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All Journal JURNAL PENDIDIKAN TAMBUSAI Andalas obstetrics and gynecology journal
Djanas, Dovy
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health Social Sciences

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Karakteristik Responden, Faktor Klinis, dan Laboratorium dengan Luaran Pasien Ibu Hamil dengan Covid-19 Sriyanti, Roza; Djanas, Dovy; Fauzan, Fauzan; Wulandari, Wira Dhika Tri
Jurnal Pendidikan Tambusai Vol. 9 No. 1 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v9i1.25051

Abstract

Pandemi Coronavirus Disease 2019 (COVID-19) telah menjadi krisis kesehatan global yang signifikan. Kehamilan dapat meningkatkan kerentanan terhadap infeksi SARS-CoV-2 dan berpotensi memperburuk manifestasi klinis dan luaran infeksi COVID-19. Penelitian ini bertujuan untuk menganalisis hubungan antara karakteristik maternal (usia ibu, usia gestasi, gravida, dan indeks massa tubuh), faktor klinis (jumlah gejala dan komorbiditas), serta parameter laboratorium dengan luaran ibu hamil dengan COVID-19. Penelitian analitik observasional dengan desain kohort retrospektif ini dilakukan di RSUP Dr. M. Djamil Padang selama periode Maret 2020 hingga Maret 2021. Hasil penelitian menunjukkan bahwa faktor-faktor yang berhubungan dengan luaran buruk pada ibu hamil dengan COVID-19 antara lain status gravida yang lebih tinggi (P=<0.001), jumlah gejala yang semakin banyak (P=<0.001), serta parameter laboratorium seperti hemoglobin (P=0.015), hematokrit (P=0.002), eosinofil (P=0.008), neutrofil segmen (P=0.001), SGPT (P=0.001), dan ureum (P=0.001). Selain itu, skor APGAR bayi yang rendah juga terkait dengan prognosis ibu yang lebih buruk (P=0.035). Temuan ini menekankan pentingnya pemantauan terhadap tanda-tanda klinis dan perubahan laboratoris untuk mengidentifikasi risiko komplikasi dan luaran pada ibu hamil dengan COVID-19.
The Efficacy of Dequalinium Chloride Against Vulvovaginitis in Pregnancy Mila Permata Sari; Djanas, Dovy; Putra, Andani Eka
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.49-62.2025

Abstract

Introduction: Vulvovaginitis affects pregnancy outcomes and managing it involves the use of metronidazole or nystatin, which can cause local or systemic side effects. Dequalinium chloride (DQC) is suggested as a new treatment option for vulvovaginitis during pregnancy with minimal side effects. Objective: To compare the effectiveness of dequalinium chloride (DQC) versus metronidazole + nystatin (MN) in treating vulvovaginitis in pregnant women during their second and third trimesters. Method: A single-blind randomized controlled trial was conducted at the Andalas Public Health Center, Padang, from January to May 2024. Pregnant women in their second and third trimesters, meeting the inclusion and exclusion criteria, were enrolled. The participants were randomly assigned to either the DQC or MN group. Vaginal swabs were taken before and after a 6-day treatment, and PCR analysis was performed. Results: Eighteen patients were treated with DQC and MN. Most participants had bacterial vaginosis (DQC 78%, MN 83%), with half having candidiasis (DQC and MN 50%) and fewer cases of trichomoniasis (28% in both groups). Significant improvements were seen in the DQC group for symptoms (p=0.000), Gardnerella vaginalis (p=0.035), and Candida albicans (p=0.021). In the MN group, significant improvements were noted for symptoms (p=0.000) and Gardnerella vaginalis (p=0.002). No significant differences were observed between the groups for symptom resolution or microbial reduction. Conclusion: DQC is as effective as metronidazole + nystatin in treating bacterial vaginosis and candidiasis in pregnancy. Keywords: Vulvovaginitis, pregnancy, dequalinium chloride, metronidazole, nystatin
PERBEDAAN RERATA FAKTOR HEMOSTASIS PADA PREEKLAMPSIA BERAT DAN EKLAMPSIA Setia, Dyhan Purna; Ferry, Ferdinal; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.1.10-15.2018

