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Trends in publication and collaboration of health-themed systematic reviews before and during the COVID-19 pandemic: A bibliometric study Chiari, Williams; Amirah, Shakira; Lemu, Yohannes K.; Subbaram, Kannan; Edwards, Robert J.; Kretchy, James-Paul; Vento, Sandro; Khader, Yousef; Rademaker, Marius
Narra X Vol. 2 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i1.106

The presence of global threats such as coronavirus disease 2019 (COVID-19) pandemic could potentially affect the research landscape, particularly that of systematic reviews. The aim of this study was to examine disparities between countries and the role of funding availability in the publication of health-themed systematic reviews. Metadata of published literature was collected from the Scopus database as of June 30, 2023. The dataset was divided into ‘pre-COVID-19 (2017–2019)’ and ‘during COVID-19 (2020–2022)’ by utilizing filter feature of the Scopus search engine. Network visualization of co-authorship was carried out on VoSviewer to identify collaborative patterns between countries. Our results suggest that most of the systematic reviews were published by authors from the United States of America (USA), both in pre-COVID-19 (n=29,463; Total link strength, TLS=32,832) and during COVID-19 (n=35,520; TLS=45,616). During COVID-19, the trend was not much different with the USA (14.6%), the UK (8.8%), and Australia (5%) in the top position among high-income countries. China (12.3%) and Iran (2.4%) topped the upper-middle-income and low-income countries groups. Publications by those who were from low-income countries were in a concerning low number; Ethiopia ranked first in this group only occupied 0.4% of the total publications (n=1,047). Furthermore, the number of publications was proportional to the number of funded studies (as observed in the top countries). However, during COVID-19 pandemic, the proportionality between funded publications and total publications was observed less. Taken altogether, our findings stress the importance of capacity building and providing more funds for on-desk research to close the disparity among countries.

Monkeypox: Immune response, vaccination and preventive efforts Ophinni, Youdiil; Frediansyah, Andri; Sirinam, Salin; Megawati, Dewi; Stoian, Ana M.; Enitan, Seyi S.; Akele, Richard Y.; Sah, Ranjit; Pongpirul, Krit; Abdeen, Ziad; Aghayeva, Sevda; Ikram, Aamer; Kebede, Yohannes; Wollina, Uwe; Subbaram, Kannan; Koyanagi, Ai; Al Serouri, Abdulwahed; Nguendo-Yongsi, H. Blaise; Edwards, Jeffrey; Sallam, Dina E.; Khader, Yousef; Viveiros-Rosa, Sandro G.; Memish, Ziad A.; Amir-Behghadami, Mehrdad; Vento, Sandro; Rademaker, Marius; Sallam, Malik
Narra J Vol. 2 No. 3 (2022): December 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i3.90

Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a self-limited disease, patients can suffer from extremely painful skin lesions and complications can occur with reported mortalities. The antigenic similarity between the smallpox virus (variola virus) and monkeypox virus can be utilized to prevent monkeypox using smallpox vaccines; treatment is also based on antivirals initially designed to treat smallpox. However, further studies are needed to fully decipher the immune response to monkeypox virus and the immune evasion mechanisms. In this review we provide an up-to-date discussion of the current state of knowledge regarding monkeypox virus with a special focus on innate immune response, immune evasion mechanisms and vaccination against the virus.

Emerging Developments on Pathogenicity, Molecular Virulence, Epidemiology and Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Subbaram, Kannan; Kannan, Hemalatha; Gatasheh, Mansour Khalil
HAYATI Journal of Biosciences Vol. 24 No. 2 (2017): April 2017
Publisher : Bogor Agricultural University, Indonesia

Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently reported virus that is associated with severe, life threatening and rapidly spreading primarily respiratory illness called the Middle East respiratory syndrome. MERS-CoV possesses a unique positive-sense single-stranded RNA and can undergo rapid mutation in the viral genome. This results in antigenic switching and genetic variation, finally leading to the emergence of novel and new MERS-CoV subtypes which are uncontrollable by vaccines. Researchers are also finding difficulties to sort out therapeutic intervention strategies for MERS-CoV. This virus can spread from human to human, but transmission from dromedary camels to humans plays a crucial epidemiological significance. Dromedary camel acts as “gene mixing vessels” for MERS-CoV and these virus particles undergo rapid change in them. Viral receptors called dipeptidyl peptidase-4 are important receptors for attachment and spread of MERS-CoV in humans. The current method of laboratory confirmation is through real-time polymerase chain reaction on bronchoalveolar lavage, sputum and tracheal aspirates. Unfortunately, till today there are no definite anti-viral drugs available for MERS-CoV.

Essential oils for COVID-19 management: A systematic review of randomized controlled trials Duta, Teuku F.; Rizki, Diva R.; Purnama , Agnia; Rademaker, Marius; Wollina, Uwe; Acharya, Yogesh; Abdeen, Ziad; Rosa, Sandro G. V.; Nielsen, Henning B.; Subbaram, Kannan
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.84

Essential oils can be a beneficial adjuvant therapy in managing coronavirus disease 2019 (COVID-19). This systematic review aims to evaluate the efficacy of essential oils in ameliorative COVID-19-related symptoms. Published studies reporting the efficacy of essential oils as adjuvant therapy for COVID-19 were screened on Scillit, Scopus, SciFinder, and PubMed (December 7th, 2022). Inclusion criteria include the randomized controlled trials (RCTs) participated by those diagnosed with COVID-19 and treated with essential oils as adjuvant therapy. Quality assessment was carried out using Cochrane ‘risk-of-bias’ 2.0 tool. A total of 2112 records were retrieved from the initial screening, which was reduced to four publications (n=344 individuals). The foregoing studies reported that essential oils could improve the recovery rate, alleviate post-COVID-19 fatigue, and prevent disease progression. Regarding their potential antiviral activity, better designed studies are needed. In conclusion, essential oils as adjuvant therapy are beneficial in ameliorating mild COVID-19 symptoms.

Trends in publication and collaboration of health-themed systematic reviews before and during the COVID-19 pandemic: A bibliometric study Chiari, Williams; Amirah, Shakira; Lemu, Yohannes K.; Subbaram, Kannan; Edwards, Robert J.; Kretchy, James-Paul; Vento, Sandro; Khader, Yousef; Rademaker, Marius
Narra X Vol. 2 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i1.106

The presence of global threats such as coronavirus disease 2019 (COVID-19) pandemic could potentially affect the research landscape, particularly that of systematic reviews. The aim of this study was to examine disparities between countries and the role of funding availability in the publication of health-themed systematic reviews. Metadata of published literature was collected from the Scopus database as of June 30, 2023. The dataset was divided into ‘pre-COVID-19 (2017–2019)’ and ‘during COVID-19 (2020–2022)’ by utilizing filter feature of the Scopus search engine. Network visualization of co-authorship was carried out on VoSviewer to identify collaborative patterns between countries. Our results suggest that most of the systematic reviews were published by authors from the United States of America (USA), both in pre-COVID-19 (n=29,463; Total link strength, TLS=32,832) and during COVID-19 (n=35,520; TLS=45,616). During COVID-19, the trend was not much different with the USA (14.6%), the UK (8.8%), and Australia (5%) in the top position among high-income countries. China (12.3%) and Iran (2.4%) topped the upper-middle-income and low-income countries groups. Publications by those who were from low-income countries were in a concerning low number; Ethiopia ranked first in this group only occupied 0.4% of the total publications (n=1,047). Furthermore, the number of publications was proportional to the number of funded studies (as observed in the top countries). However, during COVID-19 pandemic, the proportionality between funded publications and total publications was observed less. Taken altogether, our findings stress the importance of capacity building and providing more funds for on-desk research to close the disparity among countries.

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