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PERKIRAAN TINGGI BADAN BERDASARKAN TULANG PANJANG TUNGKAI KAKI PADA ANAK DI DENPASAR Dewa Ayu Agung Alit Suka Astini
E-Jurnal Medika Udayana Vol 11 No 5 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i5.P01

Abstract

Perkiraan tinggi badan yang merupakan bagian dari antropometri, berperan penting dalam rekonstruksi suatu profil biologis manusia pada antropologi forensik. Belum terdapat cara yang baku untuk perkiraan tinggi badan berdasarkan jenasah yang belum teridentifikasi. Tujuan penelitian ini adalah untuk mengembangkan model perkiraan tinggi badan dengan menggunakan panjang tulang tungkai kaki pada anak. Metode penelitian menggunakan desain observasional dengan pendekatan studi cross sectional. Subjek sejumlah 140 anak dipilih secara systematic random sampling. Untuk pengukuran tinggi badan digunakan ZT-120 Health Scale, sedangkan untuk pengukuran panjang tulang tingkai kaki digunakan spreading caliper. Perkiraan tinggi badan menggunakan model regresi linier dengan panjang tulang tungkai kaki sebagai prediktor. Hasil penelitian menunjukkan terdapat dua tulang sebagai prediktor yaitu tulang fibula kanan dan fibula kiri dengan koefisien regresi 0.916 (±4.74.78; p<0.01) dan 0.915 (±4.7820; p<0.01) secara berurutan untuk perkiraan tinggi badan pada anak. Simpulan penelitian ini adalah tulang fibula kanan dan fibula kiri dapat digunakan memperkirakan tinggi badan pada anak. Kata kunci: tulang panjang, tinggi badan, fibula, anak, tungkai.
THE EFFECT OF NOISE EXPOSURE ON THE AVERAGE NUMBER OF TEMPORAL LOBUS NEURONS IN ADULT WISTAR RATS Suka Astini, Dewa Ayu Agung Alit; Evayanti, Luh Gde; Witari, Ni Putu Diah; Sumadewi, Komang Trisna; Prima Dewi, A.A.A Asri; Anthony Kerans, Fransiscus Fiano; Kurniawati, Ida
E-Jurnal Medika Udayana Vol 13 No 07 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i07.P09

Abstract

Noise is defined as unwanted and disruptive sound, considered an environmental stressor and disturbance. Noise encompasses many aspects of modern communities, including work environments. The damaging effects of noise primarily result from the unrestricted production of free radicals into the auditory organs. Exposure to noise causes various health problems, such as hearing impairment, sleep disturbances, and interference with individual performance. Reactive oxygen species (ROS), also known as free oxygen radicals, are normal by-products of cellular aerobic metabolism. These unstable molecules can damage cellular lipids, proteins, and nucleic acids in DNA if the antioxidant balance is disrupted. Acute and chronic exposure to loud noise generates excessive free radicals and disrupts extra-auditory organs such as the nervous, endocrine, and cardiovascular systems. The purpose of this study is to analyze the relationship between noise exposure and the number of neurons in the temporal lobes of Wistar rats. The research design used is a laboratory experimental design, specifically a pure experimental design, implemented with the randomized posttest-only control group design. The research sample consists of 30 male Wistar rats randomized into 2 groups, control and treatment. The treatment group is exposed to 95dB noise for 4 hours per day for 14 days. The rats are then euthanized, and their brain tissue is fixed with 10% neutral buffered formalin. Assessment is performed using Hematoxylin Eosin staining, and analysis is conducted blindly on the average number of neurons in the rat's temporal lobes. Data is subjected to normality testing using the Shapiro-Wilk test and analyzed using independent t-tests for parametric comparison. The results show a significant difference in the mean number of neurons in the temporal lobes between rats exposed to noise and the control group (p <0.005). The conclusion of this study is that noise affects neuron cells in the temporal lobes. Keywords : noise, temporal lobe, neurons.
EVALUATING THE EFFECTIVENESS OF ANATOMY AND HISTOLOGY PRACTICUM DURING COVID-19 PANDEMIC AT FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS WARMADEWA Evayanti, Luh Gde; Sumadewi, Komang Trisna; Witari, Ni Putu Diah; Suka Astini, Dewa Ayu Agung Alit; Kerans, Fransiscus Fiano Anthony; Dewi, A.A.Ayu Asri Prima; Ekayani, Ni Wayan Diana
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P11