Abstract

Objective : To find the difference in mean hemostatic factors in severe preeclampsia and eclampsia.Method : The study was analytic descriptive using a cross sectional study design by looking at the subject's Medical Record according to the time and place of research. The sample is the entire medical record of pregnant women who suffer from preeclampsia and eclampsia in the obstetric and gynecology departments of Dr. M. Djamil Padang Hospital in the period 15 January 2016 to 31 December 2017. The assessment was in the form of assessed platelet levels, PT, APTT and D-Dimer. Samples were taken from populations that met the inclusion criteria and did not have exclusion criteria. Sampling using consecutive sampling techniques taken from the Medical Record Dr. M.Djamil Padang. Statistical analysis to assess significance using the T-Test.Result : The severity the condition of pregnancy the lower the platelet mean and PT. Significant differences were obtained between platelets in PEB and eclampsia (p> 0.05). The mean PT, APTT and D-Dimer showed no significant differences in pregnancy conditions. Statistical test with T-Test did not show significant differences in mean PT, APTT, and D-dimer between eclampsia and PEB (p> 0.05).Conclusion : There were significant differences in mean in platelets, whereas in PT, APTT, and D-dimers in PEB and eclampsia there were no significant differences.Keywords: Pregnancy, severe preeclampsia, eclampsia, platelets, PT, APTT, D-Dimer.
PERBEDAAN RERATA KADAR NATRIUM MATERNAL ANTARA PREEKLAMPSIA BERAT DAN EKLAMPSIA DI RSUP DR. M. DJAMIL PADANG Efri, Gunawan; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.1.16-20.2018

Abstract

Objective: To determine the difference in mean ratio of sodium content between pregnancy with severe preeclampsia and eclampsia.Method: This is an analytical study using a cross sectional study design. The study was conducted inMaternity room of Dr. M. Djamil Padang from January 15th, 2016 to December 31st, 2017, there were 60 patients as subjects, the sample was divided into 2 groups: severe preeclampsia and eclampsia. Furthermore, history and physical examination to obtain data and clinical diagnosis. Data is recorded in a research form that has been provided, then performed blood electrolytes of Sodium and Potassium. Statistical analysis to assess significance using T-test.Results: In the severe preeclampsia and eclampsia, multiparous parity had the highest respondent. This is consistent with the literature in which the incidence of preeclampsia is more common in late pregnancy.Conclusions: There was no significant difference in the mean sodium ratio between normal severe preeclampsia pregnancy and normal pregnancy.Keywords: pregnancy condition, severe preeclampsia, eclampsia, and sodium.
PSORIASIS PUSTULARIS DALAM KEHAMILAN Djanas, Dovy; Sulin, Djusar
Andalas Obstetrics And Gynecology Journal Vol. 1 No. 2 (2017)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.1.2.86-92.2017

Abstract

Psoriasis is a residual chronic inflammatory skin disease, characterized by a predominance of pustular eruptions accompanied by systemic symptoms such as fever lasting several days. . Psoriasis in pregnancy can lead to spontaneous abortion, stillbirth and preterm birth. Reported the case of Mrs. YS 38 years old, received from the genital skin section of RS M Djamil Padang with a diagnosis of G3P2A0H2 + pustular psoriasis. Fetomaternal ultrasound was performed, obtained biometrics: BPD: 80mm, FL: 61 mm, HL: 54 mm, AC 271 mm, AFI 10.7 cm, SDAU 2.79, estimated fetal weight 1700-1800 grams. Impression: gravid 31-32 weeks, single live fetus intra uterine. Patients are planned for administration of high doses of corticosteroids. Informed consent to the patient and family about the actions to be performed. Corticosteroid was administered as much as 30 mg long term with a dose of prednisone in tappering off every 2 weeks. The patient was discharged for control to the skin clinic and obstetrics, the patient came 12 days later and was consulted to the obstetrics department for termination of the pregnancy but from the obstetrics department there was no confirmation for termination of the pregnancy. The patient then came 13 days later with 18 hours PRM. Pregnancy termination by cesarean section was performed. a baby girl was born with LBW: 3000 gr, PB: 48 cm, A / S: 8/9, there were no congenital abnormalities such as growth disorders, cleft lip, cataracts, and polycystic kidney disease in infants. The cause of psoriasis in this case is probably pregnancy.Keywords: pustularis psoriais, psoriasis, pregnancy, corticosteroid
PERBEDAAN RERATA KADAR AKTIVIN A SERUM MATERNAL ANTARA PREEKLAMSIA BERAT DENGAN BUKAN PREEKLAMSIA BERAT Djanas, Dovy; Ariwibowo, Bayu Pramudyo; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 1 No. 1 (2017)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.1.1.30-37.2017

