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All Journal Universa Medicina Jurnal Biomedika dan Kesehatan Jurnal Pengabdian Masyarakat Trimedika
Rully Ayu Nirmalasari, Rully Ayu
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Later age at menopause was associated with higher cognitive function in post-menopausal women Rachmiyani, Irmiya; Surjadi, Lily Marliany; Nirmalasari, Rully Ayu; Imran, Yudhisman
Universa Medicina Vol 37, No 3 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (736.075 KB) | DOI: 10.18051/UnivMed.2018.v37.203-208

Abstract

BACKGROUND Menopause is a condition in which the menstrual periods have stopped for the last 12 months due to cessation of ovarial functions causing estrogen hormones to decrease. Various studies find that many factors affect cognitive function at post-menopausal age among others the decrease in estrogens, age at menopause, duration of menopause, and education. However, the effects have been subject to controversy. The aim of this study was to determine the relationship of age, age at menopause, estradiol level, and education with cognitive function among healthy post-menopausal women. METHODS A cross-sectional study was conducted involving 31 post-menopausal women between 50 to 75 years old. Data on age, age at menopause, and education were collected using a questionnaire. The estradiol levels were measured using an electrochemiluminescent immunoassay (ECLIA). The Indonesian version of the Montreal Cognitive Assessment (MoCA INA) was used to assess the cognitive function. Multiple linear regression was used to analyze the data. A p<0.05 was considered statistically significant.RESULTS Age (b=-0.086; 95% C.I.=-0.263-0.090; p=324) and estradiol levels (b=0.106; 95% C.I.=-0.018 -0.230; p=0.092) were not significantly associated with cognitive function. However, education (b=1.537; 95% C.I.=0.176-2.898; p=0.028) and age at menopause (b=0.364;0.056-0.671; p=0.022) were significantly associated with cognitive function. Age at menopause was the most influential factor of cognitive function (Beta=0.402) compared to education (Beta=0.394).CONCLUSION Later age at menopause could increase cognitive function in post-menopausal women. Our findings are that modifiable factors that delay age at menopause should receive attention, in order to promote cognitive function. Keywords: Age at menopause, estrogens, cognitive function, post-menopausal women
KEJADIAN ANEMIA DAN GANGGUAN SIKLUS HAID PADA REMAJA DI CIANGSANA - NAGRAK Nirmalasari, Rully Ayu; Surjadi, Lily Marliany; Mario, Mario; Maharani, Laksmi
Jurnal Pengabdian Masyarakat Trimedika Vol. 2 No. 2 (2025)
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/abdimastrimedika.v2i2.22921

Abstract

Background: Anemia in adolescents is a public health problem in Indonesia.  Based on the 2018 Basic Health Research (Riskesdas) report, Based on the 2018 Basic Health Research (Riskesdas) report, 32% of teenagers aged 15-24 years experienced anemia. The majority of teenagers who experience anemia are in the age range 10 – 18 years. Adolescent girls experiencing ongoing anemia can increase morbidity during pregnancy and childbirth. Level of knowledge, diet, nutritional status and menstrual cycle are factors that are said to influence anemia. Method: This activity was carried out in Desember 2023 and was attended by 30 young women aged 10-19 years in the Nagrak and Ciangsana district. The activity consists of several stages, namely interviews about the menstrual cycle, checking hemoglobin levels, checking nutritional status, and education about body mass index. Results: From this activity, it was found that 53.3% of teenagers had a normal body mass index, 96.7% had a normal waist/hip ratio, 50% of teenagers had irregular menstrual cycles, 80% had dysmenorrhea. Meanwhile, regarding the prevalence of anemia, 50% of adolescent girls have mild anemia and 13.3% have moderate anemia. Conclusion: The prevalence of anemia in adolescent girls in Nagrak and Ciangsana subdistricts is still high (63.3%), as are adolescents who experience irregular menstrual cycles and dysmenorrhea.
Dilema Managemen Tatalaksana Persalinan pada Anencephali sebagai Janin Letal Yunitra, Imelda; Wiranti, Hervi; Nirmalasari, Rully Ayu; Mayasari, Atut Cicih; Dhanardono, RM Denny; Maharani, Laksmi
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Anencephaly is a congenital anomaly of the central nervous system, caused by a disruption in brain and skull development of a fetus, which includes the disruption of the cerebral hemispheres, cerebellum, spinal cord, and pyramidal tract. This is a lethal condition that most fetuses born with this condition cannot survive after being delivered. The prevalence of this condition is 1 in 1000 deliveries. Early detection through prenatal ultrasound testing is essential to make a correct and precise plan for managing the pregnancy and delivery process, thus avoiding potential maternal complications. We reported a 33-year-old pregnant woman who was diagnosed with having anencephalic fetus at 24 weeks of pregnancy. The patient has been informed about this condition and offered a termination, but she refused to do so and is willing to continue the pregnancy. Induction of labor was planned at 40 weeks of pregnancy, but the process was impaired, so a cesarean section was performed to save the mother. The baby was delivered with anencephaly, as shown by the ultrasound result, and died 2 days after being delivered. The mother recovered well and was given education about the importance of folic acid intake for the next pregnancy. Conclusion of this case was labor management of anencephalic fetus was planned according to medical indication, with a special individual approach due to the obstetric condition. Yet, the delivery method should be based more on the mother's condition rather than the baby's, including the maternal emotional factor.
Co-Authors Atut Cicih Mayasari Dhanardono, RM Denny Laksmi Maharani Mario Mario Rachmiyani, Irmiya Surjadi, Lily Marliany Wiranti, Hervi Yudhisman Imran, Yudhisman Yunitra, Imelda