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Analisis Kualitatif Dan Kuantitatif Bahan Kimia Obat Pada Jamu Pegal Linu Di Wilayah Demak Hana Muizza; Maulita Saraswati; Estuningtyas Ayu Hapsari
Parapemikir : Jurnal Ilmiah Farmasi Vol 15, No 1 (2026): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v15i1.9917

Maraknya praktik adulterasi jamu dengan penambahan Bahan Kimia Obat (BKO) seperti parasetamol dan natrium diklofenak menimbulkan kekhawatiran terhadap keamanan konsumsi jamu, khususnya jamu pegal linu yang banyak digunakan masyarakat. Penelitian ini bertujuan untuk menganalisis keberadaan serta menentukan kadar parasetamol dan natrium diklofenak pada beberapa sampel jamu pegal linu yang diedarkan di Wilayah Demak. Metode penelitian meliputi Kromatografi Lapis Tipis (KLT) sebagai analisis kualitatif dan spektrofotometri UV-Vis sebagai analisis kuantitatif. Analisis dilakukan terhadap lima sampel jamu (a, b, c, d, dan e). Hasil analisis KLT menunjukkan bahwa tiga sampel (b, d, dan e) positif mengandung parasetamol, sedangkan empat sampel (a, b, c, dan e) positif mengandung natrium diklofenak. Hasil analisis kuantitatif menunjukkan kadar parasetamol tertinggi terdapat pada sampel d sebesar 20,906 mg per kemasan, sedangkan kadar natrium diklofenak tertinggi terdapat pada sampel a sebesar 135,24 mg per kemasan. Kesimpulan dari penelitian ini menunjukkan masih adanya praktik ilegal penambahan BKO dalam jamu yang berpotensi menimbulkan risiko kesehatan dan perlunya pengawasan yang lebih ketat oleh BPOM sesuai dengan Peraturan BPOM Nomor 25 Tahun 2023.

THE EFFECT OF CHERRY (MUNTINGIA CALABURA) JUICE ON INCREASED MEMORY IN MICE (MUS MUSCULUS) BY MORRIS WATER MAZE METHOD Maulita Saraswati; Krisantus Y Oeleu; Dhanisa Dwi N
Joseph: Journal of Science and Pharmacy Vol 1 No 1 (2021): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Cherry fruit (Muntingia calabura) contain are alkaloids, saponins, tannins, and flavonoids which serve to neutralize free radicals. Purpose: The research was conducted to know the effect of cherry fruit juice to increased memory in mice using Morris Water Maze (MWM) with the parameter time latency (the time it takes to reach the murine platform). Method: Cherry fruit (Muntingia calabura) was made in the form of juice, where cherry used as many as 50 g and then added 200 ml aquadest. A dose of cherry fruit respectively 0, 064 g/kg BW; 0.13 g/kg BW; 0.26 g/kgBW. Animal test used in this study was a White House mouse (Mus Musculus) male Balb/c strains which are divided in 5 groups, each group consists of 5 mice. There are 2 negative control group (aquadest), positive (Gingko biloba) and 3 treatment groups with cherry fruit juice (0.064; 0.13 0.26 g/kgBW). Mice induced by ethanol 10% orally. Each group of direnangkan treatment on Morris water maze to find the platform. Result: Data analysis was carried out by using one way ANOVA. The results showed that a third of the dose of cherry fruit juice 0.064; 0.13; 0.26 mg/kgBB mice can improve memory in mice. Conclusion: The effective dose of cherry fruit juice is 0.26 mg/dose kgBW because the equivalent positive control group.

