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All Journal Jurnal Pharmacopoeia Riset Informasi Kesehatan Jurnal Kefarmasian Indonesia Proceedings of The International Conference on Multidisciplinary Science
Azizah, Lailan
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Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences

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PENURUNAN KADAR GULA DARAH MENCIT PUTIH JANTAN DENGAN MENGGUNAKAN HASIL FRAKSINASI DAUN INSULIN Brata, Andy; Azizah, Lailan
Jurnal Pharmacopoeia Vol 1 No 2 (2022): September 2022
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.286 KB) | DOI: 10.33088/jp.v1i2.207

Abstract

  Daun insulin adalah daun tanaman yang mengandung seskuiterpen lakton, asam klorogenat dan flavonoid sebagai zat aktif untuk menurunkan kadar gula darah (antidiabetes). Penggunaan daun insulin (Tithonia diversifolia (Hemsl.) A. Gray) sebagai rebusan yang dipergunakan di masyarakat selama ini sebagai antidiabetes belum diketahui keefektivitasannya. Penelitian ini dilaksanakan untuk mengetahui pengaruh pemberian jenis fraksi daun insulin (Tithonia diversifolia (Hemsl.) A. Gray) bisa menurunkan kadar gula darah pada mencit putih jantan diabetes yang diinduksi dengan aloksan sebelumnya. Penelitian ini merupakan penelitian pra eksperimen dengan menggunakan desain the static-group comparison dan pembagian kelompok hewan uji dengan menggunakan rancangan acak lengkap (RAL). Hewan uji yang digunakan adalah mencit putih jantan sebanyak 42 ekor yang dibagi menjadi 6 kelompok dan terdapat 7 ekor mencit di masing-masing kelompok, kelompok hewan dibagi menjadi kelompok kontrol negatif (NaCMC), kelompok kontrol positif (glibenklamid), kelompok ekstrak etanol daun insulin 150 mg/kgbb, kelompok fraksi n-heksan 150 mg/kgbb, kelompok fraksi etil asetat 150 mg/kgbb dan kelompok fraksi air 150 mg/kgbb. Setelah itu dilakukan pengujian dengan pengecekan kadar glukosa mencit dimulai dari menit ke-35, 90, sampai 135. Ada aktivitas penurunan gula darah setelah pemberian berbagai variasi fraksi daun insulin pada mencit putih jantan yang diinduksi aloksan. Aktivitas penurunan gula darah pada pemberian berbagai variasi fraksi daun insulin pada mencit diabetes yang diinduksi dengan aloksan bermakna setelah pemberian pada menit ke-135 dengan p-value 0,027 (p<0,05).
Antidiabetic activity test result of fractionation of Bengkal Leaves (Nauclea orientalis L.) on male white mice Brata, Andy; Azizah, Lailan
Riset Informasi Kesehatan Vol 13 No 2 (2024): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v13i2.877

Abstract

Background: Bengkal leaves (Nauclea orientalis L.) is a plant that contains flavonoids as active substances to reduce blood glucose levels (antidiabetic). The use of a decoction of bengkal leaves (Nauclea orientalis L.) which has been used in the community as an antidiabetic has not yet been determined for its pharmacological activity. This research was conducted to test the activity of Bengkal leaf fractions (Nauclea orientalis L.) which were used as antidiabetic in male white mice that had been previously induced with alloxan. Method: This research is a quasi-experimental research using the static-group comparison design. The test animals used were 35 male white mice which were divided into 7 groups, namely negative control group (tragacanth), positive control group (alloxan), comparison group (glibenclamide), ethanol extract group, n-hexane fraction, ethyl acetate and Bengkal leaf water at a dose of 150mg/kgBW. After that, testing was carried out by checking the blood glucose levels of the mice starting from days 1, 3 to 7. Followed by a one-way ANOVA statistical test to obtain significant results on which day was the most effective. Then use the post hoc Duncan test to find out the best fraction that has an effect close to glibenclamide 5 mg. So it will be known whether the Bengkal leaf fraction (Nauclea orientalis L.) is effective as an antidiabetic. In the end, we will find out whether the Bengkal leaf fraction can be used as an antidiabetic drug. Results: There is antidiabetic activity after administration of various fractions of Bengkal leaves to male white mice induced by alloxan. Conclusion: Administration of ethyl acetate fraction of Bengkal leaves has antidiabetic activity in male white mice almost equivalent to glibenclamide. Bengkal leaf fraction has potential as an antidiabetic drug.
The Influence of Employee Competence on Employee Performance in The Department of Women's Empowerment, Child Protection and Community of Binjai City Azizah, Lailan; Isa Indrawan, Muhammad
Proceedings of the International Conference on Multidisciplinary Science (INTISARI) Vol. 1 No. 1 (2024): Proceedings of the International Conference on Multidisciplinary Science (INTIS
Publisher : PT. Multidisciplinary Press Indonesia

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Abstract

The aim of this research is to determine and analyze the influence of competency on employee performance at the Binjai City Women's Empowerment, Child Protection and Community Office. This research was conducted using a causal associative quantitative approach. The sample used was all employees with a total of 61 people. The results of the analysis show that competency has a significant influence on employee performance (T-statistic 2,924 > 1.670; P-value 0.005 < 0.05), which indicates that increasing competency directly increases employee performance. The result of the Adjusted R Square value is 0.112 or 11.20%, which means that employee competency has a low influence on employee performance, while the remaining 88.80% is influenced by other factors that have not been studied. This finding provides insight into the relationship between competency and performance, emphasizing the importance of competency in improving employee performance.
Effectiveness of an Organic Mask of Moringa Leaves (Moringa oleifera) and Turmeric (Curcuma longa) for Facial Care Agusriani, Agusriani; Hamilatussa'diyah, Hamilatussa'diyah; Azizah, Lailan; Fitrianingsih, Fitrianingsih
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Facial masks are cosmetic products for topical use on facial skin. Using organic components from nature can prevent irritation and skin pigment damage due to the side effects of harmful chemicals in cosmetic products in the global market. This study aims to develop a combination organic mask formulation from Moringa leaves and turmeric and test its effectiveness. This experimental study, which had a one-shot case study design, was conducted at the Pharmaceutical Technology Laboratory and Phytochemical Laboratory, Pharmacy Department, Health Polytechnic, Ministry of Health, Jambi. The formulation consisted of Moringa leaf powder and turmeric with formulas F1 (40%, 30%), F2 (50%, 25%) and F3 (60%, 20%). Further data analysis used the paired t-test. The evaluation consists of phytochemical screening, characteristic tests of the organic mask (organoleptic, pH, drying time, and homogeneity), stability tests (organoleptic, fungal growth), effectiveness tests of mask preparations (skin moisture), and antioxidant activity tests. Based on the results, formula 3 showed the best results as an organic mask preparation with moisture test results of 58.87 ± 6.24 (mean ± SD), p <0.001. The antioxidant activity results showed IC50 values of each formula were F1 (73.43 µg/ml), F2 (56.33 µg/ml), and F3 (182.11 µg/ml). This study recommends that Moringa leaves and turmeric have potential and effectiveness as antioxidant compounds that can be developed as organic mask preparations.
Co-Authors Agusriani, Agusriani Brata, Andy Fitrianingsih Fitrianingsih Hamilatussa'diyah, Hamilatussa'diyah Isa Indrawan, Muhammad