Abstract

The implementation of anatomy and histology practical sessions at Fakultas Kedokteran dan Ilmu Kesehatan (FKIK) Universitas Warmadewa during the Covid-19 pandemic still has many variations. This difference in implementation will have an influence on the achievement of student learning. This research aims to evaluate the knowledge of anatomy and histology among students by giving asynchronous learning, pre-test, post-test and practicum exam. This study using cross-sectional approach. 124 participants are 3th semester students whose active status at FKIK Universitas Warmadewa. The primary data were collected directly from practical sessions and practicum exam. The pre-test and post-test data were analyzed using paired-T test (p<0.05). The post-test and practicum exam were analyzed using Spearman rho (p<0.05). In anatomical practicum, there is an increase in post-test scores when compared to pre-test although not significant (p = 0.119). Anatomical practicum exam results have a meaningful positive correlation with post-tests (p = 0.013, r = 0.22). In histological practicum there was a significant increase in post-test scores when compared to pre-tests (p = 0.013), although practicum exam results were not significantly correlated with post-test (p = 0.410). Based on this study, improvements are needed related to technical of anatomical and histological practicums, as well as provisions related to practicums so that activities are structured
The Relationship between Body Mass Index and Blood Pressure Control in Hypertension Patients at the Sukawati I Community Health Center, Gianyar Regency Tjahyadi, I Gede Ketut Deny Patmantha Putra; Budhitresna, Anak Agung Gede; Suka Astini, Dewa Ayu Agung Alit
Jurnal Ilmu Kesehatan dan Kesehatan Vol 8 No 02 (2024): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v8i02.4580

Abstract

Background: Being overweight or obese is one of the factors that cause an increase in blood pressure. The bigger a person's body, the more blood is needed to supply nutrients and oxygen to other tissues and muscles. Bali Province, especially Gianyar Regency, has a relatively high number of hypertension sufferers. The highest estimate of hypertension sufferers is in the working area of the Sukawati I Public Health Center, with a prevalence of 8.55% of the total in Gianyar Regency of 17.35%. This research aims to determine the relationship between body mass index and blood pressure control in hypertensive patients at the Sukawati I Public Health Center, Gianyar Regency. Methods: The research design used was analytic observational with a crosssectional approach. The number of research subjects, namely 83 people, was taken by consecutive sampling technique. Data analysis will be carried out univariately and bivariate using the chi-square test method with a confidence level of 95% (p < 0.05). Results: The results of the univariate analysis showed that the majority of study subjects were aged 51-60 years (60.2%), were female (66.3%), most had normal BMI (66.3%), and 66.3% of subjects with hypertension were classified as have controlled blood control. Based on the results of statistical tests, a value of p = 0.003 (p < 0.05) was obtained, which indicated a significant relationship between body mass index and blood pressure control in hypertensive patients at the Sukawati I Public Health Center, Gianyar Regency. Conclusion: The results of this study indicate that the increasing BMI status of hypertensive patients will tend to have uncontrolled blood pressure.
Hematology Profiles in Colorectal Cancer Patients in Bali Kurniawati, Ida; Dewi, Anak Agung Ayu Asri Prima; Kerans, Fransiscus Fiano Anthony; Witari, Ni Putu Diah; Adyasputri, A A I Ayesa Febrinia; Sueta, Made Agus Dwianthara; Sumadewi, Komang Trisna; Evayanti, Luh Gde; Astini, Dewa Ayu Agung Alit Suka
Jurnal Ilmiah Kesehatan Vol 18 No 01 (2025): Jurnal Ilmiah Kesehatan (Journal of Health Science) 
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/jhs.v18i01.6936

