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UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT BUAH BIWA (Eriobotrya japonica (Thunb.) Lindl.) MENGGUNAKAN METODE DPPH DENGAN SPEKTROFOTOMETRI UV-VIS Purba, Gratia Apulina Cindylawsa; Anggita, Putri; Dhini, Fitri Wahyu
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 2 (2025): September 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i2.13070

Buah biwa (Eriobotrya japonica (Thunb.) Lindl.) mempunyai nilai gizi yang tinggi selain itu daun dan bijinya mengandung khasiat obat. Daging buah biwa mengandung asam malat, asam tartarat, asam sitrat, karoten, vitamin A, vitamin B, dan vitamin C. Tujuan penelitian ini adalah untuk menguji aktivitas antioksidan dari fraksi etil asetat buah biwa. Pengujian aktivitas antioksidan buah biwa dengan metode DPPH (2,2-diphenyl-1-picrylhydrazil) secara spektrofotometri UV-VIS. Hasil pengujian aktivitas antioksidan pada metode DPPH (2,2-diphenyl-1-picrylhydrazil) menunjukkan bahwa fraksi etil asetat buah biwa memiliki aktivitas antioksidan kategori kuat dengan nilai IC50 sebesar 68,3371 µg/mL. Hasil penelitian dapat disimpulkan bahwa fraksi etil asetat menunjukkan adanya aktivitas antioksidan yang kuat dengan metode DPPH

Determination of The Level of Paracetamol and Tramadol Hcl Mixture in Tablets by Chemometric Method by Fourier Transform Infrared Spectrophotometry Gratia Apulina Cindylawsa Purba; Muchlisyam Muchlisyam; Effendy De Lux Putra
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.50283

Fixed-dose combinations of paracetamol and tramadol HCl are effective in the treatment of moderate to severe pain. Therefore, the determination of the levels of the mixture of paracetamol and tramadol HCl is very important for the pharmaceutical industry. The purpose of this study was to determine the levels of paracetamol and tramadol HCl mixture using Fourier Transform Infrared combined with partial least square (PLS) chemometric method. This study was conducted by making a calibration model and chemometric validation of each of the five concentrations measured absorbance at specific wave numbers of paracetamol and tramadol HCl. The results of the study on PLS multivariate calibration of paracetamol and tramadol HCl with RMSECV values of 0.06279 and 0.03785, PRESS values of 0.02366 and 0.00860, and R2 values of 0.9995 0.9998, respectively. All validation parameters are within the acceptable range. This indicates that the method can be used to accurately determine drug levels without separation

UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT BUAH BIWA (Eriobotrya japonica (Thunb.) Lindl.) MENGGUNAKAN METODE DPPH DENGAN SPEKTROFOTOMETRI UV-VIS Gratia Apulina Cindylawsa Purba; Putri Anggita; Fitri Wahyu Dhini
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 2 (2025): September 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i2.13070

Buah biwa (Eriobotrya japonica (Thunb.) Lindl.) mempunyai nilai gizi yang tinggi selain itu daun dan bijinya mengandung khasiat obat. Daging buah biwa mengandung asam malat, asam tartarat, asam sitrat, karoten, vitamin A, vitamin B, dan vitamin C. Tujuan penelitian ini adalah untuk menguji aktivitas antioksidan dari fraksi etil asetat buah biwa. Pengujian aktivitas antioksidan buah biwa dengan metode DPPH (2,2-diphenyl-1-picrylhydrazil) secara spektrofotometri UV-VIS. Hasil pengujian aktivitas antioksidan pada metode DPPH (2,2-diphenyl-1-picrylhydrazil) menunjukkan bahwa fraksi etil asetat buah biwa memiliki aktivitas antioksidan kategori kuat dengan nilai IC50 sebesar 68,3371 µg/mL. Hasil penelitian dapat disimpulkan bahwa fraksi etil asetat menunjukkan adanya aktivitas antioksidan yang kuat dengan metode DPPH

Enhancement of Students’ Knowledge Regarding Appropriate Sunscreen Selection Based on SPF Variations and Skin Type Characteristics at Wirahusada Health Vocational School, Medan Gratia Apulina Cindylawsa Purba; Anggun Syafitri; Ageng Azhar Amar; Hazimah Fithryyah Mardatillah; Agnes Clara Tamba
JURNAL PENGMAS KESTRA (JPK) Vol. 6 No. 1 (2026): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7rzqxp44

