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ANALISIS BIAYA PASIEN GAGAL JANTUNG RAWAT INAP JAMKESMAS DI RSUP Dr. SARDJITO YOGYAKARTA Gigih Kenanga Sari; Mingle A Pistanty; Wahyu Purwanjani
The Shine Cahaya Dunia D-III Keperawatan Vol 5, No 2 (2020): THE SHINE CAHAYA DUNIA D-III KEPERAWATAN
Publisher : Universitas An Nuur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35720/tscd3kep.v5i2.233

Latar belakang; Pelaksanaan Jamkesmas 2010 terdapat kendala dalam hal pembayaran, tidak menutup kemungkinan terjadi pada pasien gagal jantung yang memerlukan biaya cukup tinggi Penelitian ini bertujuan untuk mengetahui berapa besar selisih antara biaya riil dengan tarif INA-CBG’s, faktor yang mempengaruhi biaya riil, dan kesesuaian terapi pasien rawat inap Jamkesmas gagal jantung di RSUP Dr. Sardjito Yogyakarta.Metode; Penelitian ini merupakan penelitian observasional analitik secara retrospektif dari berkas klaim pasien periode Januari-Oktober 2013 di RSUP Dr. Sardjito Yogyakarta. Analisis data dengan one sample t test dan uji korelasi multivariat.Hasil; besar selisih antara biaya riil dengan tarif paket INA-CBG’s I-4-12-i dengan tarif paket 2013 sebesar Rp.12.702.346, dengan tarif paket 2014 sebesar Rp.23.301.898; I-4-12-ii dengan tarif paket 2013 sebesar Rp.175.399.763, dengan tarif paket 2014 sebesar Rp.267.121.343; I-4-12-iii dengan tarif paket 2013 sebesar Rp.125.791.085, dengan tarif paket 2014 sebesar Rp.218.016.505. Faktor yang mempengaruhi biaya riil pengobatan pasien yaitu prosedur, diagnosa sekunder, LOS, umur, dan jenis kelamin. Hasil analisis obat terdapat 84 episode perawatan sesuai dan 12 episode perawatan tidak sesuai dari 96 episode perawatanKesimpulan; ada selisih positif antara biaya riil dengan tarif paket INA-CBG’s dan faktor yang mempengaruhi biaya riil pengobatan pasien yaitu prosedur, diagnosa sekunder, LOS, umur, dan jenis kelamin Kata Kunci: INA-CBG’s, Gagal Jantung, Biaya, Kesesuaian Terapi

FORMULASI DAN UJI MUTU FISIK SEDIAAN PERMEN JELLY FRAKSI ETIL ASETAT BUAH KEMUKUS (Piper cubeba L.f) Amanda Risky Damayanti; Gigih Kenanga Sari; Wahyu Purwanjani
Jurnal Farmasi IKIFA Vol. 3 No. 3 (2024): JURNAL FARMASI IKIFA VOL.3 NO.2 OKTOBER TAHUN 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

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The ethyl acetate fraction of cubeb fruit (Piper cubeba L.f) contains alkaloid, flavonoid and terpenoid compounds that function to improve memory. Jelly candy is currently popular and is one of the favorite foods in various circles, because it has a chewy characteristic, therefore a new innovation was made in developing cubeb fruit. This study aims to determine the physical quality of the ethyl acetate fraction of cubeb fruit jelly candy preparation. The physical quality test consists of organoleptic color, scent and texture, water content, ash content, reducing sugar, pH, and weight uniformity. The formulation of the jelly candy preparation uses ethyl acetate fraction and is divided into 3 formulations with the concentrations used, namely 0.488g, 0.977g, 1.955g. The results of physical quality tests of FI, FII and FIII jelly candy preparations meet the requirements according to SNI standards including: organoleptic tests of color, aroma and texture, water content, ash content, reducing sugar, pH, and weight uniformity. The ethyl acetate fraction of cubeb fruit has alkaloid, flavonoid, and terpenoid compounds. The ethyl acetate fraction of cubeb fruit can be formulated into jelly candy preparations, all formulations have good physical quality according to SNI standards and formulation I is the best formulation.

