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FORMULASI DAN UJI EFEKTIVITAS SEDIAAN GEL KOMBINASI DARI EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus) DAN DAUN PEPAYA (Carica papaya L) TERHADAP PENYEMBUHAN LUKA BAKAR TIKUS PUTIH JANTAN (Rattus norvegicus) SEMBIRING, TIO RANTI SARI
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 1 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i1.2003

ABSTRACK Background: According to research conducted at Cipto Mangunkusumo Hospital (RSCM) in 2011-2012, it was reported that the average age was 28 years from a range of 2.5 months to 76 years, while the mortality rate was 36.6% in patients with extensive burns. more than 60.0% of them all experienced death. Research was carried out at the Pharmaceutical Biology Laboratory and the Pharmaceutical Qualitative Laboratory at the Deli Husada Deli Tua Health Institute, as well as at the Pharmaceutical Preparation Technology Laboratory for the manufacture of extracts and gel preparations. The research took place from March to May 2024. This research is a laboratory experimental research. The research population is jackfruit leaves and papaya leaves. The samples used were jackfruit leaf and papaya leaf extracts with concentrations of 3%, 6%, 9%, as well as bioplacenton gel. Research procedures include making simplicia, making extracts using the maceration method, characterization of simplicia, as well as formulation and quality eval_uation of gel preparations. Effectiveness testing was carried out by observing the healing time of burn wounds in mice treated with ethanol extract gel from jackfruit leaves and papaya leaves. The results of this study showed that the effectiveness of healing burn wounds from the combination of ethanol extracts from jackfruit leaves and papaya leaves every day in each formulation. In the positive control (bioplasma) at a concentration of 6% there was no significant difference of p0.05 on days 3, 6, 12 and 15. On day 9 there was a significant difference of p0.05 in each formulation. However, it can be concluded that the 6% concentration is the most effective in healing burns. The bioplacenton gel preparation has better effectiveness in healing wounds compared to the gel preparation combining the ethanol extract of jackfruit leaves and papaya leaves. Keywords: Artocarpus heterophyllu,Carica papaya L, effectiveness test

EDUKASI PEMANFAATAN SARI BUAH TOMAT SEBAGAI SEDIAAN MASKER DI SMA SWASTA HARAPAN 1 KOTA MEDAN Marbun, Nova rianti; Sari, Sofia Elia; purba, jhan saberlan; Sembiring, Tio Ranti Sari
Jurnal Pengabdian Masyarakat Putri Hijau Vol 5 No 3 (2025): Jurnal Pengabdian Masyarakat Putri Hijau (JPMPH)
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v5i3.2469

Community Service aims to increase public knowledge and understanding regarding the use of tomato juice as a basic ingredient for natural cosmetic preparations. Tomatoes (Solanum lycopersicum) are known to contain various active substances such as lycopene, vitamin C, and antioxidants that are beneficial for skin health, including brightening, moisturizing, and protecting against free radicals. Educational activities are carried out through counseling, forcing the preparation to be made, and distributing leaflets to the target community. The results of the activities showed a significant increase in participants' knowledge regarding the benefits and how to make cosmetic preparations based on tomato juice. This program is expected to encourage the community to make more use of natural ingredients in skin care and reduce dependence on chemical products.

Edukasi Pemanfaatan Daun Kecipir (Psophocarpus tetragonolobus L.) sebagai Antihiperkolesterolemia di Rumah Sakit Sembiring Sianipar, Masria Phetheresia; Gultom, Evi Depiana; Barus, Lidia Klorida; Sembiring, Tio Ranti Sari
Jurnal Pengabdian Masyarakat Putri Hijau Vol 5 No 3 (2025): Jurnal Pengabdian Masyarakat Putri Hijau (JPMPH)
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v5i3.2470

Hypercholesterolemia is one of the leading risk factors for cardiovascular disease, with increasing global preval_ence. The use of medicinal plants as complementary therapy offers a promising alternative, one of which is winged bean leaves (Psophocarpus tetragonolobus L.), known for their flavonoid and antioxidant content. This community service activity aimed to educate the public on the potential benefits of winged bean leaves in managing high cholesterol levels. The method involved health education sessions, interactive discussions, and leaflet distribution to patients and their families at Sembiring Hospital. Results showed a 73.5% increase in participants' knowledge after the educational intervention. Education on the use of herbal remedies such as winged bean leaves plays an important role in promoting natural and accessible approaches to hypercholesterolemia prevention and management.

