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All Journal JAM : Jurnal Aplikasi Manajemen WMJ (Warmadewa Medical Journal) Inovator : Jurnal Manajemen MONETER Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Jurnal Peduli Masyarakat Narra J Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pijar : Studi Manajemen dan Bisnis Manager : Jurnal Ilmu manajemen
Anak Agung Dewi Megawati, Anak Agung Dewi
Universitas Warmadewa
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Other

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Potensi Penggunaan Materi Genetik Fetus pada Sirkulasi Maternal untuk Diagnosis Prenatal Noninvasif Penyakit Genetik Megawati, Anak Agung Dewi; Nainggolan, Ita M.; Mahendra, Agung Nova; Marzuki, Nanis S.
WMJ (Warmadewa Medical Journal) Vol 1, No 1 (2016):
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diagnosis prenatal adalah teknik diagnostik untuk menentukan kondisi fetus yang belum lahir apakah memiliki kelainan genetik ataupun kelainan lainnya. Teknik ini umumnya dilakukan pada penyakit genetik yang tidak dapat diobati di mana terminasi menjadi bahan pertimbangan. Teknik ini juga dilakukan pada kasus yang memerlukan penanganan segera pada saat prenatal dan pada kondisi yang dapat menimbulkan morbiditas atau mortalitas pada ibu. Diagnosis prenatal dapat dilakukan melalui metode invasif dan noninvasif. Metode invasif seperti amniocentesis dan biopsi villi korialis (CVS) memiliki resiko menimbulkan kecacatan bahkan kematian fetus. Pendekatan nonivasif melalui ultrasonografi belum cukup akurat untuk diagnosis penyakit genetik, sehingga masih memerlukan pengambilan sampel fetus untuk menegakkan diagnosis. Pendekatan terbaru pengambilan sampel fetus secara noninvasif dilakukan melalui pengambilan sel fetus, DNA dan mRNA fetus yang terdapat dalam sirkulasi darah maternal. Pada artikel ini dipaparkan mengenai perkembangan riset, kendala, serta potensi aplikasi klinis ketiga metode pengambilan sampel fetus tersebut. Kata kunci: diagnosis prenatal nonivasif, penyakit genetik, cell-free fetal DNA/mRNA, sel fetus  [Potential Use of Fetal Genetic Material in Maternal Circulation for Prenatal Noninvasive Diagnosis of Genetic Disease] Prenatal diagnostic technique is used to determine whether the unborn fetus is affected with a genetic disorder or other abnormality. This technique is generally carried out for a genetic disease that is not treatable, in which the termination should be considered. This technique is also performed in cases that require immediate action during the prenatal period and in conditions that can lead to morbidity or mortality of the mother. Prenatal diagnosis can be done by invasive and noninvasive methods. Invasive methods such as amniocentesis and chorionic villus sampling (CVS) have a risk of causing disability and even death of the fetus. While noninvasive approach by ultrasound is not sufficiently accurate for the diagnosis of genetic diseases, therefore further  fetal sampling is required. Noninvasive prenatal diagnosis is a new type of genetic testing done through taking fetal cells, fetal DNA and mRNA, which are found in maternal blood circulation. In this review, we present development of research, constraints, and potential clinical applications of these three methods for noninvasive sampling of the fetus. Keywords: noninvasive prenatal diagnosis, genetic disease, cell-free fetal DNA/mRNA, fetal cell
Potensi Penggunaan Materi Genetik Fetus pada Sirkulasi Maternal untuk Diagnosis Prenatal Noninvasif Penyakit Genetik Anak Agung Dewi Megawati; Ita M. Nainggolan; Agung Nova Mahendra; Nanis S. Marzuki
WMJ (Warmadewa Medical Journal) Vol 1 No 1 (2016): Mei 2016
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.1.1.4.1-9

