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All Journal CERATA Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Nanda Putri Utami Aziz
Universitas Mataram
Health Professions Medicine & Pharmacology Nursing Public Health

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Review Artikel: Validasi Metode Analisis Penetapan Kadar Cemaran Asam Retinoat Dalam Krim Pemutih Dengan Berbagai Metode Nanda Putri Utami Aziz; Dinda Ayu Lestari; Shafira Kansa Haiba; Ahmad Hidayaturrohman; Rizqa Fersiyana Deccati
CERATA Jurnal Ilmu Farmasi Vol 17 No 1 (2026): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v17i1.1445

Abstract

Asam retinoat merupakan bentuk asam dan aktif dari vitamin A (retinol) yang biasanya digunakan secara topikal sebagai anti jerawat dalam produk kosmetik karena dapat mengurangi pigmentasi. Di Indonesia, asam retinoat telah dilarang oleh BPOM RI, sehingga penting untuk dilakukan analisis kadar cemaran asam retinoat pada kosmetik. Oleh karena itu, dilakukan study literature dengan tujuan mengetahui metode apa saja yang digunakan untuk analisis cemaran asam retinoat dengan menggunakan desain Systematic Literature Review (SLR). Data diperoleh melalui database online seperti PubMed, ScienceDirect, dan Google Schoolar. Berdasarkan kriteria inklusi, didapatkan 10 artikel terdiri dari 3 penelitian yang menggunakan instrumen Ultra-Violet Spectrophotometry dan 7 penelitian menggunakan instrumen High Performance Liquid Chromatography (HPLC), Ultra High Performance Liquid Chromatography (UHPLC) & Reversed Phase High Performance Liquid Chromatography (RP-HPLC). Semua metode tersebut memenuhi syarat dari uji validasi yang meliputi uji LOD, LOQ, Linearitas, Presisi, dan Akurasi.
Efektivitas Penggunaan Obat Golongan Statin terhadap Pasien Penyakit Jantung Koroner Puji Elok Dzakirah; Karlina Dwi Febrianingsih; Baiq Haura Audina Ananta Putri; Khairinna Rifa Andira; Nanda Putri Utami Aziz; Sabila Rosyada; Tuhfatul Ulya
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 5 (2026): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i5.2373

Abstract

Coronary heart disease (CHD) is one of the leading causes of mortality worldwide and is closely associated with dyslipidemia, particularly elevated low-density lipoprotein (LDL) levels. Statins are recommended as first-line therapy to reduce LDL levels and lower the risk of cardiovascular events in patients with CHD. This literature review aimed to evaluate the effectiveness of statin therapy in patients with coronary heart disease. A literature search was conducted using Google Scholar between May 14 and May 29, 2025, with the keywords "statin drugs," "statin effectiveness," "coronary heart disease," and "LDL reduction." Articles were selected based on predetermined inclusion and exclusion criteria, resulting in ten eligible studies. The review showed that atorvastatin was the most frequently prescribed statin and consistently demonstrated effectiveness in reducing LDL levels by approximately 30–50%, increasing HDL levels, and lowering cardiovascular risk. Simvastatin was also effective in managing dyslipidemia, although several studies reported lower effectiveness compared with atorvastatin. Furthermore, a combination of rosuvastatin 10 mg and ezetimibe 10 mg was reported to be more effective in achieving LDL-C targets than high-intensity statin monotherapy in patients at very high cardiovascular risk. Overall, statins are effective for the management of coronary heart disease, with atorvastatin showing the most consistent therapeutic benefits.
Co-Authors Ahmad Hidayaturrohman Baiq Haura Audina Ananta Putri Dinda Ayu Lestari Karlina Dwi Febrianingsih Khairinna Rifa Andira Puji Elok Dzakirah Rizqa Fersiyana Deccati Sabila Rosyada Shafira Kansa Haiba Tuhfatul Ulya