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All Journal Medical Journal of Indonesia Damianus Journal of Medicine Indonesian Journal of Cancer
Hellyanti, Tantri
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Gambaran Kehamilan Ektopik pada Magnetic Resonance Imaging Siregar, Trifonia Pingkan; Djajasasmita, Fitriyadi Kusuma; Hellyanti, Tantri; Stascia, Stefani
Bahasa Indonesia Vol 22 No 3 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i3.3338

Abstract

Pendahuluan: Kehamilan ektopik (KE) adalah kehamilan dengan letak implantasi di luar kavum uterus. Diagnosis KE ditegakkan melalui tes urin, ultrasonografi, penilaian level β-hCG, dan kuretase. Ultrasonografi transvaginal adalah modalitas imejing terpilih, meskipun pada beberapa kondisi, sulit menentukan antara kehamilan awal atau KE melalui Ultrasonografi transvaginal. Pada KE dapat terjadi juga beberapa gambaran kelainan di intra-uterus/endometrium. Kasus: Seorang wanita 32 tahun dengan riwayat kehamilan ektopik 2 kali sebelum dan sekarang dengan periode menstruasi terlambat 2 bulan. Tes kehamilan positif dengan kadar β-hCG 24,411 mIU/ml. Pasien menjalani TVU dan dicurigai adanya massa intra uterin tanpa ditemukan struktur kantung gestasi (GS). Pasien diduga menderita gestational trophoblastic disease (GTD) karena pada pemeriksaan laboratorium didapatkan hasil tes kehamilan positif dan peningkatan kadar β-hCG, dan USG tidak menunjukkan adanya GS intra/ekstra kavum uteri. Pasien menjalani MR pelvis dengan hasil dicurigai adanya kantung kehamilan di adneksa kiri dan menunjukkan perubahan endometrium yang menyerupai lesi massa. Pasien menjalani operasi laparotomi dan mengungkapkan kehamilan ektopik di dalam tuba Fallopi kiri dengan hemoperitoneum masif, diagnosis ini dikonfirmasi pada hasil patologis. Simpulan: Apabila sulit menegakkan diagnosis dengan ultrasonografi transvaginal, maka modalitas MRI menjadi pilihan karena memiliki kemampuan diagnosis yang lebih baik. Pengetahuan akan gambaran klinis dan MRI pada KE sangat penting untuk menentukan diagnosis yang akurat dan penatalaksanaan yang tepat.
Prognostic Factors of Recurrent Cervical Cancer Stage IA2–IIA2: A Post-Surgical Treatment Analysis Argy, Gabriella; Nuryanto, Kartiwa Hadi; Hellyanti, Tantri
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1141

Abstract

Background: Cervical cancer is the most common female reproductive organ malignancy. Despite the prompt diagnosis and proper management based on the disease’s stage, the recurrent rate remains high, ranging from 18 to 44.3%. Prognostic factor detection may be the first step in reducing recurrent disease. To our knowledge, there are no studies that report the recurrence rate of cervical cancer and the prognostic factors in Indonesia yet. This study aims to report the recurrent rate of cervical cancer stage IA2–IIA2 and the prognostic factors.Methods: This is a retrospective cohort study. Histopathology results from 382 cervical cancer stage IA2–IIA2 patients who underwent radical hysterectomy and pelvic lymphadenectomy were reviewed. Bivariate analysis was performed to compare recurrent disease based on 7 prognostic factors: lymph node status, tumor size, depth of stromal invasion, lymphovascular space invasion (LVSI), parametrial involvement, histology type, and vaginal resection margin status.Results: Most cervical cancer patients with stage IA2–IIA2 were more than 40 years old, with a mean age was 52 years. The recurrent rate was 12%. Prognostic factors that were significantly associated with recurrence were tumor size ≥ 4 cm; RR 2.242 (95% CI 1.161–4.332) and LVSI; RR 2.037 (95% CI 1.039–3.994).Conclusions: The recurrence rate of cervical cancer stage IA2–IIA2 in Dr. Cipto Mangunkusumo National Hospital was 12%. Prognostic factors that were significantly associated with recurrence were tumor size ≥ 4 cm and LVSI.
Estrogen receptor expression in type 1 endometrial cancer and its association with lymphovascular space invasion Fidiawati, Wiwit Ade; Andrijono; Siregar, Nurjati Chairani; Prihartono, Joedo; Purwoto, Gatot; Hellyanti, Tantri
Medical Journal of Indonesia Online First
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257842

Abstract

BACKGROUND Endometrial cancer (EC) ranks sixth in female genital malignancy and originates in the endometrial lining. Estrogen receptor (ER) expression is important in EC prognosis and recurrence, influenced by the presence of lymphovascular space invasion (LVSI). This study aimed to determine the association between ER expression and LVSI in type 1 EC. METHODS A retrospective analysis was conducted on 135 patients with type 1 EC who underwent surgery at the Cipto Mangunkusumo Hospital, Jakarta, Indonesia, between January 2012 and December 2022. Immunohistochemistry (IHC) with ER antibodies was performed on all samples in April 2023. ER expression was evaluated using the Allred scoring system, and its association between ER expression (percentage and intensity stain) and LSVI was statistically analyzed. RESULTS Of 135 samples, 44 (32.6%) were LVSI-positive. No significant association was found between IHC percentage stain and LVSI (p = 0.994). However, a significant association was found between IHC stain intensity and LVSI-positive in patients with type 1 EC (p = 0.022). ER intensity score 2 had a higher LVSI risk compared to score 1 and score 3 (from 51%, 26%, and 26%, respectively). CONCLUSIONS ER expression is associated with LVSI of type 1 EC. While IHC stain percentage showed no correlation with LVSI, stain intensity was significantly linked to LVSI-positive in patients with type 1 EC. Regular assessment of ER expression can provide significant prognostic information, support hormonal therapy, and identifying clinical characteristics of tumors.
Co-Authors Andrijono Argy, Gabriella Djajasasmita, Fitriyadi Kusuma Gatot Purwoto Joedo Prihartono Kartiwa Hadi Nuryanto Nurjati Chairani Siregar Siregar, Trifonia Pingkan Stascia, Stefani Wiwit Ade Fidiawati