Abstract

Diagnosis prenatal adalah teknik diagnostik untuk menentukan kondisi fetus yang belum lahir apakah memiliki kelainan genetik ataupun kelainan lainnya. Teknik ini umumnya dilakukan pada penyakit genetik yang tidak dapat diobati di mana terminasi menjadi bahan pertimbangan. Teknik ini juga dilakukan pada kasus yang memerlukan penanganan segera pada saat prenatal dan pada kondisi yang dapat menimbulkan morbiditas atau mortalitas pada ibu. Diagnosis prenatal dapat dilakukan melalui metode invasif dan noninvasif. Metode invasif seperti amniocentesis dan biopsi villi korialis (CVS) memiliki resiko menimbulkan kecacatan bahkan kematian fetus. Pendekatan nonivasif melalui ultrasonografi belum cukup akurat untuk diagnosis penyakit genetik, sehingga masih memerlukan pengambilan sampel fetus untuk menegakkan diagnosis. Pendekatan terbaru pengambilan sampel fetus secara noninvasif dilakukan melalui pengambilan sel fetus, DNA dan mRNA fetus yang terdapat dalam sirkulasi darah maternal. Pada artikel ini dipaparkan mengenai perkembangan riset, kendala, serta potensi aplikasi klinis ketiga metode pengambilan sampel fetus tersebut.Kata kunci: diagnosis prenatal nonivasif, penyakit genetik, cell-free fetal DNA/mRNA, sel fetus.  [Potential Use of Fetal Genetic Material in Maternal Circulation for Prenatal Noninvasive Diagnosis of Genetic Disease].Prenatal diagnostic technique is used to determine whether the unborn fetus is affected with a genetic disorder or other abnormality. This technique is generally carried out for a genetic disease that is not treatable, in which the termination should be considered. This technique is also performed in cases that require immediate action during the prenatal period and in conditions that can lead to morbidity or mortality of the mother. Prenatal diagnosis can be done by invasive and noninvasive methods. Invasive methods such as amniocentesis and chorionic villus sampling (CVS) have a risk of causing disability and even death of the fetus. While noninvasive approach by ultrasound is not sufficiently accurate for the diagnosis of genetic diseases, therefore further  fetal sampling is required. Noninvasive prenatal diagnosis is a new type of genetic testing done through taking fetal cells, fetal DNA and mRNA, which are found in maternal blood circulation. In this review, we present development of research, constraints, and potential clinical applications of these three methods for noninvasive sampling of the fetus.Keywords: noninvasive prenatal diagnosis, genetic disease, cell-free fetal DNA/mRNA, fetal cell.
MODEL PENGEMBANGAN KREATIVITAS DAN INOVASI DALAM ERA EKONOMI DIGITAL (STUDI KASUS L.FASHION.ID) Lia, Neneng; Agung, Syahrum; Megawati, Dewi
Jurnal Pijar Vol 2 No 4 (2024): Jurnal Pijar : Studi Manajemen dan Bisnis
Publisher : PT Naureen Digital Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65096/pmb.v2i4.1537

Abstract

The development of the business world demands effective human resource management. However, the high unemployment rate in Indonesia highlights the need to foster creativity and innovation to create new job opportunities, especially in the digital economy era, which enables promising online business opportunities. The purpose of this research is to understand how planning models for the development of creativity and innovation can be applied in the digital economy era. The research method used is descriptive quantitative research. The population in this study consists of actors in L.Fashion.Id (resellers and customers), totaling 78 individuals. Data analysis was conducted using multiple linear regression analysis. The results of the study indicate that creativity and innovation have a significant impact on the digital economy. Additionally, the digital economy in L.Fashion.Id has increased sales volume over the past three years.
Decline of notified dengue infections in Indonesia in 2017: Discussion of the possible determinants Dhewantara, Pandji Wibawa; Jamil, Kurnia F.; Fajar, Jonny Karunia; Saktianggi, Panji Probo; Nusa, Roy; Garjito , Triwibowo Ambar; Anwar, Samsul; Firzan, Firzan; Megawati , Dewi; Sasmono, R. Tedjo; Mudatsir, Mudatsir
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.23