Phytochemical Screening of Gogauke Bio Oil as an Excellent Bio-Product for Natural Resource Management Solutions in Papua Mingle A Pistanty; Sarima; Wahyu Purwanjani
Jurnal Penelitian Pendidikan IPA Vol 11 No 11 (2025): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i11.13031

The Potential of Papua's Gogauke for Bio-Excellent Superior Products Papua possesses abundant biodiversity, and the Provincial Government is committed to green growth and sustainable natural resource management. Based on Special Autonomy, the rights of indigenous communities to protect the forests are also recognized. Local plants are often overlooked, despite having great potential. One such plant is Gogauke (Centella asiatica), traditionally used by Papuans as medicine. This plant is known to have various benefits, such as anti-inflammatory properties, wound healing, and pain relief. The objective of this research is to determine the potential of gogauke as a natural raw material for the superior product "Bio-Excellent" through phytochemical screening of the bio-oil produced. Using an experimental method, the study shows that Gogauke bio-oil has very strong potential for development. Phytochemical tests prove the product is rich in secondary metabolite compounds, including Alkaloids, Flavonoids, Triterpenoids, Tannins, Phenols, Steroids, and Glycosides. This combination of compounds provides a scientific basis for broad biological activities (antioxidant, anti-inflammatory, and antifungal). Furthermore, physical parameters (water content 9.8%, yield 44.14%) and microbiological test results (TBC and YMK) indicate that the bio-oil is safe and stable, meeting the BPOM standards for natural medicinal products. Conclusion: Gogauke bio-oil has a superior biochemical profile and high market potential, making it a promising "Bio-Excellent" product derived from Papua's sustainably managed natural resources.

UJI STABILITAS FISIK SEDIAAN FACE SPRAY EKSTRAK ETANOL 96% BIJI BUAH ALPUKAT (Persea Americana Mill) DENGAN VARIASI KONSENTRASI GLISERIN Anisa Eka Pafitri; Gigih Kenanga Sari; Wahyu Purwanjani
Nusantara Hasana Journal Vol. 6 No. 1 (2026): Nusantara Hasana Journal, June 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v6i1.2195

Avocado seeds contain secondary metabolite compounds in the form of alkaloids, flavonoids, saponins, tannins, triterpenoids and steroids. To moisturize and protect the face, spray face spray. The natural ingredients of avocado seeds can be used as a face spray because they contain antioxidants. This study aimed to analyze physical stability of Persea Americana seed extract face spray preparation against variations in glycerin concentration carried out for 6 cycles. In this research, avocado seed extract was obtained using the maceration method and formulated into a face spray preparation with varying glycerin concentrations of 20%, 25% and 30%. The physical stability test of avocado seed extract was carried out using the cycling test method for 6 cycles. P. americana seed extract could be formulated as a face spray. Variations in glycerin concentration affected the results of stability tests on face spray preparations of P. americana seed extract. The F3 formulation had the best results in the face spray preparation of avocado seed extract. Avocado seed extract could be formulated in a face spray with a concentration of 30% to give the best results

SOSIALISASI PEMANFAATAN BAHAN ALAM SEBAGAI ANTIACNE DAN KEAMANAN PENGGUNAAN ACNE PATCH PADA REMAJA Wahyu Purwanjani; Renno Ramadhani Ika Baruna; Muhammad Nur Prasetyo; Supriyanto
Jurnal Pengabdian kepada Masyarakat Cahaya Negeriku Vol 6 No 01 (2026): Jurnal Pengabdian kepada Masyarakat Cahaya Negeriku
Publisher : LPPM AN Nuur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35720/jpkm.v6i01.95

Background: Acne vulgaris is one of the most common skin problems experienced by adolescents, resulting from hormonal changes, increased sebum production, Cutibacterium acnes colonization, and pilosebaceous follicle inflammation. Limited understanding among adolescents regarding the causes of acne, appropriate treatment, and the widespread use of instant products such as acne patches without adequate knowledge of proper application and safety limits underline the importance of early skin health education. Purpose: This community service activity aimed to improve adolescents' knowledge and awareness regarding the use of natural ingredients as antiacne agents and the safe use of acne patches. Method: The activity was carried out through interactive counseling, demonstration, and distribution of educational media to adolescent participants at [name of partner school/location]. The implementation method consisted of preparation (needs assessment and material development), implementation (lectures, discussion, and demonstration of correct acne patch application), and evaluation using pretest and posttest questionnaires. Results: The results showed an increase in participants' knowledge scores after the socialization, along with high enthusiasm reflected in an active question-and-answer session. Participants also demonstrated a better understanding of natural ingredients such as tea tree oil, aloe vera, green tea extract, and Centella asiatica as alternative acne treatments, as well as an awareness of the risk of irritation from improper acne patch use, particularly on open wounds or actively infected skin. Conclusion: This activity is expected to serve as a model for sustainable education to improve skin health literacy among adolescents. Keyword: acne vulgaris; natural ingredients; acne patch; health education; adolescents