UJI AKTIVITAS GEL EKSTRAK DAUN KELOR (Maringa oelifera L.) DARI KABUPATEN BLORA TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI New Zealand Dina Permata Sari; Gigih Kenanga Sari; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 2 No 1 (2022): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: The saponin and tannin compounds in Moringa leaf extract stimulate the formation of collagen, namely in the wound healing process and in cleaning so that it is more effective in healing burns. Purpose: The purpose of this study was to determine the effect of Moringa leaf (Moringa oleifera L.) ethanol extract gel on burn healing Method: This study aims to determine the effectiveness of Moringa leaf extract gel in healing burns in rabbits. This study used 70% ethanol and divided into 3 formulas with the same extract concentration of 9%, for positive control (Biopacenton), negative control (Extract). Results: Data analysis was carried out using one way Anova. The results showed that the ethanol extract gel of Moringa leaves (Moringa oleifera L.) with a concentration of 9% with HPMC bases of 8%, 9% and 10% , had activity on the healing of burns on the backs of New Zealand strain rabbits. Conclusion: Moringa leaf ethanol extract gel (Moringa oleifera L.) can heal burns on the backs of New Zealand rabbits.

ANTIOXIDANT TEST AND PEEL-OFF GEL MASK FORMULATION EXTRACT OF RED SPINNING (Amaranthus tricolor L) LEAVES WITH VARIATIONS OF GELLING AGENT TYPES Welly Setyawan; Supriyanto; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 2 No 1 (2022): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Antioxidants are substances that inhibit or prevent cell damage due to free radical oxidation. Red spinach leaves (Amaranthus tricolor L.) contain flavonoid compounds, saponins and tanins that have antioxidant potential. The purpose of this study was to determine whether red spinach leaf extract (Amaranthus tricolor L) with various types of gelling agent has antioxidant activity and can be used as a pee-off gel mask formulation.Purpose: This study formulated a gel peel-off mask formulation with a variety of gelling agents, HPMC base 1%, Na CMC 2%and PVA 14%, with the active ingredient 3.5% red spinach leaf extract. Concentrated ethanol extract was obtained by extracting using 96% ethanol solvent maceration. Furthermore, testing the activity with the DPPH method, identifying the phytochemical content and evaluating the peel-off gel preparations using physical test parameters.Antioxidant activity quantitative test with UV-VIS spectrophotometric DPPH method at a wavelength of 517 nm with a comparison of vitamin C. Method: From the research that has been done, it can be concluded that red spinach leaves can be formulated into the most stable peel-off gel mask, namely formula III with a PVA base of 14% with an IC value of 57.04μg/ml showing the strongest antioxidant activity and closer to the test parameters gel masks and parameters against positive control.

FORMULASI GEL HAND SANITIZER EKSTRAK DAUN PEGAGAN (Centella asiatica) DAN AKTIVITASNYA TERHADAPStaphylococcus aureus Maulita Saraswati; Gigih Kenanga Sari; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 2 No 1 (2022): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Indonesia is a tropical country that has very abundant biodiversity and has various potentials for health. One of these biodiversities is pegagan leaves (Centella asiatica). Pegagan (Centella asiatica) is one of the plants that contains antibacterial substances, including flavonoids, saponins, tannins, phenols and steroids. Prevention of the spread of bacteria can be done by washing hands with soap and clean running water. Along with the development of science and technology, cleaning hands does not have to use water and soap but can use antiseptic hand gel (hand sanitizer) to kill microorganisms on the surface of the skin. Purpose: to determine whether the gotu kola leaf extract hand sanitizer gel preparation has antibacterial activity against Staphylococcus aureus Method: Extraction by maceration of pegagan leaf extract (Centella asiatica) using 96% ethanol solvent. After obtaining a thick extract, then enter it into the formulation to make a hand sanitizer gel preparation which is then tested on Staphylococcus aureus bacteria using the disc diffusion method. Results: The results of this study showed that the hand sanitizer gel with pegagan extract (Centella asiatica) showed an inhibitory effect on bacterial growth with an inhibitory value of 15.4 mm in formulation 3 with a pegagan extract concentration of 60%. Conclusion: Hand sanitizer gel from pegagan extract (Centella asiatica) has antibacterial activity against Staphylococcus aureus