Abstract

This study was conducted to quantify the trend in dengue notifications in the country in 2017 and to explore the possible determinants. Annual nation-wide dengue notification data were obtained from the National Disease Surveillance of Ministry of Health of Indonesia. Annual incidence rate (IR) and case fatality rate (CFR) in 2017 and the previous years were quantified and compared. Correlations between annual larva free index (LFI), implementation coverage of integrated vector management (IVM), El Niño Southern Oscillation (Niño3.4), Dipole Mode Index (DMI), Zika virus seropositivity and the percent change in IR and CFR of dengue were examined. The change of dengue IR and CFRs were mapped. In 2017, dengue IR was declined by 71% (22.55 per 100,000 population) compared to 2016 (77.96 per 100,000 population) while the CFR was slightly reduced from 0.79% to 0.75%. Reduction in IR and CFR occurred in 94.1% and 70.1% out of 34 provinces, respectively. The trend of dengue IR seems to be influenced by Niño3.4 but there is no clear evidence that Niño3.4 is the main reason for dengue reduction in 2017. It is difficult to elucidate that the reduction of dengue in 2017 was associated with previous Zika outbreaks. In conclusion, there was a significant reduction on dengue notifications in Indonesia in 2017. Further investigation is needed to look at the role of climate on the decline of dengue IR at finer temporal scale. In addition, study on the role of cross-protective immunity generated by Zika infection on dengue incidence is also warranted.
Acute severe hepatitis of unknown etiology in children: A mini-review Frediansyah, Andri; Sallam, Malik; Yufika, Amanda; Sharun, Khan; Iqhrammullah, Muhammad; Chandran, Deepak; Mamada, Sukamto S.; Sallam, Dina E.; Khader, Yousef; Lemu, Yohannes K.; Yusuf, Fauzi; Kretchy, James-Paul; Abdeen, Ziad; Torres-Roman, J. Smith; Acharya, Yogesh; Bondarenko, Anastasia; Ikram, Aamer; Jamil, Kurnia F.; Kotfis, Katarzyna; Koyanagi, Ai; Smith, Lee; Megawati, Dewi; Rademaker, Marius; Emran, Talha B.; Memish, Ziad A.; Vento, Sandro; Nainu, Firzan; Harapan, Harapan
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.83

Abstract

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA–E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
Monkeypox: Immune response, vaccination and preventive efforts Ophinni, Youdiil; Frediansyah, Andri; Sirinam, Salin; Megawati, Dewi; Stoian, Ana M.; Enitan, Seyi S.; Akele, Richard Y.; Sah, Ranjit; Pongpirul, Krit; Abdeen, Ziad; Aghayeva, Sevda; Ikram, Aamer; Kebede, Yohannes; Wollina, Uwe; Subbaram, Kannan; Koyanagi, Ai; Al Serouri, Abdulwahed; Nguendo-Yongsi, H. Blaise; Edwards, Jeffrey; Sallam, Dina E.; Khader, Yousef; Viveiros-Rosa, Sandro G.; Memish, Ziad A.; Amir-Behghadami, Mehrdad; Vento, Sandro; Rademaker, Marius; Sallam, Malik
Narra J Vol. 2 No. 3 (2022): December 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i3.90

Abstract

Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a self-limited disease, patients can suffer from extremely painful skin lesions and complications can occur with reported mortalities. The antigenic similarity between the smallpox virus (variola virus) and monkeypox virus can be utilized to prevent monkeypox using smallpox vaccines; treatment is also based on antivirals initially designed to treat smallpox. However, further studies are needed to fully decipher the immune response to monkeypox virus and the immune evasion mechanisms. In this review we provide an up-to-date discussion of the current state of knowledge regarding monkeypox virus with a special focus on innate immune response, immune evasion mechanisms and vaccination against the virus.
A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19 Sharun, Khan; Tiwari, Ruchi; Yatoo, Mohd I.; Natesan, Senthilkumar; Megawati, Dewi; Singh, Karam P.; Michalak, Izabela; Dhama, Kuldeep
Narra J Vol. 2 No. 3 (2022): December 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i3.92

Abstract

The emergence of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected many countries throughout the world. As urgency is a necessity, most efforts have focused on identifying small molecule drugs that can be repurposed for use as anti-SARS-CoV-2 agents. Although several drug candidates have been identified using in silico method and in vitro studies, most of these drugs require the support of in vivo data before they can be considered for clinical trials. Several drugs are considered promising therapeutic agents for COVID-19. In addition to the direct-acting antiviral drugs, supportive therapies including traditional Chinese medicine, immunotherapies, immunomodulators, and nutritional therapy could contribute a major role in treating COVID-19 patients. Some of these drugs have already been included in the treatment guidelines, recommendations, and standard operating procedures. In this article, we comprehensively review the approved and potential therapeutic drugs, immune cells-based therapies, immunomodulatory agents/drugs, herbs and plant metabolites, nutritional and dietary for COVID-19.
Pengaruh Kualitas Pelayanan dan Citra Merek Terhadap Keputusan Pembelian Pizza Hut Kuraesin, Ecin; Eldine, Achyar; Megawati, Dewi; Khofifah, Safna
INOVATOR Vol 10 No 1 (2021): MARET
Publisher : prodima@fe.uika-bogor.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/inovator.v10i1.17639