ANTIBACTERIAL ACTIVITY OF FENNEL ESSENTIAL OIL AGAINST PROPIONIBACTERIUM ACNES BACTERIA Wahyu Purwanjani; Jaka Lepangkari; Eka Ammyta PP
Joseph: Journal of Science and Pharmacy Vol 1 No 1 (2021): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Recently, natural ingredients are preferred because of their low level of toxicity to their users. Fennel has good properties as an antibacterial, so it is necessary to develop another essential oil taken from fennel to be studied for acne bacteria, namely Propionibacterium acnes. P.acnes is one of the floral bacteria on the surface of the skin, which has a role in the process of forming sebum so that acne occurs. Objective: This research was conducted to obtain the best results from the concentration of essential oils so that the essential oils with the best concentrations could be further developed in cosmetic preparations that are useful as antiacne. Method: Fennel seeds were taken and the steam detailing process was carried out for 7.5 hours. Then after the fennel essential oil was obtained, chemical compounds were tested using the Gas Chromatography-Mass Spectrophotometry (GC-MS) method to determine the chemical content of the fennel essential. Furthermore, testing the antibacterial activity of P.acnes on MHA media by inoculation of bacteria on MHA media and then the discs were immersed in different concentrations of essential oils, namely 2%, 4%, 6% and 8%. After that, compare the results of the essential oil discs with Clydamicyn positive control discs and negative control discs. Results: The identification of chemical compounds using GCMs shows that the content of several chemical constituents in essential oils is quite high, such as anetol (83.6%), Fenchone (3.58%); Linalool (0.69%); l-Limonene (3.75%); and benzaldehyde (0.41%). The antibacterial activity test of fennel essential oil against P. acnes showed a fairly large inhibitory power of 1.6 cm at a concentration of 6% fennel essential oil. Conclusion: Fennel essential oil has antibacterial activity against P.acnes bacteria so it is possible to develop it into cosmetic preparations that can inhibit the process of acne.

ANTIBACTERIAL ACTIVITY TEST OF LEAF 70% ETHANOL EXTRACT MORINGA (Moringa oleifera L.) AGAINTST BACTERIA Propionibacterium acnes Julia Sita Nur Hidayah; Supriyanto; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 2 No 1 (2022): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Medicinal plants contain a variety of active compounds, including as a source of antimicrobials that cause infection. The phytochemical content of Moringa leaf (Moringa oleifera) has the potential to inhibit the growth of acne-causing bacteria. The bacteria that causes acne, namely Propionibacterium acnes, produces the enzyme lipase which breaks down fat into fatty acids which causes inflammation of the skin tissue causing acne to appear. Purpose: To determine the potential of the ethanol extract of Moringa leaf in inhibiting the growth of the Propionibacterium acnes bacteria that causes acne. Method: Moringa leaf (Moringa oleifera) were prepared in powder form, the extract was obtained by maceration using 70% ethanol to obtain a thick extract. The thick extract was then identified for the chemical compounds Flavonoids, alkaloids, saponins, tannins and phenols. Then the ethanol-free test was carried out. Testing the antibacterial activity of the ethanol extract of Moringa leaf (Moringa oleifera) against P. acnes bacteria using paper disc diffusion and liquid solid dilution methods to determine the KHM and KBM values. Moringa leaf extract (Moringa oleifera) in this study used concentrations of 10%, 20% and 30%, clindamycin as a positive control and 10% DMSO as a negative control. Results: Identification of the chemical compounds of the ethanol extract of Moringa leaf showed the presence of flavonoids, alkaloids, saponins, tannins, and phenols. The ethanol-free test performed showed no ethanol content in the viscous extract. Diameter of the inhibition zone of the ethanol extract of Moringa leaf using the disc diffusion method showed the presence of optimum inhibition at a concentration of 30%. The KHM value for P. acnes bacteria starts at a concentration of 7.5%, and the KBM value at a concentration of 15%. Conclusion: The ethanol extract of Moringa leaf (Moringa oleifera L.) showed antibacterial activity against the growth of Propionibacterium acnes bacteria

FORMULASI GEL HAND SANITIZER EKSTRAK DAUN PEGAGAN (Centella asiatica) DAN AKTIVITASNYA TERHADAPStaphylococcus aureus Maulita Saraswati; Gigih Kenanga Sari; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 2 No 1 (2022): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Indonesia is a tropical country that has very abundant biodiversity and has various potentials for health. One of these biodiversities is pegagan leaves (Centella asiatica). Pegagan (Centella asiatica) is one of the plants that contains antibacterial substances, including flavonoids, saponins, tannins, phenols and steroids. Prevention of the spread of bacteria can be done by washing hands with soap and clean running water. Along with the development of science and technology, cleaning hands does not have to use water and soap but can use antiseptic hand gel (hand sanitizer) to kill microorganisms on the surface of the skin. Purpose: to determine whether the gotu kola leaf extract hand sanitizer gel preparation has antibacterial activity against Staphylococcus aureus Method: Extraction by maceration of pegagan leaf extract (Centella asiatica) using 96% ethanol solvent. After obtaining a thick extract, then enter it into the formulation to make a hand sanitizer gel preparation which is then tested on Staphylococcus aureus bacteria using the disc diffusion method. Results: The results of this study showed that the hand sanitizer gel with pegagan extract (Centella asiatica) showed an inhibitory effect on bacterial growth with an inhibitory value of 15.4 mm in formulation 3 with a pegagan extract concentration of 60%. Conclusion: Hand sanitizer gel from pegagan extract (Centella asiatica) has antibacterial activity against Staphylococcus aureus