PENGEMBANGAN FACEMIST KOMBINASI EKSTRAK DAUN BIDARA (Ziziphus spina cristi (L.) Desf) DAN DAUN BENALU DUKU (Dendrophthoe pentandra (L.) Miq ) SEBAGAI ANTIOKSIDAN PADA KULIT WAJAH anggara, Elysa; syafitri, anggun; sari, tio ranti
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2257

The skin needs antioxidant compounds that can ward off free radicals caused by several factors, one of which is air pollution. Bidara leaves (Zizipus spina Cristi (L) Desf) and benalu duku leaves (Dendrophthoe pentandra (L.) Miq) contain flavonoid compounds that function as antioxidants that can ward off free radicals. This study aims to formulate bidara leaf extract and benalu duku leaf into the form of Facemist preparation and determine the best Facemist product formula with the addition of bidara leaf extract, benalu leaf, and a combination of two extracts through antioxidant activity parameters. The antioxidant activity test was carried out using the DPPH (1,1-dipenyl-2-picrylhydrazyl) method. The Facemist sample was formulated into a Facemist with concentration variations: F1 : EEDB 5%, F2 : EEDBD : 5%, F3 : EEDB : 2.5% EEDBD 2.5%, F4 : EEDB : 5% EEDBD : 5%, F5 : EEDB : 10% EEDBD : 10%. Facemist preparations are eval_uated for their physical characteristics, namely organoleptic test, homogeneity test, pH test, viscosity test, dry time test, irritation test. The results showed that Facemist was a combination of bidara leaf extract and benalu duku leaf homogeneous, pH <7, had a viscosity value of <500 cps, a good drying time of <5 minutes and did not cause irritation to the skin. The formulation of Facemist preparation that has the best antioxidant activity value is F5 with antioxidant activity (IC50) of 58.33 ppm in the strong category.

UJI AKTIVITAS ANTIBAKTERI FORMULASI SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL DAUN PALA (Myristica fragrans Houtt) TERHADAP BAKTERI Staphylococcus epidermidis DAN Streptococcus sp Sanjaya, Angga Nugraha; Sari, Tio Ranti
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2258

The pala leaves contain alkaloids, flavonoids, saponins, tannins, and steroids which high antiseptic and antibacterial effects. The goal of the research make a formulation of hand sanitizer gel with etanol extreact by pala leaves (Myristica fragrans Houtt) as the antibacterial againt the Staphylococcus epidermidis and Streptococcus sp bacteria with CMC-Na base. Pala leaves hand sanitizer gel with etanol extract was formulation I 5%, formulation II 10%, and formulation III 15%. The method used in this study was antibacterial testing method used is the disc diffusion technique. Hand sanitizer gel is tested for the physical properties including organoleptic test, pH test, homogeneity test, and spreadability test. Hand sanitizer gel which has antibacterial activity against the Staphylococcus epidermidis and Streptococcus sp, bacteria is second (III) formulation in with concentration 15% that has an inhibition zone of 17 mm on bacteria Staphylococcus epidermidis and 16,86 mm on bacteria Streptococcus sp, mean while in formulation II with concentration 10% that has an inhibition zone of 13,16 mm on bacteria Staphylococcus epidermidis ang 13,16 on bacteria Streptococcus sp, mean while in formulation I with concentration 5% that has an inhibition zone of 12,02 mm on bacteria Staphylococcus epidermidis and 12,16 mm on bacteria Streptococcus sp, and the last positive control (nuvo gel hand sanitizer) that has an inhibition 17,73 mm on bacteria Stahylococcus epidermidis and 17,69 mm on bacteria Streptococcus sp. The final results of the research indicate, there is an ability of hand sanitizer gel pala leaves (Myristica fragrans Houtt) extract to prevent the growth of Staphylococcus epidermidis and Streptococcus sp bacteria with concentration of 15% hand sanitizer gel preparation.

FORMULASI DAN UJI AKTIVITAS SEDIAAN GEL ANTIACNE EKSTRAK ETANOL DAGING KURMA (Pheonix dactylifera L.) TERHADAP BAKTERI Propionibacterium acnes & Pseudomonas aeruginosa Marbun, Nova rianti; Br Sembiring, Tio Ranti Sari
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2710

Acne (acne vulgaris) is a skin inflammation caused by the overgrowth of bacteria such as Propionibacterium acnes and Pseudomonas aeruginosa. This study aims to formulate a gel preparation containing ethanol extract of date flesh and evaluate its antibacterial activity. The extract was obtained via maceration using 70% ethanol. The gel was formulated in three extract concentrations: 10%, 20%, and 30%. Physical evaluations of the gel included organoleptic properties, homogeneity, pH, spreadability, and adhesiveness, while antibacterial activity was tested using the disk diffusion method. The results showed that the 30% concentration provided the largest inhibition zone against both test bacteria. Physical evaluations confirmed that the gel preparation met the criteria for a stable topical product. It can be concluded that the ethanol extract of date flesh can be effectively formulated into an antibacterial gel preparation and has potential as a natural antiacne product.

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BONGGOL BROKOLI (Brassica oleracea L. var. Italica) DENGAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazy) Umaya, Chindy; Marbun, Nova Rianti; Br Sembiring, Tio Ranti Sari
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2732

Broccoli (Brassica oleracea L. var. Italica) is a vegetable recognized for its abundant bioactive components, such as flavonoids, tannins, saponins, and vitamin C, which are linked to antioxidant capabilities. Notwithstanding its health advantages, the broccoli stalk is frequently disregarded and underexploited, despite its potential as a source of natural antioxidant chemicals. This work aims to assess the antioxidant activity of the ethanolic extract from broccoli stalks utilizing the DPPH method and to ascertain its IC₅₀ value. The extraction was conducted via the maceration method utilizing 70% ethanol, and the antioxidant activity was assessed through UV-Vis spectrophotometry at a peak wavelength of 516 nm. The results indicated that the ethanolic extract of broccoli stem possesses considerable antioxidant activity, with an IC₅₀ value of 35.74 µg/ml. The IC₅₀ value of vitamin C was shown to be 7.67 µg/ml. The results indicate that broccoli stalks may be a significant source of natural antioxidants. The validation of the analytical method demonstrated outstanding results, including linearity (r = 0.9989), accuracy (100.57%), and precision (%RSD = 0.5646%).