Abstract

Motivasi di balik penelitian ini adalah untuk memutuskan dampak kualitas administrasi dan citra merek terhadap pilihan pembelian Pizza Cabin (Analisis Kontekstual di Pusat Perbelanjaan Pizza Cottage Yogya Bogor) baik secara bersamaan maupun secara bersamaan. Strategi yang digunakan adalah teknik kuantitatif. Strategi pengujian yang digunakan adalah dengan memanfaatkan persamaan Slovin dan mendapatkan sampel sebanyak 100 responden. Pemeriksaan informasi menggunakan uji legitimasi, uji ketergantungan, uji praduga gaya lama, investigasi relaps, investigasi koefisien kepastian dan uji spekulasi. Efek samping dari penelitian ini adalah sifat administrasi berpengaruh signifikan terhadap pilihan pembelian dengan kondisi relaps Y = 15,575 + 0,610X1, koefisien jaminan sebesar 44,9%. Uji spekulasi didapatkan t numbercrunching > t table atau (8,929 > 1,984). Dengan cara ini H0 dihilangkan dan H1 diakui, yang berarti bahwa ada pengaruh besar antara kualitas administrasi pada pilihan pembelian. Citra merek berpengaruh signifikan terhadap pilihan pembelian dengan kondisi relaps Y = 13,801 + 0,655X2 koefisien jaminan sebesar 45,3%. Uji spekulasi didapatkan t number-crunching > t table atau (9,014 > 1,984). Dengan cara ini, H0 ditolak dan H2 diakui, yang menyiratkan bahwa ada dampak besar antara Gambar Merek terhadap pilihan pembelian. Kualitas administrasi dan citra merek berpengaruh signifikan terhadap pilihan pembelian dengan kondisi relaps Y = 9,395 + 0,369X1 + 0,403X2. Nilai koefisien assurance sebesar 55,0% sedangkan kelebihan 45,0% dipengaruhi oleh variabel yang berbeda. Pengujian teori diperoleh nilai F yang ditentukan > F tabel atau (59.311 > 2.700). Sepanjang garis ini H0 diberhentikan dan H3 diakui. Hal ini menunjukkan bahwa terdapat pengaruh besar yang sinkron antara kualitas administrasi dan citra merek terhadap pilihan pembelian Pizza Cabin (Investigasi Kontekstual pada Pusat Perbelanjaan Pizza Cottage Yogya Bogor).
The Influence of Leadership and Conflict on Employee Performance Firdaus, Muhammad Aziz; Rinda, Rachmatulaily Tinakartika; Megawati, Dewi; Rahmawati, Rika
INOVATOR Vol 13 No 1 (2024): MARET
Publisher : prodima@fe.uika-bogor.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/inovator.v13i1.17661

Abstract

This research was conducted at PT Sonoco Indonesia, performance is the result of quality and quantity of work achieved by an employee in carrying out his duties in accordance with the responsibilities given to him. Performance is influenced by factors including leadership and conflict. In this study, what will be discussed is the Influence of Leadership and Conlic on Employee Performance. The population of this study is employees of PT. Sonoco Indonesia, so that the total population in this study is 150 employees. The sampling method used in this study is probability sampling based on stratified random sampling, so that a sample of 57 employees was obtained. Based on the results of the study, it can be concluded that leadership has a positive influence on employee performance, the relationship of leadership strength and conflict on employee satisfaction of PT. Sonoco Indonesia Value r = 0.822 this shows that the relationship between the variables Leadership and (X1) Conflict(X2) and Y (Performance) is very strong and positive with a determination coefficient result of 0.663 or 66.3%. The results of regression analysis Y = 4.546 +0.847 X1 + 0.047 X2 and F test Partial hypothesis with t count = 56.064 > F table = 3.17, then Ho was rejected (Ha was accepted), meaning that there was a significant influence between leadership and conflict on performance Respondents' perception of performance (Y).
Upaya Peningkatan Kesehatan Lansia dengan Senam Prolanis Hartutik, Sri; Lestari, Danis Putri; Megawati, Dewi
Jurnal Peduli Masyarakat Vol 6 No 4 (2024): Jurnal Peduli Masyarakat: Desember 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jpm.v6i4.4529