Uji Stabilitas Formulasi Sediaan Gel Nano Partikel Eksktrak Etanol Daun Singkong (Manihot esculenta Crantz) Wahyu Purwanjani; Maulita Saraswati; Gigih Kenanga Sari
Joseph: Journal of Science and Pharmacy Vol 2 No 1 (2022): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background; Peel-off gel masks are an alternative dosage form that can enhance user comfort and are expected to improve the antioxidant activity of papaya fruit. Papaya (Carica papaya) exhibits antioxidant activity due to the presence of components such as beta-carotene, vitamin C, and lycopene. Objective : This study aims to determine whether the methanol extract of papaya fruit can be formulated into a peel-off facial gel mask and to identify the optimal concentration of polyvinyl alcohol (PVA)—the main base ingredient of peel-off gel masks—that provides the best physical and chemical properties, as well as antioxidant activity with the most favorable IC50 value. Method; The extraction method used was maceration with methanol as the solvent. PVA was used at concentrations of 2.5%, 8.75%, and 17.5%. Physical property tests included organoleptic evaluation, adhesion test, and spreadability test, while chemical properties were evaluated using pH testing. Results; Based on the results, the methanol extract of papaya fruit can be successfully formulated into a peel-off facial gel mask. The formula containing 8.75% PVA met organoleptic standards, had an adhesion time of 20.16 ± 2.90 seconds, spreadability of 10.2 ± 1.28 cm, a pH value of 7.13, and an IC50 value of 80.52 µg/mL, indicating strong antioxidant activity. Conclusion : From the formulation and physical evaluation of the peel-off gel mask containing ethanol extract of tea leaves (Camellia sinensis L.), a thick brown gel with a characteristic tea leaf aroma was obtained. Evaluation results showed a pH value of 5, drying time of 20 minutes, spreadability within acceptable range, adhesion time of 8.73 seconds, and no irritation was observed during the irritation test, indicating that the peel-off gel mask is safe for use

UJI AKTIVITAS SALEP EKSTRAK DAUN JAMBU AIR (Syzygiumsemarangense) DENGAN BASIS HIDROKARBON TERHADAP PENYEMBUHAN LUKA SAYAT PADA KELINCI Rismawati Suci Safitri; Supriyanto; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 3 No 1 (2023): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Water guava leaves contain chemical compounds in the form of alkaloids, flavonoids, saponins and tannins which are effective in healing wounds. Water guava leaves are used in several countries, including Indonesia, where they are used as a traditional medicine for healing wounds. Objective: To determine the hydrocarbon ointment base of water guava leaves (Syzygium semarangense) which can provide activity in healing cuts in rabbits. Method: Water guava leaf extract was obtained using the meseration method, then thickened and carried out a phytochemical screening test and thin layer chromatography to determine the compound content of water guava leaf extract which functions for healing cut wounds. Then it is formulated in the form of an ointment and the physical quality of the ointment is tested including organoleptic test, homogeneity, pH test, spreadability test, adhesiveness test, viscosity test, and ointment type test. Making an ointment formulation using water guava leaf extract using 3 (three) test animals with 5 (five) treatment groups, namely water guava leaf extract ointment with 10%, 15% and 20% hydrocarbon base, negative control with ointment base, control positive for povidone iodine 10%. All rabbits were injured with a wound length of 2 cm with a depth of ± 0.2 cm. The wound was smeared 3 times a day with the tested ointment. Wound observations were carried out every day (days 0 to 14). Data analysis was carried out using One-Way ANOVA.Results: The results of phytochemical screening tests and thin layer chromatography show that water guava leaves contain alkaloids, flavonoids, tannins and saponins. The formulation of water guava leaf extract ointment with a hydrocarbon base meets the physical quality test requirements for ointments such as organoleptic tests, homogeneity, pH, spreadability, stickiness, viscosity and the type of ointment produced is A/M, except for the spreadability at a concentration of 20% due to the addition The higher concentration of cera alba and vaseline causes the spreadability of the ointment to become lower. The wound narrows, forms a scab and closes the wound. The statistical test results had a significant effect on wound healing in rabbits, namely (p<0.05). Conclusion: Providing an ointment with ethanol extract of water guava leaves (Syzygium semarangense) with a hydrocarbon base at a concentration of 10% provides the most optimal effect on healing cuts in rabbits.

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