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UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL 96% DAUN BELIMBING WULUH (Averrhoa bilimbi L.) DENGAN VARIASI KONSENTRASI GLISERIN Nike Wijayanti; Wahyu Purwanjani; Supriyanto
Joseph: Journal of Science and Pharmacy Vol 6 No 1 (2026): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Bilimbi leaves (Averrhoa bilimbi L.) contain secondary metabolites that have potential as antioxidants. The development of cream preparations requires evaluation of physical stability, Glycerine as a humectant plays a role in influencing the physical stability of the preparation. Purpose: This study aimed to evaluate the effect of varying glycerine concentrations on the physical stability of 96% ethanol extract creams from starfruit leaves. Method: The extract was obtained by maceration using 96% ethanol and formulated into three cream formulations with glycerine concentrations of 10%, 15%, and 20%. Accelerated stability testing was conducted using the cycling test method for 6 cycles (12 days). Qualitative analysis included the identification of secondary metabolite compounds using thin-layer chromatography (TLC) as well as descriptive evaluation of organoleptic properties, homogeneity, and cream type. Quantitative analysis included pH, spreadability, adhesion, and viscosity tests, which were statistically analysed using the One Way ANOVA test if the data were normally distributed and homogeneous (p ≥ 0.05), while data that did not meet the requirements were analysed using the Kruskal–Wallis and Mann–Whitney tests. Results: Starfruit leaf extract was found to contain flavonoids, saponins, alkaloids, and tannins. All cream formulations showed good physical stability with pH suitable for skin, spreadability and adhesion meeting requirements, viscosity in accordance with SNI standards, and an oil-in-water (O/W) type. Conclusion: The 96% ethanol extract cream of starfruit leaves with varying glycerin concentrations showed good organoleptic characteristics, was homogeneous, had an oil-in-water (O/W) type, and met the requirements for pH, viscosity, spreadability, and adhesion before and after stability testing in all formulations. Varying glycerin concentrations affected the physical stability of the preparation. Formulation III with a glycerin concentration variation of 20% showed more optimal and stable physical stability compared to other formulations.
ANALISIS PENGGUNAAN METFORMIN DAN GLUDEPATIC® SEBAGAI ANTIDIABETIK ORAL DI APOTEK KUSUMA FARMA KUDUS TAHUN 2019 Supriyanto; Endra Pujiastuti
The Shine Cahaya Dunia S-1 Keperawatan Vol. 5 No. 2 (2020): THE SHINE CAHAYA DUNIA - S1 KEPERAWATAN
Publisher : LPPM Universitas An Nuur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35720/

Abstract

Latar Belakang; Diabetes mellitus tipe II merupakan tipe diabetes yang paling umum, lebih banyak penderitanya dibandingkan dengan diabetes tipe I. Perkembangan ilmu pengetahuan pengobatan Diabetes Mellitus kini mengalami kemajuan yang cukup besar, dengan adanya berbagai jenis obat anti Diabetes  dalam  sediaan  generik maupun paten. Tujuan pemnelitian ini adalah untuk mengetahui perbedaan penggunaan obat antidiabetes tipe II (oral) dalam penelitian ini  adalah tablet Metformin dan Gludepatic® di Apotek Kusuma Farma Kudus.Metode; Penelitian ini disusun berdasarkan hasil penelitian di Apotek Kusuma Farma Kudus. Penelitian yang dilakukan dengan mengambil data dari rekapitulasi pengeluaran obat yang datanya tersimpan di komputer Apotek Kusuma Farma Kudus dengan di dukung studi pustaka dan publikasi yang ada. Metode yang  digunakan  adalah dengan mengumpulkan data di lapangan yang diambil di  Apotek  Kusuma Farma Kudus berdasarkan rekapitulasi pemakaian obat pada tahun 2019. Hasil pengamatan dianalisis dengan menggunakan metode uji Independent samples t-test  (uji  t  untuk dua sampel independen/bebas).Hasil; Hasil data yang telah diolah didapatkan bahwa penggunaan Metformin dan Gludepatic® tidak terdapat perbedaan yang signifikan. Hal ini dikuatkan  dengan adanya data penggunaan Metformin dengan jumlah 1095 tablet dan Gludepatic® dengan jumlah 695. Hasil dapat dilihat menggunakan uji Independent samples t-test  bahwa Lavene‘s Testdidapatkan sig 0,002 < 0,050 maka H0 ditolak. Kesimpulan; Tidak  ada  perbedaan yang signifikan dalam penggunaan Metformin dan Gludepatic sebagai obat antidiabetik oral 
Co-Authors Endra Pujiastut Endra Pujiastuti Endra Pujiastuti Estuningtyas Ayu Hapsari Eva Natalia Gigih Kenanga Sari Indriani Dini Mustava Julia Sita Nur Hidayah Maulina Nur Maulita Saraswati Miki Rofi’atun Masriah Muhammad Nur Prasetyo Nike Wijayanti Renno Ramadhani Ika Baruna Rismawati Suci Safitri Sinta ardani Wahyu Purwanjani Welly Setyawan