Abstract

At the start of preelampsia there is a failure of cytotrophoblst invasion into the maternal spiral arteries that will lead to decreased uteroplacetal perfusion which will be followed by the failure of the unit fetoplacenter to get enough oxygen from the room intervillous that ultimately lead to a state of hypoxia in placenta. This will cause the expenditure of TNF-α dan IL-1β from placenta and a factors called hypoxia-inducible transcription factors that will spur the trophoblast to produce activin A lot more. This research was conducted by cross sectional method in maternal room of obstetrics and gynecology department of Central General Hospital of Dr. M. Djamil Padang from August 2015 until February 2016 with 20 patients of severe preeclampsia and 20 patients not severe preeclampsia, who met inclusion criteria and there is no exclusion criteria. Then performed statistical analysis using Mann-Whitney test to determine difference in mean maternal activin A serum levels of severe preeclampsia and not severe preeclampsia. The mean maternal serum levels of activin A in severe preeclampsia is 32,55 ± 1,84 ng/ml and in pregnancy with no severe preeclampsia is 8,59 ± 0,59 ng/ ml. Difference in mean maternal serum level of activin A in the two groups was statistically significant (p=0,001). Ma-ternal serum activin A levels is significantly higher in severe preeclampsia than pregnancy with no severe preeclampsia.Keywords: Activin A, severe preeclampsia, not severe preeclampsia
HUBUNGAN LAMANYA PEMBERIAN MAGNESIUM SULFATE PADA PASIEN PEB DAN EKLAMPSIA DENGAN KEJADIAN HIPERMAGNESIUM DI RSUP DR. M. DJAMIL PADANG Mayuliani, Mayuliani; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.1.21-25.2018

Abstract

Objective :To find out the relationship between the duration of MgS04 administration in severe preeclampsia patients and eclampsia with the incidence of hypermagnesium.Method :This study is a comparative observational study using a cross sectional study design. The study was conducted in the medical record of Dr.M.Djamil Padang Hospital during the period January 1, 2016 to August 31, 2017 of pregnant women with severe preeclampsia and eclampsia, found 30 study subjects who met the inclusion criteria. Furthermore, data is recorded in a research form that has been provided, then carried out research data processing. Statistical analysis to assess significance using the chi-square test.Results : Magnesium levels increased in pregnant women with severe preeclampsia and eclampsia by 21 correspondents. Increased Magnesium levels in patients with severe preeclampsia and eclampsia who received MgS04 treatment for 48 hours by 16 correspondents (84.2%) and 5 correspondents with MgS04 administration for 24 hours.Conclusion : There is a significant relationship between the duration of Magnesium Sulfate with the incidence of hyperpermagnesium in patients with severe preeclampsia and eclampsia. Keywords: severe preeclampsia, eclampsia, magnesium sulfate, magnesium levels
Diagnostic Value of Cyclooxygenase-2 Serum Levels in Predicting Preterm Labor Suhandri, Wiwin; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol 4, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.1.28-34.2020