“UJI EFEKTIVITAS FORMULASI EKSTRAK ETANOL BUAH PARE (Momordica charantia L.) DENGAN DAUN PEPAYA (Carica Papaya L.) SEBAGAI LOTION AEDES AEGYPTI” SEMBIRING, TIO RANTI SARI; Simorangkir, Delisma Marsauli
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2734

Flaviviridae, genus Flavivirus, and group of arthropod-borne viruses. Aedes mosquitoes, particularly Aedes aegypti or Aedes albopictus, are the primary vectors of dengue disease transmission. A product that is used in skin-protection cosmetics to protect the skin from mosquito bites is anti-mosquito lotion (repellent). Water, emulsifying agents, humectants, and fatty ingredients make up lotion preparations. The bitter gourd and papaya leaves employed in this study were the active ingredients used to make lotion preparations. The lotion formulation used in this investigation contained flavonoid chemicals at varied extract concentrations of 0%, 2%, 4%, and 6%. The bitter gourd's and leaves' active components Because papaya is known to contain a lot of antioxidants, it can be used as an insecticide and lotion to ward against mosquitoes. According to SNI-16-4399-1996, preparations for anti-mosquito lotion made from papaya leaves and bitter melon extract pass the physical quality test because they are all homogeneous, have an oil-in-water emulsion type, are stable during storage for two weeks, and do not irritate the skin. Anti-mosquito lotion made with bitter melon fruit extract and papaya leaves, which is distinguished by the presence of dead mosquitoes in each formulation, has an effect on the effectiveness as an insecticide or repellent against mosquitoes on the skin that is applied. The extract lotion preparations' concentration The most powerful insecticide or mosquito repellant is a 6% extract of bitter gourd fruit and papaya leaves.

EDUKASI PENCEGAHAN GANGGUAN OTOT RANGKA AKIBAT KERJA (GOTRAK) PADA PERAWAT DI RUMAH SAKIT DJASAMEN SARAGIH KOTA PEMATANG SIANTAR TAHUN 2023 Gina Kristina; Tio Ranti; Hariati
Pengabdian Deli Sumatera Vol 3 No 2 (2024): Artikel Pengabdian Juli 2024
Publisher : LLPM Universitas Deli Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Keluhan sistem otot rangka pada umumnya terjadi karena kontraksi otot yang berlebihan akibat pemberian beban kerja yang terlalu berat dengan durasi pembebanan yang panjang. Postur kerja yang salah merupakan salah satu risiko ergonomi yang paling berpengaruh terhadap terjadinya gangguan otot rangka akibat kerja Ergonomi merupakan ilmu yang mempelajari keserasian kerja dalam suatu sistem. Pada penerapannya pekerjaan akan menjadi aman bagi pekerja/manusia dan efisiensi kerja meningkat maka tercapai kesejahteraan manusia. Penerapan ergonomi yang benar di tempat kerja bertujuan agar pekerja dalam bekerja selalu dalam keadaan sehat, nyaman, aman, produktif dan sejahtera. Sebaliknya apabila penerapan ergonomi dilakukan dengan tidak benar malah berakibat timbulnya keluhan, penyakit kerja dari pekerja akibat pekerjaannya. Faktor individu berupa umur, jenis kelamin, kebiasaan merokok, kesegaran jasmani, kekuatan fisik, masa kerja, dan Indeks Masa Tubuh (IMT).

FORMULASI DAN UJI AKTIVITAS SEDIAAN GEL ANTIACNE EKSTRAK ETANOL DAGING KURMA (Pheonix dactylifera L.) TERHADAP BAKTERI Propionibacterium acnes & Pseudomonas aeruginosa Marbun, Nova rianti; Br Sembiring, Tio Ranti Sari
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2710

Acne (acne vulgaris) is a skin inflammation caused by the overgrowth of bacteria such as Propionibacterium acnes and Pseudomonas aeruginosa. This study aims to formulate a gel preparation containing ethanol extract of date flesh and evaluate its antibacterial activity. The extract was obtained via maceration using 70% ethanol. The gel was formulated in three extract concentrations: 10%, 20%, and 30%. Physical evaluations of the gel included organoleptic properties, homogeneity, pH, spreadability, and adhesiveness, while antibacterial activity was tested using the disk diffusion method. The results showed that the 30% concentration provided the largest inhibition zone against both test bacteria. Physical evaluations confirmed that the gel preparation met the criteria for a stable topical product. It can be concluded that the ethanol extract of date flesh can be effectively formulated into an antibacterial gel preparation and has potential as a natural antiacne product.

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