Abstract

Colorectal cancer is a leading cause of cancer-related deaths worldwide. This study explores blood profile and cancer staging in colorectal cancer patients in Bali. It was a descriptive-analytical study that collected demographic and clinical data from medical records of colorectal cancer patients at Prof. Dr. I.G.N.G. Ngoerah Hospital. The results of the study showed the basic characteristics and hematology profiles of 100 colorectal cancer patients. The average age of patients was 55.6 ± 11.4 years, with 54% of the total sample being male. The average body mass index (BMI) was 21.1 ± 3.6 kg/m², with an average height of 161.9 ± 6.1 cm and an average weight of 55.3 ± 10.0 kg. Laboratory tests revealed an average hemoglobin (Hb) level of 11.0 ± 3.6 g/dL, red blood cell count of 4.0 ± 0.9 million/μL, white blood cell count of 11.2 ± 7.3 thousand/μL, and platelet count of 302.8 ± 154.8 thousand/μL. The average hematocrit (HCT) level was 33.7 ± 6.6 L/L. Liver function parameters indicated average aspartate aminotransferase (AST/SGOT) levels of 45.6 ± 63.6 U/L and alanine aminotransferase (ALT/SGPT) levels of 24.6 ± 29.4 U/L. Renal function was described by an average blood urea nitrogen (BUN) level of 21.8 ± 21.0 mg/dL, urea levels of 21.9 ± 21.2 mg/dL, and creatinine levels of 2.3 ± 11.5 mg/dL. Our study highlights the importance of hematology profiles in colorectal cancer patients as part of cancer screening examination. Further study with a larger number of samples and more diverse populations is needed to analyze the relation between variables.
The Role of Antioxidant Therapy in the Management of Type 2 Diabetes Mellitus: A Literature Review Astini, Dewa Ayu Agung Alit Suka; Yasa, I Wayan Putu Sutirta; Jawi, I Made; Wande, I Nyoman
Review of Primary Care Practice and Education Vol 8, No 1 (2025): January
Publisher : Faculty of Medicine, Public Health, and Nursing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/rpcpe.104276

