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All Journal Jurnal Kesehatan Amanah Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Karlina Dwi Febrianingsih
Universitas Mataram
Health Professions Nursing Public Health

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Review Artikel: Analisis Drug Related Problems (DRP) pada Pasien Diabetes Melitus Karlina Dwi Febrianingsih; Aulya Nur’ain
Jurnal Kesehatan Amanah Vol. 10 No. 2 (2026): Oktober: Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v10i2.1232

Abstract

Diabetes mellitus is a chronic disease that requires long-term pharmacological therapy, increasing the risk of Drug Related Problems (DRPs). DRPs can affect the success of therapy, increase the risk of complications, and reduce the patient's quality of life. This article aims to identify the use of antidiabetic drugs, the characteristics of DRPs, and their clinical implications. The method used was a literature review of articles from 2016-2026 that are relevant to the analysis of DRPs in diabetes mellitus patients. The results of the study indicate that metformin is the most widely used antidiabetic drug, both as a single therapy and in combination. The dominant types of DRPs include drug interactions, inappropriate drug selection, inappropriate dosages, omissions from therapy, and use of drugs without indications. These DRPs can cause hypoglycemia, failure to achieve glycemic control targets, an increased risk of complications, and increased duration and cost of treatment. Based on the results of the study, it is concluded that DRPs remain a challenge in the management of diabetes mellitus therapy, requiring more optimal monitoring and an active role of pharmacists through medication review to improve the safety, effectiveness, and quality of treatment.
Efektivitas Penggunaan Obat Golongan Statin terhadap Pasien Penyakit Jantung Koroner Puji Elok Dzakirah; Karlina Dwi Febrianingsih; Baiq Haura Audina Ananta Putri; Khairinna Rifa Andira; Nanda Putri Utami Aziz; Sabila Rosyada; Tuhfatul Ulya
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 5 (2026): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i5.2373

Abstract

Coronary heart disease (CHD) is one of the leading causes of mortality worldwide and is closely associated with dyslipidemia, particularly elevated low-density lipoprotein (LDL) levels. Statins are recommended as first-line therapy to reduce LDL levels and lower the risk of cardiovascular events in patients with CHD. This literature review aimed to evaluate the effectiveness of statin therapy in patients with coronary heart disease. A literature search was conducted using Google Scholar between May 14 and May 29, 2025, with the keywords "statin drugs," "statin effectiveness," "coronary heart disease," and "LDL reduction." Articles were selected based on predetermined inclusion and exclusion criteria, resulting in ten eligible studies. The review showed that atorvastatin was the most frequently prescribed statin and consistently demonstrated effectiveness in reducing LDL levels by approximately 30–50%, increasing HDL levels, and lowering cardiovascular risk. Simvastatin was also effective in managing dyslipidemia, although several studies reported lower effectiveness compared with atorvastatin. Furthermore, a combination of rosuvastatin 10 mg and ezetimibe 10 mg was reported to be more effective in achieving LDL-C targets than high-intensity statin monotherapy in patients at very high cardiovascular risk. Overall, statins are effective for the management of coronary heart disease, with atorvastatin showing the most consistent therapeutic benefits.
Co-Authors Aulya Nur’ain Baiq Haura Audina Ananta Putri Khairinna Rifa Andira Nanda Putri Utami Aziz Puji Elok Dzakirah Sabila Rosyada Tuhfatul Ulya