Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Komang Trisna Sumadewi
Anatomy and Histology Departement, Faculty of Medicine and Health Science, Universitas Warmadewa, Denpasar, Indonesia
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Effect of Annona muricata Leaf Extract on Hepatic Histopathology and Hepatocyte Index in a Diabetic Rattus norvegicus Model Dewa Ayu Agung Alit Suka Astini; Desak Putu Oki Lestari; Luh Gde Evayanti; Ni Putu Diah Witari; Komang Trisna Sumadewi; Fransiscus Fiano Anthony Kerans; Ida Ayu Laxmi Ananda Dewi Manuaba; Ni Made Gita Kusuma Dewi; Syaifiyatul H
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 2 (2026): VOLUME 27, NUMBER 2, August, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2722026127-133

Abstract

Background: The oxidative stress caused by diabetes mellitus (DM) damages hepatocytes and reduces liver function. In this context, flavonoids and acetogenins found in soursop (Annona muricata L.) leaf have hepatoprotective and antioxidant qualities. Therefore, this study aimed to assess the effect of Annona muricata leaf extract on hepatocyte index and hepatic histopathology in diabetic Wistar rats.Methods: In a laboratory experiment, 16 male Wistar rats weighing 100–150 g and aged 2-3 months were given a high-fat diet and an injection of streptozotocin (27.5 mg/kg BW) to induce type 2 diabetes. Rats were placed in a randomized posttest-only control group. For 21 days, these experimental animals were split into two groups at random, namely control (n = 8) receiving aquadest, and treatment group (n = 8) receiving Annona muricata leaf extract at a dose of 100 mg/kg BW. Hematoxylin-eosin staining was used to analyze hepatic histopathology, and a quantitative evaluation of hepatocyte index was conducted. The independent t-test and Mann-Whitney U test were adopted to assess the data. Results: There was a significant difference (p=0.041) in hepatocyte index between treatment and control groups. Treatment group had less hepatocyte deterioration than the control, according to histopathological scoring (p=0.037).Conclusion: Diabetic Wistar rats treated with Annona muricata leaf extract showed better hepatocyte index and decreased hepatic degeneration, suggesting hepatoprotective potential
Co-Authors Desak Putu Oki Lestari Fransiscus Fiano Anthony Kerans Ida Ayu Laxmi Ananda Dewi Manuaba Luh Gde Evayanti Ni Made Gita Kusuma Dewi Ni Putu Diah Witari, Ni Putu Suka Astini, Dewa Ayu Agung Alit Syaifiyatul H