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease and has become a global problem due to the rapid increase in the number of cases. This disease is characterized by chronic hyperglycemia caused by insulin resistance and pancreatic beta cell dysfunction. The occurrence of oxidative stress is known to play a central role in the development of T2DM complications, through increased reactive oxygen species (ROS) that worsen insulin resistance, worsen beta cell function, and trigger complications such as cardiovascular complications, nephropathy, and neuropathy. Objectives: This literature review aims to evaluate the scientific evidence supporting the use of antioxidant therapy as an additional approach in the management of T2DM, focusing on the effectiveness and mechanism of action of antioxidant compounds on glycemic parameters, oxidative stress, and diabetes complications. Methods: A literature search was conducted through databases on ScienceDirect, PubMed, and Google Scholar, with the keywords "antioxidant therapy", "type 2 diabetes mellitus", "oxidative stress", and "diabetes management". The selected articles included in vitro, in vivo studies, and clinical trials published in the period 2013-2023. Literature review focused on the biochemical mechanisms of antioxidant compounds and clinical outcomes related to glycemic parameters and diabetes complications. The literature extraction process was carried out from January to March 2024. Results: Supplementation of vitamin D, vitamin E, vitamin C, polyphenols, saponins, and flavonoids has been proven to reduce blood glucose levels and increase insulin sensitivity in type 2 diabetes mellitus. The mechanism involves increasing antioxidant activity, regulating glucose homeostasis, as well as modulating signaling pathways such as AMPK, PPAR, and GLUT4. Conclusions: This bioactive compound has potential as an adjunct therapy in the management of type 2 diabetes mellitus by targeting oxidative stress and insulin resistance. Further research is needed to determine optimal dosage and long-term effectiveness.
The effect of soursop leaf extract on pancreatic beta cell count and fasting blood glucose in male wistar rats exposed to a high-fat diet and streptozotocin Astini, Dewa Ayu Agung Alit Suka; Gunawan, H Ari; Santoso, R Mochamad Wirono Aman; Andajani, Susilowati; Basori, Ahmad
Folia Medica Indonesiana Vol. 53, No. 1
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Based on some researches known that soursop leaf extract can improve beta cell injury. The aims of this study was to analyze the effect of soursop leaf extract on fasting blood glucose (FBG) and pancreatic beta cell number in male Wistar rats wich were exposed to a high-fat diet and streptozotocin. This study design is the only randomized posttest control group design. The total sample size is 50 male Wistar rats. The independent variable: high-fat diet, STZ, and soursop leaf extract; the dependent variable: pancreatic beta cells number, and FBG3. Data tested for normality with Kolmogorov-Smirnov (a=0.05) and tested of homogeneity with Levene (a =0.05). Comparison test between groups with Kruskal-Wallis (a=0.05), followed by Mann Whitney. Correlation test with Pearson (a=0.05) between dose of the soursop leaf extract and FBG3, and between dose and the number of pancreatic beta cells. The results of this study showed that the soursop leaf extract at a dose of 100 mg/kg and 150 mg/kg have an effect on fasting blood glucose levels and panreatic beta cells number;2)There is a significant negative correlation between the orograstric lavage of soursop leaf extract with FBG3 (r=-0.647;p<0.001), the increasing doses of soursop leaf extract, further lowering fasting blood glucose levels;3)There is a significant positive correlation between the orograstric lavage of soursop leaf extract with the number of pancreatic beta cells (r=0,759;p<0,001), the increasing doses of soursop leaf extract, further increasing pancreatic beta cells number. In conclusion, increasing doses of soursop leaf extract, further lowering fasting blood glucose and increasing the number of pancreatic beta cells.
Noise Exposure-Induced Functional Anatomical Changes: Impact on Superoxide Dismutase, Tumor Necrosis Factor-Alpha, and Adiponectin Suka Astini, Dewa Ayu Agung Alit; Luh Gde Evayanti; Sri Ratna Dewi
JURNAL KESEHATAN LINGKUNGAN Vol. 18 No. 1 (2026): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v18i1.2026.1-9

Abstract

Introduction: Environmental noise is a non-auditory stressor that can trigger inflammatory and oxidative responses in the body. Continuous noise exposure is associated with increased production of pro-inflammatory cytokines and reactive oxygen species (ROS). This can disrupt the body's cellular balance. This study aimed to determine the effects of chronic noise exposure on serum superoxide dismutase (SOD), tumor necrosis factor-alpha (TNF-α), and adiponectin levels in wistar rats. Methods: This study used a laboratory based experimental design, involving twenty-four adult male Wistar rats. The rats were randomly divided into two groups: a control group and a treatment group. The treatment group was exposed to 95 dB noise for four hours daily for 14 consecutive days, while the control group received no exposure. SOD, TNF-α, and adiponectin levels were determined using ELISA. The independent t-test was used for statistical analysis. Results and Discussion: TNF-α was significantly higher (p < 0.05) and adiponectin was significantly lower (p < 0.05) in the treatment group than in the control group. SOD levels did not differ significantly across groups (p > 0.05). Noise exposure causes metabolic and inflammatory disruptions, as evidenced by the rise in TNF-α and fall in adiponectin, but the SOD levels remain unchanged, suggesting a limited antioxidant response. Conclusion: An inflammatory response and decreased adiponectin were caused by noise exposure at 95 dB for 14 days, suggesting a possible risk of metabolic dysfunction. Nonetheless, the stability of SOD levels indicates that enzymatic antioxidant action is maintained in these circumstances.
Negative Impact of Noise Exposure on the Mean Number of Neurons in the Frontal Lobe of Adult Wistar Rats Evayanti, Luh Gde; Astini, Dewa Ayu Agung Alit Suka; Sumadewi, Komang Trisna; Witari, Ni Putu Diah; Wijaya, Putu Austin Widyasari; Ekayanti, Ni Wayan Sri; Ekayani, Ni Wayan Diana
Jambura Medical and Health Science Journal Vol 5, No 1 (2026): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v5i1.32905

