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All Journal JURNAL PENDIDIKAN TAMBUSAI Andalas obstetrics and gynecology journal
Djanas, Dovy
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health Social Sciences

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Karakteristik Responden, Faktor Klinis, dan Laboratorium dengan Luaran Pasien Ibu Hamil dengan Covid-19 Sriyanti, Roza; Djanas, Dovy; Fauzan, Fauzan; Wulandari, Wira Dhika Tri
Jurnal Pendidikan Tambusai Vol. 9 No. 1 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

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Abstract

Pandemi Coronavirus Disease 2019 (COVID-19) telah menjadi krisis kesehatan global yang signifikan. Kehamilan dapat meningkatkan kerentanan terhadap infeksi SARS-CoV-2 dan berpotensi memperburuk manifestasi klinis dan luaran infeksi COVID-19. Penelitian ini bertujuan untuk menganalisis hubungan antara karakteristik maternal (usia ibu, usia gestasi, gravida, dan indeks massa tubuh), faktor klinis (jumlah gejala dan komorbiditas), serta parameter laboratorium dengan luaran ibu hamil dengan COVID-19. Penelitian analitik observasional dengan desain kohort retrospektif ini dilakukan di RSUP Dr. M. Djamil Padang selama periode Maret 2020 hingga Maret 2021. Hasil penelitian menunjukkan bahwa faktor-faktor yang berhubungan dengan luaran buruk pada ibu hamil dengan COVID-19 antara lain status gravida yang lebih tinggi (P=<0.001), jumlah gejala yang semakin banyak (P=<0.001), serta parameter laboratorium seperti hemoglobin (P=0.015), hematokrit (P=0.002), eosinofil (P=0.008), neutrofil segmen (P=0.001), SGPT (P=0.001), dan ureum (P=0.001). Selain itu, skor APGAR bayi yang rendah juga terkait dengan prognosis ibu yang lebih buruk (P=0.035). Temuan ini menekankan pentingnya pemantauan terhadap tanda-tanda klinis dan perubahan laboratoris untuk mengidentifikasi risiko komplikasi dan luaran pada ibu hamil dengan COVID-19.
The Efficacy of Dequalinium Chloride Against Vulvovaginitis in Pregnancy Mila Permata Sari; Djanas, Dovy; Putra, Andani Eka
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.49-62.2025

Abstract

Introduction: Vulvovaginitis affects pregnancy outcomes and managing it involves the use of metronidazole or nystatin, which can cause local or systemic side effects. Dequalinium chloride (DQC) is suggested as a new treatment option for vulvovaginitis during pregnancy with minimal side effects. Objective: To compare the effectiveness of dequalinium chloride (DQC) versus metronidazole + nystatin (MN) in treating vulvovaginitis in pregnant women during their second and third trimesters. Method: A single-blind randomized controlled trial was conducted at the Andalas Public Health Center, Padang, from January to May 2024. Pregnant women in their second and third trimesters, meeting the inclusion and exclusion criteria, were enrolled. The participants were randomly assigned to either the DQC or MN group. Vaginal swabs were taken before and after a 6-day treatment, and PCR analysis was performed. Results: Eighteen patients were treated with DQC and MN. Most participants had bacterial vaginosis (DQC 78%, MN 83%), with half having candidiasis (DQC and MN 50%) and fewer cases of trichomoniasis (28% in both groups). Significant improvements were seen in the DQC group for symptoms (p=0.000), Gardnerella vaginalis (p=0.035), and Candida albicans (p=0.021). In the MN group, significant improvements were noted for symptoms (p=0.000) and Gardnerella vaginalis (p=0.002). No significant differences were observed between the groups for symptom resolution or microbial reduction. Conclusion: DQC is as effective as metronidazole + nystatin in treating bacterial vaginosis and candidiasis in pregnancy. Keywords: Vulvovaginitis, pregnancy, dequalinium chloride, metronidazole, nystatin
PERBEDAAN RERATA FAKTOR HEMOSTASIS PADA PREEKLAMPSIA BERAT DAN EKLAMPSIA Setia, Dyhan Purna; Ferry, Ferdinal; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.1.10-15.2018

Abstract

Objective : To find the difference in mean hemostatic factors in severe preeclampsia and eclampsia.Method : The study was analytic descriptive using a cross sectional study design by looking at the subject's Medical Record according to the time and place of research. The sample is the entire medical record of pregnant women who suffer from preeclampsia and eclampsia in the obstetric and gynecology departments of Dr. M. Djamil Padang Hospital in the period 15 January 2016 to 31 December 2017. The assessment was in the form of assessed platelet levels, PT, APTT and D-Dimer. Samples were taken from populations that met the inclusion criteria and did not have exclusion criteria. Sampling using consecutive sampling techniques taken from the Medical Record Dr. M.Djamil Padang. Statistical analysis to assess significance using the T-Test.Result : The severity the condition of pregnancy the lower the platelet mean and PT. Significant differences were obtained between platelets in PEB and eclampsia (p> 0.05). The mean PT, APTT and D-Dimer showed no significant differences in pregnancy conditions. Statistical test with T-Test did not show significant differences in mean PT, APTT, and D-dimer between eclampsia and PEB (p> 0.05).Conclusion : There were significant differences in mean in platelets, whereas in PT, APTT, and D-dimers in PEB and eclampsia there were no significant differences.Keywords: Pregnancy, severe preeclampsia, eclampsia, platelets, PT, APTT, D-Dimer.
PERBEDAAN RERATA KADAR NATRIUM MATERNAL ANTARA PREEKLAMPSIA BERAT DAN EKLAMPSIA DI RSUP DR. M. DJAMIL PADANG Efri, Gunawan; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.1.16-20.2018

