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All Journal Jurnal Kedokteran JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Kefarmasian AKFARINDO Jurnal Pengabdian Masyarakat Sains Indonesia (Indonesian Journal Of Science Community Services) Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Sains dan Kesehatan
Raisya Hasina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health Social Sciences Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

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Preliminary In Vitro Antiplatelet Potential of Ipomoea pes-caprae from North Lombok with Adenosine Diphosphate-Induced Platelet Aggregation Ilsa Hunaifi; Dewi Suryani; Lalu Husnul Hidayat; Muhammad Naufal Farras Ananta; Muhammad Iqbal Farobbi; Nisa Isneni Hanifa; Raisya Hasina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.229-246

Abstract

Background: Cardiovascular diseases, particularly ischemic stroke, remain a global health burden, necessitating potential candidate for further antiplatelet with fewer side effects. Objectives: This study aimed to evaluate the antiplatelet potential of ethanolic extracts from the leaves and stems of Ipomoea pes-caprae (Katang-katang) from North Lombok, Indonesia, through ADP-induced platelet aggregation. Phytochemical screening, total tannin quantification, and in vitro antiplatelet assays were conducted. Methods: The leaves and stems were macerated with 96% ethanol, followed by qualitative phytochemical tests, Folin-Ciocalteu-based tannin analysis, and platelet aggregation inhibition assays using human platelet-rich plasma. Results: The extracts contained alkaloids, flavonoids, and tannins, with higher tannin levels in leaves (4.02 ± 0.02 mgEAT/g) than stems (3.67 ± 0.17 mgEAT/g). Concentration-dependent antiplatelet activity was observed, with leaf extracts showing inhibition (85.9% at 2000 μg/mL) compared to stems (79.5%) and aspirin (77.3%). IC₅₀ values were 727.78 μg/mL (leaves) and 349.95 μg/mL (stems). Statistical analysis confirmed significant differences across concentrations (p < 0.05). Conclusion: These findings demonstrate that Ipomoea pes-caprae exhibits potent antiplatelet activity, attributed to its tannin and phytochemical content, with leaves being more effective. Although these findings suggest preliminary antiplatelet potential, further analysis is required to validate the method using aspirin IC₅₀, and subsequent in vivo and pharmacological investigations are necessary before therapeutic application can be claimed.
Co-Authors Amira Baiq Fitria Maharani Candra Dwipayana Hamdin Candra Eka Puspitasari Chairun Wiedyaningsih Dewi Suryani Dila Ayu Lestari Dyke Gita Wirasisya Gusti Ayu Putu Sri Erwinayanti Hesti Wulandari Ilsa Hunaifi Iman Surya Pratama Lalu Husnul Hidayat Muhammad Iqbal Farobbi Muhammad Naufal Farras Ananta Ni Made Amelia Ratnata Dewi Nisa Isneni Hanifa Pratami, Baiq Nona Rusdianti Probosuseno Probosuseno Siti Rahmatul Aini Wahida Hajrin Yohanes Juliantoni