Abstract

Introduction: Noise exposure can induce oxidative stress and alter neurotransmitter dynamics within the nervous system. This oxidative stress is also associated with structural changes in the layers of the cerebrum. However, the effects of noise exposure on neuronal populations remain inadequately understood. This study aims to quantify the mean number of neurons in the frontal lobe of Wistar rats subjected to noise exposure.Methods: This study utilized an experimental design characterized by a randomized post-test only control group framework. A total of 30 male Wistar rats were selected through simple random sampling and subsequently divided into two groups: a control group without treatment (C1, n=15) and an experimental group exposed to 95 dB noise (E1, n=15) for four hours daily. Following a two-week exposure period, their brain tissue was excised and preserved in 10% neutral buffered formalin. Histological assessment was conducted using Hematoxylin and Eosin staining to evaluate the mean number of neurons in the frontal lobe. Statistical analysis was performed using the independent T-test.Results: The mean number of neurons was 1053.33 ± 55.529 in the E1 group and 720.167 ± 61.135 in the C1 group. The mean neurons of the frontal lobe of Wistar rats in the E1 group ws lower than the C1 group significantly (P 0.001).Conclusion: Neuronal death in the frontal lobe resulting from noise-induced stress can induce structural alterations within this region, leading to detrimental effects on cognitive function and behavior. Keywords: Frontal lobe, neuron, noise, stress
Tingkat Stres Mahasiswa Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa selama Pembelajaran Daring pada masa Pandemi COVID-19 Nindya Ayu Wulandari; Dewa Ayu Agung Alit Suka Astini; I Wayan Eka Arsana
Aesculapius Medical Journal Vol 2 No 2 (2022): Agustus
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.2.2.2022.69 - 75