Abstract

Senam prolanis merupakan salah satu bentuk olahraga. Senam prolanis meningkatkan daya tahan paru-paru dan jantung. Peningkatan aktifitas saat senam, akan meningkatkan metabolisme dan membakar lemak, serta mencegah terjadinya penyakit kardiovaskuler seperti stroke dan penyakit jantung. Pemerintah Indonesia melalui puskesmas melakukan penanganan hipertensi dengan Program Indonesia Sehat Dengan Pendekatan Keluarga (PIS-PK) dan aktifitas fisik. Program yang saat ini sedang dilaksanakan melalui puskesmas yaitu, Program Indonesia Sehat Dengan Pendekatan Keluarga (PIS-PK) dan senam Prolanis (Program Pengelolahan Penyakit Kronis). Senam prolanis adalah bentuk latihan senam aerobik program dari pemerintah yang dijalankan oleh Badan Penyelengaraan Jaminan Sosial (BPJS). Kegiatan ini diikuti oleh 20 lansia yang dilakukan selama 4 minggu setiap hari sabtu pagi. Kegiatan dilakukan dalam bentuk penyuluhan kesehatan dan demonstrasi senam prolanis. Sebelum diberikan senam, peserta dilakukan pengukuran tekanan darah (pre test) dan setelah diberikan senam prolanis peserta dilakukan pengecekan tekanan darah (post test). Hasil Kegiatan setelah dilaksanakannya kegiatan senam prolanis, responden sudah mengerti tentang pengertian, tujuan, manfaat senam prolanis dan cara pelaksanaan senam prolanis. Kader kesehatan dapat mengaktifkan dan meneruskan program senam prolanis supaya terlaksana secara rutin setiap minggunya.
Co-Authors Abdeen, Ziad Acharya, Yogesh Aghayeva, Sevda Agung Nova Mahendra Agung Wibowo Akele, Richard Y. Al Fahrezi, Muhammad Farid Al Serouri, Abdulwahed Aliyah, Hikmatul Amir-Behghadami, Mehrdad Andri Frediansyah, Andri Bondarenko, Anastasia Chandran, Deepak Denia Maulani Dhama, Kuldeep Ecin Kuraesin Edwards, Jeffrey Eldine, Achyar Emran, Talha B. Enitan, Seyi S. Fahriah, Siti Fajar, Jonny Karunia Fauzi Yusuf, Fauzi Firdaus, Abdan Jamaludin Firdaus, Muhammad Aziz Firzan Nainu Firzan, Firzan Garjito , Triwibowo Ambar Hannisa Rahmaniar Hasnin Harapan Harapan Helma Helma Ikram, Aamer Iqhrammullah, Muhammad Ita M. Nainggolan Ita M. Nainggolan Kebede, Yohannes Khader, Yousef Khofifah, Safna Kotfis, Katarzyna Koyanagi, Ai Kretchy, James-Paul Kurnia F. Jamil Kusumah, Ajeng Bella Liani Laksana, Rangga Shalyn Pancasakti Lemu, Yohannes K. Lestari, Danis Putri Lia, Neneng Mamada, Sukamto S. Memish, Ziad A. Michalak, Izabela Mudatsir Mudatsir Muhamad Azis Firdaus Muniroh, Leny Murti, Ni Nyoman Nanis S. Marzuki Nanis S. Marzuki, Nanis S. Natesan, Senthilkumar Nguendo-Yongsi, H. Blaise Ophinni, Youdiil Pandji Wibawa Dhewantara Pasiriani, Novi Pongpirul, Krit Popy Novita Pasaribu Rachmatullaily Tinakartika Rinda Rademaker, Marius Rahmat Mulyana Dali Riany, Desmy Rika Rahmawati Rinda, Rachmatulaily Tinakartika Roy Nusa Sah, Ranjit Saktianggi, Panji Probo Sallam, Dina E. Sallam, Malik Samsul Anwar Saputra, Andika Guruh Sasmono, R. Tedjo Sharun, Khan Singh, Karam P. Sirinam, Salin Smith, Lee Sri Hartutik Stoian, Ana M. Subbaram, Kannan Sundari, Fuji Amelia Syahrum Agung Titing Suharti Tiwari, Ruchi Torres-Roman, J. Smith Vento, Sandro Viveiros-Rosa, Sandro G. Wollina, Uwe Yatoo, Mohd I. Yudiana, Yudiana Yufika, Amanda