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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Biomedika dan Kesehatan
Lisnawati, Yuyun
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Hubungan Parameter Laboratorium dengan Derajat Klinis COVID-19 pada Kehamilan Nirmalasari, Rully Ayu; Surjadi, Lily Marliany; Maharani, Laksmi; Lisnawati, Yuyun; Mangun, Dhea
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.291-299

Abstract

Background Pregnant women were one of the most susceptible groups because they are vulnerable to respiratory infection. They may get more severe symptoms due to their physiological changes during pregnancy including the immunological response. This study was performed to find whether there is an association between laboratory parameters (Hb, leukocytes, platelet, neutrophils, lymphocyte, monocyte, NLR, PLR and CRP) and the severity of Covid-19 infection in pregnant women. Methods This study is a retrospective cohort study using secondary data from patient’s medical records at Persahabatan General Hospital, Jakarta from March to June 2021. Results Pregnancy cases with COVID-19 in this study were in the mean of 29 year age. Most of them are in the third trimester of pregnancy. 80.5% from 67 patients have no- mild symptom while 19.5% have moderate to severe symptom. There are no difference in vital sign nor oxygen saturation at first admission. Lower level was found in the parameter of leukocyte, lymphocyte and monocyte.  Neutrophil, neutrophil-to-lymphocyte ratio and C-reactive Protein increase as the degree of severity increase.  The mean neutrophil in pregnant women with moderate to severe COVID-19 symptom was 80.49±7.47 while median NLR value was of 6.76 (2.73-18.71) . Conclusions Neutrophil, neutrophil-to-lymphocyte ratio and C-reactive Protein has associate significantly to severity symtomps of COVID-19 in pregnancy.
Inflammatory Marker and their Association with COVID-19 Severity in Pregnant Women Lisnawati, Yuyun; Purnadiputra, Akbar; Widyakusuma, Lucky Savitry; Pudyastuti, Sri; Sari, Amanda Mustika
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 1 January 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i1.2686

Abstract

Abstract : Objective: To analyze the correlation between blood markers; C-Reactive Protein (CRP), D-Dimer, Neutrophil-to-Lymphocyte Ratio (NLR) and the severity of COVID-19 in pregnant women during the 2020 pandemic at Persahabatan Hospital, Jakarta. Method :This cross-sectional study was conducted at Persahabatan Hospital, a National Respiratory Referral Center in Jakarta. A total of 525 pregnant women with confirmed COVID-19 who met the inclusion criteria were included in the study. Laboratory markers, including CRP, D-Dimer, and NLR, were analyzed and categorized as normal or elevated. Data were analyzed using the Chi-square test, and correlations were evaluated using Spearman’s rank correlation coefficient. Result :The results showed that elevated biomarkers were significantly correlated with increased disease severity. CRP (>10 mg/L), D-Dimer (>3333 mg/L), and NLR (?5.8) were all associated with moderate to severe disease. All biomarkers demonstrated a significant correlation with disease severity (p < 0.005). Conclusion: Elevated CRP, D-Dimer, and NLR levels are associated with increased disease severity in pregnant women with COVID-19, suggesting their potential role as practical indicators for disease severity assessment. Keywords : Covid 19, CRP, D-Dimer, NLR, Pregnant.
Co-Authors Laksmi Maharani Mangun, Dhea Purnadiputra, Akbar Rully Ayu Nirmalasari, Rully Ayu Sari, Amanda Mustika Sri Pudyastuti Surjadi, Lily Marliany Widyakusuma, Lucky Savitry