Uji Stabilitas Formulasi Sediaan Gel Nano Partikel Eksktrak Etanol Daun Singkong (Manihot esculenta Crantz) Wahyu Purwanjani; Maulita Saraswati; Gigih Kenanga Sari
Joseph: Journal of Science and Pharmacy Vol 2 No 1 (2022): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background; Peel-off gel masks are an alternative dosage form that can enhance user comfort and are expected to improve the antioxidant activity of papaya fruit. Papaya (Carica papaya) exhibits antioxidant activity due to the presence of components such as beta-carotene, vitamin C, and lycopene. Objective : This study aims to determine whether the methanol extract of papaya fruit can be formulated into a peel-off facial gel mask and to identify the optimal concentration of polyvinyl alcohol (PVA)—the main base ingredient of peel-off gel masks—that provides the best physical and chemical properties, as well as antioxidant activity with the most favorable IC50 value. Method; The extraction method used was maceration with methanol as the solvent. PVA was used at concentrations of 2.5%, 8.75%, and 17.5%. Physical property tests included organoleptic evaluation, adhesion test, and spreadability test, while chemical properties were evaluated using pH testing. Results; Based on the results, the methanol extract of papaya fruit can be successfully formulated into a peel-off facial gel mask. The formula containing 8.75% PVA met organoleptic standards, had an adhesion time of 20.16 ± 2.90 seconds, spreadability of 10.2 ± 1.28 cm, a pH value of 7.13, and an IC50 value of 80.52 µg/mL, indicating strong antioxidant activity. Conclusion : From the formulation and physical evaluation of the peel-off gel mask containing ethanol extract of tea leaves (Camellia sinensis L.), a thick brown gel with a characteristic tea leaf aroma was obtained. Evaluation results showed a pH value of 5, drying time of 20 minutes, spreadability within acceptable range, adhesion time of 8.73 seconds, and no irritation was observed during the irritation test, indicating that the peel-off gel mask is safe for use

UJI ANTIOKSIDAN DARI FORMULASI SEDIAAN FACE MIST EKSTRAK DAUN JAMBU AIR (Syzygium samarangense) Katharina Anrina; Gigih Kenanga Sari; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 3 No 1 (2023): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background :Antioxidants are compounds that can neutralize free radicals. One of the most frequently used antioxidant cosmetic preparations is face mist. Purpose : To make face mist preparations of water guava leaf extract (Syzygium samarangense) with good physical quality and IC50 value. Method : Water guava leaf extract (Syzygium samarangense) was macerated with 70% ethanol solvent and tested for water content, drying shrinkage, ethanol free, and chemical compound content. Next, evaluation of the preparation was carried out and antioxidant test were carried out on the face mist of water guava leaves (Syzygium samarangense) with concentrations of extract FI 3 grams, FII 5 grams, and FIII 7 grams using the UV-VIS spectrophotometric DPPH (1,1-diphenyl-2-picrylhydrazyl) method at wavelength of 517 nm with ratio of vitamin C. Result : This research shows that water guava leaf extract (Syzygium samarangense) can be used as a good face mist preparation and contains flavonoids, saponin, tannin, and triterpenoid which act as antioxidant. On the face mist preparation of guava leaf extract (Syzygium samarangense) produced good physical quality and the IC50 value at FI was 24,54 ppm, FII was 17,61 ppm, and FIII was 8,86 ppm, so that face mist preparation had the best antioxidant content is an FIII preparation with an IC50 value of 8,86 ppm. Conclusion : Water guava leaf extract (Syzygium samarangense) can be made into a face mist with good physical quality and produces the best antioxidant antivity in FIII preparations with an IC50 value of 8,86 ppm