Abstract

Objective: To determine the value of serum cyclooxygenase 2 in predicting preterm laborMethod: Examination of serum COX-2 levels by ELISA method in pregnant women with 28 weeks to 36 weeks of pregnancy compared with pregnant women with ≥37 weeks of gestation at the time of first stage of active phaseResults: It is known that the average COX-2 level in preterm labor is 21.88 ± 18.22 higher than in term labor which is 4.88 ± 2.35 ng / ml, the statistical test results obtained p = <0.001 serum Cyclooxygenase 2 at preterm deliveries and term deliveries. The value of serum cyclooxygenase 2 levels in predicting preterm labor is at a cut point of 7.0.0 ng / ml with a sensitivity of 86.1% and a specificity of 86.1%Conclusion: There were significant differences in serum cyclooxygenase 2 levels in preterm labor and term delivery Keywords: cyclooxygenase 2, memprediksi persalinan preterm, persalinan preterm.
The Mean Difference of Hemostatic Factors in Severe Preeclampsia and Eclampsia Setia, Dyhan Purna; Ferry, Ferdinal; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol 4, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.1.22-27.2020

Abstract

The aim of this study was to see the difference in the mean ratio of sodium levels between pregnancy with severe preeclampsia and eclampsia. The method in this research is an analytical study using a cross sectional design. The research was conducted in the delivery room Dr. M. Djamil Padang from 15 January 2016 to 31 December 2017. There were 60 patients as research subjects, the sample was divided into 2 groups, namely severe preeclampsia (PEB) and eclampsia. Anamnesis and physical examination were then carried out to obtain data and clinical diagnosis. The data were recorded in a research form that had been provided, then the blood electrolytes were examined for sodium and potassium. Statistical analysis to assess meaning using the T-test. The results showed that in the PEB and Eclampsia groups, it was found that multiparity parity had the highest respondents. This is in accordance with the literature where the incidence of preeclampsia is more often found at gestational age near term. The conclusion of this study there was no significant difference in the mean sodium ratio between preeclampsia, PEB and eclampsia. Keywords: pregnancy condition, PEB, eclampsia, platelet, PT, APTT, and D-Dimer
Perbedaan Rerata Rasio Kadar Natrium Kalium Maternal Antara Preeklamsia Berat Dan Eklamsia Syaputra, Gunawan Efri; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol 4, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.1.48-52.2020

Abstract

Background: Preeclampsia is a pregnancy-specific syndrome in the form of reduced organ perfusion due to vasospasm and endothelial activation that occurs after 20 weeks of gestational age. eclampsia is the occurrence of seizures in a woman with preeclampsia, Sodium (Na +) and Potassium (K +) play an important role in preeclampsia and eclampsia.Objective: To see the difference in mean sodium potassium ratio between pregnancy with severe preeclampsia and eclampsia.Methods: The study was analytic descriptive using a cross sectional study design by looking at the medical records of the subjects according to the time and place of the study. Samples are all medical records of pregnant women who suffer from pre-eclampsia and eclampsia in the obstetric and gynecology section of  RSUP DR.M.Djamil padang in the period of 15 January 2016 to 31 December 2017, the values of which are sodium, potassium levels and sodium and potassium ratios. Samples were taken from populations that met the inclusion criteria and did not have exclusion criteria. Sampling using a consecuvite sampling technique which was taken from the medical records of RSUP DR. M. Djamil Padang Statistical analysis to assess significance using the T-test.Results: In the Severe preeclampsia and Eclampsia groups it was found that multipara parity had the highest respondents. This is in accordance with the literature where the incidence of preeclampsia is more often found at near term gestational age.Conclusion: There is no significant difference in the average sodium potassium ratio between Severe preeclampsia and EclampsiaKeywords: Severe preeclampsia, eclampsia, sodium and potassium
Co-Authors Andani Eka Putra Ariwibowo, Bayu Pramudyo Efri, Gunawan Farnas, Heri Fauzan . Ferry, Ferdinal Fitriansyah, Irwin Hafni Bachtiar Marni, Herti Mayuliani, Mayuliani Mila Permata Sari Purnomo, Satrio Budhi Setia, Dyhan Purna Sriyanti, Roza Suhandri, Wiwin Sulin, Djusar Syaputra, Gunawan Efri Syntia Ambelina Utama, Try Genta Wulandari, Wira Dhika Tri