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All Journal Majalah Farmaseutik Pharmaceutical Sciences and Research (PSR)
Siswanto, Soni
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Medicine & Pharmacology

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Association of Environmental Pollutants Exposure with Pulmonary Fibrosis: A Mini Review of Molecular Mechanism Mediated Siswanto, Soni; Wardhani, Bantari W.K.
Pharmaceutical Sciences and Research Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Pulmonary fibrosis is a specific form of chronic progressive interstitial lung disease. Deposition of extracellular matrix, mainly collagen, is the pathogenic characteristic of pulmonary fibrosis. Many reports show that environmental pollutants, particularly asbestos, silica, mercury, cadmium, and benzo(a)pyrene, are contributed in the etiology of lung injury and a risk factor in the development of idiopathic pulmonary fibrosis (IPF) in humans. Based on its physicochemical properties, environmental pollutant-induced pulmonary fibrosis can be developed after a particular type or dose of exposure. To date, some studies have focused on variant pollutants that are induced. However, the molecular mechanism of various pollutants to cause lung injury, which leads to pulmonary fibrosis, remained unexplored. Hence, this narrative review articles describe its molecular mechanism in generating pulmonary fibrosis comprehensively. It is helpful to portray the IPF pathogenesis and its drug discovery and development. Collectively, this article also revealed animal models which can be useful for IPF drug development research.
Dyspepsia: An Integrated Review of Diagnosis, Classification, and Mechanisms of Modern and Herbal Medications Solihat, Citra Kurnia; Rahmawati, Fita; Siswanto, Soni
Majalah Farmaseutik Vol 22, No 1 (2026): IN PRESS
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i1.105933

Abstract

Dyspepsia is a common and complex disorder characterized by symptoms such as epigastric pain, bloating, and early satiety, which significantly impact patients' quality of life. The pathophysiology of dyspepsia remains poorly understood, with multiple underlying factors including Helicobacter pylori infection, gastric motility disturbances, and visceral hypersensitivity. Modern therapeutic strategies primarily focus on acid suppression and motility enhancement, with Proton Pump Inhibitors (PPIs), H2 blockers, and prokinetic agents as standard treatments. The advent of novel therapies, such as potassium-competitive acid blockers (P-CABs) like Tegoprazan, offers promising alternatives with faster onset and longer-lasting effects. Herbal therapies, including turmeric, ginger, and licorice, have also been explored, showing potential benefits in symptom relief and gastric protection. Despite these advances, the effectiveness of treatment remains variable, and a tailored approach based on patient-specific factors is recommended. This review highlights the current treatment modalities, including both modern and traditional approaches, with a focus on pharmacological and non-pharmacological therapies for dyspepsia.
Co-Authors Agung Endro Nugroho Dyaningtyas Dewi Putri Pamungkas Fita Rahmawati Priyasana, I Putu Solihat, Citra Kurnia Wardhani, Bantari W.K. Yosi Bayu Murti