Excessive exposure to ultraviolet (UV) radiation can cause various adverse effects on the skin, including erythema, premature skin aging, and an increased risk of skin cancer. One of the most effective preventive measures is the proper use of sunscreen selected according to its Sun Protection Factor (SPF) value and individual skin characteristics. However, adolescents' knowledge regarding appropriate sunscreen selection remains limited. This community service program aimed to improve students' knowledge and awareness of selecting appropriate sunscreen based on SPF variation and skin type characteristics. The program employed a participatory educational approach through health education sessions, interactive discussions, demonstrations, and skin condition assessments using a skin analyzer. The activity was conducted at Wirahusada Health Vocational High School, Medan, involving 20 students as participants. The educational materials covered UV radiation, skin types, SPF classification, sunscreen types, and the correct application of sunscreen. Skin condition assessments were performed to determine participants' skin moisture levels as the basis for providing appropriate sunscreen recommendations. The assessment results revealed that 11 participants (55.5%) had normal skin moisture, 7 participants (35.0%) had dry skin, and 2 participants (10.0%) had moist skin. Throughout the program, participants demonstrated high enthusiasm and active engagement during the educational sessions and discussions. The integration of health education with skin condition assessment effectively enhanced participants' understanding of selecting sunscreen according to their individual skin characteristics. Overall, this community service program successfully improved students' knowledge and awareness regarding the appropriate use of sunscreen as an essential strategy for protecting skin health from the harmful effects of ultraviolet radiation.

FORMULASI EKSTRAK ETANOL BUAH PARE DAN DAUN PEPAYA SEBAGAI LOSION REPELAN Aedes aegypti Gratia Apulina Cindylawsa Purba; Delisma Marsauli Simorangkir; Tio Ranti Sari Br Sembiring; Putri Anggita
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2949

Dengue Hemorrhagic Fever (DHF) is a disease caused by the dengue virus from the genus Flavivirus and the family Flaviviridae, transmitted through the bites of Aedes aegypti and Aedes albopictus. One preventive measure can be achieved by using mosquito repellent lotion as a protective topical preparation. Bitter melon and papaya leaves contain flavonoids and antioxidants that have potential as natural repellent agents. This study aimed to evaluate the effectiveness of lotion formulations containing bitter melon and papaya leaf extracts at concentrations of 0%, 2%, 4%, and 6%. The research method included preparing lotion formulations based on an oil-in-water emulsion, followed by physical quality testing according to SNI 16-4399-1996, including assessments of homogeneity, emulsion type, two-week stability, and skin irritation. Repellent effectiveness was tested by observing the number of mosquitoes that died after contacting skin treated with the lotion. The results show that all formulations meet the physical quality requirements, are homogeneous, stable, possess an oil-in-water emulsion type, and do not cause skin irritation. The extracts increase mosquito repellency, as indicated by the greater number of dead mosquitoes with higher extract concentrations. The 6% formulation is the most effective concentration as a repellent or insecticidal agent against Aedes aegypti.

Validasi Metode Analisis KCKT untuk Penetapan Kadar Parasetamol dalam Sediaan Tablet Generik dan Bermerek M. Deddy Harfiansyah; Gratia Apulina Cindylawsa Purba; Fitria Fitria; Ummi Khairani Rambe; Ageng Azhar Amar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1107

Background: Paracetamol is one of the most widely used analgesic and antipyretic drugs, and quality control of its dosage forms is crucial to ensure therapeutic effectiveness. Objective: This study aimed to validate a simple, rapid, and reliable High-Performance Liquid Chromatography (HPLC) method for the determination of paracetamol content in generic and branded tablet formulations. Methods: The chromatographic analysis was performed on a C18 column using a mobile phase of distilled water and methanol (3:1, v/v) with a flow rate of 1.0 mL.min–1, injection volume of 20 µL, and detection wavelength at 243 nm. Validation parameters including system suitability, linearity, accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ) were evaluated according to pharmacopeial guidelines. Results: The method demonstrated excellent linearity over the range of 8–12 µg.mL–1 (r = 0.9998), with LOD and LOQ values of 0.13 µg.mL–1 and 0.40 µg.mL–1, respectively. Accuracy values were 99.00% for generic and 98.86% for branded tablets, while precision showed %RSD of 0.53% and 0.68%. The paracetamol content was 101.47% and 100.20% for generic and branded formulations, respectively, meeting pharmacopeial standards (90–110%). Conclusion: The validated HPLC method proved to be accurate, precise, and sensitive for the quantitative determination of paracetamol in tablet dosage forms. This method is suitable for routine quality control and can be extended for stability or pharmacokinetic studies.

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