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All Journal Acta Biochimica Indonesiana Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI)
Rozi Abdullah
Departemen Farmakologi Dan Terapeutik Fakultas Kedokteran Universitas Andalas
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Dose-dependent effects of Stevia rebaudiana leaf extract on malondialdehyde and catalase activity in alloxan-induced hyperglycemic rats Zhira Shada Athaya; Eti Yerizel; Dinda Aprilia; Rozi Abdullah; Fadrian; Westi Permata Wati; Husna Yetti
Acta Biochimica Indonesiana Vol. 9 No. 1 (2026): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.232

Abstract

Background: Diabetes mellitus-induced hyperglycemia triggers oxidative stress, characterized by elevated malondialdehyde (MDA) and impaired catalase (CAT) activity. Stevia rebaudiana, rich in steviol glycosides and polyphenols, demonstrates promising antioxidant properties, yet systematic dose-response data on oxidative stress biomarkers remain limited. Objectives: To evaluate the dose-dependent effects of stevia leaf extract on serum MDA levels and CAT activity in alloxan-induced hyperglycemic rats. Methods: Twenty-five male Wistar rats were allocated into normal control, diabetic control (alloxan 120 mg/kg), and three treatment groups receiving alloxan plus stevia extract at 100, 200, or 400 mg/kg body weight orally for 14 days (n=5/group). Serum MDA and CAT were measured spectrophotometrically. Results: Diabetic control showed significantly elevated MDA (2.68±0.62 mg/dL) versus normal control (1.78±0.30 mg/dL). Stevia extract dose-dependently reduced MDA: 1.70±0.19, 1.54±0.20, and 1.38±0.09 mg/dL at 100, 200, and 400 mg/kg, respectively, representing 36.6%, 42.5%, and 48.5% reduction. The 400 mg/kg dose achieved MDA levels comparable to normal control. CAT activity showed dose-dependent restoration trend (7.92±0.76 to 8.58±0.52 mg/dL). Conclusion: Stevia leaf extract (400 mg/kg BW) effectively reduces oxidative stress in hyperglycemic rats through significant dose-dependent MDA reduction, with potential catalase benefits requiring further investigation.
Peran Reflux Symptom Index dalam diagnostik terapi pasien Laryngopharyngeal Reflux sebelum dan sesudah diberikan Lansoprazole di Poliklinik THT-KL RSUP Dr. M. Djamil Padang.: Indonesia Febrina Monica; Ade Asyari; Saptino Miro; Al Hafiz; Rozi Abdullah; Abdiana Abdiana
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 3 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v3i1.58

Abstract

Pendahuluan : Laryngopharyngeal Reflux(LPR) adalah pergerakan retrograde dari isi lambung ke daerah laring, faring, trakea, dan bronkus yang berkontak dengan jaringan pada traktus aerodigestif atas yang dapat menimbulkan jejas. Diagnosis dari LPR dapat ditegakkan dengan tindakan non-invasif yaitu dengan Reflux Symptom Index(RSI) dan Reflux Finding Score(RFS), RSI dapat digunakan dalam membantu dokter untuk menilai tingkat keparahan gejala penderita LPR saat pemeriksaan maupun setelah pengobatan. Metode : Jenis penelitian ini adalah analitik observasional dengan pendekatan studi kohort prospektif melalui observasi pasien yang didiagonosis LPR dari nilai RSI yang didapatkan. Jumlah sampel minimal dari hasil perhitungan uji hipotesis beda rata-rata pada 2 kelompok dependen adalah 18 orang. Hasil : Nilai rata-rata sebelum dan sesudah diberikan terapi PPI 21,50±5,969 dan 15,90±9,008 (me=13,5;min=5;maks=36). Hasil uji Wilcoxon Signed Rank Test didapatkan analisis nilai rata-rata RSI sebelum dan sesudah adalah p=0,002. Kesimpulan : didapatkan perubahan bermakna nilai rata-rata RSI sebelum dan sesudah diberikan PPI pada pasien LPR.Kata kunci: Laryngopharyngeal Reflux, Reflux Symptom Index,Proton Pump Inhibitor
Co-Authors Abdiana Abdiana, Abdiana Ade Asyari Al Hafiz Dinda Aprilia Eti Yerizel Fadrian, Fadrian Febrina Monica Husna Yetti Saptino Miro Westi Permata Wati Zhira Shada Athaya