon, right colon, rectum). This study collected the data on NLR, PLR, and CEA levels. The Mann-Whitney, Spearman Rho, and Kruskal-Wallis tests were used for statistical analysis by the research objectives (significant if p<0.05). There were differences in median PLR (194.47 vs. 201.18; p=0.045) and CEA (3.3 ng/mL vs. 11.95 ng/mL; p<0.001) between the metastatic and non-metastatic groups, whereas there was no significant difference of median NLR between the two groups (2.77 vs. 2.79; p=0.438). No correlation was found between the NLR, PLR, and CEA level values with the location of CRC (p-values 0.978, 0.511,  0.419, respectively). PLR and CEA values were higher in metastatic CRC than in non-metastatic CRC, while NLR value was not significantly different. There was no correlation between the NLR, PLR, and CEA level values with the CRC site.  
PEMERIKSAAN MICROALBUMINURIA DENGAN MENGGUNAKAN METODE IMMUNOTURBIDIMETRI Atmanto, Y. Kusumo Adi Arji; Tenri Esa; Uleng Bahrun
Jurnal Medika Hutama Vol. 5 No. 04 Juli (2024): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mikroalbuminuria (MA) adalah suatu kondisi terdapatnya albumin di dalam urine. MA telah dikaitkan dengan adanya penyakit ginjal diabetes. MA sendiri bukan bukti pasti adanya nefropati, namun beberapa penderita diabetes tipe 1 dan tipe 2 dengan MA akan berkembang menjadi nefropati dari waktu ke waktu. Pada pasien yang menderita hipertensi dan diabetes, MA sebagai petanda dari disfungsi endotelial dan peningkatan risiko morbiditas serta mortalitas kardiovaskular. Tes MA diindikasikan sebagai tes skrining, diagnosis, dan pemantauan terapi penyakit ginjal dan kardiovaskular. Tes skrining dilakukan pada setiap pasien yang berisiko mengalami MA di mana hasil tes akan memberikan informasi tentang tingkat risiko kardiovaskular dan ginjal, serta implikasi terapeutik. Metode-metode yang dipakai dalam pengukuran kuantitatif albumin yaitu: High Performance Liquid Chromatography (HPLC), Immunonephelometry, Immunoturbidimetry, Radioimmunoassay. Turbidimetry adalah pengukuran kehilangan cahaya yang melewati larutan, sedangkan nephelometry adalah pengukuran peningkatan cahaya yang dipantulkan ke arah yang berbeda. Seringkali antibodi digunakan dengan metode turbidimetry dan nephelometry ini disebut metode immunoturbidimetry dan immunonephelometry. Metode ini digunakan untuk mengukur konsentrasi partikel besar (seperti kompleks antigen-antibodi, prealbumin, dan protein serum lainnya) yang karena ukurannya tidak dapat diukur dengan spektroskopi absorbsi. Pada Immunoturbidimetry dilakukan deteksi sinar yang ditransmisikan ke arah depan dan pengukuran terhadap pengurangan kadar transmisi sinar yang disebabkan oleh kekeruhan yang terjadi akibat pembentukan partikel akibat adanya kompleks antigen-antibodi. Keywords: Mikroalbuminuria, immunoturbidimetry, kompleks antigen-antibodi
Demographics, Clinical Features, Laboratory Results Characteristic of COVID-19 Patients at Dr. Wahidin Sudirohusodo Hospital Lolongan, Calvarica Lun; Esa, Tenri; Bahrun, Uleng
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2320

Abstract

Coronavirus Disease 2019 (COVID-19) has spread throughout the world since 2020. WHO declared COVID-19 as a pandemic. Pandemic status has now ended, but the rapid spread of COVID-19 can be a concern to anticipate a new spike. Various studies and results regarding characteristics of COVID-19 patients such as age, gender, clinical symptoms, and laboratory examination results have been carried out to provide an overview of various factors that can support COVID-19 infection. Based on this, authors are interested in identifying characteristics of COVID-19 patients based on age, gender, origin, education, occupation, dominant symptoms, severity, COVID-19 biomarkers (NLR, CRP, procalcitonin, D-dimer, ferritin), and CT value at Dr. Wahidin Sudirohusodo Hospital as COVID-19 referral center in Eastern Indonesia. This study aimed to determine the characteristics of COVID-19 patients at Dr. Wahidin Sudirohusodo Hospital, Makassar. A descriptive cross-sectional study on 650 COVID-19 patients was performed at Dr. Wahidin Sudirohusodo Hospital, from January 2020–July 2022. The data were described based on age, gender, regional origin, education, occupation, severity (asymptomatic, mild, moderate, severe, and critical), dominant symptoms, laboratory biomarker (NLR, CRP, procalcitonin, D-dimer, ferritin) and CT value. There were more males than females (52.8% vs. 47.2%), age range 26-35 years (20.3%), from South Sulawesi (91.3%), non-PNS (37.1%), and senior high school education was the largest (29.2%). Dominant symptoms were respiratory distress (26.9%) and mild severity (41.7%). Based on the results of COVID-19 biomarker research, it is known that the range of COVID-19 biomarkers differs between mild and critical degrees. In mild degrees, the range of COVID-19 biomarkers is lower than critical degrees. It is known that the range of each biomarker in mild degree NLR 1.02-7.14, CRP 0.20-35.20 mg/l, procalcitonin 0.05-0.75 ng/mL, D-dimer 0.11-1.04 µg/mL, and ferritin 16.15-402,40 ng/mL. Higher COVID-19 susceptibility among males and certain occupational groups. Symptoms vary widely, with some cases showing no symptoms. Disease severity ranges from mild to asymptomatic, with biomarkers indicating progression.
Co-Authors Abd. Rahim Mubarak Andi Ita Maghfirah Arifa Moidady Atmanto, Y. Kusumo Adi Arji Faigah Aprilia Sy Faraid Hardjoeno . Ibrahim Abd Samad Irda Handayani Liong Boy Kurniawan, Liong Boy Lolongan, Calvarica Lun Mansyur Arif Nurahmi Nurahmi Nurhayana Sennang Nurhayana Sennang, Nurhayana Parabang, Budi Putri Hidayasyah Purnama Lestari Rahim Mubarak Ramla Tongko Sherly Purnamawaty Uleng Bahrun Uleng Bahrun Uleng Bahrun, Uleng Yanty Tandirogang Yunianingsih Selanno Yuyun Widaningsih Yuyun Widaningsih