Uji Stabilitas Sediaan Krim Ekstrak Daun Belimbing Wuluh (Averhoa blimbi L.) dengan Variasi Konsentrasi Emulgator Maulita Saraswati; Gigih Kenanga Sari; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 3 No 1 (2023): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Belimbing wuluh (Averrhoa bilimbi L.) has been widely utilized as a traditional medicinal ingredient due to its antioxidant and anti-inflammatory properties. A stable cream preparation formulation is very important to maintain the effectiveness of its active ingredients. Therefore, this study aims to evaluate the physical stability of Belimbing wuluh leaf extract cream preparation with variations in emulgator concentration. Purpose: To determine the effect of varying TEA concentration on cream stability, determining the effect of variations in stearic acid concentration on cream stability, determining the optimal concentration of TEA and stearic acid to obtain a stable cream formulation. Method: This study used an experimental method with a cream formulation containing stearic acid (10%, 12%, 14%) and triethanolamine (TEA) (4%, 5%, 6%). Stability evaluation was done through organoleptic test, pH, viscosity, spreadability, adhesiveness, and cycling test. Results: The cream preparation showed good homogeneity with a light brown color and characteristic odor of the extract. The pH value ranged from 7.50 to 8.04, in accordance with topical cream standards. Viscosity increased as the concentration of stearic acid and TEA increased. Spreadability and stickiness decreased after the accelerated stability test, but remained within acceptable limits. Conclusion: Cream formulations with a combination of stearic acid and TEA provide good physical stability. The formula with 14% stearic acid and 6% TEA showed more optimal physical characteristics than the other formulas

UJI AKTIVITAS ANTIBAKTERI SEDIAAN FACE TONER EKSTRAK ETANOL 70% DAUN SALAM (Syzygium polyanthum) TERHADAP BAKTERIStaphylococcus aureus Sony Hartono; Wahyu Purwanjani; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 4 No 1 (2024): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Salam leaves contain several chemical compounds including alkaloids, flavonoids, saponins, triterpenoids and tannins which are active compounds that are effective as drugs that can cure infectious diseases caused by bacteria. Purpose: The purpose of this study was to determine the antibacterial activity of bay leaf extract face toner preparations against Staphylococcus aureus bacteria. Method: Bay leaves are extracted with 70% ethanol by maceration. The ethanol extract of bay leaves is formulated into a facial toner preparation and then tested for antibacterial activity using the disc diffusion method or the Kirby Bauer method. Results: The results of the research show that the face toner preparation with 70% ethanol extract of salam (Syzygium polyanthum) contains alkaloid compounds, flavonoids, saponins, triterpenoids and tannins. Ethanol extract of salam leaf has antibacterial activity against Staphylococcus aureus with the inhibition zone diameter of F1 of 10.28 mm, F2 of 11.24 mm, and F3 of 12.24 mm. Conclusion: Facial toner preparation of bay leaf extract (Syzygium polyanthum) provides the strongest antibacterial activity in F3 against the growth of Staphylococcus aureus bacteria with an inhibitory zone diameter of 12.24 mm

UJI AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) TERHADAP BAKTERI Staphylococcus epidermidis Iva Juliyanti; Maulita Saraswati; Estuningtyas Ayu Hapsari
Joseph: Journal of Science and Pharmacy Vol 4 No 1 (2024): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Red dragon fruit skin has many benefits, but currently the utilization of red dragon fruit skin has not been carried out optimally so that it becomes environmental waste. One of the benefits is as an antibacterial because it contains flavonoids, alkaloids, saponins, and tannins. Purpose: To determine the potential of red dragon fruit peel extract in inhibiting bacterial growth against Staphylococcus epidermidis bacteria. Method: Red dragon fruit peel was macerated with 70% ethanol, characterized by specific parameters and nonspecific parameters and tested for antibacterial activity using the disc method with concentrations of 10%, 20%, and 40%, then the results of the antibacterial data obtained were tested by oneway-Anova analysis and Post Hoc Tukey. Results: The yield results obtained were 10.66%, dark brown in color, sour smell, sticky and thick texture. Red dragon fruit peel extract contains flavonoids, alkaloids, tannins, saponins, and phenols. The extract is free from ethanol. The moisture content of the powder was found to be 9.85±0.057. Specific gravity 0.956±0.006. Bacterial test results obtained 10% concentration 4.1mm, 20% concentration 8.1mm, 40% concentration 16mm, positive control 31.2mm. The results of data analysis are significant at 0.000, and each concentration has a significant difference. Conclusion: Red dragon fruit peel extract has antibacterial activity against Staphylococcus epidermidis

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