Abstract

Objective: To determine the difference in mean ratio of sodium content between pregnancy with severe preeclampsia and eclampsia.Method: This is an analytical study using a cross sectional study design. The study was conducted inMaternity room of Dr. M. Djamil Padang from January 15th, 2016 to December 31st, 2017, there were 60 patients as subjects, the sample was divided into 2 groups: severe preeclampsia and eclampsia. Furthermore, history and physical examination to obtain data and clinical diagnosis. Data is recorded in a research form that has been provided, then performed blood electrolytes of Sodium and Potassium. Statistical analysis to assess significance using T-test.Results: In the severe preeclampsia and eclampsia, multiparous parity had the highest respondent. This is consistent with the literature in which the incidence of preeclampsia is more common in late pregnancy.Conclusions: There was no significant difference in the mean sodium ratio between normal severe preeclampsia pregnancy and normal pregnancy.Keywords: pregnancy condition, severe preeclampsia, eclampsia, and sodium.
PSORIASIS PUSTULARIS DALAM KEHAMILAN Djanas, Dovy; Sulin, Djusar
Andalas Obstetrics And Gynecology Journal Vol. 1 No. 2 (2017)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.1.2.86-92.2017

Abstract

Psoriasis is a residual chronic inflammatory skin disease, characterized by a predominance of pustular eruptions accompanied by systemic symptoms such as fever lasting several days. . Psoriasis in pregnancy can lead to spontaneous abortion, stillbirth and preterm birth. Reported the case of Mrs. YS 38 years old, received from the genital skin section of RS M Djamil Padang with a diagnosis of G3P2A0H2 + pustular psoriasis. Fetomaternal ultrasound was performed, obtained biometrics: BPD: 80mm, FL: 61 mm, HL: 54 mm, AC 271 mm, AFI 10.7 cm, SDAU 2.79, estimated fetal weight 1700-1800 grams. Impression: gravid 31-32 weeks, single live fetus intra uterine. Patients are planned for administration of high doses of corticosteroids. Informed consent to the patient and family about the actions to be performed. Corticosteroid was administered as much as 30 mg long term with a dose of prednisone in tappering off every 2 weeks. The patient was discharged for control to the skin clinic and obstetrics, the patient came 12 days later and was consulted to the obstetrics department for termination of the pregnancy but from the obstetrics department there was no confirmation for termination of the pregnancy. The patient then came 13 days later with 18 hours PRM. Pregnancy termination by cesarean section was performed. a baby girl was born with LBW: 3000 gr, PB: 48 cm, A / S: 8/9, there were no congenital abnormalities such as growth disorders, cleft lip, cataracts, and polycystic kidney disease in infants. The cause of psoriasis in this case is probably pregnancy.Keywords: pustularis psoriais, psoriasis, pregnancy, corticosteroid
PERBEDAAN RERATA KADAR AKTIVIN A SERUM MATERNAL ANTARA PREEKLAMSIA BERAT DENGAN BUKAN PREEKLAMSIA BERAT Djanas, Dovy; Ariwibowo, Bayu Pramudyo; Bachtiar, Hafni
Andalas Obstetrics And Gynecology Journal Vol. 1 No. 1 (2017)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.1.1.30-37.2017

Abstract

At the start of preelampsia there is a failure of cytotrophoblst invasion into the maternal spiral arteries that will lead to decreased uteroplacetal perfusion which will be followed by the failure of the unit fetoplacenter to get enough oxygen from the room intervillous that ultimately lead to a state of hypoxia in placenta. This will cause the expenditure of TNF-α dan IL-1β from placenta and a factors called hypoxia-inducible transcription factors that will spur the trophoblast to produce activin A lot more. This research was conducted by cross sectional method in maternal room of obstetrics and gynecology department of Central General Hospital of Dr. M. Djamil Padang from August 2015 until February 2016 with 20 patients of severe preeclampsia and 20 patients not severe preeclampsia, who met inclusion criteria and there is no exclusion criteria. Then performed statistical analysis using Mann-Whitney test to determine difference in mean maternal activin A serum levels of severe preeclampsia and not severe preeclampsia. The mean maternal serum levels of activin A in severe preeclampsia is 32,55 ± 1,84 ng/ml and in pregnancy with no severe preeclampsia is 8,59 ± 0,59 ng/ ml. Difference in mean maternal serum level of activin A in the two groups was statistically significant (p=0,001). Ma-ternal serum activin A levels is significantly higher in severe preeclampsia than pregnancy with no severe preeclampsia.Keywords: Activin A, severe preeclampsia, not severe preeclampsia
Co-Authors Andani Eka Putra Ariwibowo, Bayu Pramudyo Efri, Gunawan Fauzan . Ferry, Ferdinal Hafni Bachtiar Mila Permata Sari Setia, Dyhan Purna Sriyanti, Roza Sulin, Djusar Wulandari, Wira Dhika Tri