Abstract

Due to the COVID-19 pandemic, the government issued a social policy. Social restriction policy has forced the medical faculties around the world to change their conventional learning system into an online learning system. An online learning system may cause some problems due to limited network and a change in the assessment system. This can have an impact on the mental health of students. The purpose of this study was to determine the stress level of students from the Faculty of Medicine and Health Sciences at Warmadewa University during online learning in the midst of COVID-19 pandemic. The research was carried out in December 2021, where the learning system at the Faculty of Medicine and Health Sciences, Warmadewa University was still largely carried out online learning. A descriptive method with a cross sectional design was used, with a total of 110 subjects. Data were collected using the Medical Student Stressor Questionnaire. The data were analyzed by descriptive statistical analysis and presented as a frequency distribution table.The results showed that most of the students experienced moderate stress (46.4%). Based on age, the highest stress level was found in students aged 21 years old (57,6%). Based on gender, most of the stress levels obtained were higher in female students (52,5%). Based on the class, the highest stress level was found in 2018 class students (57,1%). This research shows that most of the students of the Faculty of Medicine and Health Sciences at Warmadewa University experienced moderate stress in the brave learning system during the COVID-19 pandemic, especially at the age of 21, female, and class 2018.
Co-Authors A A I Ayesa Febrinia Adyasputri A. A. Ayu Asri Prima Dewi A. A. S. Ayu Santhi Sueningrum A.A. Made Semariyani A.A.Ayu Asri Prima Dewi Aanak Agung Ayu Asri Prima Dewi Agus Praktyasa Anak Agung Ayu Asri Prima Dewi Anak Agung Ayu Asri Prima Dewi Anak Agung Ayu Asri Prima Dewi Anak Agung Ayu Asri Prima Dewi Anak Agung Ayu Asri Prima Dewi Anak Agung Gede Budhitresna Anak Agung Ngurah Agung Bayu Sutha Anak Agung Ngurah Agung Bayu Sutha Asri Prima Dewi AA Ayu Asri Prima Dewi, Anak Agung Ayu Basori, Ahmad Citra Udiyani Desak Putu Oki Lestari Dewa Ayu Ratna Juwita Dewi, A.A.Ayu Asri Prima Dewi, Anak Agung Ayu Asri Prima Ekayanti, Ni Wayan Sri Evayanti, Luh Gede Fransiscus Fiano Anthony Kerans Fransiscus Fiano Anthony Kerans Fransiscus Fiano Anthony Kerans Fransiscus Fiano Anthony Kerans Fransiscus Fiano Anthony Kerans Fransiscus Kerans Gede Agus Surya Pratama Gunawan, H Ari I Gusti Ngurah Putu Sana I Made Jawi I Nyoman Sueta I Nyoman Wande I Wayan Eka Arsana I Wayan Eka Arsana I Wayan Putu Sutirta Yasa I Wayan Sudiarta I Wayan Sudiarta I Wayan Suwitra Ida Ayu Laxmi Ananda Dewi Manuaba Ida Ayu Laxmi Ananda Dewi Manuaba Ida Ayu Laxmi Ananda Dewi Manuaba Ida Ayu Laxmi Ananda Dewi Manuaba Ida Ayu Laxmi Ananda Dewi Manuaba Ida Ayu Laxmi Ananda Dewi Manuaba Ida Kurniawati Ida Kurniawati Ida Kurniawati Ida Kurniawati Ida Kurniawati, Ida Indra Wijaya K Tangking Widarsa Kadek Agus Kurniawan Kadek Agus Wirya Sanjaya Putra Kadek Agus Wirya Sanjaya Putra Komang Nindya Ayu Wulandari Komang Permata Indah Sari Luh Gde Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Putri Wulandari dewi Made Adwitya Krisna Kinasih Made Dharmesti Wijaya Mira Mulya Dewi Cok Istri Agung Murdhana Putere, Sagung Putri Permana Lestari Ni Kadek Elmy Saniathi Ni Ketut Witri Nurcahyani Ni Luh Putu Putri Setianingsih Ni Made Gita Kusuma Dewi Ni Made Gita Kusuma Dewi Ni Made Gita Kusuma Dewi Ni Made Gita Kusuma Dewi Ni Made Gita Kusuma Dewi Ni Putu Diah Witari Ni Putu Diah Witari, Ni Putu Ni Putu Galih Prestina Neda Ni Putu Indah Kusumadewi Riandra Ni Wayan Armerinayanti, Ni Wayan Ni Wayan Diana Ekayani Ni Wayan Sri Ekayanti Ni Wayan Widhidewi Nia Calista Santoso Nindya Ayu Wulandari Pande Ayu Naya Kasih Permatananda Pratiwi, Anny Eka Prima Dewi, A.A.A Asri Putu Asih Primatanti Putu Asih Primatanti Putu Austin Widyasari Wijaya Putu Indah Budi Apsari dewi Ratna Juwita Rima Kusuma Ningrum Saktivi Harkitasari, Saktivi Sang Nyoman Suriana Santoso, R Mochamad Wirono Aman Sri Ratna Dewi Sudiarta I Wayan Sueta, Made Agus Dwianthara Susilowati Andajani, Susilowati Syaifiyatul H Tjahyadi, I Gede Ketut Deny Patmantha Putra Toddy Hendrawan Yupardhi, Toddy Hendrawan Trisna Sumadewi, Komang Trisnia, Putu Ayunda Winianti, Ni Wayan